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ISS Utilization and Countermeasure Validation: Implementing the Critical Path Roadmap to Reduce Uncertainties of Extended Human Spaceflight Expeditions

Human exploration of space requires the ability to understand and mitigate risks to crews exposed to the conditions associated with such missions. This becomes a greater imperative as we prepare for interplanetary expeditions involving humans who will be subjected to long transit periods in microgravity as they travel to a distant planet such as Mars, embark and live on the planet's surface for an extended time, and finally, return to the 1 g environment of Earth. We need to know, more definitively, what the human health, safety, and performance risks are, and how to prevent or counteract them throughout all phases of a long duration mission. The Johnson Space Center's Space and Life Sciences Directorate along with the National Space Biomedical Research Institute (NSBRI) have been engaged in a strategic planning effort that identifies the most critical risks confronting humans who will venture forth on such missions and the types of research and technology efforts required to mitigate and otherwise reduce the probability and/or severity of those risks. This paper describes the unique approach used to define, assess and prioritize the risks and presents the results of the assessment with an emphasis on the research and technology priorities that will help us to meet the challenge of long duration human spaceflight missions.

Leveton, Lauren B.↗

Bone Density Following Three Years of Recovery from Long-Duration Space-Flight

Bone loss during long-duration space flight is well recognized, but the long-term implications on bone health following return from flight remain unclear. Among US crew who were involved in long-duration missions in space (Mir and ISS), we have previously shown that at approximately 12 months following return, men, but not women, had BMD values at most sites that were still lower than would be expected had they not been exposed to a prolonged period of microgravity. We now extend our observations to 3 years of follow-up post-flight. Using their age, pre-flight BMD and follow-up time, post-flight BMD values for each US crew were predicted based on the model developed from the community sample. We found BMD measures to be either stable or improve by 3 years relative to their immediate post-flight BMD, however only total hip BMD still remains significantly lower than would be expected had they not been exposed to microgravity. Among male US crew, who have had their BMD measured following at least 3 years of recovery post long-duration flight, they continue to have lower BMD at the hip than would be expected, raising potential concerns regarding future hip fracture risk.

Amin, S.↗

Solar Sail Application to Comet Nucleus Sample Return

Many comets have perihelions at distances within 1.0 Astronomical Unit (AU) from the sun. These comets typically are inclined out of the ecliptic. We propose that a solar sail spacecraft could be used to increase the inclination of the orbit to match that of these 1.0 AU comets. The solar sail spacecraft would match the orbit velocity for a short period of time, which would be long enough for a container to be injected into the comet's nucleus. The container would be extended from a long durable tether so that the solar sail would not be required to enter into the potentially degrading environment of the comet s atmosphere. Once the container has been filled with sample material, the tether is retracted. The solar sail would then lower its inclination and fly back to Earth for the sample return. In this paper, we describe the selection of cometary targets, the mission design, and the solar sailcraft design suitable for sail-comet rendezvous as well as possible rendezvous scenarios.

Taylor, Travis S.↗

EGS Collab - Hydraulic Fracturing Test Measurements on the 4100L of SURF

This package includes data from two days of testing at the Sanford Underground Research Facility (SURF) on the 4100 level. The tests were performed in borehole TV4100 in the battery charging alcove south of the Yates shaft. TV4100 is a vertical borehole ~50 meters deep. A series of hydraulic fracture (mini-frac) and reopening tests were conducted at various depths to investigate the magnitude and direction of the minimum principal stress in that area of the mine. Apparent features of the pressure time/pressure injected volume curves are the onset of fracture, peak pressure, and the initial shut in pressure (ISIP). The raw data files include a Readme with the day, time, and location of each file. The files are organized into 9 columns: time (sec), flow meter (V), Pressure of Return (V), Pressure of Packer (V), Pressure of Injection (V), flow (gpm), Pressure of Return (psi), Pressure of Packer (psi), Pressure of Injection (psi). The shift reports are a short log of how the tests were run in the two-day period. An American Geophysical Union (AGU) 2019 presentation by Ingraham et al. is shown to provide visualization/interpretation of the data. The columns which report voltage (V) show the unscaled voltage value from the transducer, which was recorded in case pressure values needed to be rescaled due to incorrect calibration factors. This was not necessary. Results reported in the AGU poster were filtered with a moving average to remove pump noise before presentation. Note that the logging and impression packer results are included in separate datasets managed by Lawrence Berkeley Laboratory.

