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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 649 records · Page 36
All sourcesNASA NTRSDOE OSTI
NASA NTRS2012

Small-Scale Mechanical Characterization of Space-Exposed Fluorinated Ethylene Propylene Recovered from the Hubble Space Telescope

Multi-layer insulation panels from the Hubble Space Telescope have been recovered after 19.1 years of on-orbit service and micro-tensile experiments have been performed to characterize the effect of space exposure on the mechanical response of the outermost layer. This outer layer, 127 m thick fluorinated ethylene propylene with a 100 nm thick vapor deposited aluminum reflective coating, maintained significant tensile ductility but exhibited a degradation of strength that scales with severity of space exposure. This change in properties is attributed to damage from incident solar flux, atomic oxygen damage, and thermal cycling.

Jones, J. S.↗
NASA NTRS2012

Induction of Cell Death through Alteration of Oxidants and Antioxidants in Epithelial Cells Exposed to High Energy Protons

Radiation affects several cellular and molecular processes including double strand breakage, modifications of sugar moieties and bases. In outer space, protons are the primary radiation source which poses a range of potential health risks to astronauts. On the other hand, the use of proton radiation for tumor radiation therapy is increasing as it largely spares healthy tissues while killing tumor tissues. Although radiation related research has been conducted extensively, the molecular toxicology and cellular mechanisms affected by proton radiation remain poorly understood. Therefore, in the present study, we irradiated rat epithelial cells (LE) with different doses of protons and investigated their effects on cell proliferation and cell death. Our data showed an inhibition of cell proliferation in proton irradiated cells with a significant dose dependent activation and repression of reactive oxygen species (ROS) and antioxidants, glutathione and superoxide dismutase respectively as compared to control cells. In addition, apoptotic related genes such as caspase-3 and -8 activities were induced in a dose dependent manner with corresponding increased levels of DNA fragmentation in proton irradiated cells than control cells. Together, our results show that proton radiation alters oxidant and antioxidant levels in the cells to activate apoptotic pathway for cell death.

Ramesh, Govindarajan↗
NASA NTRS2013

Analysis of International Space Station Vehicle Materials Exposed on Materials International Space Station Experiment from 2001 to 2011

Since August 2001, the Materials on International Space Station Experiment (MISSE) has provided data on a variety of materials and spacecraft components, including samples chosen to provide sustaining engineering and life extension data for the International Space Station vehicle itself. This Technical Publication is by no means a complete set of MISSE data but does provide changes in solar absorptance, infrared emittance, and visual appearance due to atomic oxygen, ultraviolet radiation, and thermal cycling in vacuum. Conversion coatings, anodizes, thermal control coatings with organic and inorganic binders, multilayer insulation components, optical materials, and part markings are discussed.

Finckenor, M. M.↗
NASA NTRS2014

Modeling of Blood Lead Levels in Astronauts Exposed to Lead from Microgravity-Accelerated Bone Loss

Human exposure to lead has been associated with toxicity to multiple organ systems. Studies of various population groups with relatively low blood lead concentrations (<10 μg/dL) have indicated associations of blood lead level with lower cognitive test scores in children, later onset of puberty in girls, and increased blood pressure and cardiovascular mortality rates in adults. Cognitive effects are considered by regulatory agencies to be the most sensitive endpoint at low doses. Although ~95% of the body burden of lead is stored in the bones, the adverse effects of lead correlate with the concentration of lead in the blood better than with that in the bones. NASA has found that prolonged exposure to microgravity during spaceflight results in a significant loss of bone minerals, the extent of which varies from individual to individual and from bone to bone, but generally averages about 0.5% per month. During such bone loss, lead that had been stored in bones would be released along with calcium. The effects on the concentration of lead in the blood (PbB) of various concentrations of lead in drinking water (PbW) and of lead released from bones due to accelerated osteoporosis in microgravity, as well as changes in exposure to environmental lead before, during, and after spaceflight were evaluated using a physiologically based pharmacokinetic (PBPK) model that incorporated exposure to environmental lead both on earth and in flight and included temporarily increased rates of osteoporosis during spaceflight.

Garcia, H.↗
NASA NTRS2014

Persistent Expression Changes of Fibrosis Related Genes in the Lung Tissues of Rats Exposed to Lunar Dust Particles

The Moon's surface is covered by a layer of reactive dust, containing 1-2% of respirable fine dust (< 3 microns). The habitable area of any lunar landing vehicle would inevitably be contaminated with lunar dust that could pose a health risk. The purpose of the study is to evaluate the toxicity of Apollo moon dust in rodents through inhalation to assess the health risk of dust exposures to humans and to identify the mechanisms and potential pathways involved in lunar dust-induced toxicity. Ccl3, Ccl12, Cxcl2, Cxcl5, Itgb8, Tnf, Ldhc, Clec4e, Bmp7, and Smad6, showed persistently significant expression changes in the lung tissue. The expression of several of these genes were dose- and time- dependent, and were significantly correlated with other pathological. Our previous data showed that no pathological changes were detected in low dose groups. However, several genes, primarily produced by lung epithelial, were significantly altered persistently in response to low-dose dust exposure. The data presented in this study, for the first time, explores the molecular mechanisms of lunar dust induced toxicity, contributing not only the risk assessment for future space exploration, but also understandings of the dust-induced toxicity to humans on earth.

