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NASA NTRSDate not supplied

MicroRNA Based Countermeasure Rescue Health Risks Associated with Space Radiation and Microgravity

From our earlier work, we demonstrated a circulating microRNA (miRNA) signature that is present and involved with the general increased health risks during spaceflight. From this work we demonstrated that this miRNA signature impacted the overall biology and health with both the microgravity and space radiation components of the space environment. We showed that this miRNA signature can be an optimal biomarker for health risk and also has potential to be utilized as a countermeasure to mitigate the damage caused by the space environment by utilizing a human 3D microvascular tissue model. By applying a novel self-delivery system to target 3 miRNAs (i.e. antagomirs) from our spaceflight miRNA signature impacting cardiovascular health risks, we were able to completely mitigate damage caused by exposure to simulated Galactic Cosmic Ray (GCR) irradiation. Here we further expand on the countermeasure experiments to uncover the specific novel biology involved with this countermeasure and in vivo experiments that demonstrates that these antagomirs rescue damage caused to certain organs due to both microgravity and space radiation. Specifically, the miRNAs rescued damage to the heart and immune suppression that occurred in addition to other key biology. In addition, we have also observed with the 3D microvascular tissue model improved DNA double strand break repair machinery which can also contribute to improved recovery and protection against damage caused by space radiation. This work expands on our previous work and further uncovers how a potential minimally invasive countermeasure can be used to mitigate space environment effects.

Angela Kubik↗

NASA NTRSDate not supplied

Indirect Magnetic Measurements on the Aerodynamic Heating Facility (AHF)

The arc jet complex at NASA Ames Research Center (ARC) investigates various thermal protection systems (TPS) and their performance in high enthalpy flow environments to improve heat shields used in atmospheric entry. The arc jet operates by inducing an arc between two electrodes and passing the heated gas through a supersonic nozzle. The arc plasma is typically a partially ionized air mixture at low temperature (< 2 eV) but operates for long periods of time (up to 30 min) at high power (< 60 MW). However, simulations using the in-house ARC Heater Simulator (ARCHeS) code predict that the arc is still unstable to MHD instabilities, primarily the kink instability, which limit the operational envelope of the facility [1]. Consequently, it is important to better characterize these instabilities to improve facility stability and extend operational ranges. Due to the high enthalpy and long timescales (i.e., minutes) arc diagnostics must be non-invasive (i.e., optical or magnetic). This work will cover the development of tri-axial magnetic hall sensors for arc jet instabilities and subsequent 3D characterization of arc motion. The latest results describing the kink instability amplitude, frequency and wavelength will be presented and represent the first measurements of this instability in a NASA arc jet facility. References: [1] Meurisse, J. (2018). 3D Unsteady Model of Arc Heater Plasma Flow Using the ARC Heater Simulator (ARCHeS), APS Gaseous Electronics Conference, 2018: APS.

Sebastian Vicente Colom↗

NASA NTRSDate not supplied

Auxetic Thermo-Responsive Shape-Memory Polyurethane Aerogels

Shape memory polymer aerogels are stimuli-responsive aerogel materials that incorporate polymer aerogel characteristics such as flexibility at low density, and high porosity with shape-changing capabilities upon exposure to external stimuli. By designing the structure of these materials at meso- to macroscale, their shape memory response can be efficiently engineered to show an auxetic response such as a negative Poisson’s ratio, leading to an active and tunable metamaterial. We present a material technology based on a shape memory polyurethane aerogel derived from aliphatic triisocyanate and triethylene glycol, which demonstrates and remembers an auxetic shape change through a thermomechanical cycle first below, and then back again above the glass transition temperature of the polyurethane. Our auxetic shape memory polyurethane aerogels exhibit a significant auxetic response with a negative Poisson’s ratio of approximately -0.8 at 15% compressive strain. This technology is expected to impact multiple areas of interest in relation to commercial, aeronautic, and aerospace industries. Potential applications include minimally invasive medical technologies, soft robotics, and self-deployable structures and habitats. Structure-property relationships of the auxetic shape memory polymer aerogels will be discussed.

