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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 649 records · Page 36
All sourcesNASA NTRSDOE OSTI
NASA NTRS2011

CPRIT/Johnson Space Center, September, 2011 (Cancer Prevention and Research Institute of Texas)

JSC researchers study carcinogenesis, cancer prevention and treatment along with epidemiological (primarily retrospective and longitudinal) studies, modeling, and interactions with the environment such as radiation, nutritional, and endocrine changes related to space flight along with behaviors such as smoking. Cancer research is a major focus for human space flight due to the exposure to space radiation which consists of particles of varying charges and energies, and secondary neutrons. The JSC laboratories collaborate with investigators from the U.S. as well as our European and Japanese partners. We use accelerator facilities at the Brookhaven National Laboratory, Loma Linda University and Los Alamos National Laboratory that generate high energy charged particles and neutrons to simulate cosmic radiation and solar particle events. The research using cultured cells and animals concentrates on damage and repair from the level of DNA to organ tissues, due to exposure to simulated space radiation exposure, that contribute to the induction of leukemia and solid tumors in most major tissues such as lung, colon, liver and breast. The goal of the research is to develop a mathematical model that can predict cancer morbidity and mortality risks with sufficient accuracy for a given space mission.

Davis, Jeffrey↗
NASA NTRS2017

Detection of DNA Damage by Space Radiation in Human Fibroblasts Flown on the International Space Station

Space radiation consists of energetic charged particles of varying charges and energies. Exposure of astronauts to space radiation on future long duration missions to Mars, or missions back to the Moon, is expected to result in deleterious consequences such as cancer and comprised central nervous system (CNS) functions. Space radiation can also cause mutation in microorganisms, and potentially influence the evolution of life in space. Measurement of the space radiation environment has been conducted since the very beginning of the space program. Compared to the quantification of the space radiation environment using physical detectors, reports on the direct measurement of biological consequences of space radiation exposure have been limited, due primarily to the low dose and low dose rate nature of the environment. Most of the biological assays fail to detect the radiation effects at acute doses that are lower than 5 centiSieverts. In a recent study, we flew cultured confluent human fibroblasts in mostly G1 phase of the cell cycle to the International Space Station (ISS). The cells were fixed in space after arriving on the ISS for 3 and 14 days, respectively. The fixed cells were later returned to the ground and subsequently stained with the gamma-H2AX (Histone family, member X) antibody that are commonly used as a marker for DNA damage, particularly DNA double strand breaks, induced by both low-and high-linear energy transfer radiation. In our present study, the gamma-H2AX (Histone family, member X) foci were captured with a laser confocal microscope. To confirm that some large track-like foci were from space radiation exposure, we also exposed, on the ground, the same type of cells to both low-and high-linear energy transfer protons, and high-linear energy transfer Fe ions. In addition, we exposed the cells to low dose rate gamma rays, in order to rule out the possibility that the large track-like foci can be induced by chronic low-linear energy transfer radiation.

Lu, Tao↗
NASA NTRS1989

Boundary-Value Problem For Magnetic-Cutoff Rigidities

Field equations yield overview of motions of many charged particles. Alternative approach developed for calculation of magnetic cutoff rigidities of electrically-charged particles in static magnetic field. New formulation involves partial differential field equation treated as boundary-value problem. Tracing of trajectories needed only to supply boundary conditions.

Edmonds, Larry D.↗
NASA NTRS1976

Dynamics of the Jovian magnetosphere and energetic particle radiation

Inferences are drawn from Jovian magnetosphere data acquired in the flybys of Pioneer 10 and Pioneer 11. Data on the outer magnetosphere and the inner core, and on observed 10-hr variations in particle intensity, are summarized, with attention given to the immense size and complexity of the magnetosphere and the behavior of trapped charged particles. The data support the maintenance and acceleration of charged particles trapped in Jupiter's magnetic field by inward diffusion in violation of the third adiabatic invariant. Prodigious quantities of high-energy particles are found to escape from Jupiter into interplanetary space, and MHD waves in the circumjovian plasma are considered. Whether the 10-hr variations are spatial or temporal in origin is weighed in favor of the latter. Production and loss mechanisms for the particles, and the nature of the Jovian magnetosphere itself, are noted among questions remaining obscure.

Simpson, J. A.↗
NASA NTRS1991

Magnetic radiation shielding - An idea whose time has returned?

