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At least 577 records · Page 32

Illusory sensations in aircraft flight and weightlessness

Clearly misleading illusions only appear when the vestibular input is of a nonconflicting nature. A number of experiments with blind goldfish were conducted since the vestibular system of the goldfish is homologous in many respects to that of man. Inertial stimuli were given by linear acceleration of the entire aquarium with the fish in it. A high-speed movie camera and three-axis accelerometers were used to record the fish responses. It was found that fish, if subjected to horizontal linear acceleration, behave as if the moving force acting on the otoliths were a gravitational force component and not an inertial reacting force.

Von Baumgarten, R. J.↗

Mo-99 Concentration and processing by Solvent Extraction and Ion Exchange

Normally derived from its transient-equilibrium parent molybdenum-99 ( 99 Mo) (t½ = 66 h), the short-lived isotope technetium-99m ( 99m Tc) (t ½ = 6.0 h) is the most widely used medical isotope in diagnostic imaging today. The National Nuclear Security Administration’s (NNSA’s) Material Management and Minimization (M3) program—established under the auspices of the American Medical Isotope Production Act—has been tasked with facilitating the work of domestic 99 Mo suppliers that do not use highly enriched uranium (HEU). Superconducting electron linear accelerators that employ high-Z converter targets can generate bremsstrahlung photons and neutron fluxes that can induce photonuclear reactions and uranium (U) fission. Argonne, in collaboration with industrial partners, has been developing the process chemistry for superconducting linear accelerator (LINAC)-irradiated triuranium octoxide (U 3 O 8 ) targets to produce 99 Mo. In short, the process involves dissolving the irradiated targets in nitric acid, which simultaneously releases valuable fission products (xenon and iodine). After adjusting the acid concentration, producers process the feed using tri-n-butyl phosphate (TBP), then mix the raffinate derived from this extraction cycle with a phosphinic acid such as Cyanex 272 or di(2-ethylhexyl) phosphoric acid (HDEHP), which is selective for Mo (molybdenum liquid liquid extraction [MoLLE]). In the next step, a concentration column comprising an anion exchange platform is used to decontaminate the remaining fission products, generating a pure 99 Mo stream in sodium hydroxide (NaOH)/sodium chloride (NaCl).

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEA↗

The ReA electron-beam ion trap charge breeder for reacceleration of rare isotopes

ReA is a post-accelerator at the National Superconducting Cyclotron Laboratory at Michigan State University. ReA is designed to reaccelerate rare isotopes to energies of a few MeV/u following production by projectile fragmentation and thermalization in a gas cell. The facility consists of four main components: an electron-beam ion trap (EBIT) charge breeder, an achromatic charge-over-mass (Q/A) separator, a radio-frequency quadrupole accelerator, and a superconducting radio-frequency linear accelerator. The EBIT charge breeder was specifically designed to efficiently capture continuous beams of singly charged ions injected at low energy (<60 keV), charge breed in less than 50 ms, and extract highly charged ions to the Q/A separator for charge-state selection and reacceleration through the accelerator structures. The use of highly charged ions to reach high beam energies is a key aspect that makes ReA a compact and cost-efficient post-accelerator. The EBIT is characterized by a high-current electron gun, a long multi-electrode trap structure and a dual magnet to provide both the high electron-beam current density necessary for fast charge breeding of short-lived isotopes as well as the high capture probability of injected beams. This paper presents an overview and the status of the ReA EBIT, which has extracted for reacceleration tests stable {sup 20}Ne{sup 8+} ion beams produced from injected gas and more recently {sup 39}K{sup 16+} beams by injecting stable {sup 39,41}K{sup +} ions from an external ion source.

