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At least 595 records · Page 33

Effect of swim exercise training on human muscle fiber function

The effect of swim exercise training on the human muscle fiber function was investigated in swimmers trained in a typical collegiate swim-training program followed by an intensified 10-day training period. The measured parameters included the peak tension (P0), negative log molar Ca(2+) concentration (pCa)-force, and maximal shortening speed (Vmax) of the slow-twitch type I and fast-twitch type II fibers obtained by biopsy from the deltoid muscle. The P0 values were found to be not altered after either the training or the 10-day intensive program. The type I fibers from the trained swimmers showed pCa-force curves shifted to the right, such that higher free Ca(2+) levels were required to elicit a given percent of P0. The training program significantly increased the Vmax in the type I fibers and decreased that of the type II fibers, and the 10-day intensive training produced a further significant decrease of the type II fibers.

Fitts, R. H.↗

The Cretaceous-Tertiary Impact Crater and the Cosmic Projectile that Produced it

Evidence gathered to date from topographic data, geophysical data, well logs, and drill-core samples indicates that the buried Chicxulub basin, the source crater for the approximately 65 Ma Cretaceous-Tertiary (K/T) boundary deposits, is approximately 300 km in diameter. A prominent topographic ridge and a ring of gravity anomalies mark the position of the basin rim at approximately 150 km from the center. Wells in this region recovered thick sequences of impact-generated breccias at 200-300 m below present sea level. Inside the rim, which has been severely modified by erosion following impact, the subsurface basin continues to deepen until near the center it is approximately 1 km deep. The best planetary analog for this crater appears to be the 270 km-diameter Mead basin on Venus. Seismic reflection data indicate that the central zone of downward displacement and excavation (the transient crater is approximately 130 km in diameter, consistent with previous studies of gravity anomaly data). Our analysis of projectile characteristics utilizes this information, coupled with conventional scaling relationships, and geochemical constraints on the mass of extraterrestrial material deposited within the K/T boundary layer. Results indicate that the Chicxulub crater would most likely be formed by a long-period comet composed primarily of nonsilicate materials (ice, hydrocarbons, etc.) and subordinate amounts (less than or equal to 50 percent) primitive chondritic material. This collision would have released the energy equivalent to between 4 x 10(exp 8) and 4 x 10(exp 9) megatons of TNT. Studies of terrestrial impact rates suggest that such an event would have a mean production rate of approximately 1.25 x 10(exp -9) y(exp -1). This rate is considerably lower than that of the major mass extinctions over the last 250 million years (approximately 5 x 10(exp -7) y(exp -1). Consequently, while there is substantial circumstantial evidence establishing the cause-effect link between the Chicxulub basin forming event and the K/T biological extinctions, the results of our analysis do not support models of impact as a common or singular causative agent of mass extinctions on Earth.

Sharpton, Virgil L.↗

Clustering of moderate luminosity X-ray-selected type 1 and type 2 AGNs at z ∼ 3

We investigate, for the first time at z ∼ 3, the clustering properties of 189 Type 1 and 157 Type 2 X-ray active galactic nuclei (AGNs) of moderate luminosity ((L {sub bol}) = 10{sup 45.3} erg s{sup –1}), with photometric or spectroscopic redshifts in the range 2.2 < z < 6.8. These samples are based on Chandra and XMM-Newton data in COSMOS. We find that Type 1 and Type 2 COSMOS AGNs at z ∼ 3 inhabit DMHs with typical mass of log M{sub h} = 12.84{sub −0.11}{sup +0.10} and 11.73{sub −0.45}{sup +0.39} h {sup –1} M {sub ☉}, respectively. This result requires a drop in the halo masses of Type 1 and 2 COSMOS AGNs at z ∼ 3 compared to z ≲ 2 XMM-COSMOS AGNs with similar luminosities. Additionally, we infer that unobscured COSMOS AGNs at z ∼ 3 reside in 10 times more massive halos compared to obscured COSMOS AGNs, at the 2.6σ level. This result extends to z ∼ 3 the results found in COSMOS at z ≲ 2, and rules out the picture in which obscuration is purely an orientation effect. A model which assumes that the AGNs activity is triggered by major mergers is quite successful in predicting both the low halo mass of COSMOS AGNs and the typical mass of luminous SDSS quasars at z ∼ 3, with the latter inhabiting more massive halos respect to moderate luminosity AGNs. Alternatively we can argue, at least for Type 1 COSMOS AGNs, that they are possibly representative of an early phase of fast (i.e., Eddington limited) BH growth induced by cosmic cold flows or disk instabilities. Given the moderate luminosity, these new fast growing BHs have masses of ∼10{sup 7-8} M {sub ☉} at z ∼ 3 which might evolve into ∼10{sup 8.5-9} M {sub ☉} mass BHs at z = 0. Following our clustering measurements, we argue that this fast BH growth at z ∼ 3 in AGNs with moderate luminosity occurs in DMHs with typical mass of ∼ 6× 10{sup 12} h {sup –1} M {sub ☉}.