One solution to the problem of shielding crew from particulate radiation in space is to use active electromagnetic shielding. Practical types of shield include the magnetic shield, in which a strong magnetic field diverts charged particles from the crew region, and the magnetic/electrostatic plasma shield, in which an electrostatic field shields the crew from positively charged particles, while a magnetic field confines electrons from the space plasma to provide charge neutrality. Advances in technology include high-strength composite materials, high-temperature superconductors, numerical computational solutions to particle transport in electromagnetic fields, and a technology base for construction and operation of large superconducting magnets. These advances make electromagnetic shielding a practical alternative for near-term future missions.

Landis, Geoffrey A.↗
NASA NTRS1979

The stability of water on Io

Various processes have been examined to determine their impact on water loss from Io and the formation of an anhydrous surface. Thermal escape, photolysis, and gas-phase charged particle interactions are shown to be unimportant. Recent laboratory experiments have shown that charged-particle sputtering is likely to be an effective mechanism for the removal of water ice from Io's surface. Vaporization of ice by meteoroid impacts may also be significant. The overall sputtering rate appears to be sufficiently high that the formation of a substantial regolith due to meteoroid bombardment will be prevented. However, meteoroid bombardment is probably capable of maintaining a thin (about 500 microns) overturned surface layer from which all free water has been removed by sputtering. Alternatively, a thick anhydrous surface layer may have formed on Io as the result of primordial heating. The survival of such a layer to the present implies the absence of subsequent water evolution onto the surface of the satellite.

Pilcher, C. B.↗
NASA NTRS1994

Fiber-Optic Ammeter

In addition to fiber-optic loop, apparatus includes stable source of coherent light and high-resolution optical receiver. Magnetic field generated by electric current measured via Faraday effect. Developed to measure electric currents and/or magnetic fields in outer space as part of effort to determine number densities and directions of movement of electrically charged particles; loop of low-loss optical fiber made large enough so number of charged particles encircled adaquate for measurement. Apparatus also used on Earth in noncontact measurements of electric currents.

Wyntjes, Geert↗
NASA NTRS2014

Faraday Cup Array Integrated with a Readout IC and Method for Manufacture Thereof

A detector array and method for making the detector array. The array includes a substrate including a plurality of trenches formed therein, and includes a plurality of collectors electrically isolated from each other, formed on the walls of the trenches, and configured to collect charge particles incident on respective ones of the collectors and to output from said collectors signals indicative of charged particle collection. The array includes a plurality of readout circuits disposed on a side of the substrate opposite openings to the collectors. The readout circuits are configured to read charge collection signals from respective ones of the plurality of collectors.

Bower, Christopher A.↗
NASA NTRS2014

Comparison of Model Calculations of Biological Damage from Exposure to Heavy Ions with Measurements

The space environment consists of a varying field of radiation particles including high-energy ions, with spacecraft shielding material providing the major protection to astronauts from harmful exposure. Unlike low-LET gamma or X rays, the presence of shielding does not always reduce the radiation risks for energetic charged-particle exposure. Dose delivered by the charged particle increases sharply at the Bragg peak. However, the Bragg curve does not necessarily represent the biological damage along the particle path since biological effects are influenced by the track structures of both primary and secondary particles. Therefore, the ''biological Bragg curve'' is dependent on the energy and the type of the primary particle and may vary for different biological end points. Measurements of the induction of micronuclei (MN) have made across the Bragg curve in human fibroblasts exposed to energetic silicon and iron ions in vitro at two different energies, 300 MeV/nucleon and 1 GeV/nucleon. Although the data did not reveal an increased yield of MN at the location of the Bragg peak, the increased inhibition of cell progression, which is related to cell death, was found at the Bragg peak location. These results are compared to the calculations of biological damage using a stochastic Monte-Carlo track structure model, Galactic Cosmic Ray Event-based Risk Model (GERM) code (Cucinotta, et al., 2011). The GERM code estimates the basic physical properties along the passage of heavy ions in tissue and shielding materials, by which the experimental set-up can be interpreted. The code can also be used to describe the biophysical events of interest in radiobiology, cancer therapy, and space exploration. The calculation has shown that the severely damaged cells at the Bragg peak are more likely to go through reproductive death, the so called "overkill".