43 PARTICLE ACCELERATORS↗

SU-E-T-270: Diffusion Synthetic Acceleration for Linear Boltzmann Transport Equation

Purpose: Linear Boltzmann transport equation (LBTE) is as accurate as the Monte Carlo method (MC) for dose calculation in photon/particle therapy (LBTE is a deterministic and Eulerian formulation and MC is a statistical and Lagrangian description). An advantage of LBTE is that numerous acceleration techniques can be utilized for acceleration. This work is to explore the acceleration of LBTE via diffusion synthetic acceleration (DSA). Methods: For simplicity, two-dimensional, steady-state, and within-group LBTE is considered with two angular dimensions and two spatial dimensions. The discrete ordinate method is developed for solving this integro-differential equation. The angular variables are discretized using a level-symmetric quadrature set on the unit sphere. The spatial variables are discretized on the structured grid based on the diamond scheme. The source-iteration method (SI) is used to solve the discretized system.Since SI is slow in optically thick and highly scattering regime. DSA is developed to accelerate SI. The motivation for DSA is that diffusion equation (DE) is a good approximation of LBTE in the above regime. However, DE is much cheaper than LBTE computationally since DE only involves spatial variables. Thus, in each DSA iteration, DSA adds to the SI step a computationally-negligible DE step, i.e., to first solve DE with the SI residual as source term, and then compensate the SI solution with DE solution. Results: DSA was benchmarked and compared with SI. The difference between two methods was within 0.12% which verifies the accuracy of DSA, while DSA demonstrated the great advantage in speed, e.g., the reduction of iteration number to 6% and 4% respectively for cases with 100 and 1,000 scattering-absorption ratio that commonly occur in clinical dose calculation. Conclusion: DSA has been developed as one of many possible means for accelerating the numerical solver of LBTE for dose calculation. The authors were partially supported by the NSFC (#11405105), the 973 Program (#2015CB856000) and the Shanghai Pujiang Talent Program (#14PJ1404500)

60 APPLIED LIFE SCIENCES↗

Evaluation of Computed Tomography Techniques for Material Identification in Low Level and Intermediate Level Waste - 16648

Measures required to assure long term safe storage of Low-level and intermediate-level short-lived (LIL/SL) waste generated by the nuclear-power industry in France include the characterization of the waste and identification of materials within the waste. Digital Radiography (DR) techniques using x-ray at energies in the 6 MeV range have been shown to be effective for validation of the integrity of the concrete containers, and it was considered that the use of this technique together with the addition of Computed Tomography (CT) techniques could effectively identify materials within the waste. This paper describes the initial evaluation of two DR imaging techniques and two CT techniques using x-ray energy spectra up to 9 MeV to inspect a surrogate waste package, which comprised an outer concrete cylindrical container of 1400 mm diameter with 148 mm wall thickness, and an overall volume of 2 meters cubed, within which a 200 liter drum containing representative heterogeneous inactive waste, was placed in the center and the annulus between the 200 liter drum and the outer cylindrical package was filled with cement grout. The surrogate waste within the 200 liter drum comprised three separate layers of high density, medium density and low density mixed materials. The equipment used was a linear accelerator producing high energy spectra at either 6 MeV or 9 MeV and a high-precision CT manipulator with X, Y, Z and rotation motions, which were common to all techniques investigated. Two different digital detectors were used in the DR and CT performance evaluations, a Digital Detector Array (DDA) comprising a columnar Thallium-doped Cesium-Iodide scintillator screen in intimate contact with a 2 k by 2 k array of amorphous silicon detectors, 200 μm x 200 μm in area, and a Linear Diode Array (LDA) comprising a line of Cadmium-Tungstate columns, 1 cm thick and 400 μm x 400 μm in area. The work comprised evaluations of linear accelerator spectra and the attenuation effects of the waste container and contents, image acquisition performance of each detector, and CT techniques using area detector and linear detector. The results presented in this paper include mathematical evaluation of the two CT techniques, and analysis of measurement data, digital images, CT reconstruction images, and estimated material densities. The data was compared with recorded details and photographs of the actual configuration of materials within the surrogate waste. The Digital Detector Array can generate CT inspection volumes with considerable resolution and detail for the low-density and medium-density sections of the surrogate waste, however, the high-density sections were not imaged with sufficient detail and the images contained a large number of artifacts mainly due to the detectors lack of high energy photon stopping power. Materials identification with the Digital Detector Array, while possible for certain materials, for materials in the steel to plastic density range the attenuation values of the voxels in the reconstruction are too similar and difficult to resolve from the artifacts present. The Linear Diode Array can generate CT inspection volumes of regions of interest of the low-density and medium-density sections with considerable resolution and contrast, and potentially acceptable levels of resolution and contrast of the high-density section of the waste. While a few artifacts were present in the reconstructions, the majority are not due to the fundamental properties of the detector and are considered to be correctable. Materials identification with the LDA inspection data appear to be viable, with steel, copper, and higher-density metals being readily be distinguished from other materials on the basis of voxel value. Future work is needed to obtain a better definition of optimum spatial resolution and inspection speed, and to develop a system of 'calibration rods' which would consist of a series of 50 mm diameter cylinders of 7 materials; Plastic, Teflon, Concrete, Aluminum, Copper, Tungsten and Lead. The cylinders will be distributed at a certain radius in the surrogate waste and will be used as reference points in the evaluation and demonstration of the contrastive performance for the low, medium and high-density cases. The ability to identify the materials within a sealed waste container, by nondestructive examination, enables the verification of waste acceptance criteria without the need to open the waste containers. This eliminates the need for complex and expensive equipment to open and remotely handle the intermediate level waste, avoids potential hazards and risk of personnel dose uptake, and does not increase the volume of waste caused by repackaging of materials after examination and the decontamination or disposal of equipment used.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Low-Frequency Otolith Function in Microgravity: A Re-Evaluation of the Otolith Tilt-Translation Reinterpretation (OTTR) Hypothesis

