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At least 559 records · Page 31

Quantitative analysis of aortic regurgitation: real-time 3-dimensional and 2-dimensional color Doppler echocardiographic method--a clinical and a chronic animal study

BACKGROUND: For evaluating patients with aortic regurgitation (AR), regurgitant volumes, left ventricular (LV) stroke volumes (SV), and absolute LV volumes are valuable indices. AIM: The aim of this study was to validate the combination of real-time 3-dimensional echocardiography (3DE) and semiautomated digital color Doppler cardiac flow measurement (ACM) for quantifying absolute LV volumes, LVSV, and AR volumes using an animal model of chronic AR and to investigate its clinical applicability. METHODS: In 8 sheep, a total of 26 hemodynamic states were obtained pharmacologically 20 weeks after the aortic valve noncoronary (n = 4) or right coronary (n = 4) leaflet was incised to produce AR. Reference standard LVSV and AR volume were determined using the electromagnetic flow method (EM). Simultaneous epicardial real-time 3DE studies were performed to obtain LV end-diastolic volumes (LVEDV), end-systolic volumes (LVESV), and LVSV by subtracting LVESV from LVEDV. Simultaneous ACM was performed to obtain LVSV and transmitral flows; AR volume was calculated by subtracting transmitral flow volume from LVSV. In a total of 19 patients with AR, real-time 3DE and ACM were used to obtain LVSVs and these were compared with each other. RESULTS: A strong relationship was found between LVSV derived from EM and those from the real-time 3DE (r = 0.93, P <.001, mean difference (3D - EM) = -1.0 +/- 9.8 mL). A good relationship between LVSV and AR volumes derived from EM and those by ACM was found (r = 0.88, P <.001). A good relationship between LVSV derived from real-time 3DE and that from ACM was observed (r = 0.73, P <.01, mean difference = 2.5 +/- 7.9 mL). In patients, a good relationship between LVSV obtained by real-time 3DE and ACM was found (r = 0.90, P <.001, mean difference = 0.6 +/- 9.8 mL). CONCLUSION: The combination of ACM and real-time 3DE for quantifying LV volumes, LVSV, and AR volumes was validated by the chronic animal study and was shown to be clinically applicable.

Validation Studies↗

Semi-Empirical Validation of the Cross-Band Relative Absorption Technique for the Measurement of Molecular Mixing Ratios

Studies were performed to carry out semi-empirical validation of a new measurement approach we propose for molecular mixing ratios determination. The approach is based on relative measurements in bands of O2 and other molecules and as such may be best described as cross band relative absorption (CoBRA). . The current validation studies rely upon well verified and established theoretical and experimental databases, satellite data assimilations and modeling codes such as HITRAN, line-by-line radiative transfer model (LBLRTM), and the modern-era retrospective analysis for research and applications (MERRA). The approach holds promise for atmospheric mixing ratio measurements of CO2 and a variety of other molecules currently under investigation for several future satellite lidar missions. One of the advantages of the method is a significant reduction of the temperature sensitivity uncertainties which is illustrated with application to the ASCENDS mission for the measurement of CO2 mixing ratios (XCO2). Additional advantages of the method include the possibility to closely match cross-band weighting function combinations which is harder to achieve using conventional differential absorption techniques and the potential for additional corrections for water vapor and other interferences without using the data from numerical weather prediction (NWP) models.

Pliutau, Denis↗

Comparison of ER-2 Aircraft and POAM-III, MLS, and SAGE-II Satellite Measurements During SOLVE Using Traditional Correlative Analysis and Trajectory Hunting Technique