15 GEOTHERMAL ENERGY↗

Experiment module concepts study. Volume 5 book 1, appendix A: Shuttle only task

Results of a preliminary investigation of the effect on the candidate experiment program implementation of experiment module operations in the absence of an orbiting space station and with the availability of the space shuttle orbiter vehicle only are presented. The fundamental hardware elements for shuttle-only operation of the program are: (1) integrated common experiment modules CM-1, CM-3, and CM-4, together with the propulsion slice; (2) support modules capable of supplying on-orbit crew life support, power, data management, and other services normally provided by a space station; (3) dormancy kits to enable normally attached modules to remain in orbit while shuttle returns to earth; and (4) shuttle orbiter. Preliminary cost estimates for 30 day on-orbit and 5 day on-orbit capabilities for a four year implementation period are $4.2 billion and $2.1 billion, respectively.

Source record↗

The role of 1,25-dihydroxyvitamin D in the inhibition of bone formation induced by skeletal unloading

Skeletal unloading results in osteopenia. To examine the involvement of vitamin D in this process, the rear limbs of growing rats were unloaded and alterations in bone calcium and bone histology were related to changes in serum calcium (Ca), inorganic phosphorus (P sub i), 25-hydroxyvitamin D (25-OH-D), 24,25-dihydroxyvitamin D (24,25(OH)2D and 1,25-dihydroxyvitamin D (1,25(OH)2D. Acute skeletal unloading induced a transitory inhibition of Ca accumulation in unloaded bones. This was accompanied by a transitory rise in serum Ca, a 21% decrease in longitudinal bone growth (P 0.01), a 32% decrease in bone surface lined with osteoblasts (P .05), no change in bone surface lined with osteoclasts and a decrease in circulating (1,25(OH)2D. No significant changes in the serum concentrations of P sub i, 25-OH-D or 24,25(OH)2D were observed. After 2 weeks of unloading, bone Ca stabilized at approximately 70% of control and serum Ca and 1,25(OH)2D returned to control values. Maintenance of a constant serum 1,25(OH)2D concentration by chronic infusion of 1,25(OH)2D (Alza osmotic minipump) throughout the study period did not prevent the bone changes induced by acute unloading. These results suggest that acute skeletal unloading in the growing rat produces a transitory inhibition of bone formation which in turn produces a transitory hypercalcemia.

Halloran, B. P.↗

Automated information retrieval using CLIPS

Expert systems have considerable potential to assist computer users in managing the large volume of information available to them. One possible use of an expert system is to model the information retrieval interests of a human user and then make recommendations to the user as to articles of interest. At Cal Poly, a prototype expert system written in the C Language Integrated Production System (CLIPS) serves as an Automated Information Retrieval System (AIRS). AIRS monitors a user's reading preferences, develops a profile of the user, and then evaluates items returned from the information base. When prompted by the user, AIRS returns a list of items of interest to the user. In order to minimize the impact on system resources, AIRS is designed to run in the background during periods of light system use.

Raines, Rodney Doyle, III↗

Three Alternative Symbol-Lock Detectors

Three symbol-lock detectors proposed as alternatives in advanced receivers processing non-return-to-zero binary data signals. Two perform operations similar to those of older square-law and absolute-value types. However, integrals computed during nonoverlapping symbol periods and, therefore, only one integrator needed in each such detector. Proposed detectors simpler, but performances worse because noises in overlapping samples correlated, whereas noises in nonoverlapping samples not correlated. Third detector is signal-power-estimator type. Signal integrated during successive half symbol cycles, and therefore only one integrator needed. Half-cycle integrals multiplied to eliminate effect of symbol polarity, and products accumulated during M-cycle observation period to smooth out estimate of signal power. If estimated signal power exceeds threshold, delta, then lock declared.