On Earth, the low-frequency afferent signal from the otoliths encodes head tilt with respect to the gravitational vertical, and the higher frequency components reflect both tilt and linear acceleration of the head. In microgravity, static tilt of the head does not influence otolith output, and the relationship between sensory input from the vestibular organs, and the visual, proprioceptive and somatosensory systems, would be disrupted. Several researchers have proposed that in 0-g this conflict may induce a reinterpretation of all otolith signals by the brain to encode only linear translation (otolith tilt-translation reinterpretation or OTTR). Ocular counter-rolling (OCR) is a low-frequency otolith-mediated reflex, which generates compensatory torsional eye movements (rotation about the visual axis) towards the spatial vertical during static roll tilt with a gain of approximately 10%. Transient linear acceleration and off-axis centrifugation at a constant angular velocity can also generate OCR. According to the OTTR hypothesis, OCR should be reduced in microgravity, and immediately upon return from a 0-g environment. Results to date have been inconclusive. OCR was reduced following the 10 day Spacelab-1 mission in response to leftward roll tilts (28-56% in 3 subjects and unchanged in one subject), and sinusoidal linear oscillations at 0.4 and 0.8 Hz. OCR gain declined 70% in four monkeys following a 14 day COSMOS mission. Following a 30 day MIR mission OCR gain decreased in one astronaut, but increased in two others following a 180 day mission. We have studied the affect of microgravity on low-frequency otolith function as part of a larger study of the interaction of vision and the vestibular system. This experiment (E-047) involved off-axis centrifugation of payload crewmembers and flew aboard the recent Neurolab mission (STS 90). Presented below are preliminary results focusing on perception and the OCR response during both centrifugation and static tilt.

Moore, Steven T.↗

Demonstration of transmission high energy electron microscopy

High energy electrons have been used to investigate an extension of transmission electron microscopy. This technique, transmission high energy electron microscopy (THEEM), provides two additional capabilities to electron microscopy. First, high energy electrons are more penetrating than low energy electrons, and thus, they are able to image through thicker samples. Second, the accelerating mode of a radio-frequency linear accelerator provides fast exposures, down to 1 ps, which are ideal for flash radiography, making THEEM well suited to study the evolution of fast material processes under dynamic conditions. Lastly, initial investigations with static objects and during material processing have been performed to investigate the capabilities of this technique.

