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At least 613 records · Page 34

Advanced imaging of the macrostructure and microstructure of bone

Noninvasive and/or nondestructive techniques are capable of providing more macro- or microstructural information about bone than standard bone densitometry. Although the latter provides important information about osteoporotic fracture risk, numerous studies indicate that bone strength is only partially explained by bone mineral density. Quantitative assessment of macro- and microstructural features may improve our ability to estimate bone strength. The methods available for quantitatively assessing macrostructure include (besides conventional radiographs) quantitative computed tomography (QCT) and volumetric quantitative computed tomography (vQCT). Methods for assessing microstructure of trabecular bone noninvasively and/or nondestructively include high-resolution computed tomography (hrCT), micro-computed tomography (muCT), high-resolution magnetic resonance (hrMR), and micromagnetic resonance (muMR). vQCT, hrCT and hrMR are generally applicable in vivo; muCT and muMR are principally applicable in vitro. Although considerable progress has been made in the noninvasive and/or nondestructive imaging of the macro- and microstructure of bone, considerable challenges and dilemmas remain. From a technical perspective, the balance between spatial resolution versus sampling size, or between signal-to-noise versus radiation dose or acquisition time, needs further consideration, as do the trade-offs between the complexity and expense of equipment and the availability and accessibility of the methods. The relative merits of in vitro imaging and its ultrahigh resolution but invasiveness versus those of in vivo imaging and its modest resolution but noninvasiveness also deserve careful attention. From a clinical perspective, the challenges for bone imaging include balancing the relative advantages of simple bone densitometry against the more complex architectural features of bone or, similarly, the deeper research requirements against the broader clinical needs. The considerable potential biological differences between the peripheral appendicular skeleton and the central axial skeleton have to be addressed further. Finally, the relative merits of these sophisticated imaging techniques have to be weighed with respect to their applications as diagnostic procedures requiring high accuracy or reliability on one hand and their monitoring applications requiring high precision or reproducibility on the other. Copyright 2000 S. Karger AG, Basel.

NASA Discipline Musculoskeletal↗

Preliminary Investigation of Impact of Technological Impairment on Trajectory-Based Operations

The Next Generation Air Transportation System (NextGen) incorporates collaborative air traffic management and Trajectory-Based Operations (TBO) in order to significantly increase the capacity, efficiency, and predictability of operations in the National Airspace System (NAS), without decreasing safety. This is enabled by airspace users and service providers sharing knowledge about operations that allows prediction of the complete 4D flight trajectory with as little uncertainty as possible. Additionally, new software and hardware technology is critical to reaching NextGen goals, especially with regard to TBO. What if the technologies that are critical for TBO were to be impaired or fail completely? Should there be a malfunction of a piece of the technology, it must be ensured that the whole system does not break down completely or suffer severe impairment. Instead, operations need to be maintained proportionally to the problem and safety needs to be ensured (graceful degradation). This paper proposes a systematic framework to investigate the vulnerability of TBO to technology disruption, and determine the impact of technological impairment on TBO. Two representative technologies are chosen for detailed investigation and the impact of their impairment on the degradation of TBO is illustrated using a weather-related scenario. XXXX There are several possible directions of future work. We believe it is desirable to develop methods to quantitatively assess the impact of technological disruption on TBO and to have the simulation tools to validate the impact. The availability of prognostics and health management methods could be leveraged to predict technological failure/disruption, thus predicting how TBO will be a ected, and possibly pro-actively mitigating the impact. It is important to develop large-scale scenarios where the e ect of technological impairment is prominent, and identify methods to quantitatively assess the extent of TBO degradation. An important goal of such an investigation is the development of failure-resistant resilient trajectory-based oper- ations. Resilience14, 15 is the property of a system to \bounce back" and resume at least a signi cant portion of its functionalities after degradation due to technological impairment(s). A systems resilience includes properties such as \bu ering capacity" (quantifying disruptions the system can absorb or adapt to without a fundamental breakdown in performance or in the systems structure), \ exibility" (ability to restructure itself in response to external changes or pressures), "margin" (how closely the system is currently operating rela- tive to one or another kind of performance boundary), \tolerance" (whether the system gracefully degrades as stress/pressure increase, or collapses quickly when pressure exceeds adaptive capacity), etc. Future work needs to focus on quantifying and improving the resilience of TBO, and identifying resilient design solutions for aviation.