Shihabi, Mazen M.↗

Conceptual Design of the Space Station Fluids Module

The purpose of this paper is to describe the conceptual design of the Fluids Module for the International Space Station Alpha (ISSA). This module is part of the Space Station Fluids/Combustion Facility (SS FCF) under development at the NASA Lewis Research Center. The Fluids/Combustion Facility is one of several science facilities which are being developed to support microgravity science investigations in the US Laboratory Module of the ISSA. The SS FCF will support a multitude of fluids and combustion science investigations over the lifetime of the ISSA and return state-of-the-art science data in a timely and efficient manner to the scientific communities. This will be accomplished through modularization of hardware, with planned, periodic upgrades; modularization of like scientific investigations that make use of common facility functions; and use of orbital replacement units (ORU's) for incorporation of new technology and new functionality. Portions of the SS FCF are scheduled to become operational on-orbit in 1999. The Fluids Module is presently scheduled for launch to orbit and integration with the Fluids/Combustion Facility in 2001. The objectives of this paper are to describe the history of the Fluids Module concept, the types of fluids science investigations which will be accommodated by the module, the hardware design heritage, the hardware concept, and the hardware breadboarding efforts currently underway.

Rohn, Dennis W.↗

Conceptual design of the Space Station combustion module

The purpose of this paper is to describe the conceptual design of the Combustion Module for the International Space Station Alpha (ISSA). This module is part of the Space Station Fluids/Combustion Facility (SS FCF) under development at the NASA Lewis Research Center. The Fluids/Combustion Facility is one of several science facilities which are being developed to support microgravity science investigations in the US Laboratory Module of the ISSA. The SS FCF will support a multitude of fluids and combustion science investigations over the lifetime of the ISSA and return state-of-the-art science data in a timely and efficient manner to the scientific communities. This will be accomplished through modularization of hardware, with planned, periodic upgrades; modularization of like scientific investigations that make use of common facility functions; and through the use of orbital replacement units (ORU's) for incorporation of new technology and new functionality. The SS FCF is scheduled to become operational on-orbit in 1999. The Combustion Module is presently scheduled for launch to orbit and integration with the Fluids/Combustion Facility in 1999. The objectives of this paper are to describe the history of the Combustion Module concept, the types of combustion science investigations which will be accommodated by the module, the hardware design heritage, the hardware concept, and the hardware breadboarding efforts currently underway.

Morilak, Daniel P.↗

Flight Crew Sleep in Long-Haul Aircraft Bunk Facilities: Survey Results

Modem long-haul aircraft can fly up to 16 continuous hours and provide a 24-hour, global capability. Extra (augmented) flight crew are available on long flights to allow planned rest periods, on a rotating basis, away from the flight deck in onboard crew rest facilities (2 bunks). A NASA/FAA study is under-way to examine the quantity and quality of sleep obtained in long-haul aircraft bunks and the factors that promote or interfere with that sleep. The first phase of the study involved a retrospective survey, followed by a second phase field study to collect standard polysomnographic data during inflight bunk sleep periods. A summary of the Phase I survey results are reported here. A multi-part 54-question retrospective survey was completed by 1,404 flight crew (37% return rate) at three different major US air carriers flying B747-100, 200, 400, and MD- 11 long-haul aircraft. The questions examined demographics, quantity and quality of sleep at home and in onboard bunks, factors that promote or interfere with sleep, and effects on subsequent performance and alertness. Flight crew reported a mean bunk sleep latency of 39.4 mins (SD=28.3 mins) (n=1,276) and a mean total sleep time of 2.2 hrs (SD=1.3 hrs) (n=603). (Different flight lengths could affect overall time available for sleep.) Crew rated 25 factors for their interference or promotion of bunk sleep. Figure I portrays the average ratings for each factor across all three carriers. A principal components analysis of the 25 factors revealed three areas that promoted bunk sleep: physiological (e.g., readiness for sleep), physical environment (e.g., bunk size, privacy), and personal comfort (e.g., blankets, pillows). Five areas were identified that interfered with sleep: environmental disturbance (e.g., background noise, turbulence), luminosity (e.g., lighting), personal disturbances (e.g., bathroom trips, random thoughts), environmental discomfort (e.g., low humidity, cold), and interpersonal disturbances (e.g., bunk partner).

