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Space Biotechnology and Commercial Applications University of Florida

The Space Biotechnology and Commercial Applications grant was funded by NASA's Kennedy Space Center in FY 2002 to provide dedicated biotechnology and agricultural research focused on the regeneration of space flight environments with direct parallels in Earth-based applications for solving problems in the environment, advances in agricultural science, and other human support issues amenable to targeted biotechnology solutions. This grant had three project areas, each with multiple tasks. They are: 1) Space Agriculture and Biotechnology Research and Education, 2) Integrated Smart Nanosensors for Space Biotechnology Applications, and 3) Commercial Applications. The Space Agriculture and Biotechnology Research and Education (SABRE) Center emphasized the fundamental biology of organisms involved in space flight applications, including those involved in advanced life support environments because of their critical role in the long-term exploration of space. The SABRE Center supports research at the University of Florida and at the Space Life Sciences Laboratory (SLSL) at the Kennedy Space Center. The Integrated Smart Nanosensors for Space Biotechnology Applications component focused on developing and applying sensor technologies to space environments and agricultural systems. The research activities in nanosensors were coordinated with the SABRE portions of this grant and with the research sponsored by the NASA Environmental Systems Commercial Space Technology Center located in the Department of Environmental Engineering Sciences. Initial sensor efforts have focused on air and water quality monitoring essential to humans for living and working permanently in space, an important goal identified in NASA's strategic plan. The closed environment of a spacecraft or planetary base accentuates cause and effect relationships and environmental impacts. The limited available air and water resources emphasize the need for reuse, recycling, and system monitoring. It is essential to collect real-time information from these systems to ensure crew safety. This new class of nanosensors will be critical to monitoring the space flight environment in future NASA space systems. The Commercial Applications component of this program pursued industry partnerships to develop products for terrestrial use of NASA sponsored technologies, and in turn to stimulate growth in the biotechnology industry. For technologies demonstrating near term commercial potential, the objective is to include industry partners on or about the time of proof of concept that will not only co-invest in the technology but also take the resultant technology to the commercial market.

Phillips, Winfred↗

NASA Johnson Space Center Usability Testing and Analysis Facility (UTAF) Overview

The Usability Testing and Analysis Facility (UTAF) is part of the Space Human Factors Laboratory at the NASA Johnson Space Center in Houston, Texas. The facility provides support to the Office of Biological and Physical Research, the Space Shuttle Program, the International Space Station Program, and other NASA organizations. In addition, there are ongoing collaborative research efforts with external businesses and universities. The UTAF provides human factors analysis, evaluation, and usability testing of crew interfaces for space applications. This includes computer displays and controls, workstation systems, and work environments. The UTAF has a unique mix of capabilities, with a staff experienced in both cognitive human factors and ergonomics. The current areas of focus are: human factors applications in emergency medical care and informatics; control and display technologies for electronic procedures and instructions; voice recognition in noisy environments; crew restraint design for unique microgravity workstations; and refinement of human factors processes. This presentation will provide an overview of ongoing activities, and will address how the projects will evolve to meet new space initiatives.

Whitmore, M.↗

NASA Johnson Space Center Usability Testing and Analysis Facility (WAF) Overview

The Usability Testing and Analysis Facility (UTAF) is part of the Space Human Factors Laboratory at the NASA Johnson Space Center in Houston, Texas. The facility provides support to the Office of Biological and Physical Research, the Space Shuttle Program, the International Space Station Program, and other NASA organizations. In addition, there are ongoing collaborative research efforts with external businesses and universities. The UTAF provides human factors analysis, evaluation, and usability testing of crew interfaces for space applications. This includes computer displays and controls, workstation systems, and work environments. The UTAF has a unique mix of capabilities, with a staff experienced in both cognitive human factors and ergonomics. The current areas of focus are: human factors applications in emergency medical care and informatics; control and display technologies for electronic procedures and instructions; voice recognition in noisy environments; crew restraint design for unique microgravity workstations; and refinement of human factors processes. This presentation will provide an overview of ongoing activities, and will address how the projects will evolve to meet new space initiatives.