TBO↗

Knowledge-based system verification and validation

The objective of this task is to develop and evaluate a methodology for verification and validation (V&V) of knowledge-based systems (KBS) for space station applications with high reliability requirements. The approach consists of three interrelated tasks. The first task is to evaluate the effectiveness of various validation methods for space station applications. The second task is to recommend requirements for KBS V&V for Space Station Freedom (SSF). The third task is to recommend modifications to the SSF to support the development of KBS using effectiveness software engineering and validation techniques. To accomplish the first task, three complementary techniques will be evaluated: (1) Sensitivity Analysis (Worchester Polytechnic Institute); (2) Formal Verification of Safety Properties (SRI International); and (3) Consistency and Completeness Checking (Lockheed AI Center). During FY89 and FY90, each contractor will independently demonstrate the user of his technique on the fault detection, isolation, and reconfiguration (FDIR) KBS or the manned maneuvering unit (MMU), a rule-based system implemented in LISP. During FY91, the application of each of the techniques to other knowledge representations and KBS architectures will be addressed. After evaluation of the results of the first task and examination of Space Station Freedom V&V requirements for conventional software, a comprehensive KBS V&V methodology will be developed and documented. Development of highly reliable KBS's cannot be accomplished without effective software engineering methods. Using the results of current in-house research to develop and assess software engineering methods for KBS's as well as assessment of techniques being developed elsewhere, an effective software engineering methodology for space station KBS's will be developed, and modification of the SSF to support these tools and methods will be addressed.

Johnson, Sally C.↗

Application of quasi-deep convective clouds method for MODIS and VIIRS TEB calibration assessments

A technique to use deep convective clouds (DCC) and quasi-DCC (qDCC) for the calibration assessment of the thermal emissive bands (TEB) on remote sensing instruments has proven feasible. The Terra and Aqua MODIS and S-NPP and NOAA-20 VIIRS TEB calibration uses a nonlinear algorithm whose nonlinear coefficients rely on on-orbit black body (BB) warm-up and cool-down (WUCD) activities for updates. However, the limited BB temperature range affects the calibration’s uncertainty. The DCC core, one of the coldest Earth scenes, is suitable for MODIS calibration assessments; more specifically, for the evaluation of the offset effect in its TEB quadratic calibration function. Moreover, nighttime qDCC measurements provide the advantage of removing solar reflectance effects, thus enhancing the assessment’s accuracy for the midwave infrared TEB. In this paper, the qDCC method is applied to the Terra MODIS and VIIRS TEB. Their stabilities are assessed using long-term DCC and qDCC trending measurements over the instruments’ entire missions. The measurements from bands with an approximately 11-μm wavelength are used to identify the DCC pixels. MODIS band31 (~ 11m) has demonstrated stable performance and accurate calibration for both instruments throughout their respective missions. MODIS band31 can therefore be used as a reference for the other TEB. Furthermore, it also allows for a Terra and Aqua MODIS TEB cross-comparison. The assessment results, along with the calibration uncertainty and Level 1B product impact modeling, can be quite helpful for calibration improvements.

MODIS↗

Testing Functions of One and Two Arguments

Software to evaluate functions of one or two arguments is too often tested or certified, or the accuracy assessed, by ad hoc methods. Systematic methods to test, certify or assess the accuracy of single- or double-precision functions of one or two arguments, and supporting software, are described here.

software software evaluation arguments↗

Development of load-dependent Ritz vector method for structural dynamic analysis of large space structures

The development and preliminary assessment of a method for dynamic structural analysis based on load-dependent Ritz vectors are presented. The vector basis is orthogonalized with respect to the mass and structural stiffness in order that the equations of motion can be uncoupled and efficient analysis of large space structure performed. A series of computer programs was developed based on the algorithm for generating the orthogonal load-dependent Ritz vectors. Transient dynamic analysis performed on the Space Station Freedom using the software was found to provide solutions that require a smaller number of vectors than the modal analysis method. Error norm based on the participation of the mass distribution of the structure and spatial distribution of structural loading, respectively, were developed in order to provide an indication of vector truncation. These norms are computed before the transient analysis is performed. An assessment of these norms through a convergence study of the structural response was performed. The results from this assessment indicate that the error norms can provide a means of judging the quality of the vector basis and accuracy of the transient dynamic solution.

