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At least 613 records · Page 34

Quantifying Platelet Margination in Diabetic Blood Flow

According to this article, patients with type 2 diabetes mellitus (T2DM) develop thrombotic abnormalities strongly associated with cardiovascular diseases. In addition to the changes of numerous coagulation factors such as elevated levels of thrombin and fibrinogen, the abnormal rheological effects of red blood cells (RBCs) and platelets flowing in blood are crucial in platelet adhesion and thrombus formation in T2DM. An important process contributing to the latter is the platelet margination. We employ the dissipative particle dynamics method to seamlessly model cells, plasma, and vessel walls. We perform a systematic study on RBC and platelet transport in cylindrical vessels by considering different cell shapes, sizes, and RBC deformabilities in healthy and T2DM blood, as well as variable flowrates and hematocrit. In particular, we use cellular-level RBC and platelet models with parameters derived from patient-specific data and present a sensitivity study. We find T2DM RBCs, which are less deformable compared to normal RBCs, lower the transport of platelets toward the vessel walls, whereas platelets with higher mean volume (often observed in T2DM) lead to enhanced margination. Furthermore, increasing the flowrate or hematocrit enhances platelet margination. We also investigated the effect of platelet shape and observed a nonmonotonic variation with the highest near-wall concentration corresponding to platelets with a moderate aspect ratio of 0.38. We examine the role of white blood cells (WBCs), whose count is increased notably in T2DM patients. We find that WBC rolling or WBC adhesion tends to decrease platelet margination due to hydrodynamic effects. To the best of our knowledge, such simulations of blood including all blood cells have not been performed before, and our quantitative findings can help separate the effects of hydrodynamic interactions from adhesive interactions and potentially shed light on the associated pathological processes in T2DM such as increased inflammatory response, platelet activation and adhesion, and ultimately thrombus formation.

Biophysics↗

Machine learning materials physics: Surrogate optimization and multi-fidelity algorithms predict precipitate morphology in an alternative to phase field dynamics

Machine learning has been effective at detecting patterns and predicting the response of systems that behave free of natural laws. Examples include learning crowd dynamics, recommender systems and autonomous mobility. There also have been applications to the search for new materials that draw upon big-data classification problems. Though, when it comes to physical systems governed by conservation laws, the role of machine learning has been more limited. Here, we present our recent work in exploring the role of machine learning methods in discovering, or aiding, the search for physics. Specifically, we focus on using machine learning algorithms to represent high-dimensional free energy surfaces with the goal of identifying precipitate morphologies in alloy systems. Traditionally, this problem has been approached by combining phase field models, which impose first-order dynamics, with elasticity, to traverse a free energy landscape in search of minima. Equilibrium precipitate morphologies occur at these minima. Here, we exploit the machine learning methods to represent high-dimensional data, combined with surrogate optimization, sensitivity analysis and multifidelity modeling as an alternate framework to explore phenomena controlled by energy extremization. This combination of data-driven methods offers an alternative to the imposition of first-order dynamics via phase field methods, and represents one aspect of applying machine learning to materials physics.

42 ENGINEERING↗

Effect of soot concentration on radiative transport in a 2 m JP-8 pool fire

Hubbard et al. (2024) investigated conjugate heat transfer in a 7.9 m JP-8 pool fire, utilizing both heavily sooting and non-sooting fuel models. Their findings indicated that all models produced pool radiative heat fluxes within the measurement uncertainty for large-scale outdoor experiments. This study aims to further investigate the influence of soot concentration on radiative transport. To this end, Large Eddy Simulations (LES) of a 2 m diameter JP-8 pool fire were conducted, employing four turbulent combustion chemistry models: the Eddy Dissipation Concept (EDC) and three variants of flamelet model. Additionally, three variations of the one-equation subgrid scale turbulence kinetic energy model, and multiple mesh resolutions were utilized. The primary validation metrics were pool radiative heat flux and plume radiative fraction, with simulation data compared to experimental results published by Blanchat et al. (2010). The EDC model produced high soot concentrations near the pool surface, resulting in a significant shielding effect. In contrast, the flamelet combustion model has different kinetic limiters for soot production, leading to soot formation higher in the flame, where it can be more readily oxidized. Flamelet models incorporating both acetylene and benzene contributions to soot growth demonstrated better agreement with experimental data. To assess the sensitivity of pool radiative heat flux to soot mass concentration, we used a one-dimensional approximation over a wide range of soot concentrations and compared it to three-dimensional solutions obtained using Discrete Ordinates. Furthermore, this analysis illustrates the impacts of soot shielding and Turbulence Radiation Interactions (TRI), with TRI emission enhancement factors predicted to be in the range of 3–5 near the edges of the plume.

