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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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NASA NTRS1992

Grid generation research at OSU

In the last two years, effort was concentrated on: (1) surface modeling; (2) surface grid generation; and (3) 3-D flow space grid generation. The surface modeling shares the same objectives as the surface modeling in computer aided design (CAD), so software available in CAD can in principle be used for solid modeling. Unfortunately, however, the CAD software cannot be easily used in practice for grid generation purposes, because they are not designed to provide appropriate data base for grid generation. Therefore, we started developing a generalized surface modeling software from scratch, that provides the data base for the surface grid generation. Generating surface grid is an important step in generating a 3-D space for flow space. To generate a surface grid on a given surface representation, we developed a unique algorithm that works on any non-smooth surfaces. Once the surface grid is generated, a 3-D space can be generated. For this purpose, we also developed a new algorithm, which is a hybrid of the hyperbolic and the elliptic grid generation methods. With this hybrid method, orthogonality of the grid near the solid boundary can be easily achieved without introducing empirical fudge factors. Work to develop 2-D and 3-D grids for turbomachinery blade geometries was performed, and as an extension of this research we are planning to develop an adaptive grid procedure with an interactive grid environment.

Nakamura, S.↗
NASA NTRS1994

Understanding software faults and their role in software reliability modeling

This study is a direct result of an on-going project to model the reliability of a large real-time control avionics system. In previous modeling efforts with this system, hardware reliability models were applied in modeling the reliability behavior of this system. In an attempt to enhance the performance of the adapted reliability models, certain software attributes were introduced in these models to control for differences between programs and also sequential executions of the same program. As the basic nature of the software attributes that affect software reliability become better understood in the modeling process, this information begins to have important implications on the software development process. A significant problem arises when raw attribute measures are to be used in statistical models as predictors, for example, of measures of software quality. This is because many of the metrics are highly correlated. Consider the two attributes: lines of code, LOC, and number of program statements, Stmts. In this case, it is quite obvious that a program with a high value of LOC probably will also have a relatively high value of Stmts. In the case of low level languages, such as assembly language programs, there might be a one-to-one relationship between the statement count and the lines of code. When there is a complete absence of linear relationship among the metrics, they are said to be orthogonal or uncorrelated. Usually the lack of orthogonality is not serious enough to affect a statistical analysis. However, for the purposes of some statistical analysis such as multiple regression, the software metrics are so strongly interrelated that the regression results may be ambiguous and possibly even misleading. Typically, it is difficult to estimate the unique effects of individual software metrics in the regression equation. The estimated values of the coefficients are very sensitive to slight changes in the data and to the addition or deletion of variables in the regression equation. Since most of the existing metrics have common elements and are linear combinations of these common elements, it seems reasonable to investigate the structure of the underlying common factors or components that make up the raw metrics. The technique we have chosen to use to explore this structure is a procedure called principal components analysis. Principal components analysis is a decomposition technique that may be used to detect and analyze collinearity in software metrics. When confronted with a large number of metrics measuring a single construct, it may be desirable to represent the set by some smaller number of variables that convey all, or most, of the information in the original set. Principal components are linear transformations of a set of random variables that summarize the information contained in the variables. The transformations are chosen so that the first component accounts for the maximal amount of variation of the measures of any possible linear transform; the second component accounts for the maximal amount of residual variation; and so on. The principal components are constructed so that they represent transformed scores on dimensions that are orthogonal. Through the use of principal components analysis, it is possible to have a set of highly related software attributes mapped into a small number of uncorrelated attribute domains. This definitively solves the problem of multi-collinearity in subsequent regression analysis. There are many software metrics in the literature, but principal component analysis reveals that there are few distinct sources of variation, i.e. dimensions, in this set of metrics. It would appear perfectly reasonable to characterize the measurable attributes of a program with a simple function of a small number of orthogonal metrics each of which represents a distinct software attribute domain.