Ricles, James M.↗

Formal Verification of a Conflict Resolution and Recovery Algorithm

New air traffic management concepts distribute the duty of traffic separation among system participants. As a consequence, these concepts have a greater dependency and rely heavily on on-board software and hardware systems. One example of a new on-board capability in a distributed air traffic management system is air traffic conflict detection and resolution (CD&R). Traditional methods for safety assessment such as human-in-the-loop simulations, testing, and flight experiments may not be sufficient for this highly distributed system as the set of possible scenarios is too large to have a reasonable coverage. This paper proposes a new method for the safety assessment of avionics systems that makes use of formal methods to drive the development of critical systems. As a case study of this approach, the mechanical veri.cation of an algorithm for air traffic conflict resolution and recovery called RR3D is presented. The RR3D algorithm uses a geometric optimization technique to provide a choice of resolution and recovery maneuvers. If the aircraft adheres to these maneuvers, they will bring the aircraft out of conflict and the aircraft will follow a conflict-free path to its original destination. Veri.cation of RR3D is carried out using the Prototype Verification System (PVS).

Maddalon, Jeffrey↗

Muscle recruitment variations during wrist flexion exercise: MR evaluation

OBJECTIVE: Many exercise protocols used in physiological studies assume homogeneous and diffuse muscle recruitment. To test this assumption during a "standard" wrist flexion protocol, variations in muscle recruitment were assessed using MRI in eight healthy subjects. MATERIALS AND METHODS: Variations were assessed by comparing the right to the left forearms and the effect of slight (15 degrees) pronation or supination at the wrist. RESULTS: Postexercise imaging showed focal regions of increased signal intensity (SI), indicating relatively strong recruitment, most often in entire muscles, although occasionally only in subvolumes of muscles. In 15 of 26 studies, flexor carpi radialis (FCR) showed more SI than flexor carpi ulnaris, while in 11 studies SI in these muscles increased equivalently. Relatively greater FCR recruitment was seen during pronation and/or use of the nondominant side. Palmaris longus, a wrist flexor, did not appear recruited in 4 of 11 forearms in which it was present. A portion of the superficial finger flexor became hyperintense in 89% of studies, while recruitment of the deep finger flexor was seen only in 43%. CONCLUSION: Inter- and intraindividual variations in forearm muscle recruitment should be anticipated in physiological studies of standard wrist flexion exercise protocols.

NASA Discipline Cardiopulmonary↗

Investigation of Current Methods to Identify Helicopter Gear Health

This paper provides an overview of current vibration methods used to identify the health of helicopter transmission gears. The gears are critical to the transmission system that provides propulsion, lift and maneuvering of the helicopter. This paper reviews techniques used to process vibration data to calculate conditions indicators (CI s), guidelines used by the government aviation authorities in developing and certifying the Health and Usage Monitoring System (HUMS), condition and health indicators used in commercial HUMS, and different methods used to set thresholds to detect damage. Initial assessment of a method to set thresholds for vibration based condition indicators applied to flight and test rig data by evaluating differences in distributions between comparable transmissions are also discussed. Gear condition indicator FM4 values are compared on an OH58 helicopter during 14 maneuvers and an OH58 transmission test stand during crack propagation tests. Preliminary results show the distributions between healthy helicopter and rig data are comparable and distributions between healthy and damaged gears show significant differences.

