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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 577 records · Page 32
All sourcesNASA NTRSDOE OSTI
DOE OSTI2024

Coupling Kinesin Spindle Protein and Aurora B Inhibition with Apoptosis Induction Enhances Oral Cancer Cell Killing

Many proteins regulating mitosis have emerged as targets for cancer therapy, including the kinesin spindle protein (KSP) and Aurora kinase B (AurB). KSP is crucial for proper spindle pole separation during mitosis, while AurB plays roles in chromosome segregation and cytokinesis. Agents targeting KSP and AurB selectively affect dividing cells and have shown significant activity in vitro. However, these drugs, despite advancing to clinical trials, often yield unsatisfactory outcomes as monotherapy, likely due to variable responses driven by cyclin B degradation and apoptosis signal accumulation networks. Accumulated data suggest that combining emerging antimitotics with various cytostatic drugs can enhance tumor-killing effects compared to monotherapy. Here, we investigated the impact of inhibiting anti-apoptotic signals with the BH3-mimetic Navitoclax in oral cancer cells treated with the selective KSP inhibitor, Ispinesib, or AurB inhibitor, Barasertib, aiming to potentiate cell death. The combination of BH3-mimetics with both KSP and AurB inhibitors synergistically induced substantial cell death, primarily through apoptosis. A mechanistic analysis underlying this synergistic activity, undertaken by live-cell imaging, is presented. Our data underscore the importance of combining BH3-mimetics with antimitotics in clinical trials to maximize their effectiveness.

Silva, João P. N. (ORCID:0000000344554286)↗
NASA NTRS1962

The Analysis of a Vortex Type Magnetohydrodynamic Induction Generator

Consideration it is given to the performance to the characteristics of an AC magnetohydrodynamic power generator, A rotating magnetic field is imposed on the vortex flow of an electrically conducting fluid, which is injected tangentially into an annulus formed by two nonconducting concentric cylinders and two nonconducting end plates. A perturbation technique is used to determine the two dimensional velocity and three dimensional electromagnetic field and current distributions. Finally, the generated power, the ohmic losses, the effective power and the electrical efficiency of the converter system are calculated.

MAGNETOHYDRODYNAMIC GENERATOR↗
NASA NTRS1968

Alternating current electromagnetic servo induction meter

Electromagnetic device accurately indicates the responses of various sensors in high performance flight research aircraft to conditions encountered in flight. The device responds to sensor inputs to move a slideable armature along an indicator scale by the force of currents induced in the armature winding.

Bogue, R. K.↗