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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 613 records · Page 34
All sourcesNASA NTRSDOE OSTI
NASA NTRS2012

New Therapeutic Window of Regenerative Opportunity in Diabetic Retinopathy by VESGEN Analysis

Vascular pattern may serve as a useful new biomarker principle of complex, multi-scale signaling in pathological, physiological angiogenesis and microvascular remodeling. Each angiogenesis stimulator or inhibitor we have analyzed, including VEGF, bFGF, TGF-beta1, angiostatin and triamcinolone acetonide, has induced a novel "fingerprint" or "signature" biomarker vascular pattern that is spatio-temporally unique. Remodeling vasculature thereby provides an informative read-out of dominant molecular signaling, when analyzed by innovative, fractal-based VESsel GENeration (VESGEN) Analysis software. Using VESGEN to analyze ophthalmic clinical vascular images, we recently introduced a potential paradigm shift to the understanding of early-stage progression that suggests new regenerative opportunities for human diabetic retinopathy (DR), the major blinding disease for working-aged adults. In a pilot study, we discovered that angiogenesis oscillates as a surprising, homeostatic-like regeneration of retinal vessels during early progression of DR (IOVS 51(1):498). Results suggest that the term non-proliferative DR may be a misnomer. In new studies, normalization of the vasculature will be determined from the response of vascular pattern to therapeutic monitoring and treatment. We have mapped and quantified in vivo experimental models of angiogenesis, lymphangiogenesis and intravital blood flow from cellular/molecular to higher systems levels that include a murine model of infant retinopathy of prematurity (ROP); developing and pathological coronary and placental-like vessel models; progressive intestinal inflammation, growing murine tumors, and other pathological, physiological and therapeutically treated tissues of transgenic mice and avian embryos. Vascular Alterations, Visual Impairments (VIIP) & Increased Intracranial Pressure (ICP), Immunosuppression & Bone Loss: NASA-defined risk categories for human space exploration and ISS Utilization

Parsons-Wingert, Patricia A.↗
NASA NTRS2014

Petrology and Geochemistry of Unbrecciated Harzburgitic Diogenite MIL 07001: A Window Into Vestan Geological Evolution

There is a strong case that asteroid 4 Vesta is the parent of the howardite, eucrite and diogenite (HED) meteorites. Models developed for the geological evolution of Vesta can satisfy the compositions of basaltic eucrites that dominate in the upper crust. The bulk compositional characteristics of diogenites - cumulate harzburgites and orthopyroxenites from the lower crust - do not fit into global magma ocean models that can describe the compositions of basaltic and cumulate eucrites. Recent more detailed formation models do make provision for a more complicated origin for diogenites, but this model has yet to be completely vetted. Compositional studies of bulk samples has led to the hypothesis that many diogenites were formed late by interaction of their parent melts with a eucritic crust, but those observations may alternatively be explained by subsolidus equilibration of trace elements between orthopyroxene and plagioclase and Ca-phosphate in the rocks. Differences in radiogenic Mg-26 content between diogenites and eucrites favors early formation of the former, not later formation. Understanding the origin of diogenites is crucial for understanding the petrologic evolution of Vesta. We have been doing coordinated studies of a suite of diogenites including petrologic investigations, bulk rock major and trace element studies, and in situ trace element analyses of orthopyroxene. Here we will focus on an especially unusual, and potentially key, diogenite, MIL 07001.

Mittlefehldt, D. W.↗
NASA NTRS2013

Appendix 2. Guide for Running AgMIP Climate Scenario Generation Tools with R in Windows, Version 2.3

This Guide explains how to create climate series and climate change scenarios by using the AgMip Climate team's methodology as outlined in the AgMIP Guide for Regional Assessment: Handbook of Methods and Procedures. It details how to: install R and the required packages to run the AgMIP Climate Scenario Generation scripts, and create climate scenarios from CMIP5 GCMs using a 30-year baseline daily weather dataset. The Guide also outlines a workflow that can be modified for application to your own climate data.

handbooks↗
NASA NTRS2015

Laser Radar Through the Window (LRTW) Coordinate Correction Method

A method for corrections of measurements of points of interests measured by beams of radiation propagating through stratified media including performance of ray-tracing of at least one ray lunched from a metrology instrument in a direction of an apparent point of interest, calculation a path length of the ray through stratified medium, and determination of coordinates of true position of the point interest using the at least one path length and the direction of propagation of the ray.