Zhang, Ye↗
NASA NTRS2014

Immune Alterations in Rats Exposed to Airborne Lunar Dust

The lunar surface is covered by a layer of fine, reactive dust. Very little is known regarding the toxicity of lunar dust on human physiology. This study assessed the toxicity of airborne lunar dust exposure in rats on pulmonary and systemic immune parameters.

Crucian, Brian↗
NASA NTRS2014

The 2011 Outburst of Recurrent Nova T Pyx: X-Ray Observations Expose the White Dwarf Mass and Ejection Dynamics

The recurrent nova T Pyx underwent its sixth historical outburst in 2011, and became the subject of an intensive multi-wavelength observational campaign.We analyze data from the Swift and Suzaku satellites to produce a detailed X-ray light curve augmented by epochs of spectral information. X-ray observations yield mostly non-detections in the first four months of outburst, but both a super-soft and hard X-ray component rise rapidly after Day 115. The super-soft X-ray component, attributable to the photosphere of the nuclear-burning white dwarf, is relatively cool (approximately 45 electron volts) and implies that the white dwarf in T Pyx is significantly below the Chandrasekhar mass (approximately 1 M). The late turn-on time of the super-soft component yields a large nova ejecta mass (approximately greater than 10(exp −5) solar mass), consistent with estimates at other wavelengths. The hard X-ray component is well fit by a approximately 1 kiloelectron volt thermal plasma, and is attributed to shocks internal to the 2011 nova ejecta. The presence of a strong oxygen line in this thermal plasma on Day 194 requires a significantly super-solar abundance of oxygen and implies that the ejecta are polluted by white dwarf material. The X-ray light curve can be explained by a dual-phase ejection, with a significant delay between the first and second ejection phases, and the second ejection finally released two months after outburst. A delayed ejection is consistent with optical and radio observations of T Pyx, but the physical mechanism producing such a delay remains a mystery.

nova T Pyx↗
NASA NTRS2015

Exposing Microorganisms in the Stratosphere for Planetary Protection Project

Earths stratosphere is similar to the surface of Mars: rarified air which is dry, cold, and irradiated. E-MIST is a balloon payload that has 4 independently rotating skewers that hold known quantities of spore-forming bacteria isolated from spacecraft assembly facilities at NASA. Knowing the survival profile of microbes in the stratosphere can uniquely contribute to NASA Planetary Protection for Mars.Objectives 1. Collect environmental data in the stratosphere to understand factors impacting microbial survival. 2. Determine of surviving microbes (compared to starting quantities). 3. Examine microbial DNA mutations induced by stratosphere exposure.

Technology Portfolio System↗
NASA NTRS2017

Exposing the Strategies that Can Reduce the Obstacles: Improving the Science User Experience

It is now well established that pursuing generic solutions to what seem are common problems in Earth science data access and use can often lead to disappointing results for both system developers and the intended users. This presentation focuses on real-world experience of managing a large and complex data system, NASAs Earth Science Data and Information Science System (EOSDIS), whose mission is to serve both broad user communities and those in smaller niche applications of Earth science data and services. In the talk, we focus on our experiences with known data user obstacles characterizing EOSDIS approaches, including various technological techniques, for engaging and bolstering, where possible, user experiences with EOSDIS. For improving how existing and prospective users discover and access NASA data from EOSDIS we introduce our cross-archive tool: Earthdata Search. This new search and order tool further empowers users to quickly access data sets using clever and intuitive features. The Worldview data visualization tool is also discussed highlighting how many users are now performing extensive data exploration without necessarily downloading data. Also, we explore our EOSDIS data discovery and access webinars, data recipes and short tutorials, targeted technical and data publications, user profiles and social media as additional tools and methods used for improving our outreach and communications to a diverse user community. These efforts have paid substantial dividends for our user communities by allowing us to target discipline specific community needs. The desired take-away from this presentation will be an improved understanding of how EOSDIS has approached, and in several instances achieved, removing or lowering the barriers to data access and use. As we look ahead to more complex Earth science missions, EOSDIS will continue to focus on our user communities, both broad and specialized, so that our overall data system can continue to serve the needs of science and applications users.

communications↗
NASA NTRS2017

Exposing NASA's Earth Observations to the Applications Community and Public

NASA's Earth Observing System (EOS) generates a wealth of data products which are generally intended for scientific research. In recent years, however, this data has also become more accessible to the applications community and public through the Worldview app and Global Imagery Browse Services (GIBS). These mapping interfaces provide historical and near real time access to NASA's Earth observations for a wide range of uses. This presentation will focus on how the applications community, public, and media use these interfaces for decision-making, leisure, and anything in between.

web mappin↗
NASA NTRS2016

Exposing Hidden Parts of the SE Process: MBSE Patterns and Tools for Tracking and Traceability

