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NASA NTRSDate not supplied

Multi-angle Imaging SpectroRadiometer

MISR views the sunlit Earth simultaneously at nine widely spaced angles and provides ongoing global coverage with high spatial detail. Its imagery is carefully calibrated to provide accurate measures of the brightness, contrast, and color of reflected sunlight. MISR provides new types of information for scientists studying Earth's climate, such as the regional and global distribution of different types of atmospheric particles and aerosols. The change in reflection at different view angles provides the means to distinguish aerosol types, cloud forms, and land surface cover. Combined with stereoscopic techniques, this enables construction of 3-D cloud models and estimation of the total amount of sunlight reflected by Earth's diverse environments. MISR was built for NASA by the Jet Propulsion Laboratory (JPL) in Pasadena, California. It is part of NASA's first Earth Observing System (EOS) spacecraft, the Terra spacecraft, which was launched into polar orbit from Vandenberg Air Force Base on December 18, 1999. MISR has been continuously providing data since February 24, 2000. [Mission Objectives] The MISR instrument acquires systematic multi-angle measurements for global monitoring of top-of-atmosphere and surface albedos and for measuring the shortwave radiative properties of aerosols, clouds, and surface scenes in order to characterize their impact on the Earth's climate. The Earth's climate is constantly changing -- as a consequence of both natural processes and human activities. Scientists care a great deal about even small changes in Earth's climate, since they can affect our comfort and well-being, and possibly our survival. A few years of below-average rainfall, an unusually cold winter, or a change in emissions from a coal-burning power plant, can influence the quality of life of people, plants, and animals in the region involved. The goal of NASA's Earth Observing System (EOS) is to increase our understanding of the climate changes that are occurring on our planet, and the reasons for these changes, so we are better equipped to anticipate and prepare for the future. The MISR instrument is a part of EOS. Its role is to measure the amount of sunlight scattered in different directions under natural conditions. These measurements will help quantify the amount of solar energy that heats the Earth's surface and atmosphere, and the changes that occur in them over the lifetime of the MISR instrument. From the MISR observations, we are also learning more about those components of the Earth's environment that scatter sunlight: particles in the atmosphere, the planet's surface, and clouds. MISR monitors changes in surface reflection properties, in atmospheric aerosol content and composition, and in cloudiness. Scientists use these data to study land use changes, air pollution, volcanic eruptions, as well as processes such as desertification, deforestation, and soil erosion. As part of the EOS program, computer models that predict future climate will be improved by the results of these studies. [Temporal_Coverage: Start_Date=2000-02-24; Stop_Date=] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180].

Diner, David J.↗
DOE OSTI2021

Stove Solutions: Improving Health, Safety, and the Environment in Darfur with Fuel-Efficient Cookstoves

Nearly three billion people across the globe cook every day using open, three-stone fires, or rudimentary stoves that burn biomass such as wood, agricultural waste, animal dung, and charcoal. Cooking with these traditional cookstoves is inefficient and grossly polluting, harming health and the environment, and contributing to global warming. In many places worldwide, women must walk for hours to collect firewood, risking their safety and sacrificing energy and time that could be used to earn a living. While often overlooked as a major contributor to the global burden of disease, cooking over open fires indoors is the largest environmental health risk in developing countries, and exposes women (and the young children near them) to amounts of smoke equivalent to burning 1,000 cigarettes inside the home. In Darfur, Sudan, where about 2.7 million people have been displaced from their homes by conflict, the situation is particularly dire. Each day, Darfuri women face the difficult choice between risking sexual assault during treks to collect firewood or selling a portion of their family’s meager food rations for cash to purchase wood. Here, the Berkeley-Darfur Stove, developed by scientists at the Lawrence Berkeley National Laboratory (LBNL) and volunteers from UC Berkeley and Engineers Without Borders, is a metal stove that reduces the need for firewood by more than half, owing to its improved combustion and heat transfer efficiencies. LBNL has partnered with a nonprofit organization, Potential Energy, and a number of aid organizations to disseminate more than 22,000 Berkeley-Darfur Stoves to Darfuri women. Several hundred thousand more are needed.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2021