Whitmore, M.↗

NASA Johnson Space Center Usability Testing and Analysis facility (UTAF) Overview

The Usability Testing and Analysis Facility (UTAF) is part of the Space Human Factors Laboratory at the NASA Johnson Space Center in Houston, Texas. The facility performs research for NASA's HumanSystems Integration Program, under the HumanSystems Research and Technology Division. Specifically, the UTAF provides human factors support for space vehicles, including the International Space Station, the Space Shuttle, and the forthcoming Crew Exploration Vehicle. In addition, there are ongoing collaborative research efforts with external corporations and universities. The UTAF provides human factors analysis, evaluation, and usability testing of crew interfaces for space applications. This includes computer displays and controls, workstation systems, and work environments. The UTAF has a unique mix of capabilities, with a staff experienced in both cognitive human factors and ergonomics. The current areas of focus are: human factors applications in emergency medical care and informatics; control and display technologies for electronic procedures and instructions; voice recognition in noisy environments; crew restraint design for unique microgravity workstations; and refinement of human factors processes and requirements. This presentation will provide an overview of ongoing activities, and will address how the UTAF projects will evolve to meet new space initiatives.

Whitmore, Mihriban↗

Overview of the Graphical User Interface for the GERM Code (GCR Event-Based Risk Model

The descriptions of biophysical events from heavy ions are of interest in radiobiology, cancer therapy, and space exploration. The biophysical description of the passage of heavy ions in tissue and shielding materials is best described by a stochastic approach that includes both ion track structure and nuclear interactions. A new computer model called the GCR Event-based Risk Model (GERM) code was developed for the description of biophysical events from heavy ion beams at the NASA Space Radiation Laboratory (NSRL). The GERM code calculates basic physical and biophysical quantities of high-energy protons and heavy ions that have been studied at NSRL for the purpose of simulating space radiobiological effects. For mono-energetic beams, the code evaluates the linear-energy transfer (LET), range (R), and absorption in tissue equivalent material for a given Charge (Z), Mass Number (A) and kinetic energy (E) of an ion. In addition, a set of biophysical properties are evaluated such as the Poisson distribution of ion or delta-ray hits for a specified cellular area, cell survival curves, and mutation and tumor probabilities. The GERM code also calculates the radiation transport of the beam line for either a fixed number of user-specified depths or at multiple positions along the Bragg curve of the particle. The contributions from primary ion and nuclear secondaries are evaluated. The GERM code accounts for the major nuclear interaction processes of importance for describing heavy ion beams, including nuclear fragmentation, elastic scattering, and knockout-cascade processes by using the quantum multiple scattering fragmentation (QMSFRG) model. The QMSFRG model has been shown to be in excellent agreement with available experimental data for nuclear fragmentation cross sections, and has been used by the GERM code for application to thick target experiments. The GERM code provides scientists participating in NSRL experiments with the data needed for the interpretation of their experiments, including the ability to model the beam line, the shielding of samples and sample holders, and the estimates of basic physical and biological outputs of the designed experiments. We present an overview of the GERM code GUI, as well as providing training applications.

Kim, Myung-Hee↗

Southeast Ecological Observatory Network (SEEON) Workshop on Ecological Sensors and Information Technology. Report on Second SEEON Workshop

