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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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547 records · Page 31
All sourcesNASA NTRSDOE OSTI
DOE OSTI2022

Prospective Study Reveals Host Microbial Determinants of Clinical Response to Fecal Microbiota Transplant Therapy in Type 2 Diabetes Patients

Increasing evidence shows that alterations in gut microbiome (GM) contribute to the development of type 2 diabetes mellitus (T2DM), and fecal microbiota transplantation (FMT) successfully treats various human diseases. However, the benefits of FMT therapy to T2DM patients remain unknown. We enrolled 17 patients with T2DM for nonblinded, one-armed intervention trial of FMT. A total of 20 healthy individuals were recruited as the baseline control. HbA1c% and metabolic parameter change were evaluated in 17 T2DM patients 12 weeks after they received FMT from healthy donors. The GM composition was characterized by 16S rRNA gene amplicon sequencing from fecal samples prior to and 12 weeks after FMT treatment. We found that the GM of T2DM patients was reconstituted by FMT. We observed a statistically significant decrease in HbA1c% (from 7.565 ± 0.148 to 7.190 ± 0.210, p<0.01), blood glucose (from 8.483 ± 0.497 to 7.286 ± 0.454 mmol/L, p<0.01), and uric acid (from 309.4 ± 21.5 to 259.1 ± 15.8 µmol/L, p<0.01) while a significant increase in postprandial C-peptide (from 4.503 ± 0.600 to 5.471 ± 0.728 ng/ml, p<0.01) at 12 weeks after FMT. Closely evaluating the changes in these assays, we found individual variability in response to FMT treatment. Out of 17 T2DM patients, 11 were found to significantly improve T2DM symptoms. The FMT responders have significantly higher levels of the family Rikenellaceae and the genus Anaerotruncus (family Ruminococcaceae) in their pretreated fecal in comparison to nonresponders, which could predict the clinical response with an area under the curve of 0.83. Our findings suggest that certain T2DM patients can potentially benefit from FMT, and the pretreated abundance of Rikenellaceae and Anaerotruncus in the fecal of patients may serve as potential biomarkers for selecting T2DM patients to receive FMT.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2020

Aboveground Wood Production Is Sustained in the First Growing Season after Phloem-Disrupting Disturbance

Carbon (C) cycling processes are particularly dynamic following disturbance, with initial responses often indicative of longer-term change. In northern Michigan, USA, we initiated the Forest Resilience Threshold Experiment (FoRTE) to identify the processes that sustain or lead to the decline of C cycling rates across multiple levels (0, 45, 65 and 85% targeted gross leaf area index loss) of disturbance severity and, in response, to separate disturbance types preferentially targeting large or small diameter trees. Simulating the effects of boring insects, we stem girdled > 3600 trees below diameter at breast height (DBH), immediately and permanently disrupting the phloem. Weekly DBH measurements of girdled and otherwise healthy trees (n > 700) revealed small but significant increases in daily aboveground wood net primary production (ANPP w ) in the 65 and 85% disturbance severity treatments that emerged six weeks after girdling. However, we observed minimal change in end-of-season leaf area index and no significant differences in annual ANPP w among disturbance severities or between disturbance types, suggesting continued C fixation by girdled trees sustained stand-scale wood production in the first growing season after disturbance. We hypothesized higher disturbance severities would favor the growth of early successional species but observed no significant difference between early and middle to late successional species’ contributions to ANPP w across the disturbance severity gradient. We conclude that ANPP w stability immediately following phloem disruption is dependent on the continued, but inevitably temporary, growth of phloem-disrupted trees. Our findings provide insight into the tree-to-ecosystem mechanisms supporting stand-scale wood production stability in the first growing season following a phloem-disrupting disturbance.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2022

Energy I-Corps Annual Report 2021

The U.S. Department of Energy invests millions of dollars every year into the national lab complex. This investment allows the national laboratories to tackle the critical scientific challenges of our time - from renewable energy to quantum computing to creating a more resilient energy grid. The discoveries and innovations being developed by the labs have an even greater impact when we invest in bringing these ideas to the market where they can benefit the nation and world. To better arm researchers to collaborate with industry and turn research and development into demonstration and deployment, DOE employs Energy I-Corps to help researchers gain industry insight to guide innovation. Energy I-Corps invites teams of researchers to participate in an intensive two-month training during which the researchers define technology value propositions, conduct customer discovery interviews, and explore viable market pathways for their technologies. Researchers return to their labs with a framework for industry engagement to guide future research and inform a culture of market engagement within the lab environment. In this way, Energy I-Corps ensures our investment in the national labs and maintains and strengthens long-term U.S. competitiveness.

cohort↗
DOE OSTI2022

Energy Transitions Initiative Partnership Project: ETIPP Technical Assistance Informational Webinar

This webinar is for prospective applicants (i.e., remote, island, and islanded communities) interested in applying to the U.S. Department of Energy's Energy Transitions Initiative Partnership Program (ETIPP) in spring of 2022. This webinar provides an overview of ETIPP and technical assistance, introduces the ETIPP regional partners, summarizes two ongoing ETIPP projects, discusses the 2022 application process, and closes with a question-and-answer session. This webinar is hosted by the National Renewable Energy Laboratory, which is part of the ETIPP partner network.

Alaska Center for Energy and Power↗
DOE OSTI2023

Clean Energy to Communities (C2C) Program Kickoff Webinar

This webinar kicked off the launch of the DOE EERE's Clean Energy to Communities (C2C) technical assistance program. It includes EERE's goals, a history of the C2C program development and structure, and details on its in-depth partnerships and Energyshed.

C2C↗
DOE OSTI2024

C2C: Clean Energy to Communities

The Clean Energy to Communities (C2C) program advances community-led clean energy progress by providing local governments, electric utilities, and community-based organizations with cuttingedge analysis and validation from the U.S. Department of Energy's national laboratories. The program offers tailored support across the renewable power, grid, mobility, and buildings sectors that ranges from short term consultation with energy experts to multi-year technical assistance partnerships and direct funding.

C2C↗
DOE OSTI2025

Energy to Communities (E2C) Annual Highlights 2024

In 2024, E2C provided customized technical assistance to more than 200 organizations across the country on topics within four categories: energy generation and grid, transportation, buildings, and reliability and recovery.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