Rosekind, Mark R.↗

Combining Information on Multiple Detection Techniques to Estimate the Effect of Patent Foramen Ovale on Susceptibility to Decompression Illness

The assembly and the maintenance of the International Space Station is expected to require hundreds of extravehicular excursions (EVA's) in the next 10 years. During an EVA, in order to allow movement and bending of limbs, spacesuit pressures are reduced to about 4.3 psi. as compared with about 14.7 psi. for normal atmospheric pressure at sea level. However, the exposure of astronauts to reduced pressures in spacesuits, is conducive to fonnation and growth of gas bubbles within venous blood or tissues, which could cause decompression illness (DCI), a pathology best known to occur among deep-sea divers when they return to the surface. To reduce the risk of DCI, astronauts adjust to the reduced pressure in stages for a prolonged time known as a "pre-breathe" period prior to their extravehicular activity. Despite the use of pre-breathe protocols, an increased risk of DCI can arise for about 25% of humans who have a small hole, known as a patent foramen ovale (PFO), between two chambers of the heart. The atrial septum's fossa oval is, an embryological remnant of a flap between the septae primum and secundum allows fetal right atrial blood to pass into the left atrium, and usually closes after birth (Hagen, et al,. 1984). If fusion does not occur, a valve-like opening, the foramen ovale persists between the two atria. It has been suggested that astronauts with PFO's might be at greater risk of stroke or other serious neurological DCI because bubbles from a venous site may traverse a PFO, travel to the aorta and then enter the cerebral circulatory system causing a stroke (Figure 1). Astronauts are not now screened for PFO's, however consideration is being given to doing so. Here, we study three main methods abbreviated here as "ITE", "TCD" and "TEE", for detecting PFO's in living subjects. All involve the introduction of bubbles into a vein, immediately after which a sensory probe attempts to detect the bubbles in systemic circulation. Presence of the injected bubbles in the systemic circulation is indicative of a PFO. More detailed descriptions are given after the explanation of PFO's under Figure I. Even if a true PFO affects the risk of DCI, there remains a question of how effective screening would be if the detection method has errors of omission and/or commission. Of the three methods studied here, TEE is the "gold standard", matching autopsy results with near-perfect sensitivity and specificity (Schneider, et al. , 1996). However TEE is also the most difficult method to implement, requiring an internal esophagal probe, and is therefore not widely used. Currently, the easiest to use and most common PFO detection method is TTE, which uses an external chest probe. This method has a specificity of near 100%, but suffers from a low sensitivity rate (about 30%). More recently, TCD has been developed, which uses ultrasound probes to detect the presence of bubbles in cerebral arteries. Studies indicate that TCD is quite effective, having a sensitivity of about 91% and a specificity of about 93% (Droste, et al., 1999) when applied correctly, however implementation is difficult and requires considerable training.

Feiveson, Alan H.↗

Digital Interface Board to Control Phase and Amplitude of Four Channels

An increasing number of parts are designed with digital control interfaces, including phase shifters and variable attenuators. When designing an antenna array in which each antenna has independent amplitude and phase control, the number of digital control lines that must be set simultaneously can grow very large. Use of a parallel interface would require separate line drivers, more parts, and thus additional failure points. A convenient form of control where single-phase shifters or attenuators could be set or the whole set could be programmed with an update rate of 100 Hz is needed to solve this problem. A digital interface board with a field-programmable gate array (FPGA) can simultaneously control an essentially arbitrary number of digital control lines with a serial command interface requiring only three wires. A small set of short, high-level commands provides a simple programming interface for an external controller. Parity bits are used to validate the control commands. Output timing is controlled within the FPGA to allow for rapid update rates of the phase shifters and attenuators. This technology has been used to set and monitor eight 5-bit control signals via a serial UART (universal asynchronous receiver/transmitter) interface. The digital interface board controls the phase and amplitude of the signals for each element in the array. A host computer running Agilent VEE sends commands via serial UART connection to a Xilinx VirtexII FPGA. The commands are decoded, and either outputs are set or telemetry data is sent back to the host computer describing the status and the current phase and amplitude settings. This technology is an integral part of a closed-loop system in which the angle of arrival of an X-band uplink signal is detected and the appropriate phase shifts are applied to the Ka-band downlink signal to electronically steer the array back in the direction of the uplink signal. It will also be used in the non-beam-steering case to compensate for phase shift variations through power amplifiers. The digital interface board can be used to set four 5-bit phase shifters and four 5-bit attenuators and monitor their current settings. Additionally, it is useful outside of the closed-loop system for beamsteering alone. When the VEE program is started, it prompts the user to initialize variables (to zero) or skip initialization. After that, the program enters into a continuous loop waiting for the telemetry period to elapse or a button to be pushed. A telemetry request is sent when the telemetry period is elapsed (every five seconds). Pushing one of the set or reset buttons will send the appropriate command. When a command is sent, the interface status is returned, and the user will be notified by a pop-up window if any error has occurred. The program runs until the End Program button is depressed.