Dempsey, Paula J.↗

Investigation of Current Methods to Identify Helicopter Gear Health

This paper provides an overview of current vibration methods used to identify the health of helicopter transmission gears. The gears are critical to the transmission system that provides propulsion, lift and maneuvering of the helicopter. This paper reviews techniques used to process vibration data to calculate conditions indicators (CI's), guidelines used by the government aviation authorities in developing and certifying the Health and Usage Monitoring System (HUMS), condition and health indicators used in commercial HUMS, and different methods used to set thresholds to detect damage. Initial assessment of a method to set thresholds for vibration based condition indicators applied to flight and test rig data by evaluating differences in distributions between comparable transmissions are also discussed. Gear condition indicator FM4 values are compared on an OH58 helicopter during 14 maneuvers and an OH58 transmission test stand during crack propagation tests. Preliminary results show the distributions between healthy helicopter and rig data are comparable and distributions between healthy and damaged gears show significant differences.

Dempsey, Paula J.↗

Wall Interference in Two-Dimensional Wind Tunnels

Viscosity and tunnel-wall constraints introduced via boundary conditions. TWINTN4 computer program developed to implement method of posttest assessment of wall interference in two-dimensional wind tunnels. Offers two methods for combining sidewall boundary-layer effects with upper and lower wall interference. In sequential procedure, Sewall method used to define flow free of sidewall effects, then assessed for upper and lower wall effects. In unified procedure, wind-tunnel flow equations altered to incorporate effects from all four walls at once. Program written in FORTRAN IV for batch execution.

Kemp, William B., Jr.↗

A direct viable count method for the enumeration of attached bacteria and assessment of biofilm disinfection

This report describes the adaptation of an in situ direct viable count (in situ DVC) method in biofilm disinfection studies. The results obtained with this technique were compared to two other enumeration methods, the plate count (PC) and conventional direct viable count (c-DVC). An environmental isolate (Klebsiella pneumoniae Kp1) was used to form biofilms on stainless steel coupons in a stirred batch reactor. The in situ DVC method was applied to directly assess the viability of bacteria in biofilms without disturbing the integrity of the interfacial community. As additional advantages, the results were observed after 4 h instead of the 24 h incubation time required for colony formation and total cell numbers that remained on the substratum were enumerated. Chlorine and monochloramine were used to determine the susceptibilities of attached and planktonic bacteria to disinfection treatment using this novel analytical approach. The planktonic cells in the reactor showed no significant change in susceptibility to disinfectants during the period of biofilm formation. In addition, the attached cells did not reveal any more resistance to disinfection than planktonic cells. The disinfection studies of young biofilms indicated that 0.25 mg/l free chlorine (at pH 7.2) and 1 mg/l monochloramine (at pH 9.0) have comparable disinfection efficiencies at 25 degrees C. Although being a weaker disinfectant, monochloramine was more effective in removing attached bacteria from the substratum than free chlorine. The in situ DVC method always showed at least one log higher viable cell densities than the PC method, suggesting that the in situ DVC method is more efficient in the enumeration of biofilm bacteria. The results also indicated that the in situ DVC method can provide more accurate information regarding the cell numbers and viability of bacteria within biofilms following disinfection.

NASA Discipline Number 04-10↗

Making Human Spaceflight Practical and Affordable: Spacecraft Designs and their Degree of Operability

As we push toward new and diverse space transportation capabilities, reduction in operations cost becomes increasingly important. Achieving affordable and safe human spaceflight capabilities will be the mark of success for new programs and new providers. The ability to perceive the operational implications of design decisions is crucial in developing safe yet cost competitive space transportation systems. Any human spaceflight program - government or commercial - must make countless decisions either to implement spacecraft system capabilities or adopt operational constraints or workarounds to account for the lack of such spacecraft capabilities. These decisions can benefit from the collective experience that NASA has accumulated in building and operating crewed spacecraft over the last five decades. This paper reviews NASA s history in developing and operating human rated spacecraft, reviewing the key aspects of spacecraft design and their resultant impacts on operations phase complexity and cost. Specific examples from current and past programs - including the Space Shuttle and International Space Station - are provided to illustrate design traits that either increase or increase cost and complexity associated with spacecraft operations. These examples address factors such as overall design performance margins, levels of redundancy, degree of automated failure response, type and quantity of command and telemetry interfaces, and the definition of reference scenarios for analysis and test. Each example - from early program requirements, design implementation and resulting real-time operations experience - to tell the end-to-end "story" Based on these experiences, specific techniques are recommended to enable earlier and more effective assessment of operations concerns during the design process. A formal method for the assessment of spacecraft operability is defined and results of such operability assessments for recent spacecraft designs are provided. Recent experience in applying these techniques to Orion spacecraft development is reviewed to highlight the direct benefits of early operational assessment and collaborative development efforts.