79 ASTRONOMY AND ASTROPHYSICS↗

DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms

Background: Duodenal cytochrome b (DCYTB) is a ferrireductase that functions together with divalent metal transporter 1 (DMT1) to mediate dietary iron reduction and uptake in the duodenum. DCYTB is also a member of a 16-gene iron regulatory gene signature (IRGS) that predicts metastasis-free survival in breast cancer patients. To better understand the relationship between DCYTB and breast cancer, we explored in detail the prognostic significance and molecular function of DCYTB in breast cancer. Methods: The prognostic significance of DCYTB expression was evaluated using publicly available microarray data. Signaling Pathway Impact Analysis (SPIA) of microarray data was used to identify potential novel functions of DCYTB. The role of DCYTB was assessed using immunohistochemistry and measurements of iron uptake, iron metabolism, and FAK signaling. Results: High DCYTB expression was associated with prolonged survival in two large independent cohorts, together totaling 1610 patients (cohort #1, p = 1.6e-11, n = 741; cohort #2, p = 1.2e-05, n = 869; log-rank test) as well as in the Gene expression-based Outcome for Breast cancer Online (GOBO) cohort (p < 1.0e-05, n = 1379). High DCYTB expression was also associated with increased survival in homogeneously treated groups of patients who received either tamoxifen or chemotherapy. Immunohistochemistry revealed that DCYTB is localized on the plasma membrane of breast epithelial cells, and that expression is dramatically reduced in high-grade tumors. Surprisingly, neither overexpression nor knockdown of DCYTB affected levels of ferritin H, transferrin receptor, labile iron or total cellular iron in breast cancer cells. Because SPIA pathway analysis of patient microarray data revealed an association between DCYTB and the focal adhesion pathway, we examined the influence of DCYTB on FAK activation in breast cancer cells. These experiments reveal that DCYTB reduces adhesion and activation of focal adhesion kinase (FAK) and its adapter protein paxillin. Conclusions: DCYTB is an important predictor of outcome and is associated with response to therapy in breast cancer patients. DCYTB does not affect intracellular iron in breast cancer cells. Instead, DCYTB may retard cancer progression by reducing activation of FAK, a kinase that plays a central role in tumor cell adhesion and metastasis.

60 APPLIED LIFE SCIENCES↗

Panama leaf water potential census 2015-2019

This dataset contains values of leaf water potential from a monthly census of predawn and midday measurements conducted on nine trees in each of two sites in Panama from December 2015 to July 2019. The dataset includes individual measurements that were made with a pressure chamber. The measurements were made on the focal trees to complement concurrent measurements of sap flow. The trees were also intensively measured for leaf-level physiological condition during the 2016 ENSO campaign conducted by NGEE-tropics. A subset of measurements was made on leaves that were sealed in plastic bags and protected from solar radiation before they were collected, such that the measurements assessed branch water potential. The dataset contains a csv file that has columns for the time, location, and value of each measurement. The dataset also contains a metadata file, column description file, and an E-Field log file in the recommended NGEE-Tropic formats.