Sadeq Malakooti↗

NASA NTRS2021

Colorado Ecological Forecasting: Monitoring Post-fire Cheatgrass (Bromus tectorum) Distribution to Inform Management Planning

Cheatgrass (Bromus tectorum) is a species of concern across the western United States as it has the potential to outcompete native plant species, reduce biodiversity, and diminish nutrient availability for ungulates. Furthermore, because cheatgrass can quickly dominate disturbed landscapes it has the potential to exacerbate wildfire risk by increasing fuel loads. In 2020, the Cameron Peak fire burned more than 200,000 acres on the Arapaho and Roosevelt National Forests in Colorado. These issues are of imminent concern for our partners at the Forest Service (USFS), as they are tasked with wildfire risk and invasive species mitigation. Disturbances such as wildfires can substantially increase the rate and extent of cheatgrass spread. Current cheatgrass mitigation methods rely on field crews to physically locate cheatgrass on the landscape, which takes time, money, and extensive manpower. Here, we developed two Random Forest models within the Software for Assisted Habitat Modeling (SAHM) using remote sensing predictors derived from Sentinel-2 MultiSpectral Instrument (MSI) and Shuttle Radar Topography Mission (SRTM). The first model identified suitable cheatgrass habitat while the other detected cheatgrass presence during the 2021 growing season. Topographic variables were found to be the most important in driving the habitat suitability model. Cheatgrass detection was also found to be possible within a short timespan with limited imagery surrounding a phenological shift of the plant. Maps produced from these models provide natural resource managers the ability to implement early detection and rapid response to prevent the spread of cheatgrass to new locations.

DEVELOP Tech Paper↗

NASA NTRS2021

Meta-aerogels: Auxetic Shape-memory Polyurethane Aerogels

Shape-memory poly(isocyanurate-urethane) (PIR-PUR) aerogels are low-density monolithic nanoporous solids that remember and return to their permanent shape through a heating actuation step. Herein, through structural design at the macro scale, the shape-memory response is augmented with an auxetic effect manifested by a negative Poisson’s ratio of approximately -0.8 at 15% compressive strain. Thus, auxetic shape-memory PIR-PUR monoliths experience volume contraction upon compression at a temperature above the glass transition temperature of the base polymer (Tg ~ 30 °C), and they can be stowed indefinitely in that temporary shape by cooling below Tg. By heating back above Tg, the compressed/shrunk form expands back to their original shape/size. This technology is relevant to a broad range of industries spanning the commercial, aeronautical, and aerospace sectors. The materials are referred to as meta-aerogels and their potential applications include minimally invasive medical devices, soft robotics, and in situations where volume is at a premium, as for example for storage of deployable space structures and planetary habitats during transport to the point of service.

Sadeq Malakooti↗

NASA NTRSDate not supplied

Method Development for In-situ Detection of Latent Herpesvirus DNA from Saliva using Nanopore Sequencing

