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At least 577 records · Page 32

SERFE PLSS Component Lessons Learned from ISS

NASA has been developing a new spacesuit, called the Exploration Extravehicular Mobility Unit (xEMU) for over a decade. This spacesuit is under development to support missions to the International Space Station (ISS) and also to the Moon. Improvements in the life and robustness of the Portable Life Support System (PLSS) has been a major objective of these efforts. The Suit Water Membrane Evaporator (SWME) was chosen as the technology to provide cooling to the xEMU and has undergone several iterations of development over this period. An ISS flight experiment centered around the SWME and other thermal control loop (TCL) technologies was developed and tested in an ISS EXpedite PRocessing of Experiments to the Space Station (EXPRESS) rack from November of 2020 to August of 2022. In addition to the SWME, the SWME EXPRESS Rack Flight Experiment (SERFE) contains several technologies from the xEMU project and demonstrated their performance in micro-gravity and over an extended duration. These included two dissimilar water pumps, custom check valves, custom bypass relieve valves, a custom thermal control valve, development pressure and temperature sensors, and the thermal loop controller. This paper presents PLSS component lessons learned after return of the SERFE flight unit in August of 2022. The SERFE team took the flight unit apart and handed hardware components over to hardware owners to see how parts of the TCL managed after almost 2 years on the ISS and 25 simulated EVAs (Exploration Extravehicular Activity) on orbit. The team performed inspection, testing, and analysis and provided lessons learned on PLSS components for NASA’s prototype spacesuit. This analysis included how well SWME maintained its heat rejection capability, as well as looked at the robustness of the other TCL hardware.

SERFE↗

SERFE PLSS Component Lessons Learned from ISS

NASA has been developing a new spacesuit, called the Exploration Extravehicular Mobility Unit (xEMU) for over a decade. This spacesuit is under development to support missions to the International Space Station (ISS) and also to the Moon. Improvements in the life and robustness of the Portable Life Support System (PLSS) has been a major objective of these efforts. The Suit Water Membrane Evaporator (SWME) was chosen as the technology to provide cooling to the xEMU and has undergone several iterations of development over this period. An ISS flight experiment centered around the SWME and other thermal control loop (TCL) technologies was developed and tested in an ISS EXpedite PRocessing of Experiments to the Space Station (EXPRESS) rack from November of 2020 to August of 2022. In addition to the SWME, the SWME EXPRESS Rack Flight Experiment (SERFE) contains several technologies from the xEMU project and demonstrated their performance in micro-gravity and over an extended duration. These included two dissimilar water pumps, custom check valves, custom bypass relieve valves, a custom thermal control valve, development pressure and temperature sensors, and the thermal loop controller. This paper presents PLSS component lessons learned after return of the SERFE flight unit in August of 2022. The SERFE team took the flight unit apart and handed hardware components over to hardware owners to see how parts of the TCL managed after almost 2 years on the ISS and 25 simulated EVAs (Exploration Extravehicular Activity) on orbit. The team performed inspection, testing, and analysis and provided lessons learned on PLSS components for NASA’s prototype spacesuit. This analysis included how well SWME maintained its heat rejection capability, as well as looked at the robustness of the other TCL hardware.

SERFE↗

Development of an Inertial Sensor-based Methodology for Spacesuited Geology Task Assessments during Simulated Lunar Extravehicular Activities