Kim, Myung-Hee Y.↗
NASA NTRS1983

Voyager 2 observations of energetic particle variations in the Ganymede wake region - A possible acceleration mechanism

Voyager 2's passage through the downstream corotation region of Ganymede found disturbances in the field and particle environment. Large fluctuations in the intensities and energy spectra of ions in the 0.1-to 4.0-MeV interval were also observed with the low energy charged particle experiment. All ion species were evidently affected, up through medium (C, N, O) nuclei. Electrons intensities, while disturbed, did not behave similarly to the ions. These effects are probably associated with the wake produced by the absorption of Jovian magnetospheric corotating plasma by Ganymede. A two-dimensional theoretical model for perturbed field in the wake region is proposed and it is shown by direct numerical simulation of exact particle trajectories that such perturbations are capable of modulating the charged particle energies to about the observed amount for the observed magnetic and plasma parameters. Analysis shows that the energization process is dependent on the pitch angles of the energetic ions and the process itself is nonadiabatic (the Larmor radius is approximately the size of the disturbance region).

Tariq, G.F.↗
NASA NTRS2005

In Vitro Experimental Model to Investigate the Biological Effects across the Bragg Curve of High-LET Radiation

The space environment consists of a varying field of radiation particles including high energy ions, with a spacecrafts shielding material providing the only major protection to astronauts from harmful exposure. Unlike lowLET gamma or Xrays, the presence of shielding does not always reduce the radiation risks for energetic charged particle exposure since the dose delivered by the charged particle increases sharply as the particle approaches the end of its range, a position known as the Bragg peak and the correlating spatial dose distribution identified as the Bragg curve. The Bragg curve does not necessarily represent the biological damage along the particle traversal since biological effects are influenced by the track structure of both primary and secondary particles. Therefore, the biological Bragg curve is dependent of the energy and the type of the primary particle, and may vary for different biological endpoints. Here we describe a unique irradiation geometry and experimental system to measure the biological response across the Bragg curve in one consistent biological sample. Polyethylene shielding was used to achieve a Bragg curve distribution with the beam geometry parallel to a monolayer of fibroblast cells. We present data that highlights the differential formation of DNA double strand breaks (DSBs) and chromosomal deletions across the Bragg curve in human fibroblasts irradiated with 600 MeV/nucleon iron ion beams. Qualitative analyses of gammaH2AX fluorescence, a known marker of DSBs, indicated potentially increased clustering of DNA damage before the Bragg peak, enhanced homogenous distribution at the peak, and provided visual evidence of high linear energy transfer (LET) particle traversal of cells beyond the Bragg peak in agreement with one-dimensional transport approximations. A biological response curve generated for micronuclei induction across the Bragg curve for 600 MeV/n Fe ions did not reveal an increase in the yield of micronuclei at the Bragg peak location. Assessment of such biological parameters employing the described in vitro experimental system may provide improved platforms to measure a number of biological consequences of shielding materials across the Bragg curve for high charge and energy (HZE) ions.

Desai, N.↗
NASA NTRS1980

Io and its plasma environment

The interaction of Io with its plasma torus and the Jovian magnetic field is described and examined in the context of several currently popular models. Three specific matters are addressed. First, features implied by sub-Alfvenic flow which must be common to all models are discussed. Next, the magnetic signature observed near Io by the Goddard Space Flight Center Voyager 1 magnetometer is examined and it is pointed out that the preliminary estimate of 5,000,000 A current may be an overestimate. Good fits are obtained with alternative current distributions which yield currents as small as 700,000 A through Io. The best fits are obtained for an Alfven Mach number of 0.15, but good fits are also found for Alfven Mach numbers between 0.1 and 0.25. Lastly, the crucial role of charged particle data for probing the near Io interaction is pointed out. Published data from the low energy charged particle (LECP) detector are made to suggest that Io has an intrinsic magnetic field of magnitude comparable with earlier estimates. Predictions are made which can test this picture as further data become available.

Southwood, D. J.↗
NASA NTRS2014

High Density Faraday Cup Array or Other Open Trench Structures and Method of Manufacture Thereof

A detector array and method for making the detector array. The detector array includes a substrate including a plurality of trenches formed therein, and a plurality of collectors electrically isolated from each other, formed on the walls of the trenches, and configured to collect charged particles incident on respective ones of the collectors and to output from the collectors signals indicative of charged particle collection. In the detector array, adjacent ones of the plurality of trenches are disposed in a staggered configuration relative to one another. The method forms in a substrate a plurality of trenches across a surface of the substrate such that adjacent ones of the trenches are in a staggered sequence relative to one another, forms in the plurality of trenches a plurality of collectors, and connects a plurality of electrodes respectively to the collectors.

