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DOE OSTI2024

Detection of MeV-Scale Gammas from Pion/Muon Nuclear Capture With the LArIAT Liquid Argon TPC

LArIAT (Liquid Argon In A Testbeam) is a LArTPC experiment at Fermilab which aims to understand and characterize interactions of neutrino final-state products with Argon. Tracks for pions and muons in LArTPCs are difficult to differentiate since both particles exhibit very similar ionization densities. We are exploring unique new particle discrimination capabilities for pions and muons by exploiting information from small, isolated ionization depositions, referred to as "blips", reconstructed near the endpoint of stopping tracks. These blips are formed by gammas emitted when an at-rest pion or muon captures on the argon nucleus. The relatively low beam energy provided by LArIAT makes it uniquely suited for performing this demonstration. In this talk, an overview of event candidate selection and reconstruct blips corresponding to our signal of interest, nuclear captures of pions and muons at rest inside LArIAT's TPC, and how we estimate and subtract backgrounds from these capture-at-rest blip signals.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2024

DECOVALEX-2023: Task F1 Final Report

DECOVALEX-2023 Task F is a comparison of models and methods for post-closure performance assessment (PA) of a deep geologic repository for radioactive waste. The general aims of Task F are to build confidence in the models, methods, and software used for PA and to stimulate additional research and development in PA methodologies. The task objectives are to motivate development of PA modelling skills and capabilities, to examine the influence of model choices on calculated repository performance, and to compare the uncertainties introduced by model choices to other sources of uncertainty. Task F involves no actual experiment or site. It is a PA modelling exercise that requires the conceptual development of hypothetical repository designs and geologic settings. Because three of the teams were interested in salt and the rest of the teams were interested in crystalline rock, Task F was split into two branches: Task F1 for crystalline rock and Task F2 for salt. This report is for Task F1, crystalline rock. Teams from seven countries (Canada, Czech Republic, Germany, Korea, Sweden, Taiwan, and United States) participated in Task F1. The teams worked together to define the features, events, and processes of the reference case repository and established a set of performance measures. In addition, they defined a set of benchmark problems designed to test and compare modelling capabilities for fracture flow and transport at different scales. The repository design and benchmark problems are documented in a Task Specification that evolved over time as the group honed the specifications. The benchmark problems verified that each team can aptly model flow and transport in fractured media in 1-, 2-, and 3-dimensions. Two general approaches were used for the 3-dimensional benchmarks: discrete fracture network (DFN) and equivalent continuous porous medium (ECPM). DFN modelling involves explicit meshing of each fracture while ECPM modelling aims to capture the effective porosity and directional permeability of each cell in a space-filling mesh as affected by intersecting fractures. In some models, a combination of the two is used, i.e., DFN for large known fractures and ECPM for the rest of the domain. Transport is solved by using either the advection-dispersion equation or particle tracking. Although some variation is observed among model breakthrough curves in the benchmark problems, there is strong agreement in breakthrough behaviour up to at least the 75 th percentile for all benchmarks. At the 90 th percentile, breakthrough results show larger differences, suggesting several models retain substantially higher fractions of tracer in regions of slower moving water. In addition to the flow and transport benchmarks, several teams completed the source term benchmark, verifying capabilities for modelling radionuclide decay and ingrowth, waste package breach, instant release fractions, fuel matrix degradation rates, and radionuclide solubility limitations. The reference case is conceptualized as a generic spent fuel repository at a depth of 450 m in fractured crystalline rock. The repository has 50 parallel backfilled drifts, each with 50 deposition holes 6 m apart. Each deposition hole contains a 4-PWR waste package and bentonite buffer. The rock domain is 5 km in length, 2 km in width, and 1 km in depth. It has 6 deterministic fractured deformation zones and a multitude of stochastic fractures. Teams generally used the ECPM approach for the entire rock or a hybrid approach in which the deterministic fracture zones are modelled with a DFN and the rest of the rock is modelled by ECPM. Of the reference case problems specified, only the results of the initial reference case problem are compared in this report. The initial problem focuses on transport from the deposition holes to the surface, i.e., it neglects waste package performance. Tracers are released at all waste package locations at time zero and tracked for their releases to the near field and ground surface. The water fluxes calculated at the ground surface entry and exit regions of the domain are similar for all models except for two that have considerably lower fluxes. For tracer transport, large differences are observed among models in the magnitude of tracer transported. Much of the difference appears to be due to how the repository is implemented and hence the different degrees of repository simplification. Models that exclude the drifts, buffer, and backfill from the domain tend to show greater release of tracers and radionuclides from the repository. The initial study presented here indicates that major differences in modelling important processes within the repository (e.g., diffusion through buffer and backfill) can produce broadly different release and transport results, especially when those processes are excluded. Even for the models that included all specified features, events, and processes, the results show significant differences and demonstrate the importance of examining multiple modelling approaches in performance assessment. The differences in results observed in this study are expected to motivate teams to either increase complexity in future versions of the reference case models or to improve methods to account for the effects of simplified features and processes. Either way, future improvements in these models are expected to produce results that more closely agree.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
NASA NTRS1972