Research toward latent herpesvirus reactivation has been intensively addressed through Space Shuttle and International Space Station (ISS) investigations. This work has provided the understanding that persistent reactivation of herpesviruses from asymptomatic crew can be detected through viral shedding in saliva, urine, and blood. Occasionally, viral reactivation from the latency stage can pose a threat to crew health (clinical manifestation) before, during, and after flight missions. Furthermore, previous work detailing correlations with immunity indicate that monitoring viral reactivation could be implemented to assess potential immune dysfunction. While in-flight monitoring is desirable, there is no well-established procedure or method for real-time evaluations, and research to date has relied on postflight, ground-based analysis. The development of portable molecular technologies like the miniPCR™ (miniPCR Bio) thermal cycler and the MinION™ sequencer (Oxford Nanopore Technologies) have confirmed that real-time monitoring is possible in extreme and low resource environments. These devices, combined with simple sample preparation methods, have been used to demonstrate bacterial identification onboard the ISS, as well as rapid viral detection in remote locations on Earth. The work here builds upon previous molecular advancements onboard the ISS toward the development and validation of a spaceflight-compatible method for viral detection from crew samples. Several herpesviruses can be detected in saliva, which provides a non-invasive means to collect samples for monitoring. While the basis for this method lies in previous spaceflight investigations, key points for method optimization include DNA extraction from saliva, viral primer selection, and bioinformatic processes for data analysis. To increase viral yield, numerous DNA extraction methods have been evaluated and will be discussed in detail. For initial development and testing, varicella-zoster virus (VZV) is being targeted though open reading frame 51 and 63 (ORF51, ORF63), as the replication origin-binding protein is highly expressed during latency. Optimization of the thermal cycling parameters has resulted in the ability to test the entire process. The full method has been tested with both viral VZV DNA standards and saliva spiked with varying concentrations of VZV. Viral sequence data were mapped to the reference sequence using minimap2. Prior to mapping, DNA sequencing reads were filtered for length and quality, barcodes were removed, and alignment identity calculated. Following further assessments, statistics were compared across multiple sequencing experiments and are being used to determine the success of the protocols. Forward work will include the incorporation of herpes simplex virus 1 (HSV-1) and Epstein-Barr virus (EBV) primers as well as the validation of results to the terrestrial qPCR standard assay. Upon full validation of the developed method, saliva will be collected from 20 healthy subjects and spiked with viral DNA. These samples will be split and assayed with the MinION and standard qPCR assay.

Hang N Nguyen↗

NASA NTRSDate not supplied

Electromagnetic Pain Relief/Blocking: Feasibility Assessment

CONTEXT/BACKGROUND Astronauts use pharmaceuticals during spaceflight to manage acute and chronic pain, but use of analgesics will have drawbacks for exploration-class missions because the shelf life of these medications is limited, resupply will be curtailed, astronauts may develop tolerance and/or addiction to these medications, and side effects can include impairment of cognitive abilities. Electromagnetic devices have been developed that treat pain terrestrially by affecting neuromodulation–dubbed “electroceuticals”, these devices have varied mechanisms of action that either stimulate or suppress neural activity in the central nervous system or peripheral nerves. OBJECTIVE/PURPOSE The available literature was reviewed and FDA-approved pain treatments (both pharmacological and non-pharmacological), as well as those currently under development, were assessed for their suitability for use in exploration class spaceflight missions. DATA SOURCES Due to the COVID-19 pandemic and the resulting closure of libraries, data sources were restricted to those available digitally. Online database searches included PubMed, U.S. Patent and Trademark Office, federal grant award databases (National Aeronautics and Space Administration (NASA), Department of Defense (DoD), National Institutes of Health (NIH)), and general internet searches. More than 1,600 records were reviewed in this effort. STUDY SELECTION/ELIGIBILITY CRITERIA Targeted searches included different aspects of pain management. Priority was given to review studies, to cover as much of the available literature as possible in this limited effort. STUDY APPRAISAL AND SYNTHESIS METHODS/DATA EXTRACTION AND DATA SYNTHESIS The titles of the studies and the awards that were obtained by searching online databases were reviewed and further information was sought for the relevant titles. Abstracts or award summaries were generally available online; for journal abstracts, full text articles were either available online or were requested via interlibrary loan. RESULTS An overwhelming majority of the literature focuses on the treatment of chronic rather than acute pain because it is assumed that acute pain only rarely fails to resolve and instead transitions into chronic pain when the central nervous system becomes hypersensitized. The available electromagnetic devices marketed for pain treatment have varying levels of invasiveness, use different mechanisms of action, and have demonstrated varying efficacy when evaluated scientifically. A truly noninvasive, highly efficient device is desired for use during spaceflight. One portable, self-contained, FDA-approved device was identified that, from preliminarily assessment, best met these criteria; the device noninvasively applies pulsed shortwave therapy (PSWT) to modify pain signals from peripheral nerves, however, the device has limited battery life and the effects are relatively non-selective in type of neural signal modified. LIMITATIONS This current effort, although extensive, did not identify a comprehensive list of all alternatives for pain treatment. Once the pandemic limitations are lifted, a longer, more thorough effort may find additional options. CONCLUSIONS/IMPLICATIONS The ideal electromagnetic pain treatment device for use on exploration-class spaceflight missions does not yet exist, but it may be available soon. It is not feasible for NASA to develop medical devices due to the schedule constraints for pending exploration-class missions, but adapting a promising device that is already FDA-approved might be an option. Monitoring research that is ongoing at other federal agencies is recommended, and further review of the candidate PSWT device identified in this current effort may be warranted.