A fundamental goal of the new National Science Foundation (NSF) initiative National Ecological Observatory Network (NEON) is to provide timely and broad access to the ecological data collected at NEON sites. Information management and data collection will be critical components to achieving this goal and a successful NEON implementation. The Southeast Ecological Observatory Network (SEEON) working group recognized the importance of information management and sensor technology in its first planning workshop and recommended that interested parties in the region come together to discuss these subjects in the context of the needs and capabilities of a southeast regional ecological observatory network. In February 2004, 28 participants from 14 organizations including academic institutions, state and federal agencies, private and non-profit entities convened at the Space Life Sciences Laboratory (SLSL) at the Kennedy Space Center, Florida for two days of presentations and discussions on ecological sensors and information management. Some of the participants were previously involved in the first SEEON workshop or other meetings concerned with NEON, but many were somewhat new to the NEON community. Each day focused on a different technical component, i.e. ecological sensors the first day and cyber-infrastructure the second day, and were structured in a similar manner. The mornings were devoted to presentations by experts to help stimulate discussions on aspects of the focal topic held in the afternoon. The formal and informal discussions held during the workshop succeeded in validating some concerns and needs identified in the first SEEON workshop, but also served to bring to light other questions or issues that will need to be addressed as the NEON planning and design stages move forward. While the expansion of the SEEON community meant that some of the presentation and discussion time was needed to help bring the newcomers up to speed on the goals, objectives and current status of the various NEON efforts, the additional perspectives and technical expertise included in this workshop helped fuel some valuable interdisciplinary discussions that will need to continue to bring SEEON and NEON to fruition. Participants agreed that continued discussions of SEEON are needed , to keep up the momentum and that the southeast region must continue to be represented at the national level. It is vital that the all'the regions continue to push things forward for NEON to succeed.

Jones, Lori N.↗

SCaN Testbed Software Development and Lessons Learned

National Aeronautics and Space Administration (NASA) has developed an on-orbit, adaptable, Software Defined Radio (SDR)Space Telecommunications Radio System (STRS)-based testbed facility to conduct a suite of experiments to advance technologies, reduce risk, and enable future mission capabilities on the International Space Station (ISS). The SCAN Testbed Project will provide NASA, industry, other Government agencies, and academic partners the opportunity to develop and field communications, navigation, and networking technologies in the laboratory and space environment based on reconfigurable, SDR platforms and the STRS Architecture.The SDRs are a new technology for NASA, and the support infrastructure they require is different from legacy, fixed function radios. SDRs offer the ability to reconfigure on-orbit communications by changing software for new waveforms and operating systems to enable new capabilities or fix any anomalies, which was not a previous option. They are not stand alone devices, but required a new approach to effectively control them and flow data. This requires extensive software to be developed to utilize the full potential of these reconfigurable platforms. The paper focuses on development, integration and testing as related to the avionics processor system, and the software required to command, control, monitor, and interact with the SDRs, as well as the other communication payload elements. An extensive effort was required to develop the flight software and meet the NASA requirements for software quality and safety. The flight avionics must be radiation tolerant, and these processors have limited capability in comparison to terrestrial counterparts. A big challenge was that there are three SDRs onboard, and interfacing with multiple SDRs simultaneously complicatesd the effort. The effort also includes ground software, which is a key element for both the command of the payload, and displaying data created by the payload. The verification of the software was an extensive effort. The challenges of specifying a suitable test matrix with reconfigurable systems that offer numerous configurations is highlighted. Since the flight system testing requires methodical, controlled testing that limits risk, a nearly identical ground system to the on-orbit flight system was required to develop the software and write verification procedures before it was installed and tested on the flight system. The development of the SCAN testbed was an accelerated effort to meet launch constraints, and this paper discusses tradeoffs made to balance needed software functionality and still maintain the schedule. Future upgrades are discussed that optimize the avionics and allow experimenters to utilize the SCAN testbed potential.

radio communication↗

A New Blind Pointing Model Improves Large Reflector Antennas Precision Pointing at Ka-Band (32 GHz)