54 ENVIRONMENTAL SCIENCES↗

Variability Timescale and Spectral Index of Sgr A* in the Near Infrared: Approximate Bayesian Computation Analysis of the Variability of the Closest Supermassive Black Hole

Sagittarius A* (Sgr A* ) is the variable radio, near-infrared (NIR), and X-ray source associated with accretion onto the Galactic center black hole. We present an analysis of the most comprehensive NIR variability data set of Sgr A* to date: eight 24 hr epochs of continuous monitoring of Sgr A* at 4.5 μm with the IRAC instrument on the Spitzer Space Telescope, 93 epochs of 2.18 μm data from Naos Conica at the Very Large Telescope, and 30 epochs of 2.12 μm data from the NIRC2 camera at the Keck Observatory, in total 94,929 measurements. A new approximate Bayesian computation method for fitting the first-order structure function extracts information beyond current fast Fourier transformation (FFT) methods of power spectral density (PSD) estimation. With a combined fit of the data of all three observatories, the characteristic coherence timescale of Sgr A* is b 243 57 82 t = - + minutes (90% credible interval). The PSD has no detectable features on timescales down to 8.5 minutes (95% credible level), which is the ISCO orbital frequency for a dimensionless spin parameter a = 0.92. One light curve measured simultaneously at 2.12 and 4.5 μm during a low flux-density phase gave a spectral index αs = 1.6 ± 0.1 (F µ n s n -a ). This value implies that the Sgr A* NIR color becomes bluer during higher flux-density phases. The probability densities of flux densities of the combined data sets are best fit by log-normal distributions. Based on these distributions, the Sgr A* spectral energy distribution is consistent with synchrotron radiation from a nonthermal electron population from below 20 GHz through the NIR.

accretion↗

Maternal body burden of cadmium and offspring size at birth

Increasing evidence suggests an inverse association between cadmium (Cd) and size at birth, potentially greatest among female neonates. We evaluated whether greater maternal body burden of Cd is associated with reduced neonatal anthropometry (birthweight, birth length, head circumference, and ponderal index) and assessed whether these associations differ by infant sex. The analytic sample for the present study (n=396) was derived from a subcohort of 750 women randomly drawn from among all participants (N=4344) in the Omega Study, a prospective pregnancy cohort. Creatinine-corrected Cd in maternal clean-catch spot urine samples (U-Cd) was quantified by inductively coupled plasma mass spectrometry. Continuous log{sub 2}-transformed Cd (log{sub 2}-Cd) and U-Cd tertiles (low<0.29 μg/g creatinine, middle 0.29–0.42 μg/g creatinine, high≥0.43 μg/g creatinine) were used in multivariable linear regression models. Females had reduced birth length with greater U-Cd tertile, whereas males birth length marginally increased [β(95% CI) females: low=reference, middle=−0.59 cm (−1.37, 0.19), high=−0.83 cm (−1.69, 0.02), p-trend=0.08; males: low=reference, middle=0.18 cm (−0.59, 0.95), high=0.78 cm (–0.04, 1.60), p-trend=0.07; p for interaction=0.03]. The log{sub 2}-Cd by infant sex interaction was statistically significant for ponderal index [p=0.003; β(95% CI): female=0.25 kg/m{sup 3} (−0.20, 0.70); male=−0.63 kg/m{sup 3} (−1.01, −0.24)] and birth length [p<0.001; β(95% CI): female=−0.47 cm (−0.74, −0.20), male=0.32 cm (0.00, 0.65)]. Our findings suggest potential sex-specific reversal of Cd’s associations on birth length and contribute to the evidence suggesting Cd impairs fetal growth. - Highlights: • Cadmium levels in the general population potentially adversely affect size at birth. • Maternal urinary cadmium was inversely related to birth length among female infants. • For male infants, maternal cadmium was positively associated with birth length. • Maternal cadmium was also inversely related to ponderal index among male infants.

54 ENVIRONMENTAL SCIENCES↗

Robust Parameter Design on Dual Stochastic Response Models With Constrained Bayesian Optimization