47 OTHER INSTRUMENTATION↗

New generation bunch shape monitor for ion accelerators

Measuring longitudinal beam parameters is important for operation and development of high intensity linear accelerators, but it is notoriously difficult for proton and ion beams at non-relativistic energies. The Bunch Shape Monitor (BSM) is a device used for measuring the longitudinal bunch distribution in ion linacs. The existing BSM models have poor electron collection efficiency from the wire and are limited to one-dimensional measurements of the phase coordinate. In response to this problem, we have developed a new generation BSM with improved performance. The proposed design incorporates three major innovations: First, the collection efficiency was improved by adding a focusing field between the wire and the entrance slit, which will also allow measurements over a much wider dynamic range. Second, an improvement in the measurement speed was achieved by sampling longitudinal profiles of multiple energy slices simultaneously, where the BSM wire is placed at the exit of an ion spectrometer so that ions with different energies hit the wire at different horizontal coordinates along the wire. Finally, the design incorporates a motion system that can shift the wire and deflecting cavity together, enabling transverse profile measurements like a wire scanner. Here, in this paper, we will provide the design of the new BSM and report on its beam test results at the Spallation Neutron Source facility in Oak Ridge National Laboratory.

43 PARTICLE ACCELERATORS↗

Ion beams 12, Legnaro 6-8 June 2012, the 50 years (1961-2011) of the Legnaro Laboratory

A short review of the history of the Legnaro Laboratory is presented since its foundation 50 years ago by Prof. A. Rostagni of the University of Padova. The evolution of the Laboratory as a national reference center for fundamental and applied nuclear physics researches is outlined, pointing out its transformation into the INFN National Laboratories in 1968. After the first CN VdG Accelerator of 5.5 MV operating in 1961 and the AN2000 devoted to interdisciplinary researches (1971), i.e. 40 years ago, ten years later the advent of the first heavy ion facility in Italy, the XTU Tandem accelerator, and later on of the ALPI superconducting linear accelerator, was crucial for any future developments, not only in the field of nuclear physics but also for the evolution of interdisciplinary programmes with ion beams.

43 PARTICLE ACCELERATORS↗

Tilt and Translation Motion Perception during Off Vertical Axis Rotation

The effect of stimulus frequency on tilt and translation motion perception was studied during constant velocity off-vertical axis rotation (OVAR), and compared to the effect of stimulus frequency on eye movements. Fourteen healthy subjects were rotated in darkness about their longitudinal axis 10deg and 20deg off-vertical at 0.125 Hz, and 20deg offvertical at 0.5 Hz. Oculomotor responses were recorded using videography, and perceived motion was evaluated using verbal reports and a joystick with four degrees of freedom (pitch and roll tilt, mediallateral and anteriorposterior translation). During the lower frequency OVAR, subjects reported the perception of progressing along the edge of a cone. During higher frequency OVAR, subjects reported the perception of progressing along the edge of an upright cylinder. The modulation of both tilt recorded from the joystick and ocular torsion significantly increased as the tilt angle increased from 10deg to 20deg at 0.125 Hz, and then decreased at 0.5 Hz. Both tilt perception and torsion slightly lagged head orientation at 0.125 Hz. The phase lag of torsion increased at 0.5 Hz, while the phase of tilt perception did not change as a function of frequency. The amplitude of both translation perception recorded from the joystick and horizontal eye movements was negligible at 0.125 Hz and increased as a function of stimulus frequency. While the phase lead of horizontal eye movements decreased at 0.5 Hz, the phase of translation perception did not vary with stimulus frequency and was similar to the phase of tilt perception during all conditions. During dynamic linear acceleration in the absence of other sensory input (canal, vision) a change in stimulus frequency alone elicits similar changes in the amplitude of both self motion perception and eye movements. However, in contrast to the eye movements, the phase of both perceived tilt and translation motion is not altered by stimulus frequency. We conclude that the neural processing to distinguish tilt and translation linear acceleration stimuli differs between eye movements and motion perception.

Wood, Scott J.↗

Oculomotor control of primary eye position discriminates between translation and tilt

We have previously shown that fast phase axis orientation and primary eye position in rhesus monkeys are dynamically controlled by otolith signals during head rotations that involve a reorientation of the head relative to gravity. Because of the inherent ambiguity associated with primary otolith afferent coding of linear accelerations during head translation and tilts, a similar organization might also underlie the vestibulo-ocular reflex (VOR) during translation. The ability of the oculomotor system to correctly distinguish translational accelerations from gravity in the dynamic control of primary eye position has been investigated here by comparing the eye movements elicited by sinusoidal lateral and fore-aft oscillations (0.5 Hz +/- 40 cm, equivalent to +/- 0.4 g) with those during yaw rotations (180 degrees/s) about a vertically tilted axis (23.6 degrees). We found a significant modulation of primary eye position as a function of linear acceleration (gravity) during rotation but not during lateral and fore-aft translation. This modulation was enhanced during the initial phase of rotation when there was concomitant semicircular canal input. These findings suggest that control of primary eye position and fast phase axis orientation in the VOR are based on central vestibular mechanisms that discriminate between gravity and translational head acceleration.

