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At least 559 records · Page 31

Controlling quantum many-body dynamics in driven Rydberg atom arrays

Dynamic stabilization of an array Large-scale systems comprising one-dimensional chains and two-dimensional arrays of excited atoms held in a programmable optical lattice are a powerful platform with which to simulate emergent phenomena. Bluvstein et al. built an array of up to 200 Rydberg atoms and subjected the system to periodic excitation. Under such driven excitation, they found that the array of atoms stabilized, freezing periodically into what looked like time crystals. Understanding and controlling the dynamic interactions in quantum many-body systems lies at the heart of contemporary condensed matter physics and the exotic phenomena that can occur. Science , this issue p. 1355

Science & Technology - Other Topics↗

Structure-guided discovery of ancestral CRISPR-Cas13 ribonucleases

The RNA-guided ribonuclease CRISPR-Cas13 enables adaptive immunity in bacteria and programmable RNA manipulation in heterologous systems. Cas13s share limited sequence similarity, hindering discovery of related or ancestral systems. Here, to address this, we developed an automated structural-search pipeline to identify an ancestral clade of Cas13 (Cas13an) and further trace Cas13 origins to defense-associated ribonucleases. Despite being one-third the size of other Cas13s, Cas13an mediates robust programmable RNA depletion and defense against diverse bacteriophages. However, unlike its larger counterparts, Cas13an uses a single active site for both CRISPR RNA processing and RNA-guided cleavage, revealing that the ancestral nuclease domain has two modes of activity. Discovery of Cas13an deepens our understanding of CRISPR-Cas evolution and expands opportunities for precision RNA editing, showcasing the promise of structure-guided genome mining.

59 BASIC BIOLOGICAL SCIENCES↗

Hadron structure and spectroscopy at COMPASS. Overview of certain tasks

COMPASS is a fixed-target experiment at CERN with a long history and intense and diverse physics programme. In the Review we consider particular points of the existing and possible future programme: test of the chiral theory predictions with hadron beam, search for exotic charmonia, study of the EMC effect in the Drell–Yan process, search for production of bound p p-bar states and study of prompt photon production in hadronic interactions.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

An experiment for electron-hadron scattering at the LHC

Abstract Novel considerations are presented on the physics, apparatus and accelerator designs for a future, luminous, energy frontier electron-hadron ( eh ) scattering experiment at the LHC in the thirties for which key physics topics and their relation to the hadron-hadron HL-LHC physics programme are discussed. Demands are derived set by these physics topics on the design of the LHeC detector, a corresponding update of which is described. Optimisations on the accelerator design, especially the interaction region (IR), are presented. Initial accelerator considerations indicate that a common IR is possible to be built which alternately could serve eh and hh collisions while other experiments would stay on hh in either condition. A forward-backward symmetrised option of the LHeC detector is sketched which would permit extending the LHeC physics programme to also include aspects of hadron-hadron physics. The vision of a joint eh and hh physics experiment is shown to open new prospects for solving fundamental problems of high energy heavy-ion physics including the partonic structure of nuclei and the emergence of hydrodynamics in quantum field theory while the genuine TeV scale DIS physics is of unprecedented rank.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

The ALICE experiment: a journey through QCD

The ALICE experiment was proposed in 1993, to study strongly-interacting matter at extreme energy densities and temperatures. This proposal entailed a comprehensive investigation of nuclear collisions at the LHC. Its physics programme initially focused on the determination of the properties of the quark–gluon plasma (QGP), a deconfined state of quarks and gluons, created in such collisions. The ALICE physics programme has been extended to cover a broader ensemble of observables related to Quantum Chromodynamics (QCD), the theory of strong interactions. The experiment has studied Pb–Pb, Xe–Xe, p–Pb and pp collisions in the multi-TeV centre of mass energy range, during the Run 1–2 data-taking periods at the LHC (2009–2018). The aim of this review is to summarise the key ALICE physics results in this endeavor, and to discuss their implications on the current understanding of the macroscopic and microscopic properties of strongly-interacting matter at the highest temperatures reached in the laboratory. It will review the latest findings on the properties of the QGP created by heavy-ion collisions at LHC energies, and describe the surprising QGP-like effects in pp and p–Pb collisions. Measurements of few-body QCD interactions, and their impact in unraveling the structure of hadrons and hadronic interactions, will be discussed. ALICE results relevant for physics topics outside the realm of QCD will also be touched upon. Finally, prospects for future measurements with the ALICE detector in the context of its planned upgrades will also be briefly described.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Input to the European strategy for particle physics: strong-field quantum electrodynamics