In engineering system design, minimizing the variations of the quality measurements while guaranteeing their overall quality up to certain levels, namely the robust parameter design (RPD), is crucial. Recent works have dealt with the design of a system whose response-control variables relationship is a deterministic function with a complex shape and function evaluation is expensive. In this work, we propose a Bayesian optimization method for the RPD of stochastic functions. Dual stochastic response models are carefully designed for stochastic functions. The heterogeneous variance of the sample mean is addressed by the predictive mean of the log variance surrogate model in a two-step approach. We establish an acquisition function that favors exploration across the feasible and optimality-improvable regions to effectively and efficiently solve the stochastic constrained optimization problem. Further, the performance of our proposed method is demonstrated by the extensive numerical and case studies. Note to Practitioners-Many manufacturing processes involve undesirable variations, which create variations in the final products. For example, many emerging manufacturing processes, such as nanomanufacturing, involve complex physical and chemical dynamics and transformation, creating variations in the manufacturing output. In such processes, it is crucial to design the manufacturing processes or products so that they have minimum variations in their quality. Meanwhile, it is also important to maintain the overall quality of the designed processes or products. Furthermore, acquiring data from many advanced manufacturing processes is often very costly, especially in the designing stage. In this work, we propose a data-driven method that automatically finds the best setting of manufacturing processes or products with the minimum variations of quality and a given constraint on the average quality satisfied. Our proposed method is used before conducting every experiment; It analyzes the historical data from previous experiments and provides a setting to be used in the next experiment. Our proposed method efficiently utilizes the historical data, and thus finds the best robust setting by conducting only a small number of experiments.

42 ENGINEERING↗

Geomechanical Study of Bakken Formation for Improved Oil Recovery

On October 1, 2008 US DOE-sponsored research project entitled “Geomechanical Study of Bakken Formation for Improved Oil Recovery” under agreement DE-FC26-08NT0005643 officially started at The University of North Dakota (UND). This is the final report of the project; it covers the work performed during the project period of October 1, 2008 to December 31, 2013. The objectives of this project are to outline the methodology proposed to determine the in-situ stress field and geomechanical properties of the Bakken Formation in Williston Basin, North Dakota, USA to increase the success rate of horizontal drilling and hydraulic fracturing so as to improve the recovery factor of this unconventional crude oil resource from the current 3% to a higher level. The success of horizontal drilling and hydraulic fracturing depends on knowing local in-situ stress and geomechanical properties of the rocks. We propose a proactive approach to determine the in-situ stress and related geomechanical properties of the Bakken Formation in representative areas through integrated analysis of field and well data, core sample and lab experiments. Geomechanical properties are measured by AutoLab 1500 geomechanics testing system. By integrating lab testing, core observation, numerical simulation, well log and seismic image, drilling, completion, stimulation, and production data, in-situ stresses of Bakken formation are generated. These in-situ stress maps can be used as a guideline for future horizontal drilling and multi-stage fracturing design to improve the recovery of Bakken unconventional oil.

Diagnostics/Imaging↗

Analysis of the access patterns at GSFC distributed active archive center

The Goddard Space Flight Center (GSFC) Distributed Active Archive Center (DAAC) has been operational for more than two years. Its mission is to support existing and pre Earth Observing System (EOS) Earth science datasets, facilitate the scientific research, and test Earth Observing System Data and Information System (EOSDIS) concepts. Over 550,000 files and documents have been archived, and more than six Terabytes have been distributed to the scientific community. Information about user request and file access patterns, and their impact on system loading, is needed to optimize current operations and to plan for future archives. To facilitate the management of daily activities, the GSFC DAAC has developed a data base system to track correspondence, requests, ingestion and distribution. In addition, several log files which record transactions on Unitree are maintained and periodically examined. This study identifies some of the users' requests and file access patterns at the GSFC DAAC during 1995. The analysis is limited to the subset of orders for which the data files are under the control of the Hierarchical Storage Management (HSM) Unitree. The results show that most of the data volume ordered was for two data products. The volume was also mostly made up of level 3 and 4 data and most of the volume was distributed on 8 mm and 4 mm tapes. In addition, most of the volume ordered was for deliveries in North America although there was a significant world-wide use. There was a wide range of request sizes in terms of volume and number of files ordered. On an average 78.6 files were ordered per request. Using the data managed by Unitree, several caching algorithms have been evaluated for both hit rate and the overhead ('cost') associated with the movement of data from near-line devices to disks. The algorithm called LRU/2 bin was found to be the best for this workload, but the STbin algorithm also worked well.