NASA Discipline Neuroscience↗

Treatment Planning System Calculation Errors Are Present in Most Imaging and Radiation Oncology Core-Houston Phantom Failures

Purpose: The anthropomorphic phantom program at the Houston branch of the Imaging and Radiation Oncology Core (IROC-Houston) is an end-to-end test that can be used to determine whether an institution can accurately model, calculate, and deliver an intensity modulated radiation therapy dose distribution. Currently, institutions that do not meet IROC-Houston's criteria have no specific information with which to identify and correct problems. In the present study, an independent recalculation system was developed to identify treatment planning system (TPS) calculation errors. Methods and Materials: A recalculation system was commissioned and customized using IROC-Houston measurement reference dosimetry data for common linear accelerator classes. Using this system, 259 head and neck phantom irradiations were recalculated. Both the recalculation and the institution's TPS calculation were compared with the delivered dose that was measured. In cases in which the recalculation was statistically more accurate by 2% on average or 3% at a single measurement location than was the institution's TPS, the irradiation was flagged as having a “considerable” institutional calculation error. The error rates were also examined according to the linear accelerator vendor and delivery technique. Results: Surprisingly, on average, the reference recalculation system had better accuracy than the institution's TPS. Considerable TPS errors were found in 17% (n=45) of the head and neck irradiations. Also, 68% (n=13) of the irradiations that failed to meet the IROC-Houston criteria were found to have calculation errors. Conclusions: Nearly 1 in 5 institutions were found to have TPS errors in their intensity modulated radiation therapy calculations, highlighting the need for careful beam modeling and calculation in the TPS. An independent recalculation system can help identify the presence of TPS errors and pass on the knowledge to the institution.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

FLASH2: Operation, beamlines, and photon diagnostics

FLASH2, a major extension of the soft X-ray free-electron laser FLASH at DESY, turns FLASH into a multi-user FEL facility. A new undulator line is located in a separate accelerator tunnel and driven additionally by the FLASH linear accelerator. First lasing of FLASH2 was achieved in August 2014 with simultaneous user operation at FLASH1. The new FLASH2 experimental hall offers space for up to six experimental end stations, some of which will be installed permanently. The wide wavelength range spans from 4-60 nm and 0.8 nm in the 5{sup th} harmonic and in the future deep into the water window in the fundamental. While this is of high interest to users, it is challenging from the beamline instrumentation point of view. Online diagnostics - which are mostly pulse resolved - for beam intensity, position, wavelength, wave front, and pulse length have been to a large extent developed at FLASH(1) and have now been optimized for FLASH2. Pump-probe facilities for XUV-XUV, XUV optical and XUV-THz experiments will complete the FLASH2 user facility.

43 PARTICLE ACCELERATORS↗

Quasi-linear heating and acceleration in bi-Maxwellian plasmas

Quasi-linear acceleration and heating rates are derived for drifting bi-Maxwellian distribution functions in a general nonrelativistic case for arbitrary wave vectors, propagation angles, and growth/damping rates. The heating rates in a proton-electron plasma due to ion-cyclotron/kinetic Alfvén and mirror waves for a wide range of wavelengths, directions of propagation, and growth or damping rates are explicitly computed.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Comparative transduction mechanisms of hair cells in the bullfrog utriculus. 1: Responses to intracellular current

Hair cells in the bullfrog sacculus are specifically adapted to sense small-amplitude, high-frequency linear accelerations. These hair cells display many properties that are undesirable or inappropriate for hair cells that must provide static gravity sensitivity. This study resulted in part due to an interest in seeing how the transduction mechanisms of hair cells in a gravity-sensing otolith endorgan would differ from those in the bullfrog sacculus. The bullfrog utriculus is an appropriate model for these studies, because its structure is representative of higher vertebrates in general and its function as a sensor of static gravity and dynamic linear acceleration is well known. Hair cells in the bullfrog utriculus, classifiable as Type 2 by cell body and synapse morphology, differ markedly in hair bundle morphology from those in the bullfrog sacculus. Moreover, the hair bundle morphologies of utricular hair cells, unlike those in the sacculus, differ in different membrane regions.

