SEARCH · Search NASA

Results for “CONTRACT”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

SourceResearch connectionFrom yearThrough year

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 595 records · Page 33

All sources NASA NTRS DOE OSTI

NASA NTRS2018

Quality Assurance Surveillance Tool Designed for SLS EM-1 Certificate of Flight Readiness

Exploration Mission-1 (EM-1) is an uncrewed mission that is launching on the Space Launch System (SLS) Block 1 vehicle. This is a critical flight test for the agency's human deep space exploration goals. Exploration Ground Systems (EGS) Quality (SA-F2) is responsible for providing Quality Assurance Surveillance Plans (QASPs) for NASA contracts and facilities. A QASP assures products and services are provided to EGS in accordance with the contract requirements. In order to encapsulate the multiple KSC Safety and Mission Assurance surveillance and audit activities that need to be accomplished specifically for EM-1 Certificate of Flight Reediness (CoFR), a QASP tool needed to be implemented. This tool would be able to intuitively track Work Authorization Documents (WADs) under development by Test Operations Support Contract (TOSC), reviewed and accepted WADs, Government Mandatory Inspection Points (GMIPs), Nonconformances (NCs), Material Review Board (MRB) Status, Corrective Actions, Alterations, Deviations, and Waivers for flight hardware and Ground Support Equipment (GSE). This would help ensure that all SLS EM-1 flight hardware and related GSE surveillances and requirements are being recognized and completed with zero constraints identified for the mission.

Morris, Patrick↗

NASA NTRS2019

Measured Interfacial Residual Strains Produced by In-Flight Ice

The formation of ice on aircraft is a highly dynamic process during which ice will expand and contract upon freezing and undergoing changes in temperature. Finite Element Analysis (FEA) simulations were performed investigating the stress build up in a simplified case with uniform temperature changes between an idealized ice sample and acrylic substrate. These results were used to place strain gages on custom-built acrylic and aluminum specimens; these specimens were then placed in icing conditions such that ice was grown on top of the specimen. Tee rosettes were placed in two configurations adjacent to thermocouple sensors. It was hypothesized that the ice would expand on freezing and contract as the temperature of the interface returned to the equilibrium conditions. While results from the aluminum specimens matched this hypothesis, results from the acrylic specimens show a short period of contraction followed by a much larger expansion at the interface, indicating more complex ice growth thermodynamics than anticipated. Samples were observed to delaminate, and the data suggests that the residual strain is significant to the shedding of ice for in-flight applications.

residual strain↗

NASA NTRS2019

Overview of NASA's Solar Electric Propulsion Project

NASA is continuing to develop and qualify a state of the art 13 kW-class Advanced Electric Propulsion System (AEPS) for NASA exploration missions through a contract with Aerojet Rocketdyne (AR). An objective of the AEPS project is accelerate the adoption of high power electric propulsion technologies by reducing the risk and uncertainty of integrating Solar Electric Propulsion (SEP) technologies into space flight systems. NASA and AR have recently initiated testing of engineering hardware including the Hall Current Thruster (HCT), Power Processing Unit (PPU), and Xenon Flow Controller (XFC) at both the component and system levels. The successful completion of these tests will provide the required information to advance the AEPS system towards Critical Design Review. In support of the AEPS contract, NASA and JPL have been performing risk reduction activities to address specific concerns of this higher power Hall thruster propulsion system. These risk reduction activities have included long duration wear testing of the Technology Demonstration Unit (TDU) Hall thruster and cathode hardware, thermal cycling of TDU cathode heaters and coils, plasma plume measurements, and performed early circuit testing of the AEPS PPU design. In addition to the propulsion system development, the SEP project is developing the Plasma Diagnostic Package (PDP) and the SEP Testbed. The PDP is designed for use in conjunction with a high-powered electric propulsion (EP) system to characterize in-space operation. The SEP Testbed system is being developed to demonstrate integrated SEP system performance. The paper presents an overview of the NASA and the AEPS contract activities and a summary of the associated NASA in-house activities.