C A Mullenax↗

NASA NTRSDate not supplied

Space-Cent: Studying the Physiological and Anatomical Effects of Centrifugation and Head Down Tilt: 2021 Update

BACKGROUND The objective of this study was to evaluate the cerebral and ocular physiological and anatomical effects of head-down tilt bedrest (HDBR) with and without daily artificial gravity (AG) in healthy subjects to provide novel insights into possible countermeasures for the Spaceflight Associated Neuro-ocular Syndrome (SANS). Previous long-term studies using the spaceflight analog of strict 6° HDBR for 30 days revealed changes in ocular structure, including optic disc edema. The effects of an AG countermeasure using intermittent centrifugation to restore upright hydrostatic gradients and reduce the ocular and brain anatomical effects has not been explored. METHODS The effects of 60-day exposure to simulated microgravity (6° HDBR) on the cerebral, ocular and vestibular systems with and without the intervention of daily 30 minute exposure to AG (short-arm centrifugation) was evaluated in 24 healthy subjects. Non-invasive measurements of cerebral blood flow, intracranial blood volume (near infrared spectroscopy, NIRS), cerebral and ocular structure (MRI and optical coherence tomography), internal jugular vein area (ultrasound), lateral ventricular volumes (MRI), intraocular pressure, and sensorimotor/vestibular (i.e. balance and coordination) systems were made during various time-points during the bedrest study. Additional measures with ultrasound and NIRS were made during centrifugation. RESULTS The study began in Spring 2019 and all 24 subjects completed the testing by end of 2019. Data analysis continues. We report the following updated results for 2021. MRI showed significant decreases in carotid artery flow, increases in brain and CSF volumes, and aqueductal flow velocities in all subjects in HDT compared to baseline supine, but no effects of the short duration AG. All groups showed increased posterior globe flattening during bedrest compared to baseline, without protection from AG. As previously reported we observed chorioretinal folds for the first time in a bedrest analog, as well as optic disc edema, with no protection from the short-term AG. Data from the study is now being transmitted to the NASA LSDA which will allow for future research. CONCLUSIONS The 6 degree HDBR analog produced significant changes in the anatomical and physiological functions of the brain and eye in healthy subjects. Daily 30 minute exposure to AG with short-arm centrifugation had significant transient effects on physiology of the cerebrovascular system, but was not sufficient to prevent the anatomical effects of HDBR on the brain and eye.

E M Bershad↗

NASA NTRSDate not supplied

microRNA Based Countermeasure Mitigate Health Risks Associated with Space Radiation and Microgravity