The National Aeronautics and Space Administration (NASA), Jet Propulsion Laboratory (JPL)-Deep Space Network (DSN) subnet of 34-m Beam Waveguide (BWG) Antennas was recently upgraded with Ka-Band (32-GHz) frequency feeds for space research and communication. For normal telemetry tracking a Ka-Band monopulse system is used, which typically yields 1.6-mdeg mean radial error (MRE) pointing accuracy on the 34-m diameter antennas. However, for the monopulse to be able to acquire and lock, for special radio science applications where monopulse cannot be used, or as a back-up for the monopulse, high-precision open-loop blind pointing is required. This paper describes a new 4th order pointing model and calibration technique, which was developed and applied to the DSN 34-m BWG antennas yielding 1.8 to 3.0-mdeg MRE pointing accuracy and amplitude stability of 0.2 dB, at Ka-Band, and successfully used for the CASSINI spacecraft occultation experiment at Saturn and Titan. In addition, the new 4th order pointing model was used during a telemetry experiment at Ka-Band (32 GHz) utilizing the Mars Reconnaissance Orbiter (MRO) spacecraft while at a distance of 0.225 astronomical units (AU) from Earth and communicating with a DSN 34-m BWG antenna at a record high rate of 6-megabits per second (Mb/s).

DSN↗

SRAG Measurements Performed During the Orion EFT-1 Mission

The Exploration Flight Test 1 (EFT-1) was the first flight of the Orion Multi-Purpose Crew Vehicle (MPCV). The flight was launched on December 5, 2014, by a Delta IV Heavy rocket and lasted 4.5 hours. The EFT-1 trajectory involved one low altitude orbit and one high altitude orbit with an apogee of almost 6000 km. As a result of this particular flight profile, the Orion MPCV passed through intense regions of trapped protons and electron belts. In support of the radiation measurements aboard the EFT-1, the Space Radiation Analysis Group (SRAG) provided a Battery-operated Independent Radiation Detector (BIRD) based on Timepix radiation monitoring technology similar to that employed by the ISS Radiation Environmental Monitors (REM). In addition, SRAG provided a suite of optically and thermally stimulated luminescence detectors, with 2 Radiation Area Monitor (RAM) units collocated with the BIRD instrument for comparison purposes, and 6 RAM units distributed at different shielding configurations within the Orion MPCV. A summary of the EFT-1 Radiation Area Monitors (RAM) mission dose results obtained from measurements performed in the Space Radiation Dosimetry Laboratory at the NASA Johnson Space Center will be presented. Each RAM included LiF:Mg,Ti (TLD-100), (6)LiF:Mg,Ti (TLD-600), (7)LiF:Mg,Ti (TLD-700), Al2O3:C (Luxel trademark), and CaF2:Tm (TLD-300). The RAM mission dose values will be compared with the BIRD instrument total mission dose. In addition, a similar comparison will be shown for the ISS environment by comparing the ISS RAM data with data from the six Timepix-based REM units deployed on ISS as part of the NASA REM Technology Demonstration.

Gaza, Ramona↗

Microbial Bioburden on NASA Cleanroom Surfaces: Cell Counting and Fluorescence in situ Hybridization

Spacecraft assembly cleanrooms can harbor a low number of microbial cells that could contaminate hardware designed for life detection missions (known as “bioburden”). We are evaluating epifluorescence microscopy and fluorescence in situ hybridization (FISH) as rapid, accurate, and cost-effective methods to complement other contamination detection techniques. This study is part of a larger effort to characterize background organic contamination and the efficacy of cleaning procedures in Johnson Space Center (JSC) Astromaterials Curation Laboratories and Goddard Space Flight Center (GSFC) spacecraft assembly rooms. The low level of biomass required careful use of blanks during each stage of sample collection and preparation. FISH was performed using general archaeal and bacterial probes, as well as some group-specific probes. While some active bacteria were identified, a large majority of them were dead or inactive, and thus were difficult to identify by standard FISH. Our results are consistent with other studies that show that the bioburden present in clean rooms includes active, dormant, and dead cells.