Lunar surface exploration during Artemis missions will require the specific skill set of geology sampling. Apollo astronauts had extensive training and used specialized tools to collect lunar rocks, core samples, pebbles, sand, and dust. The inflexibility of the pressurized Apollo spacesuits forced sampling to be taken at a standstill posture. However, new exploration spacesuits are expected to incorporate advanced materials and joint bearings, allowing for greater mobility and a wider range of functional postures. Thus, science and exploration during Artemis missions will likely involve a variety of standing, squatting, and kneeling postures. In preparation for future lunar exploration missions, NASA provides geologic training to astronauts and other mission personnel. This professional training with a spacesuit in simulated lunar environments will enhance performance and reduce risk of injury to astronauts on the lunar surface. However, anecdotally, untrained or newly trained people wearing prototype planetary spacesuits have been observed to performing motions differently than a trained geologist would when conducting the same geology sampling tasks. Therefore, a tool for evaluating geology postures at extravehicular activity (EVA) training facilities becomes required. In this paper, we introduce a novel inertial measurement unit (IMU)-based method of geology task assessments in spacesuited conditions during simulated lunar EVAs. As a case study, two subjects (one geologist and one non-geologist) participated and donned the Mark III prototype planetary spacesuit during offloading with the spreader bar gimbal in NASA’s Active Response Gravity Offload System (ARGOS). For automated geology task assessments, the spacesuit was instrumented with three wireless IMUs (APDM Opal, OR, USA): one on the chest and one each on the left and right ankle bearings. Then subjects performed geology tasks using various tools (rake, trench, hammer chisel, scoop, and drive tube) for 45 minutes each. The chest IMU measured the torso tilt angle in the sagittal plane. We used an ensemble learning method with the ankle IMUs to discriminate between standing and kneeling activities. IMU data were processed using custom MATLAB (Mathworks, MA, USA) software. In our case study, the developed method was able to discriminate differences in standing and kneeling activity levels between subjects who were all highly experienced with spacesuited testing. Our preliminary data showed one subject maintained the constant and lower range of the upper body tilt angle while both standing and kneeling, while the other subject showed more variation of the upper body tilt angle and preferred bending the upper body rather than changing from standing to kneeling posture and vice versa. While geology experience may be a factor, these results need further investigation as suit sizing and ARGOS offloading configurations have been proven to have a significant influence on suited ARGOS tasks. Also, more subjects will be needed to complete these tasks for validation. IMU-based geology task assessments can provide useful information for geology training programs. Additionally, our IMU-based posture analysis can provide new insights into how to evaluate spacesuited geology task characteristics of astronauts during simulated lunar EVAs.

Kyoung Jae Kim↗

Machine Learning for Extravehicular Mobility Unit (EMU) Glove Inspections

The Extravehicular Mobility Unit (EMU) Glove Machine Learning Inspection project utilizes machine learning to expedite the inspection, analysis, and recommendation for continued use of space suit gloves post spacewalks. Today, ISS glove photos are individually reviewed by a team of experts to determine the conditions of space suit gloves. For this project the Microsoft Azure platform is used to perform Automated Machine Learning (AutoML) to detect issues with tagged images from previous Extravehicular Activities (EVA’s) to build a predictive model. The model analyzes a test image and deems the glove GO or NO-GO for additional EVA’s. The goal for this ML project is to decrease the time spent reviewing images by ground personnel and crewmembers in high frequency EVA locations such as the Moon and Mars. For destinations such as the Moon and Mars the goal is to give crew autonomy in determining glove conditions with limited support from Earth. This paper will outline the results to date and future work needed to expand the capability for in-situ recommendations.

EVA↗

The search for high-entropy fuel-cell catalysts using disorder descriptors

The transition to a hydrogen economy depends on efficient, affordable catalysts for fuel cells. Platinum—the industry standard for fuel-cell electrodes—is costly and scarce, highlighting the need for practical alternatives. High-entropy alloys offer vast compositional diversity and tunable properties that can mitigate these issues, yet their chemical complexity and configurational disorder have hindered rational discovery. Here, we introduce a data-driven framework that couples machine learning with first-principles disorder descriptors—including the entropy forming ability, disordered enthalpy-entropy descriptor, and electronic-structure similarity metrics to platinum—to predict alloy synthesizability and catalytic performance. These descriptors are applied for the first time in the context of fuel-cell catalyst discovery. The workflow rapidly screens more than 20 000 compositions and identifies several platinum-free candidates that are economically viable, readily scalable, and exhibit promising predicted activity. These results demonstrate that disorder descriptors are reliably predicted by machine learning models and can be effectively integrated into materials-discovery pipelines, accelerating innovation across complex compositional spaces.

fuel-cell catalysts↗

Developing predictive models for µ opioid receptor binding using machine learning and deep learning techniques