Microbial degradation of parathion

An organism capable of utilizing parathion as the sole carbon and energy source was isolated by enrichment culture techniques. The bacterium was characterized and tentatively classified as Pseudomonas aeruginosa. A pH of 7.0 - 7.5 and temperature of 30 C were found to be optimum for the consumption of parathion. Virtually no oxygen utilization was observed with resting cell suspensions when nonsolubilized parathion was employed. The use of ethanol as solvent for parathion in resting cell studies or preincubation of cells in ethanol obviated this problem and rapid parathion oxidation was demonstrable. Approximately 80% of the parathion consumed by resting cells was present terminally as carbon dioxide. Permeability of the cell to parathion or its metabolites was contingent upon the use of ethanol as either solvent or denaturant. Metabolites were tentatively identified by thin layer chromatography.

Gibson, W. L.↗
NASA NTRS1974

Vectorcardiographic results from Skylab medical experiment M092: Lower body negative pressure

Vectorcardiograms were recorded via a modified Frank lead system from all crewmen of the three Skylab missions in conjuction with the Lower Body Negative Pressure - M092 Experiment. Data were analyzed by a specially developed computer program (VECTAN). Design of the test sequences allowed direct comparisons of supine resting, Earth based (reference) vectorcardiograms with those taken during lower body negative pressure stress and those obtained at rest in orbit, as well as combinations of these conditions. Results revealed several statistically significant space flight related changes; namely, increased testing and lower body negative pressure stressed heart rates, modestly increased PR interval and corrected QTC interval, and greatly increased P and QPS loop maximal amplitudes. In addition, orientation changes in the QRS maximum vector and the J-vector at rest in space seem quite consistent among crewmen and different from those caused by the application of lower body negative pressure. No clinical abnormalities were observed. Etiology of these findings is conjectured to be, at least in part, related to fluid mass shifts occurring in weightlessness and attendant alterations in cardiovascular dynamics and myocardial autonomic control mechanisms.

Hoffler, G. W.↗
NASA NTRS1975

Skylab experiment M-092 - Results of the first manned mission

Blood pressure, heart rate, and percentage increase in leg volume were continuously recorded for the Inflight Lower Body Negative Pressure (LBNP) experiment conducted during the first manned Skylab mission. Data were collected over a 5-month preflight period as well as at approximately 3-day intervals throughout the mission. Individual variations in cardiovascular responses to LBNP during the preflight period continued to be demonstrated inflight, and measurements of the calf showed that a large volume of fluid was shifted out of the legs early in the flight. A much greater increase in leg volume occurred during inflight LBNP than in preflight tests. Resting heart rates tended to be low early in the flight and to increase slightly as it progressed, while resting blood pressure varied. The LBNP protocol was a greater stress inflight, and the tests had to be stopped early on three occasions due to impending syncopal reactions. Inflight LBNP responses seemed to predict the degree of postflight orthostatic intolerance. Postflight responses to LBNP during the first 48 hours were characterized by marked elevations in heart rate, instability in blood pressure, and considerably elevated systolic and diastolic pressures both at rest and during stress.