Afshin Beheshti↗

NASA NTRSDate not supplied

Magnetic Measurements of Arc Instabilities in Segmented Arc Heater Column

The Aerodynamic Heating Facility (AHF) at NASA Ames Research Center (ARC) generates high enthalpy, supersonic flow environments for ground testing of NASAheat shield materials. This arc jet heater operates by passing a DC arc (<3200A,<2500V) through a gas column (~10cm diameter, 2m length) and ejecting the heatedgas through a supersonic nozzle into a test chamber. The arc plasma is a partially ionized air mixture at low temperature (< 2eV) but needs to be stable for long test times (up to 30min) at high power (< 20MW). Currently, the operational envelope of the facility is limited by arc instabilities including the kink instability. Consequently, it is of interest to characterize these instabilities to better understand facility limits and inform methods to extend stable operational ranges. Due to the high enthalpy and long timescales (i.e., minutes) diagnostics must be non-invasive. This work will cover the development of two sets of magnetic sensors: differential B-dot sensors and tri-axial magnetic hall sensors and will describe initial measurements of arc motion usingthese sensors.

Kink instability↗

NASA NTRS2022

Role of RpoS in regulating stationary phase Salmonella Typhimurium pathogenesis-related stress responses under physiological low fluid shear force conditions

The discovery that biomechanical forces regulate microbial virulence was established with the finding that physiological low fluid shear (LFS) forces altered gene expression, stress responses, and virulence of the enteric pathogen Salmonella enterica serovar Typhimurium during log phase. These log phase LFS-induced phenotypes were independent of the master stress response regulator, RpoS (S). Given the central importance of RpoS in regulating stationary phase stress responses of S. Typhimurium cultured under conventional shake flask and static conditions, we examined its role in stationary phase cultures grown under physiological LFS. We constructed an isogenic rpoS mutant derivative of wild type S. Typhimurium and compared the ability of these strains to survive in vitro pathogenesis-related stresses that mimic those encountered in the infected host and environment. We also compared the ability of these strains to colonize (adhere, invade, and survive within) human intestinal epithelial cell cultures. Unexpectedly, LFS-induced resistance of stationary phase S. Typhimurium cultures to acid and bile salts stresses did not rely on RpoS. Likewise, RpoS was dispensable for stationary phase LFS cultures to adhere to and survive within intestinal epithelial cells. In contrast, the resistance of these cultures to challenge with oxidative and thermal stresses, and their invasion into intestinal epithelial cells was influenced by RpoS. These findings expand our mechanistic understanding of how physiological fluid shear forces modulate stationary phase S. Typhimurium physiology in unexpected ways and provide clues into microbial mechanobiology and nuances of Salmonella responses to microenvironmental niches in the infected host.

Karla Franco Meléndez↗

NASA NTRSDate not supplied

Grand Valley Ecological Forecasting II: Forecasting Trends in Pinyon-Juniper and Sagebrush Habitat Relative to Wildfire, Drought, Beetle Disturbance, and Treatment Impact for Management Planning

Disturbances and landcover change in pinyon-juniper and sagebrush ecosystems are exacerbated by environmental conditions such as variability in climate characteristics. Our DEVELOP team partnered with the National Park Service (NPS) in Colorado National Monument and the Bureau of Land Management (BLM) in McInnis Canyons and Dominguez-Escalante National Conservation Areas to investigate disturbances to land cover. NPS partners were interested in identifying areas at risk of pinyon-juniper die-off or encroachment by invasive species. The BLM partners prioritized identifying areas suitable for fire reduction and prevention treatment. To address these concerns, we forecasted landcover change in the Grand Valley region of Colorado using NASA Earth observation data from Landsat 5 Thematic Mapper (TM), Landsat 7 Enhanced Thematic Mapper (ETM+), Landsat 8 Operational Land Imager (OLI), and Moderate Resolution Imaging Spectroradiometer (MODIS) aboard Terra and Aqua. We collected and analyzed these data in conjunction with Term I of this project. We found that the primary drivers of forecasted landcover change in the study area were aspect and elevation. Our forecasted land cover maps, created using the Idrisi TerrSet Land Change Modeler, indicated that by 2040, ecosystems within partner management areas will likely see tree encroachment on shrublands. These maps addressed the needs of our partners by showing potential habitat suitability trends, which will inform management planning.