Opioids exert their analgesic effect by binding to the µ opioid receptor (MOR), which initiates a downstream signaling pathway, eventually inhibiting pain transmission in the spinal cord. However, current opioids are addictive, often leading to overdose contributing to the opioid crisis in the United States. Therefore, understanding the structure-activity relationship between MOR and its ligands is essential for predicting MOR binding of chemicals, which could assist in the development of non-addictive or less-addictive opioid analgesics. This study aimed to develop machine learning and deep learning models for predicting MOR binding activity of chemicals. Chemicals with MOR binding activity data were first curated from public databases and the literature. Molecular descriptors of the curated chemicals were calculated using software Mold2. The chemicals were then split into training and external validation datasets. Random forest, k-nearest neighbors, support vector machine, multi-layer perceptron, and long short-term memory models were developed and evaluated using 5-fold cross-validations and external validations, resulting in Matthews correlation coefficients of 0.528–0.654 and 0.408, respectively. Furthermore, prediction confidence and applicability domain analyses highlighted their importance to the models’ applicability. Our results suggest that the developed models could be useful for identifying MOR binders, potentially aiding in the development of non-addictive or less-addictive drugs targeting MOR.

Research & Experimental Medicine↗

Simulation Training Versus Real Time Console Training for New Flight Controllers

For new flight controllers, the two main learning tools are simulations and real time console performance training. These benefit the new flight controllers in different ways and could possibly be improved. Simulations: a) Allow for mistakes without serious consequences. b) Lets new flight controllers learn the working style of other new flight controllers. c) Lets new flight controllers eventually begin to feel like they have mastered the sim world, so therefore they must be competent in the real time world too. Real time: a) Shows new flight controllers some of the unique problems that develop and have to be accounted for when dealing with certain payloads or systems. b) Lets new flight controllers experience handovers - gathering information from the previous shift on what the room needs to be aware of and what still needs to be done. c) Gives new flight controllers confidence that they can succeed in the position they are training for when they can solve real anomalies. How Sims could be improved and more like real-time ops for the ISS Operations Controller position: a) Operations Change Requests to review. b) Fewer anomalies (but still more than real time for practice). c) Payload Planning Manager Handover sheet for the E-1 and E-3 reviews. d) Flight note in system with at least one comment to verify for the E-1 and E-3 reviews How the real time console performance training could be improved for the ISS Operations Controller position: a) Schedule the new flight controller to be on console for four days but with a different certified person each day. This will force them to be the source of knowledge about every OCR in progress, everything that has happened in those few days, and every activity on the timeline. Constellation program flight controllers will have to learn entirely from simulations, thereby losing some of the elements that they will need to have experience with for real time ops. It may help them to practice real time console performance training in the International Space Station or Space Shuttle to gather some general anomaly resolution and day-to-day task management skills.

Heaton, Amanda↗

Advanced Data Science Model for Detecting Intelligent Malware

This study focused on developing a robust artificial intelligence (AI) model capable of detecting and characterizing advanced malware in Internet of Things (IoT) devices using network data. By analyzing network traffic with various machine learning (ML) models, our AI model can identify and characterize malicious activities to significantly improve malware detection accuracy and reliability as compared to traditional methods. The developed AI/ML model was trained using network data from IoT devices, leveraging classifiers such as Random Forest, Gradient Boosting, AdaBoost, and others to optimize detection performance. This project demonstrates a scalable framework for real-time malware detection and characterization in IoT networks, capable of identifying infected devices and facilitating the necessary steps to remove or isolate them, thereby preventing further infections. Although digital twin (DT) integration is not yet implemented in the current model, it represents a promising future enhancement. By creating a virtual replica of physical IoT devices, DT technology would allow for real-time monitoring and analysis without directly accessing operational technology, thus reducing the risk of compromising or reducing the performance of actual devices. This integration would further enhance the security of IoT ecosystems, combining AI technology to better flag and detect indications of malware-infected devices within a nuclear system environment.