Johnson, R. L.↗
NASA NTRS1977

On the perihelion precession as a Machian effect

A Lagrangian is constructed which gives Newtonian gravity in the lowest-order approximation in an isotropic universe and also predicts the correct advance of the perihelion with the proper choice of a constant governing the ratio of inertial to gravitational mass. The situation considered is that of a test particle orbiting a central body with external mass at rest and distributed isotropically at large distances from the central body. In the theory developed, the perihelion advance is due to a small contribution to the test-particle inertial mass by the central attracting body rather than to a failure of the inverse-square law of attraction. Some interesting Machian features of this theory are that: (1) the local value of the gravitational constant is determined by the mass distribution of the external matter; (2) the orbits are fixed, and the perihelion advances unambiguously with respect to the external-mass distribution; (3) there are no vestiges of absolute space; (4) the perihelion precession arises from the inertial interaction of the test particle with the central mass; (5) the local rest mass is really determined by the mass distribution of the rest of the universe; and (6) a limited form of the equivalence principle is inherent in one of the equations.

Eby, P. B.↗
NASA NTRS1977

Plasma /Na+/, /Ca++/, and volume shifts and thermoregulation during exercise in man

Graded-exercise experiments are conducted on six trained male runners (19-23 yr) subjected to ergometer exercise in a program consisting of 30-min resting control period, 60 min of rest or exercise at work loads that resulted in a maximal oxygen uptake equivalent to 6% (resting), 23%, 43%, and 62% of maximal oxygen uptake, followed by 30 min of recovery. The parameters measured and discussed are rectal temperature (T-re), skin temperatures at different spots, maximal oxygen uptake, plasma volume (PV), and various plasma electrolyte and protein concentrations. The objectives are to determine whether the increased T-re during progressively greater work loads are related to plasma sodium ion and calcium ion concentrations, as well as to evaluate the influence of PV shifts on the electrolyte and osmotic concentrations. The results suggest that the shift (loss) in PV accounts for the increases in the plasma constituent concentrations that result in significant correlations with T-re.

Greenleaf, J. E.↗
NASA NTRS1980

Effect of long-term hypokinesia on the electrolytic composition of the blood in patients with osteoarticular tuberculosis

Seventy-six patients with osteoarticular tuberculosis were divided into two groups, one of which was required to maintain strict bed rest and the other of which was allowed unrestricted motor activity. A study of blood electrolyte composition in the two groups revealed that bed rest for these patients results in decreased plasma potassium calcium, and magnesium content, but that these indices improved after the patients were allowed to move freely. The study suggests that patients with osteoarticular tuberculosis who are on bed rest be carefully observed for alterations in blood electrolytes and that proper electrolyte balance be maintained.

Zakutaeva, V. P.↗
NASA NTRS1981

The negative effect of hypokinesia involving injury and preventive measures

The optimum length of bed rest for athletes suffering from broken bones is considered. Negative effects of hypokinesia induced by bed rest include general weakness and deconditioning of the muscles as well as sleeplessness, headaches, muscle pain, constipation, unstable pulse and arterial pressure, and changes in reflexes. This is considered to be the result of a vegetative dysfunction induced by the decreased flow of nerve impulses and a decrease in interoceptive and exteroceptive signals. The briefest possible period of bed rest, followed by an increase in motor activity, the prescription of a large quantity of LFK, and an active program of physical therapy are recommended. The symptomology associated with hypokinesia disappears after one month of free motor activity.

Izakson, K. A.↗
NASA NTRS1983

Closed-form solutions for feedback control with terminal constraints

The problem of closed-loop control of maneuvers between two states for linear dynamical systems, subject to an arbitrarily specified terminal state, is considered. The feedback controller design is based on finite-time quadratic regulator theory. Closed-form expressions for the optimal control law are developed. Solutions are presented for both conventional and smoothed control profiles with fixed and/or free end condition problems. In the maneuvers using control-rate penalties, smooth profiles are generated throughout the maneuvers, in the sense that the initial condition jump discontinuities have been eliminated. Several examples involving large-angle maneuvers of a spacecraft are demonstrated. Results include control maneuvers from one state to another such as rest to rest and spin to rest, which effectively justify the solutions developed in this paper.

Juang, J.-N.↗
NASA NTRS1985

Changes in cardiovascular function: Weightlessness and ground-based studies

Echocardiographic measurements were taken on members of four Space Shuttle missions before (F-10 to F-12) and twice after (L+0 and L+7 to 14 days) 7- to 9-day space flight missions. Such recordings allowed for determination of left ventricular chamber dimensions and subsequent calculations of left ventricular volume and stroke volume. Resting ventricular volume could be shown to significantly decrease 23% on L+) and to be associated with a significant 28% decrease in stroke volume. Studies 7 to 14 days layer showed amelioration of effects, but persistence of end diastolic volume change. Such findings occurred despite ability to fully ambulate and exercise during the postflight period. Comparison of findings with bed rested subjects (athletic and nonathletic) showed similar changes, but changes after bed rest were of smaller magnitude compared to the flight crews. It is concluded that space flight induces significant changes in heart volume even after short duration (7-9 days) missions. Heavy athletic conditioning preflight may contribute to the severity of the observed changes in the flight crews and to the apparent slow postflight process of recovery.