Computational fluid dynamics↗

Growth and characterization of different human rhinovirus C types in three-dimensional human airway epithelia reconstituted in vitro

New molecular diagnostic tools have recently allowed the discovery of human rhinovirus species C (HRV-C) that may be overrepresented in children with lower respiratory tract complications. Unlike HRV-A and HRV-B, HRV-C cannot be propagated in conventional immortalized cell lines and their biological properties have been difficult to study. Recent studies have described the successful amplification of HRV-C15, HRV-C11, and HRV-C41 in sinus mucosal organ cultures and in fully differentiated human airway epithelial cells. Consistent with these studies, we report that a panel of clinical HRV-C specimens including HRV-C2, HRV-C7, HRV-C12, HRV-C15, and HRV-C29 types were all capable of mediating productive infection in reconstituted 3D human primary upper airway epithelial tissues and that the virions enter and exit preferentially through the apical surface. Similar to HRV-A and HRV-B, our data support the acid sensitivity of HRV-C. We observed also that the optimum temperature requirement during HRV-C growth may be type-dependent. - Highlights: • A 3D human upper airway epithelia reconstituted in vitro supports HRV-C growth. • HRV-Cs enter and exit preferentially at the apical side of this ALI culture system. • HRV-Cs are acid sensitive. • Temperature sensitivity may be type-dependent for HRV-Cs.

60 APPLIED LIFE SCIENCES↗

Femtosecond time-resolved two-photon photoemission studies of ultrafast carrier relaxation in Cu2O photoelectrodes

Abstract Cuprous oxide (Cu 2 O) is a promising material for solar-driven water splitting to produce hydrogen. However, the relatively small accessible photovoltage limits the development of efficient Cu 2 O based photocathodes. Here, femtosecond time-resolved two-photon photoemission spectroscopy has been used to probe the electronic structure and dynamics of photoexcited charge carriers at the Cu 2 O surface as well as the interface between Cu 2 O and a platinum (Pt) adlayer. By referencing ultrafast energy-resolved surface sensitive spectroscopy to bulk data we identify the full bulk to surface transport dynamics for excited electrons rapidly localized within an intrinsic deep continuous defect band ranging from the whole crystal volume to the surface. No evidence of bulk electrons reaching the surface at the conduction band level is found resulting into a substantial loss of their energy through ultrafast trapping. Our results uncover main factors limiting the energy conversion processes in Cu 2 O and provide guidance for future material development.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Planck intermediate results. XXII. Frequency dependence of thermal emission from Galactic dust in intensity and polarization