Bill Curtiss↗

NASA NTRS2022

Noninvasive Indicators of Intracranial Pressure Before, During, and After Long-Duration Spaceflight

Weightlessness induces a cephalad shift of blood and cerebrospinal fluid that may increase intracranial pressure (ICP) during spaceflight, while lower body negative pressure (LBNP) may provide an opportunity to caudally redistribute fluids and lower ICP. To investigate the effects of spaceflight and LBNP on noninvasive indicators of ICP (nICP), we studied thirteen crewmembers before and after spaceflight in seated, supine, and 15° head-down tilt postures, and at ~45 and ~150 days of spaceflight with and without 25 mmHg LBNP. We used 4 techniques to quantify nICP: cerebral and cochlear fluid pressure (CCFP), otoacoustic emissions (OAE), ultrasound measures of optic nerve sheath diameter (ONSD), and ultrasound-based internal jugular vein pressure (IJVp). On flight day 45, two nICP measures were lower than preflight supine posture (CCFP: mean difference -98.5 -nl [CI: -190.8 to -6.1 -nl], p = 0.037]; OAE: -19.7 degrees [CI: -10.4 to -29.1 degrees], p < 0.001), but not significantly different from preflight seated measures. Conversely, ONSD was not different than any preflight posture, whereas IJVp was significantly greater than preflight seated measures (14.3 mmHg [CI: 10.1 to 18.5mmHg], p < 0.001), but not significantly different than preflight supine measures. During spaceflight, acute LBNP application did not cause a significant change in nICP indicators. These data suggest that during spaceflight nICP is not elevated above values observed in the seated posture on Earth. Invasive measures would be needed to provide absolute ICP values and more precise indications of ICP change during various phases of spaceflight.

Jessica V. Jasien↗

NASA NTRS2022

Grand Valley Ecological Forecasting II: Forecasting Trends in Pinyon-Juniper and Sagebrush Habitat Relative to Wildfire, Drought, Beetle Disturbance, and Treatment Impact for Management Planning

Disturbances and landcover change in pinyon-juniper and sagebrush ecosystems are exacerbated by environmental conditions such as variability in climate characteristics. Our DEVELOP team partnered with the National Park Service (NPS) in Colorado National Monument and the Bureau of Land Management (BLM)in McInnis Canyons and Dominguez-Escalante National Conservation Areas to investigate disturbances to land cover. NPS partners were interested in identifying areas at risk of pinyon-juniper die-off or encroachment by invasive species. The BLM partners prioritized identifying areas suitable for fire reduction/prevention treatment. To address these concerns, we forecasted landcover change in the Grand Valley region of Colorado using NASA Earth observation data from Landsat 5 Thematic Mapper (TM), Landsat 7 Enhanced Thematic Mapper (ETM+), Landsat 8 Operational Land Imager (OLI), and Moderate Resolution Imaging Spectroradiometer (MODIS) aboard Terra and Aqua. We collected and analyzed these data in conjunction with Term I of this project. We found that the primary drivers of forecasted landcover change in the study area were aspect and elevation. Our forecasted landcover change maps, created using the Idrisi TerrSet Land Change Modeler, addressed the needs of our partners by showing potential habitat suitability trends, which will inform management planning. Forecasted landcover maps indicated that by 2040, ecosystems within partner management areas will likely see tree encroachment on shrublands.

William Curtiss↗

NASA NTRSDate not supplied

Magnetic Measurements of Arc Instabilities in Segmented Arc Heater Column

The Aerodynamic Heating Facility (AHF) at NASA Ames Research Center (ARC) generates high enthalpy, supersonic flow environments for ground testing of NASAheat shield materials. This arc jet heater operates by passing a DC arc (<3200 A,<2500 V) through a gas column (~6 cm diameter, 2 m length) and ejecting the heated gas through a supersonic nozzle into a test chamber. The arc plasma is a partially ionized air mixture at low temperature (< 2 eV) but needs to be stable for long test times (up to 30 min) at high power (< 20 MW). Currently, the operational envelope of the facility is limited by arc instabilities including the kink instability. Consequently, it is of interest to characterize these instabilities to better understand facility limits and inform methods to extend stable operational ranges. Due to the high enthalpy and long timescales (i.e., minutes) diagnostics must be non-invasive. This work will cover the development of two sets of magnetic sensors: differential B-dot sensors and tri-axial magnetic hall sensors and will describe initial measurements of arc motion using these sensors.