Johnson, Theodore↗

Toward Synthesis, Analysis, and Certification of Security Protocols

Implemented security protocols are basically pieces of software which are used to (a) authenticate the other communication partners, (b) establish a secure communication channel between them (using insecure communication media), and (c) transfer data between the communication partners in such a way that these data only available to the desired receiver, but not to anyone else. Such an implementation usually consists of the following components: the protocol-engine, which controls in which sequence the messages of the protocol are sent over the network, and which controls the assembly/disassembly and processing (e.g., decryption) of the data. the cryptographic routines to actually encrypt or decrypt the data (using given keys), and t,he interface to the operating system and to the application. For a correct working of such a security protocol, all of these components must work flawlessly. Many formal-methods based techniques for the analysis of a security protocols have been developed. They range from using specific logics (e.g.: BAN-logic [4], or higher order logics [12] to model checking [2] approaches. In each approach, the analysis tries to prove that no (or at least not a modeled intruder) can get access to secret data. Otherwise, a scenario illustrating the &tack may be produced. Despite the seeming simplicity of security protocols ("only" a few messages are sent between the protocol partners in order to ensure a secure communication), many flaws have been detected. Unfortunately, even a perfect protocol engine does not guarantee flawless working of a security protocol, as incidents show. Many break-ins and security vulnerabilities are caused by exploiting errors in the implementation of the protocol engine or the underlying operating system. Attacks using buffer-overflows are a very common class of such attacks. Errors in the implementation of exception or error handling can open up additional vulnerabilities. For example, on a website with a log-in screen: multiple tries with invalid passwords caused the expected error message (too many retries). but let the user nevertheless pass. Finally, security can be compromised by silly implementation bugs or design decisions. In a commercial VPN software, all calls to the encryption routines were incidentally replaced by stubs, probably during factory testing. The product worked nicely. and the error (an open VPN) would have gone undetected, if a team member had not inspected the low-level traffic out of curiosity. Also, the use secret proprietary encryption routines can backfire, because such algorithms often exhibit weaknesses which can be exploited easily (see e.g., DVD encoding). Summarizing, there is large number of possibilities to make errors which can compromise the security of a protocol. In today s world with short time-to-market and the use of security protocols in open and hostile networks for safety-critical applications (e.g., power or air-traffic control), such slips could lead to catastrophic situations. Thus, formal methods and automatic reasoning techniques should not be used just for the formal proof of absence of an attack, but they ought to be used to provide an end-to-end tool-supported framework for security software. With such an approach all required artifacts (code, documentation, test cases) , formal analyses, and reliable certification will be generated automatically, given a single, high level specification. By a combination of program synthesis, formal protocol analysis, certification; and proof-carrying code, this goal is within practical reach, since all the important technologies for such an approach actually exist and only need to be assembled in the right way.

Schumann, Johann↗

Low-energy effective field theory below the electroweak scale: operators and matching

The gauge-invariant operators up to dimension six in the low-energy effective field theory below the electroweak scale are classified. There are 70 Hermitian dimension-five and 3631 Hermitian dimension-six operators that conserve baryon and lepton number, as well as ΔB = ±ΔL = ±1, ΔL = ±2, and ΔL = ±4 operators. The matching onto these operators from the Standard Model Effective Field Theory (SMEFT) up to order 1/Λ 2 is computed at tree level. SMEFT imposes constraints on the coefficients of the low-energy effective theory, which can be checked experimentally to determine whether the electroweak gauge symmetry is broken by a single fundamental scalar doublet as in SMEFT. Furthermore our results, when combined with the one-loop anomalous dimensions of the low-energy theory and the one-loop anomalous dimensions of SMEFT, allow one to compute the low-energy implications of new physics to leading-log accuracy, and combine them consistently with high-energy LHC constraints.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Radiation With or Without 6 Months of Androgen Suppression Therapy in Intermediate- and High-Risk Clinically Localized Prostate Cancer: A Postrandomization Analysis by Risk Group