Sandler, H.↗
NASA NTRS1990

Cockpit napping

The results of a NASA-sponsored study examining the effectiveness of a brief, preplanned cockpit rest period to improve pilot alertness and performance in nonaugmented long-haul flight operations are discussed. Four regularly scheduled trans-Pacific flight legs were studied. The shortest flight legs were about 7 h and the longest about 9.5 h, with duty periods averaging about 11 h and layovers about 25 h. Three-person B747 crews were divided randomly into two volunteer pilot groups. These crews were nonaugmented, and therefore no relief pilots were available. The rest group, consisting of four crews, was allowed a 40 min opportunity to rest during the overwater cruise portion of the flight. On a preplanned, rotating basis, individual crew members were allowed to nap. It is concluded that a preplanned cockpit nap is associated with significantly better behavioral performance and higher levels of physiological alertness and that this can be accomplished without disrupting normal flight operations or compromising safety.

Graeber, R. Curtis↗
NASA NTRS1993

Deep, wide-field, multi-band imaging of z approximately equal to 0.4 clusters and their environs

The existence of an excess population of blue galaxies in the cores of distant, rich clusters of galaxies, commonly referred to as the 'Butcher-Oemler' effect is now well established. Spectroscopy of clusters at z = 0.2-0.4 has confirmed that the luminous blue populations comprise as much as 20 percent of these clusters. This fraction is much higher that the 2 percent blue fraction found for nearby rich clusters, such as Coma, indicating that rapid galaxy evolution has occurred on a relatively short time scale. Spectroscopy has also shown that the 'blue' galaxies can basically be divided into three classes: 'starburst' galaxies with large (O II) equivalent widths, 'post-starburst' E+A galaxies (i.e. galaxies with strong Balmer lines shortward of 4000A but elliptical-like colors, and normal spiral/irregulars. Unfortunately, it is difficult to obtain enough spectra of individual galaxies in these intermediate redshift clusters to say anything statistically meaningful. Thus, limited information is available about the relative numbers of these three classes of 'blue' galaxies and the associated E/SO population in these intermediate redshift clusters. More statistically meaningful results can be derived from deep imaging of these clusters. However, the best published data to date (e.g. MacLaren et al. 1988; Dressler & Gunn 1992) are limited to the cluster cores and do not sample the galaxy luminosity functions very deeply at the bluest wavelengths. Furthermore, only limited spectro-energy distribution data is available below 4000A in the observed cluster rest frame providing limited sensitivity to 'recent' star formation activity. To improve this situation, we are currently obtaining deep, wide-field UBRI images of all known rich clusters at z approx. equals 0.4. Our main objective is to obtain the necessary color information to distinguish between the E+SO, 'E+A', and spiral/irregular galaxy populations throughout the cluster/supercluster complex. At this redshift, UBRI correspond to rest-frame 2500A/UVR bandpasses. The rest-frame UVR system provides a powerful 'blue' galaxy discriminate given the expected color distribution. Moreover, since 'hot' stars peak near 2500A, that bandpass is a powerful probe of recent star formation activity in all classes of galaxies. In particular, it is sensitive to ellipticals with 'UV excess' populations (MacLaren et al. 1988).

