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At least 577 records · Page 32

Using light and X-ray scattering to untangle complex neuronal orientations and validate diffusion MRI

Disentangling human brain connectivity requires an accurate description of nerve fiber trajectories, unveiled via detailed mapping of axonal orientations. However, this is challenging because axons can cross one another on a micrometer scale. Diffusion magnetic resonance imaging (dMRI) can be used to infer axonal connectivity because it is sensitive to axonal alignment, but it has limited spatial resolution and specificity. Scattered light imaging (SLI) and small-angle X-ray scattering (SAXS) reveal axonal orientations with microscopic resolution and high specificity, respectively. Here, we apply both scattering techniques on the same samples and cross-validate them, laying the groundwork for ground-truth axonal orientation imaging and validating dMRI. We evaluate brain regions that include unidirectional and crossing fibers in human and vervet monkey brain sections. SLI and SAXS quantitatively agree regarding in-plane fiber orientations including crossings, while dMRI agrees in the majority of voxels with small discrepancies. We further use SAXS and dMRI to confirm theoretical predictions regarding SLI determination of through-plane fiber orientations. Scattered light and X-ray imaging can provide quantitative micrometer 3D fiber orientations with high resolution and specificity, facilitating detailed investigations of complex fiber architecture in the animal and human brain.

59 BASIC BIOLOGICAL SCIENCES↗

LEGUS discovery of a light echo around supernova 2012aw

We have discovered a luminous light echo around the normal Type II-Plateau Supernova (SN) 2012aw in Messier 95 (M95; NGC 3351), detected in images obtained approximately two years after explosion with the Wide Field Channel 3 on board the Hubble Space Telescope by the Legacy ExtraGalactic Ultraviolet Survey. The multi-band observations span from the near-ultraviolet through the optical (F275W, F336W, F438W, F555W, and F814W). The apparent brightness of the echo at the time was ∼21–22 mag in all of these bands. The echo appears circular, although less obviously as a ring, with an inhomogeneous surface brightness, in particular, a prominent enhanced brightness to the southeast. The SN itself was still detectable, particularly in the redder bands. We are able to model the light echo as the time-integrated SN light scattered off of diffuse interstellar dust in the SN environment. We have assumed that this dust is analogous to that in the Milky Way with R{sub V}=3.1. The SN light curves that we consider also include models of the unobserved early burst of light from the SN shock breakout. Our analysis of the echo suggests that the distance from the SN to the scattering dust elements along the echo is ≈45 pc. The implied visual extinction for the echo-producing dust is consistent with estimates made previously from the SN itself. Finally, our estimate of the SN brightness in F814W is fainter than that measured for the red supergiant star at the precise SN location in pre-SN images, possibly indicating that the star has vanished and confirming it as the likely SN progenitor.

79 ASTRONOMY AND ASTROPHYSICS↗

Scatter-free collimated convection and cosmic-ray transport at 1 AU

Observations of solar cosmic rays between 0.1 MeV and 1 GeV are more consistent with scatter-free than diffusive propagation near 1 AU. Since these particles also are constrained to interplanetary magnetic field lines, the parallel and transverse flow are decoupled by collimated convection. Local propagation is therefore more appropriately described by Liouville's equation, and transport properties can be examined from the exact zeroeth and first moments of the equation averaged over all directions in momentum space. Observational results which may be explained directly without invoking local scattering include the decay of solar flare events as well as the radial gradient, diurnal and semidiurnal variation of galactic cosmic rays.

Roelof, E. C.↗

Light scattering by a rough surface of human skin. 2. Diffuse reflectance

Based on the previously calculated luminance factors, we have investigated the integral characteristics of light reflection from a rough surface of the skin with large-scale inhomogeneities under various conditions of the skin illumination. Shadowing of incident and scattered beams by relief elements is taken into account. Diffuse reflectances by the Gaussian and the quasi-periodic surfaces are compared and, in general, both these roughness models are shown to give similar results. We have studied the effect of the angular structure of radiation multiply scattered deep in the tissue and the refraction of rays as they propagate from the dermis to the surface of the stratum corneum on the reflection characteristics of the skin surface. The importance of these factors is demonstrated. The algorithms constructed can be included in the schemes of calculation of the light fields inside and outside the medium in solving various direct and inverse problems of optics of biological tissues. (biophotonics)

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

High altitude Venus haze from Pioneer Venus limb scans

High-resolution limb scans of Venus made with the Orbiter Cloud Photopolarimeter aboard Pioneer Venus have been used to observe the high altitude Venus haze and its variation over almost one half a Venusian year. A model for a spherical atmosphere with tangential viewing geometry was used to analyze the observations and derive the haze properties. Values are found for the particle size and refractive index, particle number density and scale height, and eddy diffusion coefficient. Single scattering computations show good agreement with observed intensities for particles smaller than 0.3 micron radius and refractive index less than 1.7, consistent with, but not limited to, concentrated sulfuric acid. Particle scale height in the 0.5 to 2 mbar pressure regions varies between 1 and 3 km over the season, latitude, and local time ranges of the observations. Detached layers of haze are sometimes present. An average particle scale height of 2.2 km at 84 km altitude yields an eddy diffusion coefficient of 130,000 sq cm/sec.