C J Huff↗

Spacecraft environments interactions: Protecting against the effects of spacecraft charging

The effects of the natural space environments on spacecraft design, development, and operation are the topic of a series of NASA Reference Publications currently being developed by the Electromagnetics and Environments Branch, Systems Analysis and Integration Laboratory, Marshall Space Flight Center. This primer, second in the series, describes the interactions between a spacecraft and the natural space plasma. Under certain environmental/spacecraft conditions, these interactions result in the phenomenon known as spacecraft charging. It is the focus of this publication to describe the phenomenon of spacecraft charging and its possible adverse effects on spacecraft and to present the key elements of a Spacecraft Charging Effects Protection Plan.

Herr, J. L.↗

The natural space environment: Effects on spacecraft

The effects of the natural space environments on spacecraft design, development, and operation are the topic of a series of NASA Reference Publications currently being developed by the Electromagnetics and Environments Branch, Systems Analysis and Integration Laboratory, Marshall Space Flight Center. This primer provides an overview of the natural space environments and their effect on spacecraft design, development, and operations, and also highlights some of the new developments in science and technology for each space environment. It is hoped that a better understanding of the space environment and its effect on spacecraft will enable program management to more effectively minimize program risks and costs, optimize design quality, and successfully achieve mission objectives.

James, Bonnie F.↗

TriTruss Packaging and Deployment Trade Study

An architecture and feasibility study of next generation In-Space Assembled Telescopes (iSAT) concluded that robotic in-space assembly of modular components is necessary to enable large (>15-meter diameter) primary apertures. The iSAT study recommended that the foundational structure be assembled from modular TriTruss modules that are packaged for launch, deployed on-orbit and robotically assembled into the final configuration. This paper will describe and summarize the results of a trade study that investigated viable concept of operations (ConOps) for the packaging and deployment (P&D) of individual planar TriTruss modules that could be assembled to form a large aperture iSAT. The ideal TriTruss P&D concept is defined as one that: allows for efficient packaging; has sufficient geometric versatility to be launch vehicle independent; provides a stiff and lightweight structure; has low mechanical complexity; and has component modularity. The P&D concept should allow for prelaunch subsystem or utility integration if required. The concept would be kinematically simple and be robotically deployed using a minimum number of specialized tools. In this first phase of an ongoing more comprehensive trade study, concepts were proposed and then evaluated based on initial metrics representing features of an ideal P&D concept. The P&D concepts evaluated are categorized as: core collapse, face collapse, and erectable structures. Sub-scale models were constructed to help understand the kinematics and mechanical complexity required to enable P&D. Based on a weighting scale, the most promising candidate P&D concepts have selected and will undergo more rigorous structural design, analysis, and testing in the study’s next phase. The ultimate goal of the comprehensive trade study will be to recommend a single TriTruss design and associated P&D concept that will be built and evaluated at NASA Langley Research Center’s In-Space Assembly Laboratory.

in-space assembly (ISA)↗

ASK Talks with Alex McCool

As a charter member at Marshall, McCool was instrumental in the design of the propulsion systems for the Saturn launch vehicles that propelled Apollo to the Moon and directed project engineering for Skylab, the first space science laboratory. Alex McCool's 48-year career includes exceptional contributions to the vehicles that launched America into orbit and carried human beings to the moon. Presently, he is the manager of the Space Shuttle Projects Office at Marshall. Among his many honors he recently received the National Space Club's 2002 Astronautics Engineer Award. The award recognizes those who have made outstanding contributions in engineering management to the national space program.

Source record↗

University Nanosatellite Program ION-F Constellation

The Space Engineering program at Utah State University has developed a small satellite, known as USUSat, under funding from AFOSR, AFRL, NASA and Utah State University's Space Dynamics Laboratory. This satellite was designed and significantly manufactured by students in the Mechanical and Aerospace Engineering and the Electrical and Computer Engineering Departments within the College of Engineering. USUSat is one of three spacecraft being designed for the Ionospheric Observation Nanosatellite Formation (ION- F). This formation comprises three 15 kg. spacecraft designed and built in cooperation by Utah State University, University of Washington, and Virginia Polytechnic Institute. The ION-F satellites are being designed and built by students at the three universities, with close coordination to insure compatibility for launch, deployment, and the formation flying mission. The JON-F mission is part of the U.S. Air Force Research Laboratory (AFRL) University Nanosatellite Program, which provides technology development and demonstrations for the TechSat2l Program. The University Nanosatellite Program involves 10 universities building nanosatellites for a launch in 2004 on two separate space shuttle missions. Additional support for the formation flying demonstration has been provided by NASA's Goddard Space Flight Center.