We compared the version 5 Microwave Limb Sounder (MLS) aboard the Upper Atmosphere Research Satellite (UARS), version 3 Polar Ozone and Aerosol Measurement-III (POAM-111) aboard the French satellite SPOT-IV, version 6.0 Stratospheric Aerosol and Gas Experiment 11 (SAGE-II) aboard the Earth Radiation Budget Satellite, and NASA ER-2 aircraft measurements made in the northern hemisphere in January-February 2000 during the SAGE III Ozone Loss and Validation Experiment (SOLVE). This study addresses one of the key scientific objectives of the SOLVE campaign, namely, to validate multi-platform satellite measurements made in the polar stratosphere during winter. This intercomparison was performed using a traditional correlative analysis (TCA) and a trajectory hunting technique (THT). Launching backward and forward trajectories from the points of measurement, the THT identifies air parcels sampled at least twice within a prescribed match criterion during the course of 5 days. We found that the ozone measurements made by these four instruments agree most of the time within 110% in the stratosphere up to 1400 K (approximately 35 km). The water vapor measurements from POAM-III and the ER-2 Harvard Lyman-alpha hygrometer and JPL laser hygrometer agree to within 10.5 ppmv (or about +/-10%) in the lower stratosphere above 380 K. The MLS and ER-2 ClO measurements agree within their error bars for the TCA. The MLS and ER-2 nitric acid measurements near 17-20 km altitude agree within their uncertainties most of the time with a hint of a positive offset by MLS according to the TCA. We also applied the AER box model constrained by the ER-2 measurements for analysis of the ClO and HN03 measurements using the THT. We found that: (1) the model values of ClO are smaller by about 0.3-0.4 (0.2) ppbv below (above) 400 K than those by MLS and (2) the HN03 comparison shows a positive offset of MLS values by approximately 1 and 1-2 ppbv below 400 K and near 450 K, respectively. It is hard to quantify the HN03 offset in the 400-440 K range because of the high sensitivity of nitric acid to the PSC schemes. Our study shows that, with some limitations (like HN03 comparison under PSC conditions), the THT is a more powerful tool for validation studies than the TCA, making conclusions of the comparison statistically more robust.

Danilin, M. Y.↗

Validation and Calibration of Energy Models with Real Vehicle Data from Chassis Dynamometer Experiments

Accurate estimation of vehicle fuel consumption typically requires detailed modeling of complex internal powertrain dynamics, often resulting in computationally intensive simulations. However, many transportation applications-such as traffic flow modeling, optimization, and control-require simplified models that are fast, interpretable, and easy to implement, while still maintaining fidelity to physical energy behavior. This work builds upon a recently developed model reduction pipeline that derives physics-like energy models from high-fidelity Autonomie vehicle simulations. These reduced models preserve essential vehicle dynamics, enabling realistic fuel consumption estimation with minimal computational overhead. While the reduced models have demonstrated strong agreement with their Autonomie counterparts, previous validation efforts have been confined to simulation environments. This study extends the validation by comparing the reduced energy model's outputs against real-world vehicle data. Focusing on the MidSUV category, we tune the baseline Autonomie model to closely replicate the characteristics of a Toyota RAV4. We then assess the accuracy of the resulting reduced model in estimating fuel consumption under actual drive conditions. Our findings suggest that, when the reference Autonomie model is properly calibrated, the simplified model produced by the reduction pipeline can provide reliable, semi-principled fuel rate estimates suitable for large-scale transportation applications.

42 ENGINEERING↗

Beyond Guesswork: Code Verification for Acoustic Duct Mode Prediction

The code used in the work (Swirl) is a frequency-domain linearized Euler equation solver that is designed to predict the effect of acoustic liners on acoustic modes propagating in realistic sheared and swirling mean flows, guiding the design of more efficient liner configurations. The purpose of this study is to validate Swirl using the Method Of Manufactured Solutions (MMS). This study also investigated the effect of the integration and spatial differencing methods on the convergence for a given Manufactured Solution. In addition, the effect of boundary condition implementation was tested. Through rigorous validation of the Swirl code using the MMS, this research underscores the significance of integration and spatial differencing methods on convergence, evaluates boundary condition implementations, and systematically assesses the impact of various filters.