Plasma diagnostics package↗

NASA NTRSDate not supplied

Extreme Environments Solar Power Project For Use Near Jupiter

The Extreme Environment Solar Power (EESP) Project goal was to develop solar cell and solar array design concept technologies for space power applications in high radiation and low solar intensity, low temperature (LILT) environments. NASA missions focused on outer planets, such as Jupiter, are subjected to intense radiation while experiencing less than ten percent of the solar flux relative to a mission in the general vicinity of Earth. Under these conditions, present solar array technology is not as efficient in converting the sun’s energy, and the solar array performance degrades quickly due to the additional radiation exposure. The EESP Project objectives were accomplished through four competitively selected contracts. These contracts were awarded with a Base and two option periods of performance. The Base requirements included System Design and Component Test & Analysis with a duration of nine and one half (9.5) months. The Option I requirements involved the fabrication of test hardware that NASA would evaluate following its delivery, and this period of performance had a duration of thirteen (13) months. The Option II requirements involved the fabrication of a scalable system prototype that can be integrated into a system level application and be demonstrated in a relevant environment. Option II had a duration of fifteen (15) months. The Transformational Array (TA) is an array concept developed by JHU-APL with Deployable Space Systems (DSS), SolAero Technologies and NewForge Technologies that proceeded through all three contract periods. The TA combines the DSS Roll Out Solar Array (ROSA) with Flexible Array Concentrator Technology (FACT) and SolAero’s Inverted Metamorphic Multijunction (IMM) solar cells for operation in the EESP Project environment. To achieve the EESP Project goals, the JHU-APL team conducted several investigations to improve performance of the solar cells and increase their efficiency, reduce outgassing contamination of the concentrators from the solar cell assembly adhesives, and to test the robustness of a sample blanket during deployment and retraction. Additionally, the team performed vibration, thermal cycling, and performance tests at a Standard Power Module (SPM) level. At the end of Option II, the JHU-APL team achieved the following performance metrics: • 39% beginning of life (BOL) cell efficiency at 5 AU and -125 C • 29% end of life (EOL) efficiency at the blanket level at 50 W/m2, -125 C and 4x1015 1 MeV e/cm2 • Increased specific power to 8 W/kg at EOL for the entire array including structure, deployment, and pointing mechanisms • Demonstrated the ability to survive numerous deploy-retract cycles without degradation • Reached a current System-Level Technology Readiness Level, TRL5 This presentation will describe the Transformational Array and component technologies and will discuss future potential uses for the system.

Anna Maria Pal↗

NASA NTRS2022

Blue Origin De-orbit Descent and Landing Tipping Point: Program Final Report

The purpose of this document is to provide a final report on the Deorbit, Descent, and Landing (DDL) Tipping Point program, a public-private partnership between Blue Origin and NASA that is partially funded by NASA contract 80LARC19C0005. In this report we summarize the results of the entire contract, including recommendations and conclusions based on the experience and results obtained. Only the portions funded by the government with associated unlimited rights are documented in detail in this report. For the work funded by Blue Origin, summaries with unlimited rights are provided for context and completeness. The Blue Origin funded work exceeded 25% of the originally proposed total program cost and included a mixture of hardware procurement and critical technology maturation. The scope of this document is a discussion of all the major tasks performed under the contract including the sensor flight demonstrations on New Shepard, the hardware in the loop lunar landing navigator demonstration, and the ground testing of the Flash LiDAR hazard sensor. The contributions from the multiple NASA teams – Johnson Space Center, Langley Research Center, Goddard Space Flight Center, and Jet Propulsion Laboratory – are described along with the contributions from Blue Origin. This document is the Final Report for statement of work item 4.1.2.10 as Deliverable 5.8.

Stefan Bieniawski↗

NASA NTRS2022

Maturation of Dynamic Power Convertors for RPS Robotic Space Exploration

NASA is developing dynamic power conversion technologies for future robotic space science and exploration missions powered by Radioisotope Power Systems (RPS). The Dynamic Radioisotope Power Systems (DRPS) Project is working to mature numerous dynamic power convertors and controllers for potential infusion into future flight generators. Maturation of power conversion technologies is being managed by the RPS Program and executed by the DRPS Project and Thermal Energy Conversion Branch located at NASA’s Glenn Research Center (GRC). Convertor maturation includes multiple convertor technology development contracts to deliver new prototypes and continued testing of relevant legacy convertors, commissioned during past projects. The convertor technology development contracts include two Stirling contractor teams and one Brayton team. All contracts have now completed prototype fabrication and testing planned during Phase 2. Government assessment of the new prototypes includes verification of performance in relevant environments and validation of the design with a focus on robustness.