Munson, John C.↗
NASA NTRS2001

Analysis of Ag/FEP Thermal Control Blanket Performance From Multiple Satellites

Materials performance data from operational spacecraft and spacecraft experiments has slowly accumulated over the years. Much of this data is obtained indirectly by analyzing temperature measurements telemetered to ground. Due to the Space Transportation System (STS) program, materials performance data has also been obtained by flying materials on satellites, or on the Space Shuttle itself, for limited periods of time, and then returning the materials to ground for post-flight examination. During the course of NASA contract NAS8-98213, the authors have extended the analysis of data reported for selected materials flown on a variety of spacecraft over the past 30 years. In this paper we discuss changes in two properties of silver- or aluminum-backed (metallized) FEP Teflon due to exposure to specific environmental factors on-orbit. First, the change in solar absorptance (alpha(sub s)) of metallized FEP Teflon as a function of particulate radiation will be discussed. Data providing the change in solar absorptance of metallized FEP as a function of days on orbit has been published for NTS-2 satellite, several NavStar Global Positioning Satellites (GPS), the SCATHA experiment, and the ML-101 satellite. The unique approach that we have taken is to calculate the absorbed radiation dose within the Ag/FEP for the various satellite orbits, and to plot the change in solar absorptance, alpha(sub s), as a function of the dose; the behavior agrees with the same data from laboratory tests. Second, the variation of the atomic oxygen induced material recession rate of metallized FEP will be discussed. Data from certain Space Shuttle flights, a Lockheed experiment [approximately 105 days in low Earth orbit (LEO)], and the Long Duration Exposure Facility allows the variation of the material recession rate of Ag/FEP to be estimated under conditions that include atomic oxygen exposure.

Pippin, Gary↗
NASA NTRS2005

Recent progress in opto-electronic oscillator

The optoelectronic oscillator (OEO) is a unique device based on photonics techniques to generate highly spectrally pure microwave signals [1]. The development of the OEO was motivated by the need for high performance oscillators in the frequency range larger than 10 GHz, where conventional electronic oscillators have a number of limitations. These limitations typically stem from the product of fQ, where f is the oscillator frequency and Q is the quality factor of the resonator in the oscillator. In conventional resonators, whether electromagnetic or piezoelectric, this product is usually a constant. Thus, as the oscillator frequency is pushed higher, the quality factor degrades, resulting in degradation of the phase noise of the oscillator. An approach to mitigate the problem is to start with a very high quality signal in the 5 to 100 MHz range generated by a quartz oscillator and multiply the frequency to achieve the desired microwave signal. Here again, frequency multiplication also results in an increase of the phase noise by a factor of 2010gN, where N is the multiplication factor.

opto-electronic oscillators↗
NASA NTRS2010

Integration Process for the Habitat Demonstration Unit

The Habitat Demonstration Unit (HDU) is an experimental exploration habitat technology and architecture test platform designed for analog demonstration activities The HDU project has required a team to integrate a variety of contributions from NASA centers and outside collaborators and poses a challenge in integrating these disparate efforts into a cohesive architecture To complete the development of the HDU from conception in June 2009 to rollout for operations in July 2010, a cohesive integration strategy has been developed to integrate the various systems of HDU and the payloads, such as the Geology Lab, that those systems will support The utilization of interface design standards and uniquely tailored reviews have allowed for an accelerated design process Scheduled activities include early fit-checks and the utilization of a Habitat avionics test bed prior to equipment installation into HDU A coordinated effort to utilize modeling and simulation systems has aided in design and integration concept development Modeling tools have been effective in hardware systems layout, cable routing and length estimation, and human factors analysis Decision processes on the shell development including the assembly sequence and the transportation have been fleshed out early on HDU to maximize the efficiency of both integration and field operations Incremental test operations leading up to an integrated systems test allows for an orderly systems test program The HDU will begin its journey as an emulation of a Pressurized Excursion Module (PEM) for 2010 field testing and then may evolve to a Pressurized Core Module (PCM) for 2011 and later field tests, depending on agency architecture decisions The HDU deployment will vary slightly from current lunar architecture plans to include developmental hardware and software items and additional systems called opportunities for technology demonstration One of the HDU challenges has been designing to be prepared for the integration of presently unanticipated systems Results of the HDU field tests will influence future designs of habitat systems.