Bower, Christopher A.↗
NASA NTRS1972

Measurement on the lunar surface of impact-produced plasma clouds.

Simultaneous enhancements of low-energy ions and negative-particle fluxes due to the impact of the Apollo 14 lunar module were observed by the lunar-based charged-particle lunar-environment experiment (CPLEE). The impact occurred 66 km away from CPLEE, and the time delay between impact and flux onset was approximately 1 min. It is argued that the observed charged particles could not have energized at the instant of impact but rather that the impact produced expanding gas clouds and that constituents of these clouds were ionized and accelerated by some continuously active acceleration mechanism. It is further shown that the acceleration mechanism could not have been a static electric field but rather is possibly a consequence of interaction between the solar wind and the gas cloud.

Reasoner, D. L.↗
NASA NTRS2006

Induction of micronuclei in human fibroblasts across the Bragg curve of energetic heavy ions

The space environment consists of a varying field of radiation particles including high energy ions, with spacecraft shielding material providing the major protection to astronauts from harmful exposure. Unlike low-L or X-rays, the presence of shielding does not always reduce the radiation risks for energetic charged particle exposure. Although the dose delivered by the charged particle increases sharply as the particle approaches the Bragg peak, the Bragg curve does not necessarily represent the biological damage along the particle traversal. The "biological Bragg curve" is dependent on the energy and the type of the primary particle, and may vary for different biological endpoints. To investigate "biological Bragg curves", we analyzed micronuclei (MN) induction along the particle traversal of Si and Fe ions at incident energies of 300 MeV/nucleon and 1 GeV/nucleon. A quantitative biological response curve did not reveal an increased yield of MN at the location of the Bragg peak. However, the ratio of mono-to bi-nucleated cells, which indicates inhibition in cell progression, increased at the Bragg peak location. These results confirm the hypothesis that "over kill" at the Bragg peak will affect the outcome of other biological endpoints.

Hada, Megumi↗
NASA NTRS1978

The nuclear and ionic charge distribution particle experiments on the ISEE-1 and ISEE-C spacecraft

The ISEE-1 and ISEE-C instruments are designed to measure the elemental abundances, charge state composition, energy spectra, and angular distributions of energetic ions in the energy range 2 keV/charge to 80 MeV/nucleon and electrons between 75 and 1300 keV. The instrument consists of three sensor systems: (1) ULECA which is an electrostatic deflection system with rectangular solid-state detectors for the 3-560 keV/charge range; (2) ULEWATT which is a double dE/dX vs E thin-window flowthrough proportional counter/solid-state detector telescope for the 0.2-80 MeV/nucleon (Fe) range; and (3) ULEZEQ which is a combination of an electrostatic deflection analyzer and a thin-window dE/dX vs E system with thin-window proportional counter and position-sensitive solid-state detector. The applications of the instruments to solar and interplanetary phenomena and to magnetospheric acceleration and trapped particles are discussed.

Hovestadt, D.↗
NASA NTRS2006

Induction of Micronuclei in Human Fibroblasts across the Bragg Curve of Energetic Si and Fe Ions

The space environment consists of a varying field of radiation particles including high-energy ions, with spacecraft shielding material providing the major protection to astronauts from harmful exposure. Unlike low-LET gamma or X-rays, the presence of shielding does not always reduce the radiation risks for energetic charged particle exposure. Since the dose delivered by the charged particle increases sharply as the particle approaches the end of its range, a position known as the Bragg peak, the Bragg curve does not necessarily represent the biological damage along the particle traversal since biological effects are influenced by the track structure of both primary and secondary particles. Therefore, the biological Bragg curve is dependent on the energy and the type of the primary particle, and may vary for different biological endpoints. We studied micronuclei (MN) induction across the Bragg curve of Si and Fe ions at incident energies of 300 MeV/nucleon and 1 GeV/nucleon. A quantitative biological response curve did not reveal an increased yield of MN at the location of the Bragg peak. However, the ratio of mono- to bi-nucleated cells, which indicates inhibition in cell progression, increased at the Bragg peak location. These results confirm the hypothesis that severely damaged cells at the Bragg peak are likely to go through reproduction death.

Wu, H.↗