Code Verification↗

Design of an Axisymmetric Afterbody Test Case for CFD Validation

As identified in the CFD Vision 2030 Study commissioned by NASA, validation of advanced RANS models and scale-resolving methods for computing turbulent flow fields must be supported by continuous improvements in fundamental, high-fidelity experiments designed specifically for CFD implementation. In accordance with this effort, the underpinnings of a new test platform referred to herein as the NASA Axisymmetric Afterbody are presented. The devised body-of-revolution is a modular platform consisting of a forebody section and afterbody section, allowing for a range of flow behaviors to be studied on interchangeable afterbody geometries. A body-of-revolution offers advantages in shape definition and fabrication, in avoiding direct contact with wind tunnel sidewalls, and in tail-sting integration to facilitate access to higher Reynolds number tunnels. The current work is focused on validation of smooth-body turbulent flow separation, for which a six-parameter body has been developed. A priori RANS computations are reported for a risk-reduction test configuration in order to demonstrate critical variation among turbulence model results for a given afterbody, ranging from barely-attached to mild separated flow. RANS studies of the effects of forebody nose (with/without) and wind tunnel boundary (slip/no-slip) on the selected afterbody are presented. Representative modeling issues that can be explored with this configuration are the effect of higher Reynolds number on separation behavior, flow physics of the progression from attached to increasingly-separated afterbody flows, and the effect of embedded longitudinal vortices on turbulence structure.

Disotell, Kevin J.↗

A diagnostic model for studying daytime urban air quality trends

A single cell Eulerian photochemical air quality simulation model was developed and validated for selected days of the 1976 St. Louis Regional Air Pollution Study (RAPS) data sets; parameterizations of variables in the model and validation studies using the model are discussed. Good agreement was obtained between measured and modeled concentrations of NO, CO, and NO2 for all days simulated. The maximum concentration of O3 was also predicted well. Predicted species concentrations were relatively insensitive to small variations in CO and NOx emissions and to the concentrations of species which are entrained as the mixed layer rises.

Brewer, D. A.↗

Validation of two-equation turbulence models for propulsion flowfields

The objective of the study is to assess the capability of two-equation turbulence models for simulating propulsion-related flowfields. The standard kappa-epsilon model with Chien's low Reynolds number formulation for near-wall effects is used as the baseline turbulence model. Several experimental test cases, representative of rocket combustor internal flowfields, are used to catalog the performance of the baseline model. Specific flowfields considered here include recirculating flow behind a backstep, mixing between coaxial jets and planar shear layers. Since turbulence solutions are notoriously dependent on grid and numerical methodology, the effects of grid refinement and artificial dissipation on numerical accuracy are studied. In the latter instance, computational results obtained with several central-differenced and upwind-based formulations are compared. Based on these results, improved turbulence modes such as enhanced kappa-epsilon models as well as other two-equation formulations (e.g., kappa-omega) are being studied. In addition, validation of swirling and reacting flowfields are also currently underway.

Deshpande, Manish↗

Development of an Axisymmetric Afterbody Test Case for Turbulent Flow Separation Validation

As identified in the CFD Vision 2030 Study commissioned by NASA, validation of advanced RANS models and scale-resolving methods for computing turbulent flows must be supported by improvements in high-quality experiments designed specifically for CFD implementation. A new test platform referred to as the Axisymmetric Afterbody allows for a range of flow behaviors to be studied on interchangeable afterbodies while facilitating access to higher Reynolds number facilities. A priori RANS computations are reported for a risk-reduction configuration to demonstrate critical variation among turbulence model results for a given afterbody, ranging from barely-attached to mild separated flow. The effects of body nose geometry and tunnel-wall boundary condition on the computed afterbody flow are explored to inform the design of an experimental test program.