Planck has mapped the intensity and polarization of the sky at microwave frequencies with unprecedented sensitivity. We use these data to characterize the frequency dependence of dust emission. We utilize the Planck 353 GHz I, Q, and U Stokes maps as dust templates, and cross-correlate them with the Planck and WMAP data at 12 frequencies from 23 to 353 GHz, over circular patches with 10° radius. The cross-correlation analysis is performed for both intensity and polarization data in a consistent manner. The conclusions are corrected for the chance correlation between the templates and the anisotropies of the cosmic microwave background. We use a mask that focuses our analysis on the diffuse interstellar medium at intermediate Galactic latitudes. We determine the spectral indices of dust emission in intensity and polarization between 100 and 353 GHz, for each sky patch. Both indices are found to be remarkably constant over the sky. The mean values, 1.59 ± 0.02 for polarization and 1.51 ± 0.01 for intensity, for a mean dust temperature of 19.6 K, are close, but significantly different (3.6σ). We determine the mean spectral energy distribution (SED) of the microwave emission, correlated with the 353 GHz dust templates, by averaging the results of the correlation over all sky patches. We find that the mean SED increases for decreasing frequencies at ν< 60 GHz for both intensity and polarization. The rise of the polarization SED towards low frequencies may be accounted for by a synchrotron component correlated with dust, with no need for any polarization of the anomalous microwave emission. We use a spectral model to separate the synchrotron and dust polarization and to characterize the spectral dependence of the dust polarization fraction. The polarization fraction (p) of the dust emission decreases by (21 ± 6)% from 353 to 70 GHz. We discuss this result within the context of existing dust models. The decrease in p could indicate differences in polarization efficiency among components of interstellar dust (e.g., carbon versus silicate grains). Our observational results provide inputs to quantify and optimize the separation between Galactic and cosmological polarization.

79 ASTRONOMY AND ASTROPHYSICS↗

Cataloging accreted stars within Gaia DR2 using deep learning

The goal of this study is to present the development of a machine learning based approach that utilizes phase space alone to separate the Gaia DR2 stars into two categories: those accreted onto the Milky Way from those that are in situ. Traditional selection methods that have been used to identify accreted stars typically rely on full 3D velocity, metallicity information, or both, which significantly reduces the number of classifiable stars. The approach advocated here is applicable to a much larger portion of Gaia DR2. Methods. A method known as “transfer learning” is shown to be effective through extensive testing on a set of mock Gaia catalogs that are based on the F IRE cosmological zoom-in hydrodynamic simulations of Milky Way-mass galaxies. The machine is first trained on simulated data using only 5D kinematics as inputs and is then further trained on a cross-matched Gaia /RAVE data set, which improves sensitivity to properties of the real Milky Way. Results. The result is a catalog that identifies ~767 000 accreted stars within Gaia DR2. This catalog can yield empirical insights into the merger history of the Milky Way and could be used to infer properties of the dark matter distribution.

Astronomy & Astrophysics↗

Origin of additional spectral features in modulated reflectance spectra of 2-dimensional semiconductor systems

High resolution photoreflectance (PR) spectroscopy study on a single GaAs/AlGaAs quantum well representing a two-dimensional (2D) system, shows additional distinct spectral features on the high energy side of the first confined heavy-hole and light-hole exciton transitions. The PR experiments involved a special dual detection technique which significantly improved the measurement sensitivity. Photoluminescence excitation spectroscopy data on the sample showed broadened step-like features around these energies. A detailed lineshape analysis, including first principles simulations, was performed to understand the origins of these additional PR spectral features. They are shown to arise primarily from inhomogeneously broadened first excited state transition of the excitons, rather than from a change in the joint density of states at the exciton continuum edge. The analysis suggests that such features are more likely in the case of 2D excitons as compared to 3D excitons in bulk material. Apart from its significance for post-growth characterization, identification of these additional PR features enables direct estimation of the exciton binding energy.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Early time implosion symmetry from two-axis shock-timing measurements on indirect drive NIF experiments

An innovative technique has been developed and used to measure the shock propagation speed along two orthogonal axes in an inertial confinement fusion indirect drive implosion target. This development builds on an existing target and diagnostic platform for measuring the shock propagation along a single axis. A 0.4 mm square aluminum mirror is installed in the ablator capsule which adds a second orthogonal view of the x-ray-driven shock speeds. The new technique adds capability for symmetry control along two directions of the shocks launched in the ablator by the laser-generated hohlraum x-ray flux. Laser power adjustments in four different azimuthal cones based on the results of this measurement can reduce time-dependent symmetry swings during the implosion. Analysis of a large data set provides experimental sensitivities of the shock parameters to the overall laser delivery and in some cases shows the effects of laser asymmetries on the pole and equator shock measurements.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