Kink instability↗

NASA NTRSDate not supplied

Why Developing A Full-Sun UV Spectrograph Sounding Rocket Is Difficult but Necessary

For a conference focused on a 20-year perspective of where we have been and where we are going, this talk will highlight specifically why we need a sounding rocket to lead the way in obtaining high-resolution UV spectroscopy of our sun-as-a-star. The currently available data is either sparse or at a much lower resolution when compared with Hubble (HST) spectra of other stars. Because of this, we cannot say with certainty if our Sun’s variability is typical. This limitation is hindering our quest to place our Sun in it’s rightful place on our star-charts. Ultraviolet light is a key component in determining this. Elements such as Hydrogen and Iron have strong emission lines here, and from them we can determine many things about the star from which they originate. The width of these spectral features can tell us about the relative plasma activity on the surface of the star, the abundance of those elements, and of course the temperatures. This has of course been done with many instruments that have very narrow field of views and/or narrow bandwidths. The only way to directly compare our Sun’s UV ”fingerprint” with other stars is to take an image of it in the same manner by which HST does: as a point source object. Our team’s aim has been to develop a sounding rocket capable of doing just that. Along the way, the many challenges we face are producing many solutions. A unique take on the traditional Rowland circle spectrograph will allow us to cover a large range of UV spectra with minimal moving parts. A novel in-situ gain calibration technique will be used in order to maintain the high level of radiometric accuracy desired. Naturally, complications arise when one takes UV measurements as you are flying out of earth’s atmosphere and back into it. Though it may be minor, the absorbed UV spectra from the atmosphere will have to be accounted for. In preparing for this, we have stumbled across a way in which those ”telluric” absorption lines may prove useful for spectral calibration purposes. In addition, raw data from previous sounding rocket missions may have hidden within them useful information for the atmospheric-physics community. In this talk, we will highlight the unique calibration problems and solutions we have faced, and how those are of greater importance to the greater heliophysics and atmospheric communities. With these amazing developments at hand, the future of heliophysics instrumentation is looking bright. This material is based upon work supported by the NSF EPSCoR RII-Track-1.2a (Non-invasive plasma diagnostics for LTP) Cooperative Agreement OIA-1655280. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation.

NASA, UAH, MSU, Sounding Rocket, Aeronomy, Instrum↗

NASA NTRSDate not supplied

MicroRNA Based Countermeasure Rescue Health Risks Associated with Space Radiation and Microgravity

Afshin Beheshti↗

NASA NTRSDate not supplied

Evolution of Dendritic Extended 3D Patterns during Directional Solidification: Microgravity Experiments in DECLIC-DSI onboard ISS and Phase-field Modeling

To characterize the dynamical formation of three-dimensional (3D) arrays of dendrites under diffusive growth conditions, in situ monitoring of a series of experiments on a transparent succinonitrile – 0.46 wt% camphor model alloy was carried out under low gravity in the DECLIC Directional Solidification Insert onboard the International Space Station. These experiments offer continuous interface observation and enable the construction of space-time evolution maps of dendrite location and primary spacing during directional solidification. We present the evolution of dendritic extended 3D patterns for a large range of parameters displaying different levels of side branching in both experiments and phase-field simulations. The combined and separate effects of macroscopic interface curvature and crystal mis-orientation are evidenced and detailed. In addition, the aligned dendritic array caused by the invasion of dendrites formed at the edge of the crucible border is investigated.

Kaihua Ji↗