NANOSATS (NANOSATELLITES)↗

The NASA Biological Institutional Scientific Collection (NBISC): Tissue and Microbe Biospecimens to Advance Space Research

The NASA Biological Institutional Scientific Collection (NBISC) is a biorepository of non-human biospecimens from NASA-funded spaceflight investigations and correlative ground studies. The collection has its roots in the 1960s through collaborations by NASA Ames Research Center with other NASA centers, universities, and international space agencies by sharing non-human biospecimens from spaceflight and space-relevant ground experiments. These collaborations have advanced the field of space exploration by helping to maximize the data gained from spaceflight and other NASA-funded experiments. NBISC coordinates closely with the Biospecimen Sharing Program (BSP) which is responsible for organized sample collection from spaceflight and ground rodent experiments. In 2022 NBISC partnered with HRP’s Biospecimen and Tissue Sharing Collection (BTSC) Program to also archive samples from HRP’s Space Radiation Element-funded studies which primarily involve rodents exposed to various radiation protocols at the NASA Space Radiation Laboratory (NSRL) and other analog facilities. To date, more than fifty thousand biospecimens from BTSC have been transferred to NBISC for distribution to the community. In 2023, NBISC embarked on a new Space Biology funded endeavor to create the Space Microbial Culture Collection (SMCC) which will serve as a central repository for microbial isolates associated with space flight, gravitational, and space radiation research. This presentation will highlight several success stories of analyses carried out using archived NBISC samples received by researchers in recent years and will detail the process for proposing and receiving samples from NBISC, BTSC and SMCC. Making available these 150,000+ unique biospecimens to the scientific research community, NBISC not only serves as a repository for storing and distributing non-human biospecimens, but also acts as a resource to enable new discoveries that will benefit NASA and humankind.

NBISC↗

The NASA Biological Institutional Scientific Collection (NBISC): Tissue and Microbe Biospecimens to Advance Space Research

The NASA Biological Institutional Scientific Collection (NBISC) is a biorepository of non-human biospecimens from NASA-funded spaceflight investigations and correlative ground studies. The collection has its roots in the 1960s through collaborations by NASA Ames Research Center with other NASA centers, universities, and international space agencies by sharing non-human biospecimens from spaceflight and space-relevant ground experiments. These collaborations have advanced the field of space exploration by helping to maximize the data gained from spaceflight and other NASA-funded experiments. NBISC coordinates closely with the Biospecimen Sharing Program (BSP) which is responsible for organized sample collection from spaceflight and ground rodent experiments. In 2022 NBISC partnered with HRP’s Biospecimen and Tissue Sharing Collection (BTSC) Program to also archive samples from HRP’s Space Radiation Element-funded studies which primarily involve rodents exposed to various radiation protocols at the NASA Space Radiation Laboratory (NSRL) and other analog facilities. To date, more than fifty thousand biospecimens from BTSC have been transferred to NBISC for distribution to the community. In 2023, NBISC embarked on a new Space Biology funded endeavor to create the Space Microbial Culture Collection (SMCC) which will serve as a central repository for microbial isolates associated with space flight, gravitational, and space radiation research. This presentation will highlight several success stories of analyses carried out using archived NBISC samples received by researchers in recent years and will detail the process for proposing and receiving samples from NBISC, BTSC and SMCC. Making available these 150,000+ unique biospecimens to the scientific research community, NBISC not only serves as a repository for storing and distributing non-human biospecimens, but also acts as a resource to enable new discoveries that will benefit NASA and humankind.

Biospecimen↗