Carnivore Survey Results for the Lawrence Livermore National Laboratory Site 300

ECORP Consulting, Inc. conducted a suite of carnivore surveys at the Lawrence Livermore National Laboratory’s (LLNL) Experimental Test Site (Site 300; project site). The project site is located east of the City of Livermore and southwest of the City of Tracy, Alameda and San Joaquin Counties, California. Mesocarnivore surveys were conducted on the project site in 2002 in preparation for the 2005 LLNL Site-Wide Environmental Impact Statement (SWEIS; Clark et al. 2003). The 2002 surveys included a combination of spotlighting, camera stations, and scat detection dog surveys. Additional scat detection dog surveys for San Joaquin kit fox (Vulpes macrotis mutica) were performed on Site 300 and the adjacent California Department of Fish and Wildlife’s (CDFW) Corral Hollow Ecological Reserve in 2018 and 2020 (Woollett 2019, 2021). A variety of species, including American badger (Taxidea taxus), coyote (Canis latrans), and bobcat (Lynx rufus), were detected during the previous surveys; however, no San Joaquin kit fox or mountain lion (Puma concolor) were detected. In support of the preparation of the new SWEIS, ECORP performed carnivore surveys to document the carnivores and other animals present on Site 300, with a focus on determining if the federally listed (endangered) and state listed (threatened) San Joaquin kit fox, CDFW Species of Special Concern (SSC) American badger, and/or mountain lion are present on Site 300. American badgers are known to occur on the property and there have been a few sporadic sightings of mountain lions, but San Joaquin kit fox have not been documented on Site 300. Although mountain lion were not detected during the 2002 survey, it has been added as a focal species for this survey because the southern and central coast evolutionary significant units of mountain lions were recently advanced by CDFW as a Candidate species for listing as “threatened” under the California Endangered Species Act.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2012

Interleaved Carbon Minibeams: An Experimental Radiosurgery Method With Clinical Potential

Purpose: To evaluate the efficacy of 'interleaved carbon minibeams' for ablating a 6.5-mm target in a rabbit brain with little damage to the surrounding brain. The method is based on the well-established tissue-sparing effect of arrays of thin planes of radiation. Methods and Materials: Broad carbon beams from the National Aeronautics and Space Agency Space Radiation Facility at Brookhaven National Laboratory were segmented into arrays of parallel, horizontal, 0.3-mm-thick planar beams (minibeams). The minibeams' gradual broadening in tissues resulted in 0.525-mm beam thickness at the target's proximal side in the spread-out Bragg peak. Interleaving was therefore implemented by choosing a 1.05 mm beam spacing on-center. The anesthetized rabbit, positioned vertically on a stage capable of rotating about a vertical axis, was exposed to arrays from four 90 Degree-Sign angles, with the stage moving up by 0.525 mm in between. This produced a solid radiation field at the target while exposing the nontargeted tissues to single minibeam arrays. The target 'physical' absorbed dose was 40.2 Gy. Results: The rabbit behaved normally during the 6-month observation period. Contrast magnetic resonance imaging and hematoxylin and eosin histology at 6 months showed substantial focal target damage with little damage to the surrounding brain. Conclusion: We plan to evaluate the method's therapeutic efficacy by comparing it with broad-beam carbon therapy in animal models. The method's merits would combine those of carbon therapy (i.e., tight target dose because of the carbon's Bragg-peak, sharp dose falloff, and high relative biological effectiveness at the target), together with the method's low impact on the nontargeted tissues. The method's smaller impact on the nontargeted brain might allow carbon therapy at higher target doses and/or lower normal tissue impact, thus leading to a more effective treatment of radioresistant tumors. It should also make the method more amenable to administration in either a single dose fraction or in a small number of fractions.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2013

Enzyme-Directed Assembly of Nanoparticles in Tumors Monitored by In Vivo Whole Animal and Ex Vivo Super-Resolution Fluorescence Imaging

Matrix metalloproteinase enzymes, overexpressed in HT-1080 human fibrocarcinoma tumors, were used to guide the accumulation and retention of an enzyme-responsive nanoparticle in a xenograft mouse model. The nanoparticles were prepared as micelles from amphiphilic block copolymers bearing a simple hydrophobic block, and a hydrophilic peptide brush. The polymers were end-labeled with Alexa Fluor 647 dyes leading to the formation of labeled micelles upon dialysis of the polymers from DMSO to aqueous buffer. This dye-labeling strategy allowed the presence of the retained material to be visualized via whole animal imaging in vivo, and in ex vivo organ analysis following intratumoral injection into HT-1080 xenograft tumors. We propose that the material is retained by virtue of an enzyme-induced accumulation process whereby particles change morphology from 20 nm spherical micelles to micron-scale aggregates, kinetically trapping them within the tumor. This hypothesis is tested here via an unprecedented super resolution fluorescence analysis of ex vivo tissue slices confirming a particle size increase occurs concomitantly with extended retention of responsive particles compared to unresponsive controls.