This document sets out the intention of the strong-field QED community to carry out, both experimentally and numerically, high-statistics parametric studies of quantum electrodynamics in the non-perturbative regime, at fields approaching and exceeding the critical or ‘Schwinger’ field of QED (F qed ≈ m 2 c 3 / eh ≈ 1.3 x 10 18 V/m) in the rest frame of a charged particle. In this regime, several exotic and fascinating phenomena are predicted to occur that have never been directly observed in the laboratory. These include Breit–Wheeler pair production, vacuum birefringence, and quantum radiation reaction. This experimental programme will also serve as a stepping stone towards studies of elusive phenomena such as elastic scattering of real photons and the conjectured perturbative breakdown of QED at extreme fields. State-of-the-art high-power laser facilities in Europe and beyond are starting to offer unique opportunities to study this uncharted regime at the intensity frontier, which is highly relevant also for the design of future multi-TeV lepton colliders. A transition from qualitative observational experiments to quantitative and high-statistics measurements can only be performed with large-scale collaborations and with systematic experimental programmes devoted to the optimisation of several aspects of these complex experiments, including detector developments, stability and tolerances studies, and laser technology.

Sarri, G. [Queen’s University Belfast (United King↗

FCC-hh: The Hadron Collider

Particle physics has arrived at an important moment of its history. The discovery of the Higgs boson, with a mass of 125 GeV, completes the matrix of particles and interactions that has constituted the “Standard Model” for several decades. This model is a consistent and predictive theory, which has so far proven successful at describing all phenomena accessible to collider experiments. However, several experimental facts do require the extension of the Standard Model and explanations are needed for observations such as the abundance of matter over antimatter, the striking evidence for dark matter and the non-zero neutrino masses. Theoretical issues such as the hierarchy problem, and, more in general, the dynamical origin of the Higgs mechanism, do likewise point to the existence of physics beyond the Standard Model. This report contains the description of a novel research infrastructure based on a highest-energy hadron collider with a centre-of-mass collision energy of 100 TeV and an integrated luminosity of at least a factor of 5 larger than the HL-LHC. It will extend the current energy frontier by almost an order of magnitude. The mass reach for direct discovery will reach several tens of TeV, and allow, for example, to produce new particles whose existence could be indirectly exposed by precision measurements during the earlier preceding e+e– collider phase. This collider will also precisely measure the Higgs self-coupling and thoroughly explore the dynamics of electroweak symmetry breaking at the TeV scale, to elucidate the nature of the electroweak phase transition. WIMPs as thermal dark matter candidates will be discovered, or ruled out. As a single project, this particle collider infrastructure will serve the world-wide physics community for about 25 years and, in combination with a lepton collider (see FCC conceptual design report volume 2), will provide a research tool until the end of the 21st century. Collision energies beyond 100 TeV can be considered when using high-temperature superconductors. The European Strategy for Particle Physics (ESPP) update 2013 stated “To stay at the forefront of particle physics, Europe needs to be in a position to propose an ambitious post-LHC accelerator project at CERN by the time of the next Strategy update”. The FCC study has implemented the ESPP recommendation by developing a long-term vision for an “accelerator project in a global context”. This document describes the detailed design and preparation of a construction project for a post-LHC circular energy frontier collider “in collaboration with national institutes, laboratories and universities worldwide”, and enhanced by a strong participation of industrial partners. Now, a coordinated preparation effort can be based on a core of an ever-growing consortium of already more than 135 institutes worldwide. The technology for constructing a high-energy circular hadron collider can be brought to the technology readiness level required for constructing within the coming ten years through a focused R&D programme. The FCC-hh concept comprises in the baseline scenario a power-saving, low-temperature superconducting magnet system based on an evolution of the Nb3Sn technology pioneered at the HL-LHC, an energy-efficient cryogenic refrigeration infrastructure based on a neon-helium (Nelium) light gas mixture, a high-reliability and low loss cryogen distribution infrastructure based on Invar, high-power distributed beam transfer using superconducting elements and local magnet energy recovery and re-use technologies that are already gradually introduced at other CERN accelerators. On a longer timescale, high-temperature superconductors can be developed together with industrial partners to achieve an even more energy efficient particle collider or to reach even higher collision energies.The re-use of the LHC and its injector chain, which also serve for a concurrently running physics programme, is an essential lever to come to an overall sustainable research infrastructure at the energy frontier. Strategic R&D for FCC-hh aims at minimising construction cost and energy consumption, while maximising the socio-economic impact. It will mitigate technology-related risks and ensure that industry can benefit from an acceptable utility. Concerning the implementation, a preparatory phase of about eight years is both necessary and adequate to establish the project governance and organisation structures, to build the international machine and experiment consortia, to develop a territorial implantation plan in agreement with the host-states’ requirements, to optimise the disposal of land and underground volumes, and to prepare the civil engineering project. Such a large-scale, international fundamental research infrastructure, tightly involving industrial partners and providing training at all education levels, will be a strong motor of economic and societal development in all participating nations. The FCC study has implemented a set of actions towards a coherent vision for the world-wide high-energy and particle physics community, providing a collaborative framework for topically complementary and geographically well-balanced contributions. This conceptual design report lays the foundation for a subsequent infrastructure preparatory and technical design phase.