Smith, Amy E.↗

Core Research Program, Year 5

Dramatic losses of bone mineral density (BMD) and muscle strength are two of the best documented changes observed in humans after prolonged exposure to microgravity. Recovery of muscle upon return to a 1-G environment is well studied, however, far less is known about the rate and completeness of BMD recovery to pre-flight values. Using the mature tail-suspended adult rat model, this proposal will focus on the temporal course of recovery in tibial bone following a 28-d period of skeletal unloading. Through the study of bone density and muscle strength in the same animal, time-points during recovery from simulated microgravity will be identified when bone is at an elevated risk for fracture. These will occur due to the rapid recovery of muscle strength coupled with a slower recovery of bone, producing a significant mismatch in functional strength of these two tissues. Once the time-point of maximal mismatch is defined, various mechanical and pharmacological interventions will be tested at and around this time-point in attempt to minimize the functional difference of bone and muscle. The outcomes of this research will have high relevance for optimizing the rehabilitation of astronauts upon return to Earth, as well as upon landing on the Martian surface before assuming arduous physical tasks. Further. it will impact significantly on rehabilitation issues common to patients experiencing long periods of limb immobilization or bed rest.

Source record↗

Technology Advancement for Active Remote Sensing of Carbon Dioxide from Space Using the ASCENDS CarbonHawk Experiment Simulator: First Results

The ASCENDS CarbonHawk Experiment Simulator (ACES) is a newly developed lidar developed at NASA Langley Research Center and funded by NASA's Earth Science Technology Office (ESTO) Instrument Incubator Program (IIP) that seeks to advance technologies critical to measuring atmospheric column carbon dioxide (CO2) mixing ratios in support of the NASA Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) mission. The technology advancements targeted include: (1) increasing the power-aperture product to approach ASCENDS mission requirements by implementing multi-aperture telescopes and multiple co-aligned laser transmitters; (2) incorporating high-efficiency, high-power Erbium-Doped Fiber Amplifiers (EDFAs); (3) developing and incorporating a high-bandwidth, low-noise HgCdTe detector and transimpedence amplifier (TIA) subsystem capable of long-duration autonomous operation on Global Hawk aircraft, and (4) advancing algorithms for cloud and aerosol discrimination. The ACES instrument architecture is being developed for operation on high-altitude aircraft and will be directly scalable to meet the ASCENDS mission requirements. These technologies are critical towards developing not only spaceborne instruments but also their airborne simulators, with lower platform requirements for size, mass, and power, and with improved instrument performance for the ASCENDS mission. ACES transmits five laser beams: three from commercial EDFAs operating near 1.57 microns, and two from the Exelis oxygen (O2) Raman fiber laser amplifier system operating near 1.26 microns. The three EDFAs are capable of transmitting up to 10 watts average optical output power each and are seeded by compact, low noise, stable, narrow-linewidth laser sources stabilized with respect to a CO2 absorption line using a multi-pass gas absorption cell. The Integrated-Path Differential Absorption (IPDA) lidar approach is used at both wavelengths to independently measure the CO2 and O2 column number densities and retrieve the average column CO2 mixing ratio. The ACES receiver uses three fiber-coupled 17.8-cm diameter athermal telescopes. The transmitter assembly consists of five fiber-coupled laser collimators and an associated Risley prism pair for each laser to co-align the outgoing laser beams and to align them with the telescope field of view. The backscattered return signals collected by the three telescopes are combined in a fiber bundle and sent to a single low noise detector. The detector/TIA development has improved the existing detector subsystem by increasing its bandwidth to 4.7 MHz from 500 kHz and increasing the duration of autonomous, service-free operation periods from 4 hours to >24 hours. The new detector subsystem enables the utilization of higher laser modulation rates, which provides greater flexibility for implementing advanced thin-cloud discrimination algorithms as well as improving range-determination resolution and error reduction. The cloud/aerosol discrimination algorithm development by Langley and Exelis features a new suite of algorithms for the minimization/elimination of bias errors in the return signal induced by the presence of intervening thin clouds. Multiple laser modulation schemes are being tested in an effort to significantly mitigate the effects of thin clouds on the retrieved CO2 column amounts. Full instrument development concluded in the spring of 2014. After ground range tests of the instrument, ACES successfully completed six test flights on the Langley Hu-25 aircraft in July, 2014, and recorded data at multiple altitudes over land and ocean surfaces with and without intervening clouds. Preliminary results from these test flights will be presented in this paper.