Environmental Molecular Sciences Laboratory↗
NASA NTRS2003

Sensory Motor Coordination in Robonaut

As a participant of the year 2000 NASA Summer Faculty Fellowship Program, I worked with the engineers of the Dexterous Robotics Laboratory at NASA Johnson Space Center on the Robonaut project. The Robonaut is an articulated torso with two dexterous arms, left and right five-fingered hands, and a head with cameras mounted on an articulated neck. This advanced space robot, now driven only teleoperatively using VR gloves, sensors and helmets, is to be upgraded to a thinking system that can find, interact with and assist humans autonomously, allowing the Crew to work with Robonaut as a (junior) member of their team. Thus, the work performed this summer was toward the goal of enabling Robonaut to operate autonomously as an intelligent assistant to astronauts. Our underlying hypothesis is that a robot can develop intelligence if it learns a set of basic behaviors (i.e., reflexes - actions tightly coupled to sensing) and through experience learns how to sequence these to solve problems or to accomplish higher-level tasks. We describe our approach to the automatic acquisition of basic behaviors as learning sensory-motor coordination (SMC). Although research in the ontogenesis of animals development from the time of conception) supports the approach of learning SMC as the foundation for intelligent, autonomous behavior, we do not know whether it will prove viable for the development of autonomy in robots. The first step in testing the hypothesis is to determine if SMC can be learned by the robot. To do this, we have taken advantage of Robonaut's teleoperated control system. When a person teleoperates Robonaut, the person's own SMC causes the robot to act purposefully. If the sensory signals that the robot detects during teleoperation are recorded over several repetitions of the same task, it should be possible through signal analysis to identify the sensory-motor couplings that accompany purposeful motion. In this report, reasons for suspecting SMC as the basis for intelligent behavior will be reviewed. A robot control system for autonomous behavior that uses learned SMC will be proposed. Techniques for the extraction of salient parameters from sensory and motor data will be discussed. Experiments with Robonaut will be discussed and preliminary data presented.

Peters, Richard Alan, II↗
NASA NTRS2009

Pulmonary Toxicity Studies of Lunar Dusts in Rodents

NASA will build an outpost on the lunar surface for long-duration human habitation and research. The surface of the Moon is covered by a layer of fine, reactive dust, and the living quarters in the lunar outpost are expected to be contaminated by lunar dust. Because the toxicity of lunar dust is not known, NASA has tasked its toxicology laboratory to evaluate the risk of exposure to the dust and to establish safe exposure limits for astronauts working in the lunar habitat. Studies of the pulmonary toxicity of a dust are generally done first in rodents by intratracheal/intrapharyngeal instillation. This toxicity screening test is then followed by an inhalation study, which requires much more of the test dust and is labor intensive. Preliminary results obtained by examining lung lavage fluid from dust-treated mice show that lunar dust was somewhat toxic (more toxic than TiO2, but less than quartz dust). More extensive studies are in progress to further examine lung lavage fluid for biomarkers of toxicity and lung tissues for histopathological lesions in rodents exposed to aged and activated (ground) lunar dust samples. In these studies, reference dusts (TiO2 and quartz) of known toxicities and have industrial exposure limits will be studied in parallel so the relative toxicity of lunar dust can be determined. The results from the instillation studies will be useful for choosing exposure concentrations for the animal inhalation study. The animal inhalation exposure will be conducted with lunar dust simulant prior to the study with the lunar dust. The experiment with the simulate will ensure that the study techniques used with actual lunar dust will be successful. The results of instillation and inhalation studies will reveal the toxicological risk of exposures and are essential for setting exposure limits on lunar dust for astronauts living in the lunar habitat.

Lam, Chiu-wing↗
DOE OSTI2025

Site Identification framework and environmental compliance for floating ocean turbines in US Waters (Abstract)

Like all potential marine energy deployment sites, characterizing the site, understanding the environmental interactions with floating tidal technology, and mapping a pathway towards regulatory acceptance will be needed to site and permit ocean current development within the Florida Current. The proposed work will be based on a modeling analysis, a desk-top review and analysis, focusing on the characteristics of the ocean current technology and environmental monitoring information on the marine animals and habitats that are specific to the appropriate latitude, particularly those that are endemic to the offshore Florida area. The analysis will also describe the state and federal authorizations required for deploying a floating tidal energy technology, with an emphasis on how they differ from those in Washington, Alaska, and Maine. Environmentally compliant sites within Florida Current will be selected based on environmental, logistical, and regulatory criteria. Recommendations on monitoring needs and adaptive management practices will be provided. The need to acquire social acceptance for the Orbital Marine Power technology will also be explored and general recommendations prepared to encourage the best acceptance in the communities of interest.