Disotell, Kevin J.↗

Validating a large geophysical data set - Experiences with satellite-derived cloud parameters

The goal of this study is to validate the global cloud parameters derived from the satellite-borne HIRS2 and MSU atmospheric sounding instrument measurements, and to use the analysis of these data as one prototype for studying large geophysical data sets in general. The HIRS2/MSU data set contains a total of 40 physical parameters, filling 25 MB/day; raw HIRS2/MSU data are available for a period exceeding 10 years. Validation involves developing a quantitative sense for the physical meaning of the derived parameters over the range of environmental conditions sampled. This is accomplished by comparing the spatial and temporal distributions of the derived quantities with similar measurements made using other techniques, and with model results. The need to work with Level 2 (point) data, rather than Level 3 (gridded) data for validation purposes is discussed, and some techniques developed for charting the assumptions made in deriving an algorithm and generating a code to produce geophysical quantities from measured radiances are presented.

Kahn, Ralph↗

AMSR2 Soil Moisture Product Validation

The Advanced Microwave Scanning Radiometer 2 (AMSR2) is part of the Global Change Observation Mission-Water (GCOM-W) mission. AMSR2 fills the void left by the loss of the Advanced Microwave Scanning Radiometer Earth Observing System (AMSR-E) after almost 10 years. Both missions provide brightness temperature observations that are used to retrieve soil moisture. Merging AMSR-E and AMSR2 will help build a consistent long-term dataset. Before tackling the integration of AMSR-E and AMSR2 it is necessary to conduct a thorough validation and assessment of the AMSR2 soil moisture products. This study focuses on validation of the AMSR2 soil moisture products by comparison with in situ reference data from a set of core validation sites. Three products that rely on different algorithms were evaluated; the JAXA Soil Moisture Algorithm (JAXA), the Land Parameter Retrieval Model (LPRM), and the Single Channel Algorithm (SCA). Results indicate that overall the SCA has the best performance based upon the metrics considered.

microwave↗

Advanced Subsonic Technology (AST) 22-Inch Low Noise Research Fan Rig Preliminary Design of ADP-Type Fan 3

This report presents results of the work completed on the preliminary design of Fan 3 of NASA s 22-inch Fan Low Noise Research project. Fan 3 was intended to build on the experience gained from Fans 1 and 2 by demonstrating noise reduction technology that surpasses 1992 levels by 6 dB. The work was performed as part of NASA s Advanced Subsonic Technology (AST) program. Work on this task was conducted in the areas of CFD code validation, acoustic prediction and validation, rotor parametric studies, and fan exit guide vane (FEGV) studies up to the time when a NASA decision was made to cancel the design, fabrication and testing phases of the work. The scope of the program changed accordingly to concentrate on two subtasks: (1) Rig data analysis and CFD code validation and (2) Fan and FEGV optimization studies. The results of the CFD code validation work showed that this tool predicts 3D flowfield features well from the blade trailing edge to about a chord downstream. The CFD tool loses accuracy as the distance from the trailing edge increases beyond a blade chord. The comparisons of noise predictions to rig test data showed that both the tone noise tool and the broadband noise tool demonstrated reasonable agreement with the data to the degree that these tools can reliably be used for design work. The section on rig airflow and inlet separation analysis describes the method used to determine total fan airflow, shows the good agreement of predicted boundary layer profiles to measured profiles, and shows separation angles of attack ranging from 29.5 to 27deg for the range of airflows tested. The results of the rotor parametric studies were significant in leading to the decision not to pursue a new rotor design for Fan 3 and resulted in recommendations to concentrate efforts on FEGV stator designs. The ensuing parametric study on FEGV designs showed the potential for 8 to 10 EPNdB noise reduction relative to the baseline.

Jeracki, Robert J.↗

Filament winding cylinders. II - Validation of the process model

Analytical and experimental studies were performed to validate the model developed by Lee and Springer for simulating the manufacturing process of filament wound composite cylinders. First, results calculated by the Lee-Springer model were compared to results of the Calius-Springer thin cylinder model. Second, temperatures and strains calculated by the Lee-Springer model were compared to data. The data used in these comparisons were generated during the course of this investigation with cylinders made of Hercules IM-6G/HBRF-55 and Fiberite T-300/976 graphite-epoxy tows. Good agreement was found between the calculated and measured stresses and strains, indicating that the model is a useful representation of the winding and curing processes.