MESA MODELS OF CLASSICAL NOVA OUTBURSTS: THE MULTICYCLE EVOLUTION AND EFFECTS OF CONVECTIVE BOUNDARY MIXING

Novae are cataclysmic variables driven by accretion of H-rich material onto a white dwarf (WD) star from its low-mass main-sequence binary companion. New time-domain observational capabilities, such as the Palomar Transient Factory and Pan-STARRS, have revealed a diversity of their behavior that should be theoretically addressed. Nova outbursts depend sensitively on nuclear physics data, and more readily available nova simulations are needed in order to effectively prioritize experimental effort in nuclear astrophysics. In this paper, we use the MESA stellar evolution code to construct multicycle nova evolution sequences with CO WD cores. We explore a range of WD masses and accretion rates as well as the effect of different cooling times before the onset of accretion. In addition, we study the dependence on the elemental abundance distribution of accreted material and convective boundary mixing at the core-envelope interface. Models with such convective boundary mixing display an enrichment of the accreted envelope with C and O from the underlying WD that is commensurate with observations. We compare our results with the previous work and investigate a new scenario for novae with the {sup 3}He-triggered convection.

79 ASTRONOMY AND ASTROPHYSICS↗

REDSHIFT 6.4 HOST GALAXIES OF 10{sup 8} SOLAR MASS BLACK HOLES: LOW STAR FORMATION RATE AND DYNAMICAL MASS

We present Atacama Large Millimeter Array observations of rest-frame far-infrared continuum and [C II] line emission in two z = 6.4 quasars with black hole masses of Almost-Equal-To 10{sup 8} M{sub Sun }. CFHQS J0210-0456 is detected in the continuum with a 1.2 mm flux of 120 {+-} 35 {mu}Jy, whereas CFHQS J2329-0301 is undetected at a similar noise level. J2329-0301 has a star formation rate limit of <40 M{sub Sun} yr{sup -1}, considerably below the typical value at all redshifts for this bolometric luminosity. Through comparison with hydro simulations, we speculate that this quasar is observed at a relatively rare phase where quasar feedback has effectively shut down star formation in the host galaxy. [C II] emission is also detected only in J0210-0456. The ratio of [C II] to far-infrared luminosity is similar to that of low-redshift galaxies of comparable luminosity, suggesting that the previous finding of an offset in the relationships between this ratio and far-infrared luminosity at low and high redshifts may be partially due to a selection effect due to the limited sensitivity of previous continuum data. The [C II] line of J0210-0456 is relatively narrow (FWHM = 189 {+-} 18 km s{sup -1}), indicating a dynamical mass substantially lower than expected from the local black hole-velocity dispersion correlation. The [C II] line is marginally resolved at 0.''7 resolution with the blue and red wings spatially offset by 0.''5 (3 kpc) and a smooth velocity gradient of 100 km s{sup -1} across a scale of 6 kpc, possibly due to the rotation of a galaxy-wide disk. These observations are consistent with the idea that stellar mass growth lags black hole accretion for quasars at this epoch with respect to more recent times.

79 ASTRONOMY AND ASTROPHYSICS↗

THE INNER DISK STRUCTURE, DISK-PLANET INTERACTIONS, AND TEMPORAL EVOLUTION IN THE β PICTORIS SYSTEM: A TWO-EPOCH HST/STIS CORONAGRAPHIC STUDY

We present deep Hubble Space Telescope/Space Telescope Imaging Spectrograph coronagraphic images of the β Pic debris disk obtained at two epochs separated by 15 yr. The new images and the re-reduction of the 1997 data provide the most sensitive and detailed views of the disk at optical wavelengths as well as the yet smallest inner working angle optical coronagraphic image of the disk. Our observations characterize the large-scale and inner-disk asymmetries and we identify multiple breaks in the disk radial surface brightness profile. We study in detail the radial and vertical disk structure and show that the disk is warped. We explore the disk at the location of the β Pic b super-Jupiter and find that the disk surface brightness slope is continuous between 0.''5 and 2.''0, arguing for no change at the separations where β Pic b orbits. The two epoch images constrain the disk's surface brightness evolution on orbital and radiation pressure blow-out timescales. We place an upper limit of 3% on the disk surface brightness change between 3'' and 5'', including the locations of the disk warp, and the CO and dust clumps. We discuss the new observations in the context of high-resolution multi-wavelength images and divide the disk asymmetries in two groups: axisymmetric and non-axisymmetric. The axisymmetric structures (warp, large-scale butterfly, etc.) are consistent with disk structure models that include interactions of a planetesimal belt and a non-coplanar giant planet. The non-axisymmetric features, however, require a different explanation.