43 PARTICLE ACCELERATORS↗

HE-LHC: The High-Energy Large Hadron Collider

Particle physics has arrived at an important moment of its history. The discovery of the Higgs boson, with a mass of 125 GeV, completes the matrix of particles and interactions that has constituted the “Standard Model” for several decades. This model is a consistent and predictive theory, which has so far proven successful at describing all phenomena accessible to collider experiments. However, several experimental facts do require the extension of the Standard Model and explanations are needed for observations such as the abundance of matter over antimatter, the striking evidence for dark matter and the non-zero neutrino masses. Theoretical issues such as the hierarchy problem, and, more in general, the dynamical origin of the Higgs mechanism, do likewise point to the existence of physics beyond the Standard Model. This report contains the description of a novel research infrastructure based on a high-energy hadron collider, which extends the current energy frontier by almost a factor 2 (27 TeV collision energy) and an integrated luminosity of at least a factor of 3 larger than the HL-LHC. In connection with four experimental detectors, this infrastructure will deepen our understanding of the origin of the electroweak symmetry breaking, allow a first measurement of the Higgs self-coupling, double the HL-LHC discovery reach and allow for in-depth studies of new physics signals arising from future LHC measurements. This collider would directly produce particles at significant rates at scales up to 12 TeV. The project re-uses the existing LHC underground infrastructure and large parts of the injector chain at CERN. This particle collider would succeed the HL-LHC directly and serve the world-wide physics community for about 20 years beyond the middle of the 21st century. The European Strategy for Particle Physics (ESPP) update 2013 stated “To stay at the forefront of particle physics, Europe needs to be in a position to propose an ambitious post-LHC accelerator project at CERN by the time of the next Strategy update”. The FCC study has implemented the ESPP recommendation by developing a vision for an “accelerator project in a global context”. This document describes the detailed design and preparation of a construction project for a post-LHC circular high-energy hadron collider “in collaboration with national institutes, laboratories and universities worldwide”, and enhanced by a strong participation of industrial partners. Now, a coordinated preparation effort can be based on a core of an ever-growing consortium of already more than 135 institutes worldwide. The technology for constructing a High-Energy LHC can be brought to the technology readiness level required for construction within the coming ten years through a committed and focused R&D programme. The concept comprises a power-saving, low-temperature superconducting magnet system based on an evolution of the Nb3Sn technology pioneered at the HL-LHC, an energy-efficient cryogenic refrigeration infrastructure based on a neon-helium (Nelium) light gas mixture, a high-reliability and low loss cryogen distribution infrastructure based on Invar, high-power distributed beam transfer using superconducting elements and local magnet energy recovery and re-use technologies that are already gradually introduced at other CERN accelerators. Re-use of the LHC underground civil infrastructure worth about 500 million CHF at the time of its construction, extension of the surface sites and use of the existing injector chain that also serve for a concurrently running physics programme are levers to come to a sustainable research infrastructure at the energy frontier. Strategic R&D for HE-LHC aims at minimising construction cost and energy consumption, while maximising the socio-economic impact. It needs to mitigate technology-related risks and ensure that industry can benefit from an acceptable economic utility. Concerning the implementation, a preparatory phase of about eight years is both necessary and adequate to establish the project governance and organisation structures, to build the international machine and experiment consortia, to develop a territorial implantation plan considering the constraints emerging from using the existing infrastructure and the host states’ requirements, optimising the use of land, resources and preparing the construction project. Such a large-scale, international fundamental research infrastructure, tightly involving industrial partners and providing training at all education levels, will be a strong motor of economic and societal development in all participating nations. The FCC study has implemented a set of actions towards a coherent vision for the world-wide high-energy and particle physics community, providing a collaborative framework for topically complementary and geographically well-balanced contributions. This conceptual design report lays the foundation for a subsequent infrastructure preparatory and technical design phase.