42 ENGINEERING↗

Machine learning for the redox potential prediction of molecules in organic redox flow battery

Here, organic redox flow batteries (ORFB) are recognized as an innovative technology for the large-scale storage of renewable energy. The redox potential of organic redox-active molecules plays a vital role in their performance. Advanced screening techniques like high-throughput experiment and machine learning (ML) have significantly enhanced organic material performance and transformed the field of ORFB. However, the scarcity of experimental data poses a considerable challenge for ML model development in this domain. In our study, we developed lightweight graph-based Gaussian process regression (GPR) models with GPU-accelerated marginalized graph kernel and hybrid kernel to predict the redox potentials of organic redox-active molecules for ORFBs, specifically focusing on small datasets. To evaluate model accuracy, we created a new experimental database of organic redox-active molecules by the data from hundreds of published papers and assembled previous computational datasets. We also considered some key parameters, such as pH conditions and solvent type, to assess their impact on redox potential prediction. Our GPR model predicted redox potentials with high accuracy across all datasets using minimal training data. The study provides powerful tools for molecule screening and design and delivers valuable guidance on designing training datasets for costly experiments.

25 ENERGY STORAGE↗

Prediction of Specificity of α-Conotoxins to Subtypes of Human Nicotinic Acetylcholine Receptors with Semi-supervised Machine Learning

Conotoxins are a family of highly toxic neurotoxins composed of cysteine-rich peptides produced by marine cone snails. The most lethal cone snail species to humans is Conus geographus, with fatality rates of up to ∼65% from a single sting, which is caused mostly by the activity of α-conotoxins against human nicotinic acetylcholine receptors (nAChRs). While sequence-based machine learning (ML) classifiers have been trained to identify targets of conotoxins binding voltage-gated ion channels, no ML model has been built to predict the subtype-specific nAChR targets of α-conotoxins. Here, we trained an ML model in a semi-supervised manner to predict the specificity of α-conotoxin binding toward different human nAChR subtypes to overcome the challenge of limited data in subtype-specific nAChR targets of α-conotoxins and the issue that one α-conotoxin can bind multiple nAChR subtypes with high selectivity. We considered additional features of sequences of α-conotoxins in training our ML model, including the secondary structure propensities and electrostatic properties, which resulted in better prediction capability for the ML model. Notably, we identify that most α-conotoxins bind to α3β2, α1γδ, and α7 subtypes of human nAChRs. Our findings from this study provide a framework for predicting targets of various kinds of toxins.

59 BASIC BIOLOGICAL SCIENCES↗

A Machine Learning Approach to Objective Identification of Dust in Satellite Imagery

Airborne dust has broad adverse effects on human activity, including aviation, human health, and agriculture. Remote sensing observations are used to detect dust and aerosols in the atmosphere using long established techniques. False color Red-Green-Blue (RGB) imagery using band differences sensitive to dust absorption (Dust RGB) is currently used operationally to assist forecasters and decision-makers in identifying dust at night, but there are still limitations, subjectivity, and nuances to image interpretation making night-time dust identification difficult even for experts. This study applies machine learning to the problem of night-time dust detection with a simple random forest (RF) model using Geostationary Operational Environmental Satellite-16 (GOES-16) Advanced Baseline Imager (ABI) infrared imagery, band differences sensitive to dust absorption, and Dust RGB color components as inputs to the model. The RF model achieves an Area-Under-Curve (AUC) of 0.97 with a standard deviation of 0.04 for dust cases. For images with dust present, the model correctly labels 85% of dust pixels and 99.96% of no-dust pixels for all dust images in the validation data set. The addition of a single null case to the training data set drastically reduces error in labeling no-dust pixels as dust from 45% to 14.5%. Application of the machine learning model to the April 13–14, 2019 dust event demonstrates the ability of the model to identify dust during night-time hours when visual dust detection is limited by the cooling ground surface characteristics.