Gill, Tracy↗
NASA NTRS2013

SynGenics Optimization System (SynOptSys)

The SynGenics Optimization System (SynOptSys) software application optimizes a product with respect to multiple, competing criteria using statistical Design of Experiments, Response-Surface Methodology, and the Desirability Optimization Methodology. The user is not required to be skilled in the underlying math; thus, SynOptSys can help designers and product developers overcome the barriers that prevent them from using powerful techniques to develop better pro ducts in a less costly manner. SynOpt-Sys is applicable to the design of any product or process with multiple criteria to meet, and at least two factors that influence achievement of those criteria. The user begins with a selected solution principle or system concept and a set of criteria that needs to be satisfied. The criteria may be expressed in terms of documented desirements or defined responses that the future system needs to achieve. Documented desirements can be imported into SynOptSys or created and documented directly within SynOptSys. Subsequent steps include identifying factors, specifying model order for each response, designing the experiment, running the experiment and gathering the data, analyzing the results, and determining the specifications for the optimized system. The user may also enter textual information as the project progresses. Data is easily edited within SynOptSys, and the software design enables full traceability within any step in the process, and facilitates reporting as needed. SynOptSys is unique in the way responses are defined and the nuances of the goodness associated with changes in response values for each of the responses of interest. The Desirability Optimization Methodology provides the basis of this novel feature. Moreover, this is a complete, guided design and optimization process tool with embedded math that can remain invisible to the user. It is not a standalone statistical program; it is a design and optimization system.

Ventresca, Carol↗
NASA NTRS2000

Particle irradiation induces FGF2 expression in normal human lens cells

Particle Irradiation Induces FGF2 Expression in Normal Human Lens Cells. Particle radiations, including both proton and helium-ion beams, have been used to successfully treat choroidal melanoma, but with the complication of radiation-induced cataract. We have investigated a role for radiation-induced changes in the expression of basic fibroblast growth factor (FGF2) gene expression as part of the mechanism(s) underlying lens cell injury associated with cataract. Normal human lens epithelial (HLE) cells were cultured in vitro on extracellular matrix (ECM) originated from bovine corneal endothelial cells. This study reports evidence for rapid but transient induction of FGF2 transcripts, an increase of between 5- and 8-fold, within 0.5 h after exposure to particle radiation, followed by another wave of increased transcription at 2-3 h postirradiation. Immunofluorescence results confirm the enhanced levels of FGF2 protein rapidly after exposure to protons or helium ions, followed by another wave of increased activity unique to helium at 6 h postirradiation. This second wave of increased immunoreactivity was not observed in the proton-irradiated samples. Total FGF2 protein analysis after helium-ion exposures shows induced expression of three FGF2 isoforms, with an increase of up to 2-fold in the 18-kDa low-molecular-weight species. Studies of the effects of protons on individual FGF2 protein isoforms are in progress. Several mechanisms involving a role for FGF2 in radiation-induced cataract are discussed.