Scott Wilson↗

NASA NTRSDate not supplied

Maturation of Dynamic Power Convertors for RPS Robotic Space Exploration

Scott Wilson↗

NASA NTRSDate not supplied

NASA's Initial Artemis Human Landing System

In April 2020, NASA announced the selection of three companies to begin the initial phase of development of human landing systems to take the first woman and the first person of color to the lunar surface through NASA’s Artemis lunar exploration program. The selected companies were a Blue Origin-led team with Lockheed Martin, Northrup Grumman, and Draper; Dynetics (a Leidos company); and SpaceX. Contracts were awarded shortly after, kicking off a ten-month base period during which NASA worked closely with each company to finalize functional and performance requirements, confirm lander development standards, and establish baseline designs, schedules, and management plans for contract execution and human spaceflight certification. At the end of the base period, in the Spring of 2021, NASA awarded a single follow-on Option A contract to SpaceX to continue their work on Human Landing System (HLS) Starship development. Currently NASA and SpaceX are working collaboratively on Option A which will ultimately culminate in one uncrewed and one crewed mission to the lunar surface under Artemis III. This paper will provide a look at the Option A phase of development for the Human Landing System Program, including publicly available information on SpaceX’s HLS Starship design as well as near-term and future milestones for HLS and the Artemis program.

Lisa Watson-Morgan↗

NASA NTRSDate not supplied

NASA’s Human Landing System: A Sustaining Presence on the Moon

For more than a decade, efforts have been ongoing at NASA’s Marshall Space Flight Center (MSFC) in Huntsville, Alabama, to land humans and cargo on planetary bodies like the Moon and Mars and today this work continues under the Center’s Lander Programs (LP) office. In August of 2019, NASA stood up the Human Landing System (HLS) program to be responsible for spacecrafts that will land astronauts on the Moon under Artemis. Work is well underway with the historic Artemis III mission to land the first Americans on the lunar surface in more than 50 years through the Appendix H Option A [1] contract with SpaceX. In November, NASA awarded SpaceX an Option B modification to its existing HLS Appendix H contract, which will further develop its Starship HLS to meet NASA’s sustaining lander requirements for lunar missions beyond Artemis III. In September of 2022, NASA issued an HLS Sustaining Lunar Development solicitation under the NextSTEP-2 Appendix P Broad Agency Announcement [2] asking a second provider, in addition to SpaceX, to develop and demonstrate a lander that meets the program’s extended set of requirements for missions beyond Artemis III. Under the umbrella of Sustaining Lunar Development [3], these requirements will meet NASA’s needs for recurring, long-term access to the lunar surface. Proposals were received from industry late last year and NASA is planning to award an Appendix P contract in the summer of 2023. This paper will provide an update of the Lander Program office’s progress and will discuss how the program is bridging from the initial demonstration phase of development for the Human Landing System program to the Sustaining Lunar Development phase. The paper will include publicly available information on SpaceX’s Starship HLS design as well as near-term and future milestones for HLS and the Artemis program.

Lisa Watson-Morgan↗

NASA NTRS2026

NASA Hybrid Thermally Efficient Core (HyTEC) Phase 2 Q3’GFY25 to Q2’GFY26 Unlimited Rights Annual Report for CLIN 1 and 2

The HyTEC Phase 2 Project focuses on the development and demonstration of high-power density, small engine core gas turbine engine technologies. The focus of HyTEC on these small engine core technologies will provide direct benefits to the next single-aisle class aircraft in terms of thermal efficiency, as well as integrate with other technologies, through increased hybridization, as they mature to provide substantial continuous fuel burn reductions during the aircraft lifecycle. These advances will strengthen the US position in the commercial aviation engine market and enable cost benefits in commercial aviation. In Government fiscal year 26 the HyTEC Project was closed and contract moved to the Subsonic Vehicle Technologies and Tools Project. GE Aerospace is executing two major work plans as part of the HyTEC Phase 2 contract. The first is Contract Line-Item Number (CLIN) 001 and its objective is to mature High Pressure Turbine (HPT) aerodynamics technology to TRL 5 through multiple rigs so that it may be incorporated into a complete TRL 6 evaluation and unlock learnings for the engine core demonstration as applicable. CLIN 002, the second work plan, is to design, procure and test a cost shared portion of technologies on the TRL6 Compact Core test vehicle. The compact core demonstrated through HyTEC Phase 2 along with the HPT rig TRL advancement directly matures the technologies being developed as part of the CFM RISE demonstrator program which is targeting a more than 20% fuel burn reduction at the engine level versus today’s state of the art. The RISE program’s objective is to advance both the novel Open Fan architecture, compact core technologies and advanced systems such as hybrid electric needed to achieve the desired fuel burn reduction to TRL6 ahead of a new product introduction in the single-aisle class aircraft in the 2030s timeframe.