Baird, Richard A.↗

Properties of cerebellar fastigial neurons during translation, rotation, and eye movements

The most medial of the deep cerebellar nuclei, the fastigial nucleus (FN), receives sensory vestibular information and direct inhibition from the cerebellar vermis. We investigated the signal processing in the primate FN by recording single-unit activities during translational motion, rotational motion, and eye movements. Firing rate modulation during horizontal plane translation in the absence of eye movements was observed in all non-eye-movement-sensitive cells and 26% of the pursuit eye-movement-sensitive neurons in the caudal FN. Many non-eye-movement-sensitive cells recorded in the rostral FN of three fascicularis monkeys exhibited convergence of signals from both the otolith organs and the semicircular canals. At low frequencies of translation, the majority of these rostral FN cells changed their firing rates in phase with head velocity rather than linear acceleration. As frequency increased, FN vestibular neurons exhibited a wide range of response dynamics with most cells being characterized by increasing phase leads as a function of frequency. Unlike cells in the vestibular nuclei, none of the rostral FN cells responded to rotational motion alone, without simultaneously exhibiting sensitivity to translational motion. Modulation during earth-horizontal axis rotation was observed in more than half (77%) of the neurons, although with smaller gains than during translation. In contrast, only 47% of the cells changed their firing rates during earth-vertical axis rotations in the absence of a dynamic linear acceleration stimulus. These response properties suggest that the rostral FN represents a main processing center of otolith-driven information for inertial motion detection and spatial orientation.

Non-NASA Center↗

Radiation hardness characterization of LKH-5 scintillating glass

Radiation hardness is an important property to examine in scintillators to help determine their expected lifetime in application cases where significant radiation dose is expected. Industrial imaging systems using 9 MV linear accelerators for x-ray radiography are one such application where significant radiation doses are expected to the scintillators used. Cadmium tungstate scintillators (CWO) and Thallium doped Cesium Iodide scintillators (CsI(Tl)) are used in some high energy cargo x-ray radiography systems. However, CWO has a high manufacturing cost for adequately uniform crystals and CsI(Tl) does not have sufficient radiation hardness. LKH-5 glass is being investigated as a potential low cost replacement for CWO and CsI(Tl). In this experiment 36 samples of a terbium doped silicate glass called LKH-5 were irradiated at doses up to 5 MRad using a 9 MV linear accelerator, and the change in their transmission properties was observed. Additionally, the glass was discovered to be a radiation hard glass due to the relatively small change in the transmission of the glass: less than 3% per cm at its emission peak of 550 nm and 5 MRad. This is similar to CWO which has a reported reduction in transmitted light of 2% per cm at 5 MRad and the emission peak of 475 nm and better than CsI(Tl) which is reported to have a reduction in transmitted light of 5% per cm at the emission peak of 550 nm and 4.2 MRad dose. Furthermore, an annealing procedure is described that returned the transmission of the glass to pre-irradiation values.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Vestibulo-spinal reflex mechanisms

The specific objectives of experiments designed to investigate postural reflex behavior during sustained weightlessness are discussed. The first is to investigate, during prolonged weightlessness with Hoffmann response (H-reflex) measurement procedures, vestibulo-spinal reflexes associated with vestibular (otolith) responses evoked during an applied linear acceleration. This objective includes not only an evaluation of otolith-induced changes in a major postural muscle but also an investigation with this technique of the adaptive process of the vestibular system and spinal reflex mechanisms to this unique environment. The second objective is to relate space motion sickness to the results of this investigation. Finally, a return to the vestibulo-spinal and postural reflexes to normal values following the flight will be examined. The flight experiment involves activation of nerve tissue (tibial N) with electrical shock and the recording of resulting muscle activity (soleus) with surface electrodes. Soleus/spinal H-reflex testing procedures will be used in conjuction with linear acceleration through the subject's X-axis.

Reschke, M. F.↗