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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 577 records · Page 32
All sourcesNASA NTRSDOE OSTI
DOE OSTI2025

SuFEx-enabled high-throughput medicinal chemistry for developing potent tamoxifen analogs as Ebola virus entry inhibitors

Ebola virus (EBOV) causes severe hemorrhagic fever with a high mortality rate in humans. In acute infection, an abnormal immune response results in excessive inflammatory cytokines and uncontrolled systemic inflammation that can result in organ damage and multi-organ failure. While vaccines and monoclonal antibody therapies are available, there is an urgent need for effective small-molecule antivirals against EBOV. Here, we report on the optimization of tamoxifen, an EBOV-glycoprotein (GP) binder that inhibits viral entry, using our Sulfur-Fluoride Exchange (SuFEx) click chemistry-based high-throughput medicinal chemistry (HTMC) strategy. Using a “Direct-to-Biology” approach, we generated a focused library of 2,496 tamoxifen analogs overnight and screened them in a cell-based pseudo-EBOV infection assay. The HTMC workflow enabled the development of a potent EBOV entry inhibitor with submicromolar EC 50 cellular antiviral activity and more than 50-fold improvement in binding affinity against EBOV-GP compared to the parent compound. Our findings underscore the use of SuFEx-enabled HTMC for rapidly generating and assessing potential therapeutic candidates against viral and immune-mediated diseases in a cell-based assay.

Immunology↗
NASA NTRS1962

One-Dimensional Heat Conduction Through the Skin of a Vehicle upon Entering a Planetary Atmosphere at Constant Velocity and Entry Angle

Closed-form solutions of the one-dimensional heat-conduction equations for the flow of heat into a plate with a laminar boundary layer have been obtained for a configuration entering a planetary atmosphere with constant velocity and negative entry angle. The atmospheric density was assumed to obey an exponential law and the temperature was assumed constant initially. The solution is in the form of a Fourier series expansion which, for most practical applications, can be approximated by retaining only one term of the expression. The solution applies to the initial part of the entry before the maximum heating conditions are encountered.

SKIN TEMPERATURE↗
NASA NTRS1966

Entry capsule orbit determination accuracy

On-board tracking system of two-way coherent Doppler between entry capsule and orbiting bus for determining orbit of entry capsule and estimating atmospheric parameters.

COHERENT RADAR↗
NASA NTRS1968

Propulsive re-entry aerodynamics Interim report, 1 Jun. 1967 - 1 Jun. 1968

This report discusses the progress accomplished during the first year of a two-year contract to study Propulsive Re-Entry Aerodynamics. Analytical methods were developed during the first year to predict the flow field in the immediate vicinity of a planetary entry system composed of an aeroshell with a single retrorocket which exhausts into a subsonic or supersonic counterflowing planetary atmosphere. In the second year a digital computer program will be developed for the analytical solutions, and the analytical model will be tested by performing an experimental test program and comparing the experimental results with the analytical predictions. The analytical investigation considers the flow field due to a single supersonic retrorocket exhausting from an aeroshell into oncoming subsonic, transonic, or supersonic streams in the large thrusting coefficient regime, 0.5 < C(sub T) = T/q(sub ∞) A(sub m) < 15, which is the range of thrusting coefficients encountered during the terminal landing phase for planetary landing on Mars or Venus. Analyses are provided for all the geometrical features of the flow field such as the location of the terminal shock, jet boundary, and the profile for the interface between the jet and atmospheric gases. In addition, analyses are developed which describe the growth of the mixing layers along the interface and at the edge of the jet boundary and dead-air region and the reattachment of the shear layer to the aeroshell or the recompression of the shear layer in wake type flow. A comprehensive discussion of the experimental wind tunnel test program to be accomplished in Phase II is presented.

Philip O Jarvinen↗
NASA NTRS1972

The aerothermodynamic environment of the Apollo command module during superorbital entry

Aerothermodynamic measurements were obtained on two Apollo spacecraft during atmospheric entry at near-lunar-return velocities. Histories of measured pressure and of convective and radiative heating rates are compared with theoretical predictions and with wind-tunnel results. The comparisons show that pressures measured in the wind tunnel correspond to those measured in the flight environment of the entry face. Unexplained low pressures were obtained on the conical section. Measured radiative heating rates agree with predictions calculated for both visible and infrared radiation. Good agreement was found between convective heating rates measured in flight and predictions obtained by using cold wall theory adjusted for mass injection from the ablator.

Lee, D. B.↗