NASA Discipline Radiation Health↗
NASA NTRS1993

The national geomagnetic initiative

The Earth's magnetic field, through its variability over a spectrum of spatial and temporal scales, contains fundamental information on the solid Earth and geospace environment (the latter comprising the atmosphere, ionosphere, and magnetosphere). Integrated studies of the geomagnetic field have the potential to address a wide range of important processes in the deep mantle and core, asthenosphere, lithosphere, oceans, and the solar-terrestrial environment. These studies have direct applications to important societal problems, including resource assessment and exploration, natural hazard mitigation, safe navigation, and the maintenance and survivability of communications and power systems on the ground and in space. Studies of the Earth's magnetic field are supported by a variety of federal and state agencies as well as by private industry. Both basic and applied research is presently supported by several federal agencies, including the National Science Foundation (NSF), U.S. Geological Survey (USGS), U.S. Department of Energy (DOE), National Oceanic and Atmospheric Administration (NOAA), National Aeronautics and Space Administration (NASA), and U.S. Department of Defense (DOD) (through the Navy, Air Force, and Defense Mapping Agency). Although each agency has a unique, well-defined mission in geomagnetic studies, many areas of interest overlap. For example, NASA, the Navy, and USGS collaborate closely in the development of main field reference models. NASA, NSF, and the Air Force collaborate in space physics. These interagency linkages need to be strengthened. Over the past decade, new opportunities for fundamental advances in geomagnetic research have emerged as a result of three factors: well-posed, first-order scientific questions; increased interrelation of research activities dealing with geomagnetic phenomena; and recent developments in technology. These new opportunities can be exploited through a national geomagnetic initiative to define objectives and encourage coordination of efforts among federal and state agencies, academic institutions, and industry to systematically characterize the spatial and temporal behavior of the Earth's magnetic field on local, regional, and global scales in order to understand the physical processes in the solid earth and geospace environment, and to apply this understanding to a variety of scientific problems and to technical and societal needs.

Source record↗
NASA NTRS1993

A white paper: NASA virtual environment research, applications, and technology

Research support for Virtual Environment technology development has been a part of NASA's human factors research program since 1985. Under the auspices of the Office of Aeronautics and Space Technology (OAST), initial funding was provided to the Aerospace Human Factors Research Division, Ames Research Center, which resulted in the origination of this technology. Since 1985, other Centers have begun using and developing this technology. At each research and space flight center, NASA missions have been major drivers of the technology. This White Paper was the joint effort of all the Centers which have been involved in the development of technology and its applications to their unique missions. Appendix A is the list of those who have worked to prepare the document, directed by Dr. Cynthia H. Null, Ames Research Center, and Dr. James P. Jenkins, NASA Headquarters. This White Paper describes the technology and its applications in NASA Centers (Chapters 1, 2 and 3), the potential roles it can take in NASA (Chapters 4 and 5), and a roadmap of the next 5 years (FY 1994-1998). The audience for this White Paper consists of managers, engineers, scientists and the general public with an interest in Virtual Environment technology. Those who read the paper will determine whether this roadmap, or others, are to be followed.

Null, Cynthia H.↗
NASA NTRS1998

Gravitropism in caulonemata of the moss Pottia intermedia

The gravitropism of caulonemata of Pottia intermedia is described and compared with that of other mosses. Spore germination produces primary protonemata including caulonemata which give rise to buds that form the leafy moss plant, the gametophore. Primary caulonemata are negatively gravitropic but their growth and the number of filaments are limited in the dark. Axenic culture of gametophores results in the production of secondary caulonemata that usually arise near the leaf base. Secondary protonemata that form in the light are agravitropic. Secondary caulonemata that form when gametophores are placed in the dark for several days show strong negative gravitropism and grow well in the dark. When upright caulonemata are reorientated to the horizontal or are inverted, upward bending can be detected after 1 h and caulonemata reach the vertical within 1-2 d. Clear amyloplast sedimentation occurs 10-15 minutes after horizontal placement and before the start of upward curvature. This sedimentation takes place in a sub-apical zone. Amyloplast sedimentation also takes place along the length of upright and inverted Pottia protonemata. These results support the hypothesis that amyloplast sedimentation functions in gravitropic sensing since sedimentation occurs before gravitropism in Pottia and since the location and presence of a unique sedimentation zone is conserved in all four mosses known to gravitropic protonomata.