16 TIDAL AND WAVE POWER↗
DOE OSTI2015

SU-E-I-90: Characterizing Small Animal Lung Properties Using Speckle Observed with An In-Line X-Ray Phase Contrast Benchtop System

Purpose: We demonstrate a novel X-ray phase-contrast (XPC) method for lung imaging representing a paradigm shift in the way small animal functional imaging is performed. In our method, information regarding airway microstructure that is encoded within speckle texture of a single XPC radiograph is decoded to produce 2D parametric images that will spatially resolve changes in lung properties such as microstructure sizes and air volumes. Such information cannot be derived from conventional lung radiography or any other 2D imaging modality. By computing these images at different points within a breathing cycle, dynamic functional imaging will be readily achieved without the need for tomography. Methods: XPC mouse lung radiographs acquired in situ with an in-line X-ray phase contrast benchtop system. The lung air volume is varied and controlled with a small animal ventilator. XPC radiographs will be acquired for various lung air volume levels representing different phases of the respiratory cycle. Similar data will be acquired of microsphere-based lung phantoms containing hollow glass spheres with known distributions of diameters. Image texture analysis is applied to the data to investigate relationships between texture characteristics and airspace/microsphere physical properties. Results: Correlations between Fourier-based texture descriptors (FBTDs) and regional lung air volume indicate that the texture features in 2D radiographs reveal information on 3D properties of the lungs. For example, we find for a 350 × 350 πm2 lung ROI a linear relationship between injected air volume and FBTD value with slope and intercept of 8.9×10{sup 5} and 7.5, respectively. Conclusion: We demonstrate specific image texture measures related to lung speckle features are correlated with physical characteristics of refracting elements (i.e. lung air spaces). Furthermore, we present results indicating the feasibility of implementing the technique with a simple imaging system design, short exposures, and low dose which provides potential for widespread use in laboratory settings for in vivo studies. This research was supported in part by NSF Award CBET1263988.

60 APPLIED LIFE SCIENCES↗
NASA NTRS2015

Risk of Crew Adverse Health Event Due to Altered Immune Response

Determining the effect of space travel on the human immune system has proven to be extremely challenging. Limited opportunities for in-flight studies, varying mission durations, technical and logistical obstacles, small subject numbers, and a broad range of potential assays have contributed to this problem. Additionally, the inherent complexity of the immune system, with its vast array of cell populations, sub-populations, diverse regulatory molecules, and broad interactions with other physiological systems, makes determining precise variables to measure very difficult. There is also the challenge of determining the clinical significance of any observed immune alterations. Will such a change lead to disease, or is it a transient subclinical observation related to short-term stress? The effect of this problem may be observed by scanning publications associated with immunity and spaceflight, which began to appear during the 1970s. Although individually they are each valid studies, the comprehensive literature to date suffers from widely varying sampling methods and assay techniques, low subject counts, and sometimes a disparate focus on narrow aspects of immunity. The most clinically relevant data are derived from in-flight human studies, which have demonstrated altered cell-mediated immunity and reactivation of latent herpes viruses. Much more data are available from post-flight testing of humans, with clear evidence of altered cytokine production patterns, altered leukocyte distribution, continued latent viral reactivation, and evidence of dramatically altered virus-specific immunity. It is unknown if post-flight assessments relate to the in-flight condition or are a response to landing stress and readaptation. In-flight culture of cells has clearly demonstrated that immune cells are gravity-sensitive and display altered functional characteristics. It is unknown if these data are related to in vivo immune cell function or are an artifact of microgravity culture. Ground analog testing of humans and animals, as well as microgravity-analog cell culture, has demonstrated utility. However, in all cases, it is not known with certainty if these data would reflect similar testing during space travel. Given their ready availability, ground analogs may be extremely useful for assay development and the evaluation of potential countermeasures. In general, the evidence base suffers from widely disparate studies on small numbers of subjects that do not directly correlate well with each other or spaceflight itself. Also lacking are investigations of the effect of gender on adaption to spaceflight. This results in significant knowledge 'gaps' that must be filled by future studies to completely determine any clinical risk related to immunity for human exploration-class space missions. These gaps include a significant lack of in-flight data, particularly during long-duration space missions. The International Space Station represents an excellent science platform with which to address this knowledge gap. Other knowledge gaps include lack of a single validated ground analog for the phenomenon and a lack of flight-compatible laboratory equipment capable of monitoring astronauts (for either clinical or research purposes). However, enough significant data exist, as described in this manuscript, to warrant addressing this phenomenon during the utilization phase of the ISS. A recent Space Shuttle investigation has confirmed the 31 in-flight nature of immune dysregulation, demonstrating that it is not merely a post-flight phenomenon. Several current studies are ongoing onboard the ISS that should thoroughly characterize the phenomenon. NASA recognizes that if spaceflight-associated immune dysregulation persists during exploration flights in conjunction with other dangers, such as high-energy radiation, the result may be a significant clinical risk. This emphasizes the need for a continued integrated comprehensive approach to determining the effect of prolonged spaceflight, separated from transient launch and landing stresses, on human immunity. After such studies, the phenomenon will be understood, and, hopefully, a monitoring strategy will have been developed that could be used to monitor the effectiveness of countermeasure