Calius, Emilio P.↗

Multistage economic MPC for systems with a cyclic steady state: A gas network case study

Multistage model predictive control (MPC) provides a robust control strategy for dynamic systems with uncertainties and a setpoint tracking objective. Moreover, extending MPC to minimize an economic cost instead of tracking a pre-calculated optimal setpoint improves controller performance. This paper presents a novel multistage economic nonlinear model predictive control (E-NMPC) framework for dynamic systems operating under uncertainty, with specific application to natural gas transmission networks. A key innovation lies in the integration of cyclic steady-state (CSS) constraints within the multistage MPC formulation, enabling the controller to manage periodic operating conditions commonly observed in energy systems. A Lyapunov-based descent condition is enforced to ensure robust stability of the controller. The multistage economic MPC framework is validated on two gas pipeline case studies, where it successfully minimizes net energy consumption, respects operational constraints under uncertain demand profiles, and guides the network to optimal cyclic operation. The Lyapunov function remains bounded in both case studies, validating the robust stability of multistage E-NMPC.

03 NATURAL GAS↗

Prediction of forces and moments for flight vehicle control effectors: Workplan

Two research activities directed at hypersonic vehicle configurations are currently underway. The first involves the validation of a number of classical local surface inclination methods commonly employed in preliminary design studies of hypersonic flight vehicles. Unlike studies aimed at validating such methods for predicting overall vehicle aerodynamics, this effort emphasizes validating the prediction of forces and moments for flight control studies. Specifically, several vehicle configurations for which experimental or flight-test data are available are being examined. By comparing the theoretical predictions with these data, the strengths and weaknesses of the local surface inclination methods can be ascertained and possible improvements suggested. The second research effort, of significance to control during take-off and landing of most proposed hypersonic vehicle configurations, is aimed at determining the change due to ground effect in control effectiveness of highly swept delta planforms. Central to this research is the development of a vortex-lattice computer program which incorporates an unforced trailing vortex sheet and an image ground plane. With this program, the change in pitching moment of the basic vehicle due to ground proximity, and whether or not there is sufficient control power available to trim, can be determined. In addition to the current work, two different research directions are suggested for future study. The first is aimed at developing an interactive computer program to assist the flight controls engineer in determining the forces and moments generated by different types of control effectors that might be used on hypersonic vehicles. The first phase of this work would deal in the subsonic portion of the flight envelope, while later efforts would explore the supersonic/hypersonic flight regimes. The second proposed research direction would explore methods for determining the aerodynamic trim drag of a generic hypersonic flight vehicle and ways in which it can be minimized through vehicle design and trajectory optimization.

Maughmer, Mark D.↗

Tau Positron Emission Tomography for Predicting Dementia in Individuals With Mild Cognitive Impairment