Lane, W. A.↗

Computer simulations of cosmic-ray diffusion near supernova remnant shock waves

A plasma simulation model was used to study the resonant interactions between streaming cosmic-ray ions and a self-consistent spectrum of Alfven waves, such as might exist in the interstellar medium upstream of a supernova remnant shock wave. The computational model is a hybrid one, in which the background interstellar medium is an MHD fluid and the cosmic-rays are discrete kinetic particles. The particle sources for the electromagnetic fields are obtained by averaging over the fast cyclotron motions. When the perturbed magnetic field is larger than 10 percent of the background field, the macro- and microphysics are no longer correctly predicted by quasi-linear theory. The particles are trapped by the waves and show sharp jumps in their pitch-angles relative to the background magnetic field, and the effective ninety-degree scattering time for diffusion parallel to the background magnetic field is reduced to between 5 and 30 cyclotron periods. Simulation results suggest that Type 1 supernova remnants may be the principal sites of cosmic ray acceleration.

Max, C. E.↗

Time-resolved diffusion tomographic 2D and 3D imaging in highly scattering turbid media

A method for imaging objects in highly scattering turbid media. According to one embodiment of the invention, the method involves using a plurality of intersecting source/detectors sets and time-resolving equipment to generate a plurality of time-resolved intensity curves for the diffusive component of light emergent from the medium. For each of the curves, the intensities at a plurality of times are then inputted into the following inverse reconstruction algorithm to form an image of the medium: wherein W is a matrix relating output at source and detector positions r.sub.s and r.sub.d, at time t, to position r, .LAMBDA. is a regularization matrix, chosen for convenience to be diagonal, but selected in a way related to the ratio of the noise, to fluctuations in the absorption (or diffusion) X.sub.j that we are trying to determine: .LAMBDA..sub.ij =.lambda..sub.j .delta..sub.ij with .lambda..sub.j = /<.DELTA.Xj.DELTA.Xj> Y is the data collected at the detectors, and X.sup.k is the kth iterate toward the desired absorption information. An algorithm, which combines a two dimensional (2D) matrix inversion with a one-dimensional (1D) Fourier transform inversion is used to obtain images of three dimensional hidden objects in turbid scattering media.

Alfano, Robert R.↗

Time-resolved diffusion tomographic 2D and 3D imaging in highly scattering turbid media

A method for imaging objects in highly scattering turbid media. According to one embodiment of the invention, the method involves using a plurality of intersecting source/detectors sets and time-resolving equipment to generate a plurality of time-resolved intensity curves for the diffusive component of light emergent from the medium. For each of the curves, the intensities at a plurality of times are then inputted into the following inverse reconstruction algorithm to form an image of the medium: ##EQU1## wherein W is a matrix relating output at source and detector positions r.sub.s and r.sub.d, at time t, to position r, .LAMBDA. is a regularization matrix, chosen for convenience to be diagonal, but selected in a way related to the ratio of the noise, to fluctuations in the absorption (or diffusion) X.sub.j that we are trying to determine: .LAMBDA..sub.ij =.lambda..sub.j .delta..sub.ij with .lambda..sub.j = /<.DELTA.Xj.DELTA.Xj> Y is the data collected at the detectors, and X.sup.k is the kth iterate toward the desired absoption information. An algorithm, which combines a two dimensional (2D) matrix inversion with a one-dimensional (1D) Fourier transform inversion is used to obtain images of three dimensional hidden objects in turbid scattering media.

Alfano, Robert R.↗

Nonstereotypical Distribution and Effect of Ergosterol in Lipid Membranes

Ergosterol, found in fungi and some protist membranes, is understudied compared with cholesterol from animal membranes. Generally, ergosterol is assumed to modulate membranes in the same manner as cholesterol, based on their similar chemical structures. Here we reveal some fundamental structural and dynamical differences between them. Neutron diffraction shows that ergosterol is embedded in the lipid bilayer much shallower than cholesterol. Further, ergosterol does not change the membrane thickness as much as cholesterol does, indicating little condensation effect. Neutron spin echo shows that ergosterol can rigidify and soften membranes at different concentrations. The lateral lipid diffusion measured by quasielastic neutron scattering indicates that ergosterol promotes a jump diffusion of the lipid, whereas cholesterol keeps the same continuous lateral diffusion as the pure lipid membrane. Our results point to quite distinct interactions of ergosterol with membranes compared with cholesterol. These insights provide a basic understanding of membranes containing ergosterol with implications for phenomena such as lipid rafts and drug interactions.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Plasmapause diffusion