Obland, Michael D.↗

Benchmarking Cylindrical Blast Wave Theory Against the OSIRIS-REx Sample Return Capsule Reentry

Weak shock theory based on cylindrical blast waves has been used to interpret meteor infrasound, but it has not been systematically benchmarked against a non-ablating hypersonic source with independently known parameters. The objective of this study is not to propose a new theoretical framework, but to evaluate the operational validity of the existing suite of blast radius formulations against a high-fidelity ground truth dataset. The OSIRIS-REx Sample Return Capsule reentry on 24 September 2023 provides such a benchmark because the capsule geometry, trajectory, and infrasound emission points are constrained from mission data and ray tracing, reducing source-side uncertainty associated with ablation. Using observations from 39 infrasound stations, this benchmarking study evaluates six published blast radius (${R}_{0}$ ) formulations and three weak-shock transition coefficients ( C ) within a stratified atmospheric propagation model to predict signal period and peak overpressure. The benchmarking identifies the Sakurai formulation as the best-performing formulation for non-ablating bodies, with the Jones/Plooster formulation performing comparably when a physically appropriate C is adopted. Sakurai and Jones/Plooster yield linear-period median absolute percentage residuals of 9% and 11%, respectively. The period predictions show only weak sensitivity to C at these propagation distances. The Mach-diameter approximation commonly used in meteor studies overestimates ${R}_{0}$ by more than a factor of 3 in the absence of ablation. Finally, these results establish a performance baseline for applying cylindrical blast wave theory to effectively non-ablating hypersonic bodies and demonstrate that the signal period is a robust observable for constraining ${R}_{0}$.

atmospheric entry↗

Planetary Protection, Sample Return Missions and Mars Exploration: History, Status, and Future Needs

As the prospect grows for a Mars sample return mission early in the next millennium, it will be important to ensure that appropriate planetary protection (PP) controls are incorporated into the mission design and implementation from the start. The need for these PP controls is firmly based on scientific considerations and backed by a number of national and international agreements and guidelines aimed at preventing harmful cross contamination of planets and extraterrestrial bodies. The historical precedent for the use of PP measures on both unmanned and manned missions traces from post-Sputnik missions to the present, with periodic modifications as new information was obtained. In consideration of the anticipated attention to PP questions by both the scientific/technical community and the public, this paper presents a comprehensive review of the major issues and problems surrounding PP for a Mars Sample Return (MSR) mission, including an analysis of arguments that have been raised for and against the imposition of PP measures. Also discussed are the history and foundations for PP policies and requirements; important research areas needing attention prior to defining detailed PP requirements for a MSR mission; and legal and public awareness issues that must be considered with mission planning.

DeVincenzi, Donald L.↗

Planetary Protection, Sample Return Missions and Mars Exploration: History, Status, and Future Needs

As the prospect grows for a Mars sample return mission early in the next millennium, it will be important to ensure that appropriate planetary protection (PP) controls are incorporated into the mission design and implementation from the start. The need for these PP controls is firmly based on scientific considerations and backed by a number of national and international agreements and guidelines aimed at preventing harmful cross contamination of planets and extraterrestrial bodies. The historical precedent for the use of PP measures on both unmanned and manned missions traces from post-Sputnik missions to the present, with periodic modifications as new information was obtained. In consideration of the anticipated attention to PP questions by both the scientific/technical community and the public, this paper presents a comprehensive review of the major issues and problems surrounding PP for a Mars Sample Return (MSR) mission, including an analysis of arguments that have been raised for and against the imposition of PP measures. Also discussed are the history and foundations for PP policies and requirements; important research areas needing attention prior to defining detailed PP requirements for a MSR mission; and legal and public awareness issues that must be considered with mission planning.

DeVincenzi, Donald L.↗