gas turbine engine↗

DOE OSTI2025

Actuated flywheel projectile launcher

Various embodiments include an actuated projectile launcher, including: a base structure; a projectile support, and a holding area from which a projectile launches; propulsion wheels selectively driven to rotate; and support arms, each supporting at a first end thereof a separate one of the propulsion wheels and being supported at an opposed second end thereof by the base structure. The support arms are configured to move the propulsion wheels between an expanded position and a contracted position, in which the propulsion wheels are closer to one another in the contracted position as compared to the expanded position. The movement of the propulsion wheels toward the contracted position brings the propulsion wheels into engagement with the projectile and drives the projectile from the holding area.

Dullea, Kevin J.↗

NASA NTRS1992

Muscle fatigue in frog semitendinosus: alterations in contractile function

The purpose of this study was to characterize the contractile properties of the frog semitendinosus (ST) muscle before and during recovery from fatigue, to relate the observed functional changes to alterations in specific steps in the crossbridge model of muscle contraction, and to determine how fatigue affects the force-frequency relationship. The frog ST (22 degrees C) was fatigued by direct electrical stimulation with 100-ms 150-Hz trains at 1/s for 5 min. The fatigue protocol reduced peak twitch (Pt) and tetanic (Po) force to 32 and 8.5% of initial force, respectively. The decline in Pt was less than Po, in part due to a prolongation in the isometric contraction time (CT), which increased to 300% of the initial value. The isometric twitch duration was greatly prolonged as reflected by the lengthened CT and the 800% increase in the one-half relaxation time (1/2RT). Both Pt and Po showed a biphasic recovery, a rapid initial phase (2 min) followed by a slower (40 min) return to the prefatigue force. CT and 1/2RT also recovered in two phases, returning to 160 and 265% of control in the first 5 min. CT returned to the prefatigue value between 35 and 40 min, whereas even at 60 min 1/2RT was 133% of control. The maximal velocity of shortening, determined by the slack test, was significantly reduced [from 6.7 +/- 0.5 to 2.5 +/- 0.4 optimal muscle length/s] at fatigue. The force-frequency relationship was shifted to the left, so that optimal frequency for generating Po was reduced.(ABSTRACT TRUNCATED AT 250 WORDS).

NASA Discipline Musculoskeletal↗

NASA NTRS2001

Sensorimotor adaptations to microgravity in humans

Motor function is altered by microgravity, but little detail is available as to what these changes are and how changes in the individual components of the sensorimotor system affect the control of movement. Further, there is little information on whether the changes in motor performance reflect immediate or chronic adaptations to changing gravitational environments. To determine the effects of microgravity on the neural control properties of selected motor pools, four male astronauts from the NASA STS-78 mission performed motor tasks requiring the maintenance of either ankle dorsiflexor or plantarflexor torque. Torques of 10 or 50% of a maximal voluntary contraction (MVC) were requested of the subjects during 10 degrees peak-to-peak sinusoidal movements at 0.5 Hz. When 10% MVC of the plantarflexors was requested, the actual torques generated in-flight were similar to pre-flight values. Post-flight torques were higher than pre- and in-flight torques. The actual torques when 50% MVC was requested were higher in- and post-flight than pre-flight. Soleus (Sol) electromyographic (EMG) amplitudes during plantarflexion were higher in-flight than pre- or post-flight for both the 10 and 50% MVC tasks. No differences in medial gastrocnemius (MG) EMG amplitudes were observed for either the 10 or 50% MVC tasks. The EMG amplitudes of the tibialis anterior (TA), an antagonist to plantarflexion, were higher in- and post-flight than pre-flight for the 50% MVC task. During the dorsiflexion tasks, the torques generated in both the 10 and 50% MVC tasks did not differ pre-, in- and post-flight. TA EMG amplitudes were significantly higher in- than pre-flight for both the 10 or 50% MVC tasks, and remained elevated post-flight for the 50% MVC test. Both the Sol and MG EMG amplitudes were significantly higher in-flight than either pre- or post-flight for both the 10 and 50% MVC tests. These data suggest that the most consistent response to space flight was an elevation in the level of contractions of agonists and antagonists when attempting to maintain constant torques at a given level of MVC. Also, the chronic levels of EMG activity in selected ankle flexor and extensor muscles during space flight and during routine activities on Earth were recorded. Compared with pre- and post-flight values, there was a marked increase in the total EMG activity of the TA and the Sol and no change in the MG EMG activity in-flight. These data indicate that space flight, as occurs on shuttle missions, is a model of elevated activation of both flexor and extensor muscles, probably reflecting the effects of programmed work schedules in flight rather than a direct effect of microgravity.