The Bohm diffusion coefficient and observed electrostatic wave scattering are used as the bases of estimates of the smoothing effect that diffusion may have on steep plasmapause density gradients. The estimate for diffusion resulting from scattering by observed electrostatic waves is found to be much lower than that of the perpendicular Bohm diffusion coefficient for characteristic plasma temperatures and magnetic fields. This diffusion rate estimate may be too small, however, if the wave amplitudes are significantly higher for steep plasmapauses. The effects are therefore negligible for most considerations of macroscopic plasmapause dynamics, but may be significant in limiting drift wave instabilities and similar phenomena driven by the steepness of the plasmapause density gradient.

Horwitz, J. L.↗

Simulation of radiation driven fission gas diffusion in UO 2 , ThO 2 and PuO 2

Below 1000 K it is thought that fission gas diffusion in nuclear fuel during irradiation occurs through atomic mixing due to radiation damage. Here we present a molecular dynamics (MD) study of Xe, Kr, Th, U, Pu and O diffusion due to irradiation. It is concluded that the ballistic phase does not sufficiently account for the experimentally observed diffusion. Thermal spike simulations are used to confirm that electronic stopping remedies the discrepancy with experiment and the predicted diffusivities lie within the scatter of the experimental data. Here, our results predict that the diffusion coefficients are ordered such that D* 0 > D* Kr > D* Xe > D* U . For all species >98.5% of diffusivity is accounted for by electronic stopping. Fission gas diffusivity was not predicted to vary significantly between ThO 2 , UO 2 and PuO 2 , indicating that this process would not change greatly for mixed oxide fuels.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Drift shell splitting by internal geomagnetic multipoles.

Computations on an 80-coefficient model of the earth's field illustrate the 'topography' of the magnetic equatorial surface and the geometry of the drift shells of geomagnetically trapped particles. Individual terms in the spherical harmonic expansion of the geomagnetic scalar potential V(r, theta, phi) are either even or odd in cos theta, where theta = 90 deg denotes the dipole equator. Terms that are even in cos theta tend to 'warp' the equatorial surface, but do not (in first order) distort particle drift shells radially nor split the drift shells of particles having different equatorial pitch angles. Azimuthally asymmetric terms that are odd in cos theta do cause shell splitting in first order. Shell splitting at large L values (neglecting deformation of the earth's field by the solar wind) is found to be dominated by the geomagnetic octupole. At L approximately equal to 1, shell splitting is strongly enhanced by the South American and South African anomalies. When combined with pitch angle diffusion caused by atmospheric scattering, these results may be able to account for anomalous radial diffusion of inner zone electrons.

Roederer, J. G.↗

Injection and diffusive transport of suprathermal through energetic solar flare protons (35 keV to 20 MeV)

Consideration is given to the injection and interplanetary propagation of low-energy protons caused by the solar particle event of July 20, 1981, in which flare protons in the range from 35 keV to 20 MeV were observed by instruments on ISEE 3. The observed time-intensity and time-anisotropy profiles were fitted over the entire energy range using a model based on the spherically symmetric Fokker-Plank equation, including convection, diffusion, and adiabatic deceleration. The results are used to discuss the behavior of the radial interplanetary diffusion coefficient and the scattering mean free path for protons. Also, evidence is found for diffusive coronal shock acceleration of protons during the event.

Beeck, J.↗

Simulation of energy-dependent electron diffusion processes in the Earth's outer radiation belt

The radial and local diffusion processes induced by various plasma waves govern the highly energetic electron dynamics in the Earth's radiation belts, causing distinct characteristics in electron distributions at various energies. In this study, we present our simulation results of the energetic electron evolution during a geomagnetic storm using the University of California, Los Angeles 3-D diffusion code. Following the plasma sheet electron injections, the electrons at different energy bands detected by the Magnetic Electron Ion Spectrometer (MagEIS) and Relativistic Electron Proton Telescope (REPT) instruments on board the Van Allen Probes exhibit a rapid enhancement followed by a slow diffusive movement in differential energy fluxes, and the radial extent to which electrons can penetrate into depends on energy with closer penetration toward the Earth at lower energies than higher energies. We incorporate radial diffusion, local acceleration, and loss processes due to whistler mode wave observations to perform a 3-D diffusion simulation. Here, our simulation results demonstrate that chorus waves cause electron flux increase by more than 1 order of magnitude during the first 18 h, and the subsequent radial extents of the energetic electrons during the storm recovery phase are determined by the coupled radial diffusion and the pitch angle scattering by EMIC waves and plasmaspheric hiss. The radial diffusion caused by ULF waves and local plasma wave scattering are energy dependent, which lead to the observed electron flux variations with energy dependences. Lastly, this study suggests that plasma wave distributions in the inner magnetosphere are crucial for the energy-dependent intrusions of several hundred keV to several MeV electrons.