43 PARTICLE ACCELERATORS↗

Heavy-ion physics at the LHC

Heavy-ion collisions have been part of the programme of the LHC since its conception. The main nucleus–nucleus system is 208 82 + Pb + 208 82 + Pb . During the Runs 1 and 2, the LHC provided Pb+Pb collisions with centre-of-mass energy per nucleon pair √ s NN = 2.76 and 5.02 TeV, Xe+Xe with √ s NN = 5.44 TeV, and p+Pb with √ s NN = 5.02 and 8.16 TeV. The LHC performance with heavy-ion beams is described in Ref. 1. The ALICE detector was conceived to be dedicated to the study of heavy-ion collisions. The ATLAS and CMS experiments participated in the programme since the very beginning, and the LHCb experiment participated since the end of Run 1. Figure 1 shows event displays of Pb+Pb collisions from the four experiments.

Audurier, Benjamin↗

Experiences in extending parallware to support OpenACC. In: WACCPD '15 Proceedings of the Second Workshop on Accelerator Programming using Directives, Article No. 4

Porting scientific codes to accelerator-based computers using OpenACC and OpenMP is an important topic for the HPC community. Programmability, performance portability and developer productivity are key issues for the widespread use of these systems. In the scope of general-purpose parallel computing, Parallware is a new commercial OpenMP-enabling source-to-source compiler that automatically adds OpenMP capabilities in scientific programs. Thus, extending Parallware with OpenACC or OpenMP 4.x support would contribute to improve programmability and developer productivity. In contrast, the performance portability of such approach needs to be demonstrated in practice. This paper presents a preliminary study to extend Parallware with OpenACC support for GPU devices. A simple benchmark suite has been designed to mimic important features and computational patterns of real scientific applications. Handcoded OpenACC versions are compared to OpenMP versions automatically generated by Parallware. Performance is evaluated with the PGI OpenACC compiler on systems accelerated with NVIDIA GPUs.

Lobeiras, Jacobo↗

Simit: A Language for Physical Simulation

With existing programming tools, writing high-performance simulation code is labor intensive and requires sacrificing readability and portability. Here, the alternative is to prototype simulations in a high-level language like Matlab, thereby sacrificing performance. The Matlab programming model naturally describes the behavior of an entire physical system using the language of linear algebra. However, simulations also manipulate individual geometric elements, which are best represented using linked data structures like meshes. Translating between the linked data structures and linear algebra comes at significant cost, both to the programmer and to the machine. High-performance implementations avoid the cost by rephrasing the computation in terms of linked or index data structures, leaving the code complicated and monolithic, often increasing its size by an order of magnitude. In this article, we present Simit, a new language for physical simulations that lets the programmer view the system both as a linked data structure in the form of a hypergraph and as a set of global vectors, matrices, and tensors depending on what is convenient at any given time. Simit provides a novel assembly construct that makes it conceptually easy and computationally efficient to move between the two abstractions. Using the information provided by the assembly construct, the compiler generates efficient in-place computation on the graph. We demonstrate that Simit is easy to use: a Simit program is typically shorter than a Matlab program; that it is high performance: a Simit program running sequentially on a CPU performs comparably to hand-optimized simulations; and that it is portable: Simit programs can be compiled for GPUs with no change to the program, delivering 4 to 20× speedups over our optimized CPU code.

97 MATHEMATICS AND COMPUTING↗

Are Lock-Free Concurrent Algorithms Practically Wait-Free?