79 ASTRONOMY AND ASTROPHYSICS↗

A critical assessment of stellar mass measurement methods

This is the second paper in a series aimed at investigating the main sources of uncertainty in measuring the observable parameters in galaxies from their spectral energy distributions (SEDs). In the first paper we presented a detailed account of the photometric redshift measurements and an error analysis of this process. In this paper we perform a comprehensive study of the main sources of random and systematic error in stellar mass estimates for galaxies, and their relative contributions to the associated error budget. Since there is no prior knowledge of the stellar mass of galaxies (unlike their photometric redshifts), we use mock galaxy catalogs with simulated multi-waveband photometry and known redshift, stellar mass, age and extinction for individual galaxies. The multi-waveband photometry for the simulated galaxies were generated in 13 filters spanning from U-band to mid-infrared wavelengths. Given different parameters affecting stellar mass measurement (photometric signal-to-noise ratios (S/N), SED fitting errors and systematic effects), the inherent degeneracies and correlated errors, we formulated different simulated galaxy catalogs to quantify these effects individually. For comparison, we also generated catalogs based on observed photometric data of real galaxies in the Great Observatories Origins Deep Survey-South field, spanning the same passbands. The simulated and observed catalogs were provided to a number of teams within the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey collaboration to estimate the stellar masses for individual galaxies. A total of 11 teams participated, with different combinations of stellar mass measurement codes/methods, population synthesis models, star formation histories, extinction and age. For each simulated galaxy, the differences between the input stellar masses, M{sub input}, and those estimated by each team, M{sub est}, is defined as Δlog(M)≡log(M{sub estimated})−log(M{sub input}), and used to identify the most fundamental parameters affecting stellar mass estimate in galaxies, with the following results. (1) No significant bias in Δ log(M) was found among different codes, with all having comparable scatter (σ(Δlog(M))=0.136 dex). The estimated stellar mass values are seriously affected by low photometric S/N, with the rms scatter increasing for galaxies with H{sub AB}>26 mag; (2) A source of error contributing to the scatter in Δ log(M) is found to be due to photometric uncertainties (0.136 dex) and low resolution in age and extinction grids when generating the SED templates; (3) The median of stellar masses among different methods provides a stable measure of the mass associated with any given galaxy (σ(Δlog(M))=0.142 dex); (4) The Δ log(M) values are strongly correlated with deviations in age (defined as the difference between the estimated and expected values), with a weaker correlation with extinction; (5) The rms scatter in the estimated stellar masses due to free parameters (after fixing redshifts and initial mass function) are quantified and found to be σ(Δlog(M))=0.110 dex; (6) Using the observed data, we studied the sensitivity of stellar masses to both the population synthesis codes and inclusion of nebular emission lines and found them to affect the stellar mass by 0.2 and 0.3 dex respectively.

79 ASTRONOMY AND ASTROPHYSICS↗

On detecting oscillations of gamma rays into axion-like particles in turbulent and coherent magnetic fields

Background radiation fields pervade the Universe, and above a certain energy any γ-ray flux emitted by an extragalactic source should be attenuated due to e{sup +}e{sup -} pair production. The opacity could be alleviated if photons oscillated into hypothetical axion-like particles (ALPs) in ambient magnetic fields, leading to a γ-ray excess especially at high optical depths that could be detected with imaging air Cherenkov telescopes (IACTs). Here, we introduce a method to search for such a signal in γ-ray data and to estimate sensitivities for future observations. Different magnetic fields close to the γ-ray source are taken into account in which photons can convert into ALPs that then propagate unimpeded over cosmological distances until they re-convert in the magnetic field of the Milky Way. Specifically, we consider the coherent field at parsec scales in a blazar jet as well as the turbulent field inside a galaxy cluster. For the latter, we explicitly derive the transversal components of a magnetic field with gaussian turbulence which are responsible for the photon-ALP mixing. To illustrate the method, we apply it to a mock IACT array with characteristics similar to the Cherekov Telescope Array and investigate the dependence of the sensitivity to detect a γ-ray excess on the magnetic-field parameters.