Silva, David R.↗
NASA NTRS1994

An ASCA GIS spectrum of S5 0014+813 AT z = 3.384

ASCA has detected the z = 3.384 quasar S5 0014+813 up to energies of 34 keV in the quasar rest frame using the two gas imaging spectrometer (GIS) instruments. The combined X-ray spectrum has a signal-to-noise ratio of over 50 sigma and is consistent with a single power law of energy slope 0.63 +/- 0.03 over the 0.8-8 keV (observed) energy range. The spectrum is also well fitted with a simple thermal bremsstrahlung model of kT = 40 +/- 4 keV (in the quasar frame), which raises obvious possibilities for contributions to the diffuse X-ray background. A maximum solid angle of Omega(sub d)/2(pi) = 0.4(90% confidence) can be placed on the strength of a Compton reflection component above the energy of the Fe K-edge. The Fe K 6.4 keV fluorescence line has a rest frame equivalent width less than 120 eV (90% confidence) at its redshifted energy of 1.46 keV. The weakness of these features differentiates this high-luminosity, high-redshift quasar from the majority of Seyfert galaxies using its X-ray spectrum alone. The GIS slope is consistent with the slope derived by the ROSAT Position Sensitive Proportional Counter (PSPC). The normalization at 1 keV in the ASCA observation is, however, a factor 30%-40% higher than in the ROSAT observation, suggesting a significant increase in the 1 keV (observed) flux over the 31.5 months between the two observations (7.2 months, rest frame).

Elvis, Martin↗
NASA NTRS1994

Spectral energy distributions of the brightest Palomar-Green quasars at intermediate redshifts

We have combined low-dispersion International Ultraviolet Explorer (IUE) spectra with the optical/near-IR spectrophotometry of Neugebauer et al. (1987) in order to study the spectral energy distributions of seven of the brightest Palomar-Green (PG) quasars at intermediate redshifts (Z(sub em) greater than or equal to 0.9 and less than or equal to 1.5). Some of these PG quasars are barely detectable in long IUE exposures, so we have used the Gaussian Extraction (GEX) technique to maximize the signal-to-noise of the IUE data, and we have co-added all spectra available from the IUE archive for each QSO unless the ultraviolet spectra varied significantly from one exposure to the next. We have corrected the spectral energy distributions for Milky Way reddening using the observed neutral hydrogen column densities on each sight line and the gas-to-dust relation recently derived by Diplas & Savage. Six of the seven quasars are detected down to lambda much less than 700 A in the rest frame, and consequently continuum reddening due to dust in the immediate vicinity of the quasar can have a dramatic effect on the spectral energy distributions. In order to explore the possible importance of intrinsic continuum reddening, we have assembled a heuristic extinction curve which extends to lambda much less than 912 A. Using this heuristic extinction curve, we derive reasonable upper limits on the intrinsic E(B-V) for each quasar. We briefly discuss some of the implications of the derived intrinsic continuum reddening limits. We use geometrically thin accretion disk models to derive the black hole masses and accretion rates implied by the spectral energy distributions. Even if we neglect intrinsic reddening, we find that a large fraction of the quasars require super-Eddington accretion rates (which is not consistent with the thin disk assumption). Comparison of the data in this paper to a large body of data from the literature on the accretion disk M(sub BH) - M dot grid calculated by Wandel & Petrosian reveals that our quasars are among the brightest in the sky at 1450 A, and ostensibly suggests that the fraction of quasars which require super-Eddington accretion rates is much smaller than the fraction that we derive from our data alone. However, intrinsic continuum reddening has been ignored in this comparison, and a small amount of intrinsic reddening will push more of the quasars into the super-Eddington regime. We also plot the recent reverberation monitoring results on NGC 5548 and NGC 3783 on the Wandel & Petrosian grid, and we find that these Seyfert galaxies appear to vary along lines of constant M(sub BH). Continuum flux from two of the quasars in our main sample, PG 1338+416 and PG 1630+377, is detected at lambda(sub rest) less than 584 A. These quasars can in principle be used for the He I Gunn-Peterson test, but the S/N of IUE spectra of individual objects is usually too low to place interesting limits on the Gunn-Peterson optical depth. In order to improve the S/N, we have formed a composite spectrum from the spectra of five quasars detected with IUE at lambda(sub rest) less than 584 A, and we have used this composite spectrum to place a tighter limit on tau(sub GP, He I). We briefly discuss intermediate-redshift Lyman limit systems (Z(sub LL) greater than or equal to 0.5 and less than or equal to 1.6) detected in the IUE spectra of five quasars, including lower limits on N(H I) in each Lyman limit system.