Crocker, Alan R.↗

On Calculation Methods and Results for Straight Cylindrical Roller Bearing Deflection, Stiffness, and Stress

The purpose of this study was to assess some calculation methods for quantifying the relationships of bearing geometry, material properties, load, deflection, stiffness, and stress. The scope of the work was limited to two-dimensional modeling of straight cylindrical roller bearings. Preparations for studies of dynamic response of bearings with damaged surfaces motivated this work. Studies were selected to exercise and build confidence in the numerical tools. Three calculation methods were used in this work. Two of the methods were numerical solutions of the Hertz contact approach. The third method used was a combined finite element surface integral method. Example calculations were done for a single roller loaded between an inner and outer raceway for code verification. Next, a bearing with 13 rollers and all-steel construction was used as an example to do additional code verification, including an assessment of the leading order of accuracy of the finite element and surface integral method. Results from that study show that the method is at least first-order accurate. Those results also show that the contact grid refinement has a more significant influence on precision as compared to the finite element grid refinement. To explore the influence of material properties, the 13-roller bearing was modeled as made from Nitinol 60, a material with very different properties from steel and showing some potential for bearing applications. The codes were exercised to compare contact areas and stress levels for steel and Nitinol 60 bearings operating at equivalent power density. As a step toward modeling the dynamic response of bearings having surface damage, static analyses were completed to simulate a bearing with a spall or similar damage.

Krantz, Timothy L.↗

Similar Estimates of Temperature Impacts on Global Wheat Yield by Three Independent Methods

The potential impact of global temperature change on global crop yield has recently been assessed with different methods. Here we show that grid-based and point-based simulations and statistical regressions (from historic records), without deliberate adaptation or CO2 fertilization effects, produce similar estimates of temperature impact on wheat yields at global and national scales. With a 1 C global temperature increase, global wheat yield is projected to decline between 4.1% and 6.4%. Projected relative temperature impacts from different methods were similar for major wheat-producing countries China, India, USA and France, but less so for Russia. Point-based and grid-based simulations, and to some extent the statistical regressions, were consistent in projecting that warmer regions are likely to suffer more yield loss with increasing temperature than cooler regions. By forming a multi-method ensemble, it was possible to quantify 'method uncertainty' in addition to model uncertainty. This significantly improves confidence in estimates of climate impacts on global food security.

Climate impacts↗

Methodology for the Assessment of 3D Conduction Effects in an Aerothermal Wind Tunnel Test

This slide presentation reviews a method for the assessment of three-dimensional conduction effects during test in a Aerothermal Wind Tunnel. The test objectives were to duplicate and extend tests that were performed during the 1960's on thermal conduction on proturberance on a flat plate. Slides review the 1D versus 3D conduction data reduction error, the analysis process, CFD-based analysis, loose coupling method that simulates a wind tunnel test run, verification of the CFD solution, Grid convergence, Mach number trend, size trends, and a Sumary of the CFD conduction analysis. Other slides show comparisons to pretest CFD at Mach 1.5 and 2.16 and the geometries of the models and grids.

Oliver, Anthony Brandon↗

Accuracy-Based Annotation Quality Score (ABAQS) v1.0

Assessing genome annotation quality is crucial for downstream analyses, but current methods are inadequate for eukaryotes. We present Accuracy-Based Annotation Quality Score (ABAQS), a novel, minimal-data-driven method that comprehensively assesses annotation quality. ABAQS evaluates multiple factors, including genome completeness, gene model validity, and protein profile accuracy, outperforming other metrics like BUSCO and PSAURON. We applied ABAQS to over 2500 eukaryotic genomes and showed its robustness and effectiveness in evaluating genome annotation quality, making it a valuable tool for researchers working with genomic data. ABAQS reveals significant variation in annotation quality and highlights the importance of filtering in improving annotation quality and accuracy.

Haridas, Sajeet [Lawrence Berkeley National Labora↗