Purpose: Six months of androgen suppression therapy (AST) plus radiation (RT) prolongs survival vs. RT alone in men with unfavorable risk localized prostate cancer (PCa), but it is unknown if this benefit applies to all risk subgroups and, in particular, the intermediate-risk group. Methods and Materials: Among 206 men with stages T1b to T2b PCa and either a prostate-specific antigen level of >10 or a Gleason score of {>=}7 or MRI evidence of T3 disease randomized to receive 70 Gy of RT with or without 6 months of AST, Cox multivariable analysis was used to assess the impact of AST on overall survival in intermediate- and high-risk localized PCa, adjusting for age, Adult Comorbidity Evaluation 27 comorbidity score, interaction between comorbidity and treatment, and known prognostic factors. Survival estimates were compared using a two-sided log-rank test. Results: After an 8.2-year median follow-up, 74 men died. Compared to treatment with AST plus RT, treatment with RT alone was associated with an increased risk of death in intermediate-risk (adjusted hazard ratio, 3.0 [95% confidence interval, 1.3-7.2]; p = 0.01) and high-risk PCa (adjusted hazard ratio, 3.3 [95% confidence interval, 0.94-11.3]; p = 0.06). The survival benefit of adding AST was restricted to men with no or mild comorbidity in both the intermediate-risk (90.9% vs. 85.8% survival, respectively, at 7 years for AST plus RT vs. RT alone; p = 0.009) and high-risk (88.9% vs. 51.2% survival, respectively, at 7 years for AST plus RT vs. RT alone; p = 0.007) subgroups. Conclusions: In men with localized PCa who have no or mild comorbidity, adding 6 months of AST to RT was associated with improved survival for those with both intermediate-risk and high-risk disease, but in men with moderate to severe comorbidity, no benefit was observed in either risk group.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

The Great Observatories All-Sky LIRG Survey: Herschel Image Atlas and Aperture Photometry

Far-infrared images and photometry are presented for 201 Luminous and Ultraluminous Infrared Galaxies [LIRGs: log (L{sub IR}/L{sub ⊙})=11.00--11.99, ULIRGs: log (L{sub IR}/L{sub ⊙})=12.00--12.99], in the Great Observatories All-Sky LIRG Survey (GOALS), based on observations with the Herschel Space Observatory Photodetector Array Camera and Spectrometer (PACS) and the Spectral and Photometric Imaging Receiver (SPIRE) instruments. The image atlas displays each GOALS target in the three PACS bands (70, 100, and 160 μm) and the three SPIRE bands (250, 350, and 500 μm), optimized to reveal structures at both high and low surface brightness levels, with images scaled to simplify comparison of structures in the same physical areas of ∼100 × 100 kpc{sup 2}. Flux densities of companion galaxies in merging systems are provided where possible, depending on their angular separation and the spatial resolution in each passband, along with integrated system fluxes (sum of components). This data set constitutes the imaging and photometric component of the GOALS Herschel OT1 observing program, and is complementary to atlases presented for the Hubble Space Telescope, Spitzer Space Telescope, and Chandra X-ray Observatory. Collectively, these data will enable a wide range of detailed studies of active galactic nucleus and starburst activity within the most luminous infrared galaxies in the local universe.

79 ASTRONOMY AND ASTROPHYSICS↗

Map Matching and Real World Integrated Sensor Data Warehousing (Presentation)

The inclusion of interlinked temporal and spatial elements within integrated sensor data enables a tremendous degree of flexibility when analyzing multi-component datasets. The presentation illustrates how to warehouse, process, and analyze high-resolution integrated sensor datasets to support complex system analysis at the entity and system levels. The example cases presented utilizes in-vehicle sensor system data to assess vehicle performance, while integrating a map matching algorithm to link vehicle data to roads to demonstrate the enhanced analysis possible via interlinking data elements. Furthermore, in addition to the flexibility provided, the examples presented illustrate concepts of maintaining proprietary operational information (Fleet DNA) and privacy of study participants (Transportation Secure Data Center) while producing widely distributed data products. Should real-time operational data be logged at high resolution across multiple infrastructure types, map matched to their associated infrastructure, and distributed employing a similar approach; dependencies between urban environment infrastructures components could be better understood. This understanding is especially crucial for the cities of the future where transportation will rely more on grid infrastructure to support its energy demands.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Change in the Growth Rate of Localized Pancreatic Adenocarcinoma in Response to Gemcitabine, Bevacizumab, and Radiation Therapy on MDCT