Crucian, Brian↗
NASA NTRS2005

Mouse infection models for space flight immunology

Several immunological processes can be affected by space flight. However, there is little evidence to suggest that flight-induced immunological deficits lead to illness. Therefore, one of our goals has been to define models to examine host resistance during space flight. Our working hypothesis is that space flight crews will come from a heterogeneous population; the immune response gene make-up will be quite varied. It is unknown how much the immune response gene variation contributes to the potential threat from infectious organisms, allergic responses or other long term health problems (e.g. cancer). This article details recent efforts of the Kansas State University gravitational immunology group to assess how population heterogeneity impacts host health, either in laboratory experimental situations and/or using the skeletal unloading model of space-flight stress. This paper details our use of several mouse strains with several different genotypes. In particular, mice with varying MHCII allotypes and mice on the C57BL background with different genetic defects have been particularly useful tools with which to study infections by Staphylococcus aureus, Salmonella typhimurium, Pasteurella pneumotropica and Ehrlichia chaffeensis. We propose that some of these experimental challenge models will be useful to assess the effects of space flight on host resistance to infection.

Review↗
DOE OSTI2020

Engineering microscale systems for fully autonomous intracellular neural interfaces

Conventional electrodes and associated positioning systems for intracellular recording from single neurons in vitro and in vivo are large and bulky, which has largely limited their scalability. Further, acquiring successful intracellular recordings is very tedious, requiring a high degree of skill not readily achieved in a typical laboratory. We report here a robotic, MEMS-based intracellular recording system to overcome the above limitations associated with form-factor, scalability and highly skilled and tedious manual operations required for intracellular recordings. This system combines three distinct technologies: 1) novel microscale, glass-polysilicon penetrating electrode for intracellular recording, 2) electrothermal microactuators for precise microscale movement of each electrode and 3) closed-loop control algorithm for autonomous positioning of electrode inside single neurons. Here, we demonstrate the novel, fully integrated system of glass-polysilicon microelectrode, microscale actuators and controller for autonomous intracellular recordings from single neurons in the abdominal ganglion of Aplysia Californica (n = 5 cells). Consistent resting potentials (< –35 mV) and action potentials (> 60 mV) were recorded after each successful penetration attempt with the controller and microactuated glass-polysilicon microelectrodes. The success rate of penetration and quality of intracellular recordings achieved using electrothermal microactuators were comparable to that of conventional positioning systems. The MEMS-based system offers significant advantages: 1) reduction in overall size for potential use in behaving animals, 2) scalable approach to potentially realize multi-channel recordings and 3) a viable method to fully automate measurement of intracellular recordings. Furthermore, this system will be evaluated in vivo in future rodent studies.

42 ENGINEERING↗
DOE OSTI2020

Distribution Development for Residual Inventory at the New York West Valley Site - 20400