NASA Experiment Number 284036↗

NASA NTRS2001

Functional and structural adaptations of skeletal muscle to microgravity

Our purpose is to summarize the major effects of space travel on skeletal muscle with particular emphasis on factors that alter function. The primary deleterious changes are muscle atrophy and the associated decline in peak force and power. Studies on both rats and humans demonstrate a rapid loss of cell mass with microgravity. In rats, a reduction in muscle mass of up to 37% was observed within 1 week. For both species, the antigravity soleus muscle showed greater atrophy than the fast-twitch gastrocnemius. However, in the rat, the slow type I fibers atrophied more than the fast type II fibers, while in humans, the fast type II fibers were at least as susceptible to space-induced atrophy as the slow fiber type. Space flight also resulted in a significant decline in peak force. For example, the maximal voluntary contraction of the human plantar flexor muscles declined by 20-48% following 6 months in space, while a 21% decline in the peak force of the soleus type I fibers was observed after a 17-day shuttle flight. The reduced force can be attributed both to muscle atrophy and to a selective loss of contractile protein. The former was the primary cause because, when force was expressed per cross-sectional area (kNm(-2)), the human fast type II and slow type I fibers of the soleus showed no change and a 4% decrease in force, respectively. Microgravity has been shown to increase the shortening velocity of the plantar flexors. This increase can be attributed both to an elevated maximal shortening velocity (V(0)) of the individual slow and fast fibers and to an increased expression of fibers containing fast myosin. Although the cause of the former is unknown, it might result from the selective loss of the thin filament actin and an associated decline in the internal drag during cross-bridge cycling. Despite the increase in fiber V(0), peak power of the slow type I fiber was reduced following space flight. The decreased power was a direct result of the reduced force caused by the fiber atrophy. In addition to fiber atrophy and the loss of force and power, weightlessness reduces the ability of the slow soleus to oxidize fats and increases the utilization of muscle glycogen, at least in rats. This substrate change leads to an increased rate of fatigue. Finally, with return to the 1g environment of earth, rat studies have shown an increased occurrence of eccentric contraction-induced fiber damage. The damage occurs with re-loading and not in-flight, but the etiology has not been established.

Review, Tutorial↗

NASA NTRS2000

Contractile reserve and intracellular calcium regulation in mouse myocytes from normal and hypertrophied failing hearts

Mouse myocyte contractility and the changes induced by pressure overload are not fully understood. We studied contractile reserve in isolated left ventricular myocytes from mice with ascending aortic stenosis (AS) during compensatory hypertrophy (4-week AS) and the later stage of early failure (7-week AS) and from control mice. Myocyte contraction and [Ca(2+)](i) transients with fluo-3 were measured simultaneously. At baseline (0.5 Hz, 1.5 mmol/L [Ca(2+)](o), 25 degrees C), the amplitude of myocyte shortening and peak-systolic [Ca(2+)](i) in 7-week AS were not different from those of controls, whereas contraction, relaxation, and the decline of [Ca(2+)](i) transients were slower. In response to the challenge of high [Ca(2+)](o), fractional cell shortening was severely depressed with reduced peak-systolic [Ca(2+)](i) in 7-week AS compared with controls. In response to rapid pacing stimulation, cell shortening and peak-systolic [Ca(2+)](i) increased in controls, but this response was depressed in 7-week AS. In contrast, the responses to both challenge with high [Ca(2+)](o) and rapid pacing in 4-week AS were similar to those of controls. Although protein levels of Na(+)-Ca(2+) exchanger were increased in both 4-week and 7-week AS, the ratio of SR Ca(2+)-ATPase to phospholamban protein levels was depressed in 7-week AS compared with controls but not in 4-week AS. This was associated with an impaired capacity to increase sarcoplasmic reticulum Ca(2+) load during high work states in 7-week AS myocytes. In hypertrophied failing mouse myocytes, depressed contractile reserve is related to an impaired augmentation of systolic [Ca(2+)](i) and SR Ca(2+) load and simulates findings in human failing myocytes.

