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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 667 records · Page 37

Quantification of Type I Interferon Inhibition by Viral Proteins: Ebola Virus as a Case Study

Type I interferons (IFNs) are cytokines with both antiviral properties and protective roles in innate immune responses to viral infection. They induce an antiviral cellular state and link innate and adaptive immune responses. Yet, viruses have evolved different strategies to inhibit such host responses. One of them is the existence of viral proteins which subvert type I IFN responses to allow quick and successful viral replication, thus, sustaining the infection within a host. We propose mathematical models to characterise the intra-cellular mechanisms involved in viral protein antagonism of type I IFN responses, and compare three different molecular inhibition strategies. We study the Ebola viral protein, VP35, with this mathematical approach. Approximate Bayesian computation sequential Monte Carlo, together with experimental data and the mathematical models proposed, are used to perform model calibration, as well as model selection of the different hypotheses considered. Finally, we assess if model parameters are identifiable and discuss how such identifiability can be improved with new experimental data.

59 BASIC BIOLOGICAL SCIENCES↗

Modeling of the aerodynamic response to arbitrary aircraft maneuvres - A numerical validation

The regime of validity of an aerodynamic mathematical model, applicable to describe the nonlinear aerodynamic reactions to a delta wing maneuvering at high angles of attack is investigated. An unsteady vortex-lattice method is used to compute the unsteady flowfields, and thus to evaluate the aerodynamic data required by the model, in terms of specified characteristic motions. Time-histories of the aerodynamic responses to complex motions are generated by means of the model and the evaluated aerodynamic data, and are compared with baseline aerodynamic responses obtained from direct vortex-lattice computations. The validity of the mathematical modeling approach for the maneuvering delta wing is demonstrated by the close agreement of the force and moment responses obtained from the two approaches.

Katz, J.↗

Experimental and theoretical investigations of rotating algae biofilm reactors (RABRs): Areal productivity, nutrient recovery, and energy efficiency

Microalgae biofilms have been demonstrated to recover nutrients from wastewater and serve as biomass feedstock for bioproducts. However, there is a need to develop a platform to quantitatively describe microalgae biofilm production, which can provide guidance and insights for improving biomass areal productivity and nutrient uptake efficiency. Here, this paper proposes a unified experimental and theoretical framework to investigate algae biofilm growth on a rotating algae biofilm reactor (RABR). Experimental laboratory setups are used to conduct controlled experiments on testing environmental and operational factors for RABRs. We propose a differential–integral equation‐based mathematical model for microalgae biofilm cultivation guided by laboratory experimental findings. The predictive mathematical model development is coordinated with laboratory experiments of biofilm areal productivity associated with ammonia and inorganic phosphorus uptake by RABRs. The unified experimental and theoretical tool is used to investigate the effects of RABR rotating velocity, duty cycle (DC), and light intensity on algae biofilm growth, areal productivity, nutrient uptake efficiency, and energy efficiency in wastewater treatment. Our framework indicates that maintaining a reasonable light intensity range improves biomass areal productivity and nutrient uptake efficiency. Our framework also indicates that faster RABR rotation benefits biomass areal productivity. However, maximizing the nutrient uptake efficiency requires a reasonably low RABR rotating speed. Energy efficiency is strongly correlated with RABR rotating speed and DC.

09 BIOMASS FUELS↗

Robustness In Suppressing Vibrations With Adaptive Control

Report describes theoretical and experimental study of robustness of adaptive model-reference control scheme designed to suppress vibrations in large, flexible structure. Model can be mathematical model or collection of models approximating dynamics of structure, vibration sensors, and vibration-suppressing actuators.

Ih, Che-Hang C.↗

Modeling the Restraint of Liquid Jets by Surface Tension in Microgravity

An axisymmetric phase field model is developed and used to model surface tension forces on liquid jets in microgravity. The previous work in this area is reviewed and a baseline drop tower experiment selected 'for model comparison. A mathematical model is developed which includes a free surface. a symmetric centerline and wall boundaries with given contact angles. The model is solved numerically with a compact fourth order stencil on a equally spaced axisymmetric grid. After grid convergence studies, a grid is selected and all drop tower tests modeled. Agreement was assessed by comparing predicted and measured free surface rise. Trend wise agreement is good but agreement in magnitude is only fair. Suspected sources of disagreement are suspected to be lack of a turbulence model and the existence of slosh baffles in the experiment which were not included in the model.