Purpose: To depict treatment response to chemoradiotherapy by comparing tumor growth rate between treated and untreated patients and to compare depicted response with objective response according to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 guideline. Methods and Materials: This Health Insurance Portability and Accountability Act-compliant, retrospective study was approved by the institutional review board. Volume doubling time (DT) of histologically confirmed locally advanced pancreatic adenocarcinoma was calculated in 16 patients treated with chemoradiotherapy and 10 untreated patients by incorporating interscan interval ({Delta}t) and tumor volume at baseline (V0) and follow-up (V1) obtained by semiautomated segmentation into the following equation: DT = {Delta}t . log 2/log (V1/V0). Reciprocal of doubling time (RDT), which is the linear representation of tumor growth rate, was calculated by use of the following equation: RDT = 365/DT. The lowest RDT value of 2.42 in untreated patients was considered as the cutoff value for depiction of treatment response. Depicted response rate was defined as the proportion of patients with an RDT value of less than 2.42. Depicted response was compared with objective response according to the RECIST 1.1 guideline. The significance level was set at p < 0.05. Results: There was a significant difference in mean RDT between treated (range, -7.12 to 3.27; mean, -1.27; median, -1.30) and untreated (range, 2.42 to 10.74; mean, 5.33; median, 4.26) patients (p < 0.05). Reciprocal of doubling time was less than 2.42 in 14 treated patients, which corresponded to a depicted response rate of 87.50% as opposed to the objective response rate of 18.75% according to the RECIST 1.1 guideline (p < 0.05) and carbohydrate antigen 19-9 response rate of 62.50% (p > 0.05). Carbohydrate antigen 19-9 response was concordant with RDT and RECIST response in 12 patients (75.00%) ({kappa}, 0.38) and 9 patients (56.25%) ({kappa}, 0.24), respectively. Conclusions: There was a significant difference between depicted response according to RDT and objective response according to RECIST. Reciprocal of doubling time might serve as a valuable biomarker for evaluation of treatment response when depiction of small changes in tumor size is concerned.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Scaling relations for galaxies prior to reionization

The first galaxies in the universe are the building blocks of all observed galaxies. We present scaling relations for galaxies forming at redshifts z ≥ 15 when reionization is just beginning. We utilize the 'Rarepeak' cosmological radiation hydrodynamics simulation that captures the complete star formation history in over 3300 galaxies, starting with massive Population III stars that form in dark matter halos as small as ∼10{sup 6} M {sub ☉}. We make various correlations between the bulk halo quantities, such as virial, gas, and stellar masses and metallicities and their respective accretion rates, quantifying a variety of properties of the first galaxies up to halo masses of 10{sup 9} M {sub ☉}. Galaxy formation is not solely relegated to atomic cooling halos with virial temperatures greater than 10{sup 4} K, where we find a dichotomy in galaxy properties between halos above and below this critical mass scale. Halos below the atomic cooling limit have a stellar mass-halo mass relationship log M {sub *} ≅ 3.5 + 1.3log (M {sub vir}/10{sup 7} M {sub ☉}). We find a non-monotonic relationship between metallicity and halo mass for the smallest galaxies. Their initial star formation events enrich the interstellar medium and subsequent star formation to a median of 10{sup –2} Z {sub ☉} and 10{sup –1.5} Z {sub ☉}, respectively, in halos of total mass 10{sup 7} M {sub ☉}, which is then diluted by metal-poor inflows well beyond Population III pre-enrichment levels of 10{sup –3.5} Z {sub ☉}. The scaling relations presented here can be employed in models of reionization, galaxy formation, and chemical evolution in order to consider these galaxies forming prior to reionization.

79 ASTRONOMY AND ASTROPHYSICS↗

The relative importance of noise level and number of events on human reactions to noise: Community survey findings and study methods

The data from seven surveys of community response to environmental noise are reanalyzed to assess the relative influence of peak noise levels and the numbers of noise events on human response. The surveys do not agree on the value of the tradeoff between the effects of noise level and numbers of events. The value of the tradeoff cannot be confidently specified in any survey because the tradeoff estimate may have a large standard error of estimate and because the tradeoff estimate may be seriously biased by unknown noise measurement errors. Some evidence suggests a decrease in annoyance with very high numbers of noise events but this evidence is not strong enough to lead to the rejection of the conventionally accepted assumption that annoyance is related to a log transformation of the number of noise events.

Fields, J. M.↗