dust↗

Lessons Learned from the Space Shuttle Engine Cutoff System (ECO) Anomalies

The Space Shuttle Orbiter's main engine cutoff (ECO) system first failed ground checkout in April, 2005 during a first tanking test prior to Return-to-Flight. Despite significant troubleshooting and investigative efforts that followed, the root cause could not be found and intermittent anomalies continued to plague the Program. By implementing hardware upgrades, enhancing monitoring capability, and relaxing the launch rules, the Shuttle fleet was allowed to continue flying in spite of these unexplained failures. Root cause was finally determined following the launch attempts of STS-122 in December, 2007 when the anomalies repeated, which allowed drag-on instrumentation to pinpoint the fault (the ET feedthrough connector). The suspect hardware was removed and provided additional evidence towards root cause determination. Corrective action was implemented and the system has performed successfully since then. This white paper presents the lessons learned from the entire experience, beginning with the anomalies since Return-to-Flight through discovery and correction of the problem. To put these lessons in better perspective for the reader, an overview of the ECO system is presented first. Next, a chronological account of the failures and associated investigation activities is discussed. Root cause and corrective action are summarized, followed by the lessons learned.

Martinez, Hugo E.↗

AEcroscopy: A Software–Hardware Framework Empowering Microscopy Toward Automated and Autonomous Experimentation

Microscopy has been pivotal in improving the understanding of structure-function relationships at the nanoscale and is by now ubiquitous in most characterization labs. However, traditional microscopy operations are still limited largely by a human-centric click-and-go paradigm utilizing vendor-provided software, which limits the scope, utility, efficiency, effectiveness, and at times reproducibility of microscopy experiments. Here, in this work, a coupled software–hardware platform is developed that consists of a software package termed AEcroscopy (short for Automated Experiments in Microscopy), along with a field-programmable-gate-array device with LabView-built customized acquisition scripts, which overcome these limitations and provide the necessary abstractions toward full automation of microscopy platforms. The platform works across multiple vendor devices on scanning probe microscopes and electron microscopes. It enables customized scan trajectories, processing functions that can be triggered locally or remotely on processing servers, user-defined excitation waveforms, standardization of data models, and completely seamless operation through simple Python commands to enable a plethora of microscopy experiments to be performed in a reproducible, automated manner. This platform can be readily coupled with existing machine-learning libraries and simulations, to provide automated decision-making and active theory-experiment optimization to turn microscopes from characterization tools to instruments capable of autonomous model refinement and physics discovery.

47 OTHER INSTRUMENTATION↗

Automated nuclear cloud feature extraction from film

Chemical, biological, radiological, nuclear, and explosives incidents require rapid detection and characterization for appropriate response. For a nuclear detonation, visible-light cameras may be used to locate the cloud and characterize fallout deposition when coupled with numerical models. Films from the United States’ nuclear testing era compose the only sizeable collection of imagery depicting high-yield detonations. These films offer unique insights into characteristics of flows involving scales that are difficult to replicate experimentally, and they are a valuable source of data for the validation of models for nuclear fallout transport, either as part of emergency response or forensic activities. In this work, we implement modern computer vision and machine learning techniques to identify and track the cloud automatically and subsequently determine the time dependence of some of its features. We trained a ResNet-18 image classifier on hundreds of images to categorize nuclear cloud morphology. Each category or cloud regime is determined by early cloud evolution and is associated to constitutive properties of the flow, such as distribution of vorticity. Next, we identified keypoint features using the KAZE algorithm and tracked these keypoints in the images, allowing us to determine the dimensions and velocities of the cloud across film frames. These measurements converted to real-world units provide valuable experimental data that can be used in the development and validation of nuclear cloud models. We compared the results of this method against manual cloud rise measurements from two different films. In one, our automated method accelerated the feature extraction process without sacrificing measurement accuracy.

Khristy, Joel [ORNL] (ORCID:0000000209963060)↗

NuclPred v1

This tool takes a genome assembly as input and predicts per-site nucleosome occupancy as output. Trained on physical maps of nucleosome binding preferences across the fungal kingdom, NuclPred can be applied broadly across fungi (and other eukaryotes). This breadth, combined with its accuracy, means it could have both basic and applied biological implications, for example in understanding eukaryotic gene regulation and genetic engineering. Almost universally across eukaryotes, nucleosomes - each wrapping ~150 base pairs of DNA - serve to package DNA inside the nucleus, with major consequences on DNA access, gene activity and DNA integration. NuclPred was generated using a supervised deep learning approach combining convolutional and recurrent neural networks to take DNA features (nucleotides, GC content and structural information) as input, then use that information to predict the physical attractiveness DNA sequences might have for forming nucleosomes. With this information at hand, researchers can design more efficient CRISPR constructs, explore the interplay between DNA signatures and other regulators impact nucleosome locations, predict expression patterns, etc. This tool will be published as part of a manuscript currently under revision at iScience (draft attached).