Tripp, Todd M.↗
NASA NTRS1997

Development of Human Muscle Protein Measurement with MRI

It is known that micro-gravity has a strong influence on the human musculoskeletal system. A number of studies have shown that significant changes in skeletal muscles occur in both space flight and bedrest simulation. In our 5 week bedrest study, the cross-sectional area of soleus-gastrocnemius decreased about 12% while the cross-sectional area of anterior calf muscles decreased about 4%. Using volume measurements, these losses increased after 17 weeks to approximately 30% and 21% respectively. Significant muscle atrophy was also found on the SL-J crew members after only 8 days in space. It is important that these effects are fully understood so that countermeasures can be developed. The same knowledge might also be useful in preventing muscle atrophy related to other medical problems. A major problem with anatomical measurements of muscle during bed rest and microgravity is the influence of fluid shifts and water balance on the measurement of muscle volume, especially when the exposure duration is short and the atrophy is relatively small. Fluid shifts were documented in Skylab by visual observations of blood vessel distention, rapid changes in limb volume, center of mass measurements and subjective descriptions such as puffy faces and head fullness. It has been reported that the muscle water content of biopsied soleus muscles decreased following 8 hours of head down tilt bed rest. Three aspects of fluid shifts that can affect volume measurements are: first, the shift of fluid that occurs whenever there is a change from upright to a recumbent position and vice versa; second, the potential for fluid accumulation in the lower limbs resulting from muscle damage caused by overextending atrophied muscle or swelling caused by deconditioned precapillary sphincter muscles during reambulation; third, the net change of hydration level during and after bed rest or spaceflight. Because of these transitory fluid shifts, muscle protein is expected to represent muscle capacity better than does muscle volume. The purpose of this study is to test the feasibility of using MRI to quantify of muscle protein and water content changes in muscle.

Lin, Chen↗
NASA NTRS1996

Life and Microgravity Sciences Spacelab Mission: Human Research Pilot Study

The Life Sciences, Microgravity Science and Spacelab Mission contains a number of human experiments directed toward identifying the functional, metabolic and neurological characteristics of muscle weakness and atrophy during space flight. To ensure the successful completion of the flight experiments, a ground-based pilot study, designed to mimic the flight protocols as closely as possible, was carried out in the head-down tilt bed rest model. This report records the rationales, procedures, preliminary results and estimated value of the pilot study, the first of its kind, for 12 of the 13 planned experiments in human research. The bed rest study was conducted in the Human Research Facility at Ames Research Center from July 11 - August 28, 1995. Eight healthy male volunteers performed the experiments before, during and after 17 days bed rest. The immediate purposes of this simulation were to integrate the experiments, provide data in a large enough sample for publication of results, enable investigators to review individual experiments in the framework of a multi-disciplinary study and relay the experience of the pilot study to the mission specialists prior to launch.

Arnaud, Sara B.↗
NASA NTRS1999

Alterations in Cardiovascular Regulation and Function During Long-Term Simulated Microgravity

The Cardiovascular Alterations Team is conducting studies of hemodynamic regulation and susceptibility to arrhythmias resulting from sixteen days of simulated microgravity exposure. In these studies very intensive measurements are made during a short duration of bed rest. In this collaborative effort are making many of the same measurements, however much less frequently, on subjects who are exposed to a much longer duration of simulated microgravity. Alterations in cardiovascular regulation and function that occur during and after space flight have been reported. These alterations are manifested, for example, by reduced orthostatic tolerance upon reentry to the earth's gravity from space. However, the precise physiologic mechanisms responsible for these alterations remain to be fully elucidated. Perhaps, as a result, effective countermeasures have yet to be developed. In addition, numerous reports from the past 30 years suggest that the incidence of ventricular arrhythmias among astronauts is increased during space flight. However, the effects of space flight and the associated physiologic stresses on cardiac conduction processes are not known, and an increase in cardiac susceptibility to arrhythmias has never been quantified. In this project we are applying the most powerful technologies available to determine, in a ground-based study of long duration space flight, the mechanisms by which space flight affects cardiovascular function, and then on the basis of an understanding of these mechanisms to develop rational and specific countermeasures. To this end we are conducting a collaborative project with the Bone Demineralization/Calcium Metabolism Team of the National Space Biomedical Research Institute (NSBRI). The Bone Team is conducting bed rest studies in human subjects lasting 17 weeks, which provides a unique opportunity to study the effects of long duration microgravity exposure on the human cardiovascular system. We are applying a number of powerful new methods to these long term bed rest subjects, including cardiovascular system identification (CSI), microvolt level T wave alternans analysis, and cardiac magnetic resonance imaging to assess non-invasively the effects of simulated long duration space flight on the cardiovascular system.

Cohen, Richard J.↗