Non-NASA Center↗
NASA NTRS2013

A Proposal for A Lean, Fast Mars Round-Trip Mission Architecture: Using Current Technologies for A Human Mission to Mars In The 2030s

We present a lean-minded, fast-transfer mission strategy and architecture concept for a first human mission to Mars that deliberately utilizes a current-technology-favored approach by means of introducing and quantitatively dening two pivotal parameters: 1) an end-to-end Mars mission duration of approximately one year, and 2) a deep space habitat of approximately 4050 metric tons. These parameters are identified and introduced by a 2012 deep space habitat study conducted at the NASA Johnson Space Center (JSC) that focused on a subset of recognized high-engineering-risk factors that may otherwise inhibit or encumber remote space travel to destinations such as Mars or near-Earth asteroids (NEAs). Additional constraints in the study favoring current technology and a lean-minded (very short) surface stay on Mars are shown to offer such Mars mission opportunities in the 2030s, enabled by a combination of on-orbit staging, mission element pre-positioning, and unique round-trip trajectories identied by state-of-the-art astrodynamics algorithms.

Architecture↗
NASA NTRSDate not supplied

Attitude Ground System: Recent Experiences in Attitude Sensor Calibration and Upcoming Mission Support for Momentum Unloading

A key component of the mission ground system used for supporting NASA Goddard Space Flight Center space missions, known as the Attitude Ground System (AGS), is used to perform operational and analytical support for the spacecraft attitude con-trol system (ACS). The AGS is comprised of a real-time attitude analysis and moni-toring system, and a tool for performing offline analysis of the ACS system using key sensor telemetry collected and stored onboard and transmitted to the mission operations center. The AGS performs numerous functions, including independent ground attitude determination, attitude slew planning and commanding, attitude sensor calibration, and real-time monitoring of the health and safety of the ACS. The AGS is developed in MATLAB using a core library of utility functions called the Multi-Mission Three-Axis Satellite System (MTASS). The MTASS library has been used to support mission operations for over thirty NASA missions starting in the late 1990s. It is customized for each mission to meet specific mission requirements. In this paper we describe recent operational experience using the AGS to support the launch and early orbit (L&EO) phase of the Plankton, Aerosol, Cloud Ocean Ecosys-tem (PACE) and Joint Polar Satellite System (JPSS) missions. Our summary of L&EO support for PACE and JPSS includes ACS sensor calibration of the alignment and scale factors for the Star Trackers, Inertial Reference Unit, and Three-Axis Magnetometers. We will also describe new capabilities for planning and executing reaction wheel momentum unloading for the Roman Space Telescope (RST) During the spacecraft early orbit phase, the AGS is operated in the mission operations center by a team of subject matter experts that also develop and configure the AGS soft-ware. This unique approach, integrating system development and operation in a sin-gle engineering team, provides valuable expertise for quick assessment of ACS per-formance and safety; critical to anomaly resolution and mission success.

Guidance, Navigation, and Control↗
NASA NTRS2017

Cardiovascular Disease Risk in NASA Astronauts Across the Lifespan: Historical Cohort Studies

Acute effects of spaceflight on the cardiovascular system have been studied extensively, but the combined chronic effects of spaceflight and aging are not well understood. Preparation for and participation in space flight activities are potentially associated with cardiovascular disease risk factors (e.g., altered dietary and exercise habits, physical and emotional stress, circadian shifts, radiation). Further, astronauts who travel into space multiple times may be at an increased risk across their lifespan. However, comparing the risk of cardiovascular disease in astronauts to other large cohorts is difficult. For example, comparisons between astronauts and large national cohorts, such as the National Health and Nutrition Examination Survey and the National Health Information Survey, are hampered by significant differences in health status between astronauts and the general population, and most of these national studies fail to provide longitudinal data on population health. To address those limitations, NASA's Longitudinal Study of Astronaut Health previously sought to compare the astronauts to a cohort of civil servants employed at the Johnson Space Center. However, differences between the astronauts and civil servants at the beginning of the study, as well as differential follow up, limited the ability to interpret the results. To resolve some of these limitations, two unique cohorts of healthy workers, U.S. Air Force aviators and Cooper Center Longitudinal Study participants, have been identified as potential comparison populations for the astronaut corps. The Air Force cohort was chosen due to similarities in health at selection, screening, and some occupational exposures that Air Force aviators endure, many of which mirror that of the astronaut corps. The Cooper Clinic cohort, a generally healthy prevention cohort, was chosen for the vast array of clinical cardiovascular measures collected in a longitudinal manner complementary to those collected on astronauts, for a large number of subjects since 1971. The purpose of this study is to understand the incidence of cardiovascular disease outcomes and risk factors in the astronaut corps and determine whether the rates of disease are different than these two cohorts. The research questions are: 1. Are there differences in the incidence of CVD outcomes (MI, revascularization, and stroke) between each cohort and the NASA Astronaut cohort? 2. Are there differences in the incidence of CVD risks (hypertension, hyperlipidemia, arrhythmias, and diabetes) between each cohort and the NASA Astronaut cohort? 3. Are there differences between each cohort and the NASA Astronaut cohort in how CVD risk factors (e.g., lipids, behaviors) change across time? Collectively, results from these studies will enhance our understanding of how cardiovascular disease outcomes and risk factors change across time in astronauts compared to other longitudinally-studied healthy cohorts and determine if there are interactions between or additive effects of the occupational health effects of spaceflight exposure and normal aging.