Lock-free concurrent algorithms guarantee that some concurrent operation will always make progress in a finite number of steps. Yet programmers prefer to treat concurrent code as if it were wait-free, guaranteeing that all operations always make progress. Unfortunately, designing wait-free algorithms is generally a very complex task, and the resulting algorithms are not always efficient. Although obtaining efficient wait-free algorithms has been a long-time goal for the theory community, most nonblocking commercial code is only lock-free. This article suggests a simple solution to this problem. We show that for a large class of lock-free algorithms, under scheduling conditions that approximate those found in commercial hardware architectures, lock-free algorithms behave as if they are wait-free. In other words, programmers can continue to design simple lock-free algorithms instead of complex wait-free ones, and in practice, they will get wait-free progress. Our main contribution is a new way of analyzing a general class of lock-free algorithms under a stochastic scheduler. Our analysis relates the individual performance of processes to the global performance of the system using Markov chain lifting between a complex per-process chain and a simpler system progress chain. We show that lock-free algorithms are not only wait-free with probability 1 but that in fact a general subset of lock-free algorithms can be closely bounded in terms of the average number of steps required until an operation completes. Here, to the best of our knowledge, this is the first attempt to analyze progress conditions, typically stated in relation to a worst-case adversary, in a stochastic model capturing their expected asymptotic behavior.

97 MATHEMATICS AND COMPUTING↗

PapyrusKV: a high-performance parallel key-value store for distributed NVM architectures

This paper introduces PapyrusKV, a parallel embedded key-value store (KVS) for distributed high-performance computing (HPC) architectures that offer potentially massive pools of nonvolatile memory (NVM). PapyrusKV stores keys with their values in arbitrary byte arrays across multiple NVMs in a distributed system. PapyrusKV provides standard KVS operations such as put, get, and delete. More importantly, PapyrusKV provides advanced features for HPC such as dynamic consistency control, zero-copy workflow, and asynchronous checkpoint/restart. Beyond filesystems, PapyrusKV provides HPC programmers with a high-level interface to exploit distributed NVM in the system, and it transparently organizes data to achieve high performance. Also, it allows HPC applications to specialize PapyrusKV to meet their specific requirements. We empirically evaluate PapyrusKV on three HPC systems with real NVM devices: OLCF's Summitdev, TACC's Stampede, and NERSC's Cori. Our results show that PapyrusKV can offer high performance, scalability, and portability across these various distributed NVM architectures.

97 MATHEMATICS AND COMPUTING↗

Benchmarking and Evaluating Unified Memory for OpenMP GPU Offloading

Here, the latest OpenMP standard offers automatic device offloading capabilities which facilitate GPU programming. Despite this, there remain many challenges. One of these is the unified memory feature introduced in recent GPUs. GPUs in current and future HPC systems have enhanced support for unified memory space. In such systems, CPU and GPU can access each other's memory transparently, that is, the data movement is managed automatically by the underlying system software and hardware. Memory over subscription is also possible in these systems. However, there is a significant lack of knowledge about how this mechanism will perform, and how programmers should use it. We have modified several benchmarks codes, in the Rodinia benchmark suite, to study the behavior of OpenMP accelerator extensions and have used them to explore the impact of unified memory in an OpenMP context. We moreover modified the open source LLVM compiler to allow OpenMP programs to exploit unified memory. The results of our evaluation reveal that, while the performance of unified memory is comparable with that of normal GPU offloading for benchmarks with little data reuse, it suffers from significant overhead when GPU memory is over subcribed for benchmarks with large amount of data reuse. Based on these results, we provide several guidelines for programmers to achieve better performance with unified memory.