Hayden, Joseph Ethan↗
NASA NTRS2018

Time and Laser Ranging: A Window of Opportunity for Geodesy, Navigation and Metrology

Recent progress in the domain of time and frequency (T/F) standards requires important improvements of existing time distribution links. Among these, the accuracy of time transfer is actually an important part of the concerns in order to establish and maintain time & space references from ground and/or space facilities. Several time transfers by laser link projects have been carried out over the past 10 years with numerous scientific and metrological objectives. Satellite Laser ranging (SLR) has proven to be a fundamental tool, offering a straightforward, conceptually simple, highly accurate and unambiguous observable. Depending on the mission, LR is used to transmit time over two-way or one-way distances from 500 to several millions of km. The following missions and their objectives employed this technique: European Laser Timing (ELT) at 450 km, Time Transfer by Laser Link (T2L2) at 1,336 km, Laser Time Transfer (LTT) at 36,000 km, Lunar Reconnaissance Orbiter (LRO) at 350,000 km, and MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) at tens of million km. This article describes the synergy between SLR and T/F technologies developed on the ground and in space and as well as the state of the art of their exploitation. The performance and sources of limitation of such space missions are analyzed. It shows that current and future challenges lie in the improvement of the time accuracy and stability of the time for ground geodetic observatories. The role of the next generation of SLR systems is emphasized both in space and at ground level, from the point of view of GGOS and valuable exploitation of the synergy between time synchronization, ranging and data transfer.

P. Exertier↗
NASA NTRS2018

Time and Laser Ranging: A Window of Opportunity for Geodesy, Navigation, and Meteorology

Recent progress in the domain of time and frequency (T/F) standards requires important improvements in existing timedistribution links, in term of accuracy in particular. Satellite Laser Ranging (SLR) has proven to be a fundamental tool,offering a straightforward, conceptually simple, highly accurate, and unambiguous observable. Several time transfers by laserlink projects have been carried out over the past 10 years with numerous scientific and metrological objectives. Depending on the mission, SLR is used to transmit time over two-way or one-way distances from 500 to several millions of kilometers.The following missions and their objectives employed this technique: European Laser Timing (ELT, expected in 2020) at 450 km, Time Transfer by Laser Link (T2L2) at 1336 km, Laser Time Transfer at 36,000 km, Lunar Reconnaissance Orbiter at 350,000 km, and MErcury Surface, Space ENvironment, GEochemistry, and Ranging at tens of million km. This article describes the synergy between SLR and T/F technologies developed on the ground and in space and as well as the state of the art of their exploitation. The performance and sources of limitation of such space missions are analyzed. It shows that currentand future challenges lie in the improvement in the time accuracy and stability of the time for ground geodetic observatories.The role of the next generation of SLR systems is emphasized both in space and at ground level, from the point of view of Global Geodetic Observing System and valuable exploitation of the synergy between time synchronization, ranging, and data transfer.

Laser ranging↗
NASA NTRS2018

A Window in the Future of Planetary Surface Navigation

The presentation focuses on surface navigation and mapping challenges in planetary environments including Lunar and Martian surface. Imagery from precursor orbital missions are processed to provide a medium resolution, large coverage 2D and 3D maps used by the science and navigation teams. During the surface mission these mapping products together with the images captured from the on-board camera systems are used in rover localization and navigation.

planetary exploration↗
NASA NTRS2012

A Robust Initialization Scheme for a Lateral Trajectory Optimization Problem with Time of Arrival Windows

We present a robust initialization scheme that estimates parameter values for the numerical solution of a two-point boundary value problem. The two-point boundary value problem formulation stems from the optimization of a cost functional subject to the dynamics of a simplified lateral aircraft model and other constraints. Leveraging regular perturbation methods, initial parameter estimates are analytically determined and used to initialize a gradient descent optimization routine which is shown to rapidly converge over a range of initial aircraft positions and heading angles. Additionally, the velocity of the aircraft is optimized to ensure the trajectory of the aircraft terminates within a desired region in both time and space.

lateral trajectory optimization↗
NASA NTRS2016

Metabolic Control Technology: Through the Windows of Space Exploration

As human presence in space will likely extend throughout the solar system, upmass and power constraints will become of paramount importance in considering logistics of transporting experimental animals and humans into space. Life support costs will be a significant part of the mission payload. One solution may be to take advantage of the emerging science of metabolic control, which allows the metabolism of animals to be reduced to a minimal level for a period of time, and allows for subsequent restoration to normal levels. Integration of a hibernation system within deep space mission architecture will solve many problems associated with long-duration space missions, such as payload cost reduction, space flight duration logistics, and demonstrate the potential application of this technology for human astronauts.

Griko, Yuri↗