An accurate prognosis is especially pertinent in mild cognitive impairment (MCI), when individuals experience considerable uncertainty about future progression. To evaluate the prognostic value of tau positron emission tomography (PET) to predict clinical progression from MCI to dementia. This was a multicenter cohort study with external validation and a mean (SD) follow-up of 2.0 (1.1) years. Data were collected from centers in South Korea, Sweden, the US, and Switzerland from June 2014 to January 2024. Participant data were retrospectively collected and inclusion criteria were a baseline clinical diagnosis of MCI; longitudinal clinical follow-up; a Mini-Mental State Examination (MMSE) score greater than 22; and available tau PET, amyloid-β (Aβ) PET, and magnetic resonance imaging (MRI) scan less than 1 year from diagnosis. A total of 448 eligible individuals with MCI were included (331 in the discovery cohort and 117 in the validation cohort). None of these participants were excluded over the course of the study. Exposures included Tau PET, Aβ PET, and MRI. Positive results on tau PET (temporal meta–region of interest), Aβ PET (global; expressed in the standardized metric Centiloids), and MRI (Alzheimer disease [AD] signature region) was assessed using quantitative thresholds and visual reads. Clinical progression from MCI to all-cause dementia (regardless of suspected etiology) or to AD dementia (AD as suspected etiology) served as the primary outcomes. The primary analyses were receiver operating characteristics. In the discovery cohort, the mean (SD) age was 70.9 (8.5) years, 191 (58%) were male, the mean (SD) MMSE score was 27.1 (1.9), and 110 individuals with MCI (33%) converted to dementia (71 to AD dementia). Only the model with tau PET predicted all-cause dementia (area under the receiver operating characteristic curve [AUC], 0.75; 95% CI, 0.70-0.80) better than a base model including age, sex, education, and MMSE score (AUC, 0.71; 95% CI, 0.65-0.77; P = .02), while the models assessing the other neuroimaging markers did not improve prediction. In the validation cohort, tau PET replicated in predicting all-cause dementia. Compared to the base model (AUC, 0.75; 95% CI, 0.69-0.82), prediction of AD dementia in the discovery cohort was significantly improved by including tau PET (AUC, 0.84; 95% CI, 0.79-0.89; P < .001), tau PET visual read (AUC, 0.83; 95% CI, 0.78-0.88; P = .001), and Aβ PET Centiloids (AUC, 0.83; 95% CI, 0.78-0.88; P = .03). In the validation cohort, only the tau PET and the tau PET visual reads replicated in predicting AD dementia. In this study, tau-PET showed the best performance as a stand-alone marker to predict progression to dementia among individuals with MCI. This suggests that, for prognostic purposes in MCI, a tau PET scan may be the best currently available neuroimaging marker.

59 BASIC BIOLOGICAL SCIENCES↗

Performance of the Bowen ratio systems on a 22 deg slope

The Bowen ratio energy balance technique was used to assess the energy fluxes on inclined surfaces during the First ISLSCP Field Experiment (FIFE). Since air flow over sloping surface may differ from that over flat terrain, it is important to examine whether Bowen ratio measurements taken on sloping surfaces are valid. In this study, the suitability of using the Bowen ratio technique on sloping surfaces was tested by examining the assumptions that the technique requires for valid measurements. This was accomplished by studying the variation of Bowen ratio measurements along a selected slope at the FIFE site. In September 1988, four Bowen ratio systems were set up in a line along the 22 degree north-facing slope with northerly air flow (wind went up the slope). In July of 1989, six Bowen ratio systems were similarly installed with southerly air flow (the wind went down slope). Results indicated that, at distances between 10 to 40 meters from the top of the slope, no temperature or vapor pressure gradient parallel to the slope was detected. Uniform Bowen ratio values were obtained on the slope, and thus the sensible or latent heat flux should be similar along the slope. This indicates that the assumptions for valid flux measurements are reasonably met at the slope. The Bowen ratio technique should give the best estimates of the energy fluxes on slopes similar to that in this study.

Nie, D.↗

Data for 3-Hydroxypropionic Acid Recovery from Fermentation Broth through Novel Downstream Processing: Technoeconomic Analysis

This study develops and validates a simplified, fully solvent-free downstream processing (DSP) strategy for high-purity recovery of 3-hydroxypropionic acid (3-HP) from real fermentation broth containing 62.3 g/L of 3-HP. Optimized activated carbon treatment achieved 98% color removal, while Amberlite IRA-67 was operated at pH 4.5 and 30 °C to minimize product loss. This is the first integrated demonstration of a fully solvent-free DSP enabling recovery of bio-based 3-HP as both a solid sodium salt and a concentrated aqueous solution, supported by techno-economic analysis. At lab scale, the process achieved 77.3% recovery of sodium 3-HP with 83.2% (w/w) purity and produced a 30% (w/v) aqueous solution. Techno-economic analysis yielded minimum selling prices of $0.551/kg for the solution and $0.892/kg for the salt, both below target thresholds for cost-competitive bio-acrylic acid production. Overall, these results demonstrate an efficient, scalable, and economically viable industrial pathway for 3-HP recovery.

Bioproducts↗