An interesting benefit of applying Model-Based Systems Engineering (MBSE) is that the rigor and coordination intrinsic to MBSE forces us to apply Systems Engineering to our own traditional activities, processes, and products, which results in richer, more expressive models, more powerful reasoning, and a clearer and more effective Systems Engineering (SE) process. Our MBSE frameworks and languages contain semantic richness sufficient to describe our systems at any particular point in time, often with an emphasis on the description of the system at major milestones. This is unarguably a real asset. However, when we apply MBSE in service of missions that are in development, rapidly evolving, of a larger scale, and where interpersonal communication is a critical part of the design process, we discover that our frameworks and languages are still not quite rich enough to enable us to ask the kinds of questions and get the kinds of answers we want in order to address the concerns of day to day work. This paper will discuss some patterns and tools we have developed to help address some of the not-always-explicit SE concerns that we have identified through our MBSE work. Particularly, this paper will discuss flexible yet practical methods for defining and capturing maturity, workflow, and agreement traceability within our system models, extensible ways to perform and track model audits, and ways to report and interact with this knowledge in the context of MBSE applied to support NASA’s Europa Project.

Jackson, Maddalena↗
NASA NTRS2016

Exposing Hidden Parts of the SE Process: MBSE Patterns and Tools for Tracking and Traceability

An interesting benefit of applying Model-Based Systems Engineering (MBSE) is that the rigor and coordination intrinsic to MBSE forces us to apply Systems Engineering to our own traditional activities, processes, and products, which results in richer, more expressive models, more powerful reasoning, and a clearer and more effective Systems Engineering (SE) process. Our MBSE frameworks and languages contain semantic richness sufficient to describe our systems at any particular point in time, often with an emphasis on the description of the system at major milestones. This is unarguably a real asset. However, when we apply MBSE in service of missions that are in development, rapidly evolving, of a larger scale, and where interpersonal communication is a critical part of the design process, we discover that our frameworks and languages are still not quite rich enough to enable us to ask the kinds of questions and get the kinds of answers we want in order to address the concerns of day to day work. This paper will discuss some patterns and tools we have developed to help address some of the not-always-explicit SE concerns that we have identified through our MBSE work. Particularly, this paper will discuss flexible yet practical methods for defining and capturing maturity, workflow, and agreement traceability within our system models, extensible ways to perform and track model audits, and ways to report and interact with this knowledge in the context of MBSE applied to support NASA’s Europa Project

Jackson, Maddalena↗
NASA NTRS2019

Mice Exposed to Combined Chronic Low-Dose Irradiation and Modeled Microgravity Develop Long-Term Neurological Sequelae

A combination of spaceflight-relevant factors (fluid-shift and radiation) created a different gene expression profile than either factor individually. Some gene pathways including reduced transcriptional machinery, increased neurogenesis and neuropeptide production, and dysregulated cell structure and cell signaling. Gene expression differences can persist for at least 4 months after a 21- day exposure to a combination of fluid-shift and radiation in the brain tissue of mice. Brain-related transcriptional changes are dynamic during readaptation phase from exposure to spaceflight-like conditions, which may lead to long-term neurological consequences.

Overbey, Eliah G.↗
NASA NTRS2019

Mice Exposed to Combined Chronic Low-Dose Irradiation and Modeled Microgravity Develop Long-Term Neurological Sequelae

Spaceflight poses many challenges for humans. Ground-based analogs typically focus on single parameters of spaceflight and their associated acute effects. This study assesses the long-term transcriptional effects following single and combination spaceflight analog conditions using the mouse model, simulated microgravity via hindlimb unloading (HLU) and/or low-dose irradiation (LDR) for 21-days, followed by 4 months of readaptation. Changes in gene expression and epigenetic modifications in whole brain samples during readaptation were analyzed by DESeq2 and reduced representation bisulfite sequencing (RRBS). The results showed minimal gene expression alterations at 4-months within single treatment conditions of HLU and LDR. Following combined HLU+LDR, gene ontology and methylation analyses showed multiple altered pathways involved in neurogenesis and neuroplasticity, regulation of neuropeptides and cellular signaling. In brief, neurological readaptation following combined chronic LDR and HLU is a dynamic process that impacts brain structure and function and may lead to late onset neurological sequelae

Overbey, Eliah G.↗
NASA NTRSDate not supplied

Space Settlement Should Use 1 g Shielded Space Platforms, Not the 1/6 or 1/3 g, Radiation Exposed Moon or Mars

Previous missions have subjected astronauts to confined space, weightlessness, and increased radiation. These impair astronaut comfort, performance, and future health. The exploration and future settlement of space will depend on the long term presence of individual humans. This requires the development of space platforms where humans can work and live in health for many years, perhaps generations. A livable space platform must provide adequate volume, gravity, and radiation shielding. This seems easier to do in deep space or Low Earth Orbit (LEO) than on the surface of the moon or Mars. Permanently habitable deep space platforms will enable scientific and technical research, space tourism, space mission preparation, space industry development, and military surveillance and operations. The first fully habitable space station would probably be located in LEO for convenience and lower cost.

Harry W Jones↗