Mondo, Stephen↗

Atmospheric detectives: Atlas 2 teacher's guide with activities. For use with middle-school students

Can you imagine doing a science project in space? This is the challenging and exciting situation that researchers experience in Spacelab, the laboratory carried inside the Shuttle. Here, hundreds of kilometers above Earth's surface, the crews of the ATLAS missions scan, probe, and measure concentrations of chemicals and water vapor in Earth's protective bubble. So far, one ATLAS crew has rocketed into the atmosphere, watching many sunrises and sunsets come and go while activating delicate instruments and conducting experiments that monitor the complicated interactions between the Sun, the atmosphere, and Earth. We, the crew of ATLAS 2, will continue this important work aboard the Space Shuttle. Together, we will gather data that will be compared with information from satellites, balloons, and instruments on the ground. As part of the National Aeronautics and Space Administration's (NASA's) contribution to Mission to Planet Earth, ATLAS 2 will help develop a thorough picture of the Sun's output, its interaction with the atmosphere, and the well-being of Earth's middle atmosphere. Because the health of the atmosphere is of vital importance to all Earth's inhabitants, everyone should be part of this investigation. You can be active participants in exciting and vital activities: recycling and practicing other conservation methods and gathering information to learn more about how you can keep our atmosphere healthy now, as students, and in the future as informed citizens, scientists, technicians, and mathematicians.

Source record↗

International Space Station Multi-Element Integrated Test

The International Space Station offers a unique challenge for integrated testing since the entire station is not launched as an integrated vehicle. The ISS design evolved for over 10 years from the station Freedom program that was based on a "ship and shoot" approach. Ship and shoot assumed the program would accept the hardware for launch and integrate the vehicle on orbit without any ground element-to-element integrated testing. Element-to-Element powered-on integrated testing is needed to identify operational problems on the ground rather than once the hardware is on orbit. The industry is accustomed to testing an integrated vehicle and then verifying it is ready for its operational missions. These tests require ground element emulators to represent on-orbit elements. The ISS Multi-Element Integrated Tests (MEIT) are element-to-element integrated tests bringing together hardware representing several flights. The major purpose of these tests is: 1) Element-to-Element interface compatibility, 2) Systems end-to-end operability and functionality and 3) utilize on-orbit procedures with the crew and mission control center. Execution of these tests is critical since the hardware is available for only a limited period of time. Test configurations are defined which test specific interfaces or functionality. These tests develop operational confidence in the Element-to-Element interfaces and identify major problems on the ground to avoid on-orbit anomalies that could threaten mission success, element survivability or assembly activities. This paper addresses the MEIT process, configurations and lessons-learned from these tests.

Filler, Russell E.↗

Exploring the Extreme Universe! (2nd Edition)

A large array of web sites devoted to the science that the NASA Goddard Space Flight Center Laboratory for High Energy Astrophysics (LHEA) studies have been frozen in time and included on this CD. Featured are five of our 'Understanding the Extreme Universe' sites, which offer explanations about cosmic ray, gamma ray, and X-ray science and satellites, as well as cosmic distances. They also include images and engaging activities that are great for helping both children and adults to learn more about science and basic physical principles. The 'Missions That Take Us There' section contains web sites on the satellite, balloon-borne, International Space Station, and rocket missions in our Laboratory that study X-rays, gamma rays, and cosmic rays. There are also two multi-mission sites and an experiment that measures Earth's UV light in preparation for a future cosmic ray mission. Most of the sites on this CD contain high-resolution images that are great for scientific presentations, study, or just your own enjoyment. This CD shows our web sites as they existed in April of 2001. We have made sure to include the WWW address for every site, so you will know where to go to access the most current versions of them.

White, Nicholas E.↗