Charvat, Jacqueline M.↗
NASA NTRS1992

Conservative-variable average states for equilibrium gas multi-dimensional fluxes

Modern split component evaluations of the flux vector Jacobians are thoroughly analyzed for equilibrium-gas average-state determinations. It is shown that all such derivations satisfy a fundamental eigenvalue consistency theorem. A conservative-variable average state is then developed for arbitrary equilibrium-gas equations of state and curvilinear-coordinate fluxes. Original expressions for eigenvalues, sound speed, Mach number, and eigenvectors are then determined for a general average Jacobian, and it is shown that the average eigenvalues, Mach number, and eigenvectors may not coincide with their classical pointwise counterparts. A general equilibrium-gas equation of state is then discussed for conservative-variable computational fluid dynamics (CFD) Euler formulations. The associated derivations lead to unique compatibility relations that constrain the pressure Jacobian derivatives. Thereafter, alternative forms for the pressure variation and average sound speed are developed in terms of two average pressure Jacobian derivatives. Significantly, no additional degree of freedom exists in the determination of these two average partial derivatives of pressure. Therefore, they are simultaneously computed exactly without any auxiliary relation, hence without any geometric solution projection or arbitrary scale factors. Several alternative formulations are then compared and key differences highlighted with emphasis on the determination of the pressure variation and average sound speed. The relevant underlying assumptions are identified, including some subtle approximations that are inherently employed in published average-state procedures. Finally, a representative test case is discussed for which an intrinsically exact average state is determined. This exact state is then compared with the predictions of recent methods, and their inherent approximations are appropriately quantified.

Iannelli, G. S.↗
NASA NTRS1972

Transportation Systems Evaluation

A methodology for the analysis of transportation systems consisting of five major interacting elements is reported. The analysis begins with the causes of travel demand: geographic, economic, and demographic characteristics as well as attitudes toward travel. Through the analysis, the interaction of these factors with the physical and economic characteristics of the transportation system is determined. The result is an evaluation of the system from the point of view of both passenger and operator. The methodology is applicable to the intraurban transit systems as well as major airlines. Applications of the technique to analysis of a PRT system and a study of intraurban air travel are given. In the discussion several unique models or techniques are mentioned: i.e., passenger preference modeling, an integrated intraurban transit model, and a series of models to perform airline analysis.

Fanning, M. L.↗
NASA NTRS2011

Composite Overwrapped Pressure Vessels, A Primer

Due to the extensive amount of detailed information that has been published on composite overwrapped pressure vessels (COPVs), this document has been written to serve as a primer for those who desire an elementary knowledge of COPVs and the factors affecting composite safety. In this application, the word "composite" simply refers to a matrix of continuous fibers contained within a resin and wrapped over a pressure barrier to form a vessel for gas or liquid containment. COPVs are currently used at NASA to contain high pressure fluids in propulsion, science experiments, and life support applications. They have a significant weight advantage over all metal vessels but require unique design, manufacturing, and test requirements. COPVs also involve a much more complex mechanical understanding due to the interplay between the composite overwrap and the inner liner. A metallic liner is typically used in a COPV as a fluid permeation barrier. The liner design concepts and requirements have been borrowed from all-metal vessels. However, application of metallic vessel design standards to a very thin liner is not straightforward. Different failure modes exist for COPVs than for all-metal vessels, and understanding of these failure modes is at a much more rudimentary level than for metal vessels.