The New York State Energy Research and Development Authority (NYSERDA) is the owner of the Western New York Nuclear Service Center (WNYNSC), a 1,351 ha site located approximately 48 km south of Buffalo, New York. In 1962, Nuclear Fuel Services, Inc. (NFS) entered into Agreements with the Atomic Energy Commission and New York State to construct the first commercial reprocessing plant of nuclear fuel in the United States. NFS, a private company, built and operated the spent fuel reprocessing plant and waste disposal facilities, processing 640 Mg of spent nuclear fuel from 1966 to 1972 under an Atomic Energy Commission license. Nuclear fuel reprocessing operations ended in 1972 and never reopened, leaving behind radioactive and chemical wastes. Operations led to contamination in a number of facilities and locations. Some of that contamination has migrated from waste disposal zones to other layers, formations, and features on and off the WNYNSC. Phase I decommissioning activities are ongoing and involve the removal of a number of areas and structures that have been associated with contamination. The purpose of this work is to outline the approach for characterizing contamination not associated with disposed wastes, contaminated structures, or specific releases. In this work, the term, residual radiological activity, is used to describe environmental contamination that exists subsequent to the completion of Phase I decommissioning activities, that is not associated with disposed wastes, contaminated structures, or specific releases. Contamination from the Site was quantified relative to data that characterize the concentrations of radionuclides that exist in background. Background concentrations are those present in the area but having no influence from Site related activities. The existence of residual radiological activity that is elevated relative to background has the potential to contribute to future risks to human health and the environment. As a consequence, the residual inventory information is used to inform the West Valley Probabilistic Performance Assessment (PPA) model to characterize potential future risks to human health and the environment. The centralized West Valley Data Management System (DMS) was the source of information for the data assembled in this analysis. The DMS is a fairly large compilation consisting of thousands of records from investigation studies, with sample dates ranging from 1990 to present. Samples from monitoring wells, boreholes, geoprobe studies, surface water, surface soils, storm water outfalls, ventilation stack filters, plant and animal tissues, and more are included in the DMS. Results are typically reported in units of activity per unit volume. For the purpose of the analyses presented here, all results were converted into consistent units of pCi per unit volume. Since 1990, data have been collected from various locations across the WNYNSC at different times with varying frequency over the course of several decades. As a consequence, a number of potential issues can arise with respect to the assembly of a dataset that is deemed adequate for the characterization of residual radiological activity. These issues were assessed and resolved to the extent possible through careful consideration of the properties of the distributions. The intent was to use data which characterize the current state of the Site. Radionuclides can be designated to one of several groups depending on their origin. In this work the groups considered were 1) Naturally Occurring Radioactive Material (NORM), 2) fallout, and 3) Other (including power plant, medical research, etc). This grouping is a useful construct with respect to the interpretation of fixed laboratory results. For example, NORM radionuclides that exist within a decay chain should have approximately equivalent distributions of concentrations if they are representative of background conditions. Insights such as these can be used as a check to identify sample results that need to be further investigated or omitted due to issues associated with reported results from fixed laboratory analyses. This type of analysis provided a foundation for the assessment of the adequacy of sample results for use in subsequent components of an assessment. The general process for the assessment of residual radiological contamination at the Site consists of a sequence of several steps. First, for each analyte, several statistical tests were performed to assess the weight of evidence against the null hypothesis that the mean of the distribution of concentrations was equal to zero. If the mean of the distribution of concentrations for a given radionuclide was not found to be greater than zero, then it was removed from consideration as a component of the residual radiological contamination. If there was significant evidence to reject the hypothesis of the mean being equal to zero, the second step was to compare the distribution of the data from the Site to that of the corresponding background. A suite of tests was used to compare the distributions of the site and background data. The results of these tests were collectively used to determine if site data are elevated relative to background. The third step was to develop distributions using a Bayesian framework to characterize the distribution of mean of the increment present above background for each of the radionuclides. The Bayesian model implemented allowed for the comparison of site-specific records to background concentrations to better approximate contamination attributed to the Site. A final screening step was employed for radionuclides that exceed background. This screening step compared 95% upper confidence limits (UCLs) from the increment distribution developed in the previous step to the risk screening levels. This approach yields a list of analytes that were determined to be elevated relative to background.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
NASA NTRSDate not supplied

Monitoring Vegetation Impacts of Night Penning in Idaho and Oregon Grazing Allotments Using Remote Sensing

The practice of night penning, which involves corralling livestock into a fenced, secure area overnight, aims to safeguard animals from predators. Although this method has proven successful in minimizing interactions between livestock and wildlife, the extent of its impact on vegetation communities is still being explored. In this study, we used the Rangeland Analysis Platform (RAP), which aggregates spatially distributed values of vegetation composition, cover, and productivity from the Landsat missions, to quantify the effects of night penning on rangeland vegetation communities. We identified control sites that had similar topographic characteristics to night pen sites used by ranchers in Idaho and Oregon. We then quantified and compared changes in annual net primary productivity (NPP) between night pen and control sites. Our study found that RAP NPP data did not show a noticeable difference between control sites and night penning sites. When analyzed quantitatively, night pen sites showed variability in NPP before and after night penning; however, there were few discernible differences between night pen sites and control sites, suggesting that climate conditions can have more of an effect on NPP measurements compared to land management decisions. In the summer of 2024, field crews from the Natural Resource Ecology Laboratory collected biomass data from these rangeland sites, and this will be used to compare and validate RAP products while continuing to investigate the effects of night penning.