79 ASTRONOMY AND ASTROPHYSICS↗

Search for features in the spectrum of primordial perturbations using Planck and other datasets

We reconstruct the power spectrum of primordial curvature perturbations by applying a well-validated non-parametric technique employing Tikhonov regularisation to the first data release from the Planck satellite. To improve the reconstruction on small spatial scales we include data from the ground-based ACT and SPT experiments, the WiggleZ galaxy redshift survey, the CFHTLenS tomographic weak lensing survey, and spectral analysis of the Lyman-α forest. The reconstructed scalar spectrum (assuming the standard ΛCDM cosmology) is not scale-free but has an infrared cutoff at k ≲ 5 × 10{sup -4} Mpc{sup -1} and several (2−3)σ features, of which two at wavenumber k/Mpc{sup -1} 0.0018 and 0.057 had been seen already in WMAP data. A higher significance feature at k ∼ 0.12 Mpc{sup -1} is indicated by Planck data, but may be sensitive to the systematic uncertainty around multipole ℓ ∼ 1800 in the 217×217 GHz cross-spectrum. In any case accounting for the 'look elsewhere' effect decreases its global significance to ∼2σ.

79 ASTRONOMY AND ASTROPHYSICS↗

Lifetime study of the ColdADC for the Deep Underground Neutrino Experiment

ColdADC is a custom ASIC digitizer implemented in 65 nm CMOS technology using specialized techniques for long-term reliability in cryogenic environments. ColdADC was developed for use in the DUNE Far Detector complex, which will consist of four liquid argon time projection chambers. Each contains 17 kilotons liquid argon as the target material in order to measure neutrino oscillations. Approximately 40,000 ColdADC ASICs will be installed for DUNE in the first two large detectors and will be operated at cryogenic temperatures during the experiment without replacement. The lifetime of the ColdADC is a critical parameter affecting the data quality and physics sensitivity of the experiment. A measurement of the lifetime of the ColdADC was carried out, and the results shown in this paper assure orders of magnitude longer lifetime of the ColdADC than the planned operation time of the detectors.

Front-end electronics for detector readout↗

High-fidelity simultaneous detection of a trapped-ion qubit register

Qubit state detection is an important part of a quantum computation. As number of qubits in a quantum register increases, it is necessary to maintain high fidelity detection to accurately measure the multi-qubit state. Here we present experimental demonstration of high-fidelity detection of a multi-qubit trapped ion register with average single qubit detection error of 4.2(1.5) ppm and a 4-qubit state detection error of 17(2) ppm, limited by the decay lifetime of the qubit, using a novel single-photon-sensitive camera with fast data collection, excellent temporal and spatial resolution, and low instrumental crosstalk.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Exploring theoretical uncertainties in the hydrodynamic description of relativistic heavy-ion collisions

We explore theoretical uncertainties in the hydrodynamic description of relativistic heavy-ion collisions by examining the full nonlinear causality conditions and quantifying the second-order transport coefficients' role on flow observables. The causality conditions impose physical constraints on the maximum allowed values of inverse Reynolds numbers during the hydrodynamic evolution. Including additional second-order gradient terms in the Denicol-Niemi-Molnár-Rischke (DNMR) theory significantly shrinks the casual regions compared to those in the Israel-Stewart hydrodynamics. For Au + Au collisions, we find the variations of flow observables are small with and without imposing the necessary causality conditions, suggesting a robust extraction of the quark-gluon plasma's transport coefficients in previous model-to-data comparisons. However, sizable sensitivity is present in small p + Au collisions, which poses challenges to study the small systems' collectivity.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