Non-NASA Center↗

NASA NTRS2000

Subendocardial motion in hypertrophic cardiomyopathy: assessment from long- and short-axis views by pulsed tissue Doppler imaging

BACKGROUND: Tissue Doppler imaging (TDI) is a recently developed technique that allows the instantaneous measurement of intrinsic regional myocardial motion velocity. Pulsed TDI is capable of separately assessing left ventricular (LV) regional motion velocity caused by circumferential and longitudinal fiber contraction. This particular feature of function is still controversial in patients with hypertrophic cardiomyopathy (HC). METHODS: To better characterize intrinsic circumferential and longitudinal LV systolic myocardial function in HC, we used pulsed TDI to measure short- and long-axis LV motion velocities, respectively. The subendocardial motion velocity patterns at the middle of the LV posterior wall (PW) and ventricular septum (IVS) in LV parasternal and apical long-axis views were recorded by pulsed TDI in 19 patients with nonobstructive HC and in 21 normal controls (NC). RESULTS: Peak short- and long-axis systolic subendocardial velocities in both the LV PW and IVS were significantly smaller in the HC group than in the NC group, and the time to peak velocity was significantly delayed. Furthermore, peak PW systolic velocity was significantly greater along the long axis than along the short axis in the NC group (8.8 +/- 1.5 cm/s vs 8.2 +/- 1.4 cm/s, P <.05), whereas the opposite was observed in the HC group (6.1 +/- 1.2 cm/s vs 7.5 +/- 1.0 cm/s, P <.0001). No significant differences were found in either group between the long- and short-axis IVS velocities (HC: 5.9 +/- 1.4 cm/s vs 5.5 +/- 1.3 cm/s; NC: 7.8 +/- 1.3 cm/s vs 7.9 +/- 1.6 cm/s). CONCLUSIONS: By using the capability of pulsed TDI for the evaluation of intrinsic myocardial velocity instantaneously in a specific region and direction, we found impairment of LV myocardial systolic function in patients with HC not only in the hypertrophied IVS but also in the nonhypertrophied LV PW. We also found a greater decrease in LV PW velocities along the long axis than the short axis, suggesting greater impairment of long-axis contraction in patients with HC. Because our HC patients did not appear to have excessive intracavitary pressure, these results suggest that the relatively normal-appearing PW is directly affected by the HC pathologic process.

NASA Program Biomedical Research and Countermeasur↗

NASA NTRS1992

Abnormalities in intracellular calcium regulation and contractile function in myocardium from dogs with pacing-induced heart failure

24 d of rapid ventricular pacing induced dilated cardiomyopathy with both systolic and diastolic dysfunction in conscious, chronically instrumented dogs. We studied mechanical properties and intracellular calcium (Ca2+i) transients of trabeculae carneae isolated from 15 control dogs (n = 32) and 11 dogs with pacing-induced cardiac failure (n = 26). Muscles were stretched to maximum length at 30 degrees C and stimulated at 0.33 Hz; a subset (n = 17 control, n = 17 myopathic) was loaded with the [Ca2+]i indicator aequorin. Peak tension was depressed in the myopathic muscles, even in the presence of maximally effective (i.e., 16 mM) [Ca2+] in the perfusate. However, peak [Ca2+]i was similar (0.80 +/- 0.13 vs. 0.71 +/- 0.05 microM; [Ca2+]o = 2.5 mM), suggesting that a decrease in Cai2+ availability was not responsible for the decreased contractility. The time for decline from the peak of the Cai2+ transient was prolonged in the myopathic group, which correlated with prolongation of isometric contraction and relaxation. However, similar end-diastolic [Ca2+]i was achieved in both groups (0.29 +/- 0.05 vs. 0.31 +/- 0.02 microM), indicating that Cai2+ homeostasis can be maintained in myopathic hearts. The inotropic response of the myopathic muscles to milrinone was depressed compared with the controls. However, when cAMP production was stimulated by pretreatment with forskolin, the response of the myopathic muscles to milrinone was improved. Our findings provide direct evidence that abnormal [Ca2+]i handling is an important cause of contractile dysfunction in dogs with pacing-induced heart failure and suggest that deficient production of cAMP may be an important cause of these changes in excitation-contraction coupling.

Non-NASA Center↗

NASA NTRS1993

A Contracign out Success Story

This paper is based on the highly successfull Mission and Computing Support (MACS) Contract, between the Jet Propulsion Laboratory (JPL) and OAO Corporation, which encompasses a comprehensive set of work for information systems and services. JPL awarded the MACS contract in 1988 and saw very succeful operation during the first five years which were recently completed.

Contracting Outsourcing↗