Truman Anarella↗
DOE OSTI2025

Impact of developmental methylmercury exposure on avian embryonic development, hatchling growth, and survival

Abstract Methylmercury (MeHg) is a globally ubiquitous and persistent environmental toxicant that negatively affects animal behavior, health, and reproduction. In birds, MeHg is transferred from female to egg, contaminating embryos during sensitive stages of early embryonic development and growth. This toxic exposure in the prenatal environment not only induces mortality but also possible lasting impacts on physiology, health, and survival, even once hatched. The purpose of our study was to further elucidate the negative effects of MeHg exposure during avian embryonic development and explore how such exposure can impact offspring development, growth, and survival, both in ovo and posthatch. To assess this, we experimentally dosed fertile mallard and wood duck eggs with MeHg II chloride and reared developing embryos and ducklings to various endpoints. We found that embryos not only readily accumulated MeHg throughout incubation, but they also displayed varying dose-dependent disparities in body mass and morphometrics, with control individuals being larger during early and late embryonic stages of development (p < 0.05). Furthermore, hatched offspring exposed to MeHg exhibited increasingly slower growth rates between 7 to 10 and 10 to 15 days posthatch (p < 0.05), and were found to have lower survival probabilities both under controlled laboratory conditions (p < 0.005), and in the natural environment (p < 0.05). Our findings on the detrimental effects of MeHg on avian embryos and hatchlings emphasize the need for more proactive means of environmental protection and remediation to protect vulnerable avian populations and the ecosystems they inhabit.

Leaphart, James C.↗
NASA NTRS2006

Modular, Reconfigurable, High-Energy Technology Development

The Modular, Reconfigurable High-Energy (MRHE) Technology Demonstrator project was to have been a series of ground-based demonstrations to mature critical technologies needed for in-space assembly of a highpower high-voltage modular spacecraft in low Earth orbit, enabling the development of future modular solar-powered exploration cargo-transport vehicles and infrastructure. MRHE was a project in the High Energy Space Systems (HESS) Program, within NASA's Exploration Systems Research and Technology (ESR&T) Program. NASA participants included Marshall Space Flight Center (MSFC), the Jet Propulsion Laboratory (JPL), and Glenn Research Center (GRC). Contractor participants were the Boeing Phantom Works in Huntsville, AL, Lockheed Martin Advanced Technology Center in Palo Alto, CA, ENTECH, Inc. in Keller, TX, and the University of AL Huntsville (UAH). MRHE's technical objectives were to mature: (a) lightweight, efficient, high-voltage, radiation-resistant solar power generation (SPG) technologies; (b) innovative, lightweight, efficient thermal management systems; (c) efficient, 100kW-class, high-voltage power delivery systems from an SPG to an electric thruster system; (d) autonomous rendezvous and docking technology for in-space assembly of modular, reconfigurable spacecraft; (e) robotic assembly of modular space systems; and (f) modular, reconfigurable distributed avionics technologies. Maturation of these technologies was to be implemented through a series of increasingly-inclusive laboratory demonstrations that would have integrated and demonstrated two systems-of-systems: (a) the autonomous rendezvous and docking of modular spacecraft with deployable structures, robotic assembly, reconfiguration both during assembly and (b) the development and integration of an advanced thermal heat pipe and a high-voltage power delivery system with a representative lightweight high-voltage SPG array. In addition, an integrated simulation testbed would have been developed containing software models representing the technologies being matured in the laboratory demos. The testbed would have also included models for non-MRHE developed subsystems such as electric propulsion, so that end-to-end performance could have been assessed. This paper presents an overview of the MRHE Phase I activities at MSFC and its contractor partners. One of the major Phase I accomplishments is the assembly demonstration in the Lockheed Martin Advanced Technology Center (LMATC) Robot-Satellite facility, in which three robot-satellites successfully demonstrated rendezvous & docking, self-assembly, reconfiguration, adaptable GN&C, deployment, and interfaces between modules. Phase I technology maturation results from ENTECH include material recommendations for radiation hardened Stretched Lens Array (SLA) concentrator lenses, and a design concept and test results for a hi-voltage PV receiver. UAH's accomplishments include Supertube heatpipe test results, which support estimates of thermal conductivities at 30,000 times that of an equivalent silver rod. MSFC performed systems trades and developed a preliminary concept design for a 100kW-class modular reconfigurable solar electric propulsion transport vehicle, and Boeing Phantom Works in Huntsville performed assembly and rendezvous and docking trades. A concept animation video was produced by SAIC, wllich showed rendezvous and docking and SLA-square-rigger deployment in LEO.