McLaughlan, Pat B.↗
NASA NTRSDate not supplied

BioSentinel: To the Moon or Beyond?

BioSentinel, an Artemis-1 secondary spacecraft, will carry a biology experiment into deep space for the first time in 50 years. A 6U CubeSat form factor was utilized for the spacecraft and included technologies newly developed or adapted for operations beyond Earth orbit. This is the maiden deep-space voyage for the radio, propulsion system, electrical power system, and BioSensor payload. The spacecraft carries onboard budding yeast, Saccharomyces cerevisiae, as an analog to human cells to test the biological response to deep space radiation. Flying a secondary payload beyond LEO comes with unique challenges with respect to trajectory uncertainty and mission operations planning. BioSentinel does not carry propulsion for trajectory maneuvers, so plans for Comms and Power need to be developed for all trajectories. The nominal plan is a lunar flyby followed by an insertion into Heliocentric orbit. However, some possible scenarios include lunar eclipses that could severely impact the power budget during that phase of the mission, while others could result in a “Retrograde” hyperbola at swingby resulting in the spacecraft traveling inward toward Earth or even towards a collision with the lunar surface. BioSentinel’s final trajectory will not be known until after launch and deployment so possible scenarios need to be planned for ahead of time. This paper discusses the operational scenarios that were planned for as well as the actual execution of the mission operations including: command pass scheduling with the Deep Space Network, selecting bandwidth limits, medium gain antenna versus low gain antenna usage, and conserving power prior to a lunar eclipse. Note: Artemis-1 is planned to launch in the Spring of 2022

BioSentinel↗
NASA NTRS2015

Beneficial Effects of Metabolic Supression for Adoptation and Survival in Space Environment

NASA in its plans to send humans to distant destination such as Mars faces the health and physiological performance problems caused by microgravity and space radiation. While most of the environmental conditions in spacecraft during flight can be made to mimic terrestrial conditions, microgravity cannot yet be managed. This space environmental factor has a major impact on the body’s biological system forcing alterations, in order to adapt to this new environment. Most space flight and ground-based studies suggest that prolonged exposure to microgravity leads to significant skeletal muscle atrophy, bone loss, and results in suppression of total metabolism. Due to microgravity, unloaded crewmembers lose up to 1.5% of their skeletal mass and 1.8% of bone strength each month during ISS missions. Remarkably many animals, including human-size bears, which are largely inactive during the 6 to 8 months of hibernation, show no loss in bone mass and much less muscle atrophy than would be anticipated over such a prolonged period of physical inactivity. This suggests that while in a suppressed metabolic state animals have unique natural mechanisms to prevent muscle disuse and bone atrophy. The molecular mechanisms underlying these important adaptations are not yet known. Radiation exposure is the second health hazard encountered during spaceflight that can cause radiation sickness, cancer or death. This study provides new evidence that metabolic activity levels play a critical role in radioprotection. Metabolic suppression, as an adaptive response of cells to minimize damage caused by radiation, enables cells to reduce cellular dysfunction and damage, and prolong their survival despite persistent oxidative stress. Thus mechanistic understanding of metabolism offers a means for sustaining astronauts in long-duration missions. The ultimate goals of this study are to demonstrate that induced metabolic suppression in animals and humans will profoundly reduce their sensitivity to the damaging effects of radiation and microgravity as well as other kinds of stresses caused by spaceflight. The beneficial effects of suppressed metabolism induced by different factors such as temperature, nutrition, and medications, will not only mitigate the most detrimental hazards of spaceflight but also radically reduce mission life support requirements and spaceflight logistics.

Galicia, E.↗