97 MATHEMATICS AND COMPUTING↗

FLASH: FPGA-Accelerated Smart Switches with GCN Case Study

Some communication switches, e.g., the Mellanox SHArP and those in the IBM BlueGene clusters, are augmented to process packets at the application level with fixed-function collectives. This approach, however, lacks flexibility, which limits their applicability in diverse and dynamic workloads. Recently, a new type of programmable packet processor, which uses high-level languages, e.g., P4, has emerged as possible candidates. P4-based switches, however, fall short in certain applications, including machine learning, where capabilities not currently supported by P4 are needed. These include more complex calculation, such as sparse computation and fused multiply-accumulate, data-intensive floating point operations, data reuse, and significant memory. The problem addressed here is that such a switch augmentation needs to support: a large amount of state, significant flexible compute capability, and ease of programming, all while maintaining full functionality, including ensuring high throughput, and demonstrating utility. In this work, we propose a programmable look-aside-type accelerator that can be embedded into, or attached to, existing communication switch pipelines and that is capable of processing packets at line-rate. The proposed in-switch accelerator is based on mixing an ISA (subset of RISC-V instructions) with dataflow graphs (found in CGRAs). To augment performance, vector instructions are also supported. To facilitate usability, we have developed a complete toolchain to compile user-provided C/C++ codes to appropriate back-end instructions for configuring the accelerator. While this approach is flexible enough to support various workloads, in this paper, we consider Graph Convolutional Networks (GCNs) as a case study. Experimental results show that this approach considerably improves the performance of distributed GCN applications.

Haghi, Pouya↗

Orchard: Heterogeneous Parallelism and Fine-grained Fusion for Complex Tree Traversals

Many applications are designed to perform traversals ontree-likedata structures. Fusing and parallelizing these traversals enhance the performance of applications. Fusing multiple traversals improves the locality of the application. The runtime of an application can be significantly reduced by extracting parallelism and utilizing multi-threading. Prior frameworks have tried to fuse and parallelize tree traversals using coarse-grained approaches, leading to missed fine-grained opportunities for improving performance. Other frameworks have successfully supported fine-grained fusion on heterogeneous tree types but fall short regarding parallelization. We introduce a new frameworkOrchardbuilt on top ofGrafter.Orchard’s novelty lies in allowing the programmer to transform tree traversal applications by automatically applyingfine-grainedfusion and extractingheterogeneousparallelism.Orchardallows the programmer to write general tree traversal applications in a simple and elegant embedded Domain-Specific Language (eDSL). We show that the combination of fine-grained fusion and heterogeneous parallelism performs better than each alone when the conditions are met.

Computer Science↗

Complex Parsing for In-Network Acceleration of High-Energy Physics Experiments

This paper describes a novel application and evaluation of programmable networking in High-Energy Physics (HEP): a complete parser for the custom packet format used by Fermilab’s DUNE experiment. Notably, this parser is implemented on a Tofino programmable network switch and evaluated on the FABRIC testbed by using network traffic generated by the ICEBERG DUNE prototype. The parsed network traffic consists of Jumbo Ethernet frames that contain digitizations of sensor readings from ICEBERG’s detector.This work is an early investigation into providing in-network processing support for HEP experiments. The paper describes DUNE’s custom packet format, the challenges encountered when implementing a parser for that format, and an exploration of the techniques that are needed to overcome those challenges. We identify performance bottlenecks and discuss directions for future research.

Sagstad, Bjoern [IIT, Chicago] (ORCID:000900033610↗

The RNA-binding protein ELAV regulates Hox RNA processing, expression and function within the Drosophila nervous system

The regulated head-to-tail expression of Hox genes provides a coordinate system for the activation of specific programmes of cell differentiation according to axial level. Recent work indicates that Hox expression can be regulated via RNA processing but the underlying mechanisms and biological significance of this form of regulation remain poorly understood. Here we explore these issues within the developing Drosophila central nervous system (CNS). We show that the pan-neural RNA-binding protein (RBP) ELAV (Hu antigen) regulates the RNA processing patterns of the Hox gene Ultrabithorax (Ubx) within the embryonic CNS. Using a combination of biochemical, genetic and imaging approaches we demonstrate that ELAV binds to discrete elements within Ubx RNAs and that its genetic removal reduces Ubx protein expression in the CNS leading to the respecification of cellular subroutines under Ubx control, thus defining for the first time a specific cellular role of ELAV within the developing CNS. Artificial provision of ELAV in glial cells (a cell type that lacks ELAV) promotes Ubx expression, suggesting that ELAV-dependent regulation might contribute to cell type-specific Hox expression patterns within the CNS. Finally, we note that expression of abdominal A and Abdominal B is reduced in elav mutant embryos, whereas other Hox genes (Antennapedia) are not affected. Based on these results and the evolutionary conservation of ELAV and Hox genes we propose that the modulation of Hox RNA processing by ELAV serves to adapt the morphogenesis of the CNS to axial level by regulating Hox expression and consequently activating local programmes of neural differentiation.

59 BASIC BIOLOGICAL SCIENCES↗