Carrington, Connie↗
DOE OSTI2022

Autothermal Chemical Looping Oxidative Dehydrogenation of Ethane: Redox Catalyst Performance, Longevity, and Process Analysis

Energy-efficient upgrading of stranded ethane from shale gas to olefins holds the promise of increasing the supply of useful chemical feedstocks while reducing flaring-based CO 2 emissions. Previously, we reported a modular ethane-to-liquids (M-ETL) system based on a chemical looping oxidative dehydrogenation (CL-ODH) scheme. In this article, we present long-term (>1200 h) results of Li 2 CO 3 -promoted La 0.8 Sr 0.2 FeO 3 corresponding to ~4125 CL-ODH cycles in a large laboratory-scale packed bed reactor. Temperature monitoring along the bed length confirmed the exothermicity of both the oxidative dehydrogenation and regeneration steps, enabling an autothermal operation. Product gas analysis indicated that the redox catalyst maintains a high C 2+ selectivity (~90%) and ethane conversion (~67%) at 735 °C after continuous cycling of >1000 h. As a result, product distributions and heats of reactions were used to update our M-ETL process model for revised techno-economic analysis, demonstrating that the current system is economically viable with relatively low required selling prices across a wide range of operating scenarios.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2018

NBIC Biofeeds: Deploying a New, Digital Tool for Open Source Biosurveillance across Federal Agencies

The National Biosurveillance Integration Center (NBIC) is deploying a scalable, flexible open source data collection, analysis, and dissemination tool to support biosurveillance operations by the U.S. Department of Homeland Security (DHS) and its federal interagency partners.IntroductionNBIC integrates, analyzes, and distributes key information about health and disease events to help ensure the nation’s responses are well-informed, save lives, and minimize economic impact. To meet its mission objectives, NBIC utilizes a variety of data sets, including open source information, to provide comprehensive coverage of biological events occurring across the globe. NBIC Biofeeds is a digital tool designed to improve the efficiency of analyzing large volumes of open source reporting and increase the number of relevant insights gleaned from this dataset. Moreover, the tool provides a mechanism to disseminate tailored, electronic message notifications in near-real time so that NBIC can share specific information of interest to its interagency partners in a timely manner. NBIC intends to implement operational use of the capability in FY 2018. The core components of the system are data collection, curation, and dissemination of information deemed important by NBIC subject matter experts. NBIC Biofeeds has captured information from more than 70,000 unique sources published from around the globe and presents, on average, 9,000 new biosurveillance-relevant articles to users each day. NBIC leverages a variety of data feeds, including third party aggregators like Google and subscription-based feeds such as HealthMap, as well as Really Simple Syndication (RSS) feeds and web-scraping of highly relevant sources. The NBIC biosurveillance taxonomy imbedded in the tool consists of more than 600 metadata targets that cover key information for understanding the significance of an active biological event, including etiologic agents, impact to humans and animals (e.g., infection severity, healthcare workers involved, type of host), social disruption, infrastructure strain, countermeasures engaged, and ‘red flag’ characteristics (e.g., pathogen appearance in a new geographic area, unusual clinical signs). This taxonomy serves as a foundation for data curation and can be tailored by NBIC partners to more directly meet their own mission objectives. At this time, metadata is predominately captured by NBIC analysts, who manually tag information, which triggers the population of three automatically-disseminated products from the tool: 1) the NBIC Daily Biosurveillance Review, 2) immediate and daily summary email notifications, and 3) custom-designed RSS feeds. These products are meant for individual recipients in the federal interagency and for consumption by other biosurveillance information technology systems, such as the Department of Defense, Defense Threat Reduction Agency (DTRA) Biosurveillance Ecosystem (BSVE). NBIC is working in partnership with DTRA to integrate NBIC Biofeeds as an application directly into the BSVE and further develop the BSVE as an all-in-one platform for biosurveillance data analytics. To improve the efficiency and effectiveness of gaining insights using NBIC Biofeeds, developers of the tool at the Pacific Northwest National Laboratory (PNNL) are researching and testing a variety of advanced analytics techniques focused on: 1) article relevancy ratings to improve the review of queried data, 2) significance ratings to elucidate the perceived severity of an event based on reported characteristics, 3) full-text article retrieval and storage for improved machine-tagging, and 4) anomaly detection for emerging threats. Testing and implementation of new analytic capabilities in NBIC Biofeeds is planned for this fiscal year. NBIC Biofeeds was developed to serve as a sophisticated and powerful open source biosurveillance technology of value to the federal government by providing information to stakeholders conducting open source biosurveillance as well as those consuming biosurveillance information. In FY 2018, NBIC Biofeeds will begin operational use by NBIC and an initial set of users in various federal agencies. User accounts for testing purposes will be available to other federal partners, and a broad scope of federal stakeholders can receive products directly from NBIC Biofeeds based on their interests. NBIC Biofeeds is expected to enable more rapid recognition and enhanced analysis of emerging biological events by NBIC analysts. NBIC anticipates other federal agencies with biosurveillance missions will find this technology of value and intends to offer use of the platform to those federal partners that can benefit from access to the tool and information generated from NBIC Biofeeds.

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