58 GEOSCIENCES↗

Applying Nonlinear Diffusion Acceleration to Fixed-Source Problems with Anisotropic Scattering - Paper 15

Work over the last several years has demonstrated the impressive performance gains that can be attained by using Moment-Based Acceleration (MBA), or High-Order/Low-Order (HOLO), methods in a variety of transport applications. In the field of neutronics, Nonlinear Diffusion Acceleration (NDA) has been used to accelerate the solution to the fixed-source problem and the k-eigenvalue problem. These methods efficiently move a major portion of the computational work out of the full phase-space (high-order (HO)) domain into a reduced phase-space (low-order (LO)) setting. In previous implementations, NDA has only been applied to isotropic scattering problems. In this paper, we will extend this methodology to anisotropic scattering. This initial work on anisotropic scattering will focus on the 1-D multi-group neutron transport equation. This summary focuses on a fixed-source problem, but the extension to criticality problems is straight-forward via NDA-NCA. Within this paper, we have described a method for extending Nonlinear Diffusion Acceleration to solve problems with anisotropic scattering. We demonstrated that a consistent low-order system, resembling the low-order system from, could be constructed. We demonstrated that the NDA method performed exceptionally in the presence of anisotropic scattering. NDA reduced the number of iterations required to meet the convergence tolerance by a factor of 500 over source iteration for a one fixed-source problem and by 3.5-50 x for the Henyey-Greenstein problems. This method is equally well-suited for eigenvalue problems. The NDA method allows us to transition the eigenvalue iteration to the low-order domain.

61 RADIATION PROTECTION AND DOSIMETRY↗

SCATTERED EMISSION FROM z {approx} 1 GALACTIC OUTFLOWS

Mapping Mg II resonance emission scattered by galactic winds offers a means to determine the spatial extent and density of the warm outflow. Using Keck/LRIS spectroscopy, we have resolved scattered Mg II emission to the east of 32016857, a star-forming galaxy at z = 0.9392 with an outflow. The Mg II emission from this galaxy exhibits a P-Cygni profile, extends further than both the continuum and [O II] emission along the eastern side of the slit, and has a constant Doppler shift along the slit which does not follow the velocity gradient of the nebular [O II] emission. Using the Sobolev approximation, we derive the density of Mg{sup +} ions at a radius of 12-18 kpc in the outflow. We model the ionization correction and find that much of the outflowing Mg is in Mg{sup ++}. We estimate that the total mass flux could be as large as 330-500 M{sub Sun} yr{sup -1}, with the largest uncertainties coming from the depletion of Mg onto grains and the clumpiness of the warm outflow. We show that confining the warm clouds with a hot wind reduces the estimated mass flux of the warm outflow and indicates a mass-loading factor near unity in the warm phase alone. Based on the high blue luminosities that distinguish 32016857 and TKRS 4389, described by Rubin et al., from other galaxies with P-Cygni emission, we suggest that, as sensitivity to diffuse emission improves, scattering halos may prove to be a generic property of star-forming galaxies at intermediate redshifts.

79 ASTRONOMY AND ASTROPHYSICS↗

Monte Carlo study of non-diffusive relaxation of a transient thermal grating in thin membranes

In this paper, the impact of boundary scattering on non-diffusive thermal relaxation of a transient grating in thin membranes is rigorously analyzed using the multidimensional phonon Boltzmann equation. The gray Boltzmann simulation results indicate that approximating models derived from previously reported one-dimensional relaxation model and Fuchs-Sondheimer model fail to describe the thermal relaxation of membranes with thickness comparable with phonon mean free path. Effective thermal conductivities from spectral Boltzmann simulations free of any fitting parameters are shown to agree reasonably well with experimental results. These findings are important for improving our fundamental understanding of non-diffusive thermal transport in membranes and other nanostructures.

36 MATERIALS SCIENCE↗

A mechanism for ageing in a deeply supercooled molecular glass

Measurements of the decay of electric fields, formed spontaneously within vapour-deposited films of cis-methyl formate, provide the first direct assessment of the energy barrier to secondary relaxation in a molecular glass. At temperatures far below the glass transition temperature, the mechanism of relaxation is shown to be through hindered molecular rotation. Magnetically-polarised neutron scattering experiments exclude diffusion, which is demonstrated to take place only close to the glass transition temperature.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