Chato, David J.↗

A Method for Calculating the Probability of Successfully Completing a Rocket Propulsion Ground Test

Propulsion ground test facilities face the daily challenges of scheduling multiple customers into limited facility space and successfully completing their propulsion test projects. Due to budgetary and schedule constraints, NASA and industry customers are pushing to test more components, for less money, in a shorter period of time. As these new rocket engine component test programs are undertaken, the lack of technology maturity in the test articles, combined with pushing the test facilities capabilities to their limits, tends to lead to an increase in facility breakdowns and unsuccessful tests. Over the last five years Stennis Space Center's propulsion test facilities have performed hundreds of tests, collected thousands of seconds of test data, and broken numerous test facility and test article parts. While various initiatives have been implemented to provide better propulsion test techniques and improve the quality, reliability, and maintainability of goods and parts used in the propulsion test facilities, unexpected failures during testing still occur quite regularly due to the harsh environment in which the propulsion test facilities operate. Previous attempts at modeling the lifecycle of a propulsion component test project have met with little success. Each of the attempts suffered form incomplete or inconsistent data on which to base the models. By focusing on the actual test phase of the tests project rather than the formulation, design or construction phases of the test project, the quality and quantity of available data increases dramatically. A logistic regression model has been developed form the data collected over the last five years, allowing the probability of successfully completing a rocket propulsion component test to be calculated. A logistic regression model is a mathematical modeling approach that can be used to describe the relationship of several independent predictor variables X(sub 1), X(sub 2),..,X(sub k) to a binary or dichotomous dependent variable Y, where Y can only be one of two possible outcomes, in this case Success or Failure. Logistic regression has primarily been used in the fields of epidemiology and biomedical research, but lends itself to many other applications. As indicated the use of logistic regression is not new, however, modeling propulsion ground test facilities using logistic regression is both a new and unique application of the statistical technique. Results from the models provide project managers with insight and confidence into the affectivity of rocket engine component ground test projects. The initial success in modeling rocket propulsion ground test projects clears the way for more complex models to be developed in this area.

Messer, Bradley P.↗

Simultaneous Sensor and Process Fault Diagnostics for Propellant Feed System

The main objective of this research is to extract fault features from sensor faults and process faults by using advanced fault detection and isolation (FDI) algorithms. A tank system that has some common characteristics to a NASA testbed at Stennis Space Center was used to verify our proposed algorithms. First, a generic tank system was modeled. Second, a mathematical model suitable for FDI has been derived for the tank system. Third, a new and general FDI procedure has been designed to distinguish process faults and sensor faults. Extensive simulations clearly demonstrated the advantages of the new design.

Cao, J.↗

Final Report - Regulatory Considerations for Adaptive Systems

This report documents the findings of a preliminary research study into new approaches to the software design assurance of adaptive systems. We suggest a methodology to overcome the software validation and verification difficulties posed by the underlying assumption of non-adaptive software in the requirementsbased- testing verification methods in RTCA/DO-178B and C. An analysis of the relevant RTCA/DO-178B and C objectives is presented showing the reasons for the difficulties that arise in showing satisfaction of the objectives and suggested additional means by which they could be satisfied. We suggest that the software design assurance problem for adaptive systems is principally one of developing correct and complete high level requirements and system level constraints that define the necessary system functional and safety properties to assure the safe use of adaptive systems. We show how analytical techniques such as model based design, mathematical modeling and formal or formal-like methods can be used to both validate the high level functional and safety requirements, establish necessary constraints and provide the verification evidence for the satisfaction of requirements and constraints that supplements conventional testing. Finally the report identifies the follow-on research topics needed to implement this methodology.

Wilkinson, Chris↗

Predictive Simulation of Gas Adsorption in Fixed-Beds and Limitations due to the Ill-Posed Danckwerts Boundary Condition

The 1-D axially dispersed plug flow model is a mathematical model widely used for the simulation of adsorption processes. Lumped mass transfer coefficients such as the Glueckauf linear driving force (LDF) term and the axial dispersion coefficient are generally obtained by fitting simulation results to the experimental breakthrough test data. An approach is introduced where these parameters, along with the only free parameter in the energy balance equations, are individually fit to specific test data that isolates the appropriate physics. It is shown that with this approach this model provides excellent simulation results for the C02 on zeolite SA sorbent/sorbate system; however, for the H20 on zeolite SA system, non-physical deviations from constant pattern behavior occur when fitting dispersive experimental results with a large axial dispersion coefficient. A method has also been developed that determines a priori what values of the LDF and axial dispersion terms will result in non-physical simulation results for a specific sorbent/sorbate system when using the one-dimensional axially dispersed plug flow model. A relationship between the steepness of the adsorption equilibrium isotherm as indicated by the distribution factor, the magnitude of the axial dispersion and mass transfer coefficient, and the resulting non-physical behavior is derived. This relationship is intended to provide a guide for avoiding non-physical behavior by limiting the magnitude of the axial dispersion term on the basis of the mass transfer coefficient and distribution factor.

Knox, James Clinton↗

Some aspects of mathematical and chemical modeling of complex chemical processes

Some theoretical questions involved in the mathematical modeling of the kinetics of complex chemical process are discussed. The analysis is carried out for the homogeneous oxidation of ethylbenzene in the liquid phase. Particular attention is given to the determination of the general characteristics of chemical systems from an analysis of mathematical models developed on the basis of linear algebra.

Nemes, I.↗

Modeling Specular Exchange Between Concentric Cylinders in a Radiative Shielded Furnace

The objective of this research is to develop and validate mathematical models to characterize the thermal performance of a radiative shielded furnace, the University of Alabama in Huntsville (UAH) Isothermal Diffusion Oven. The mathematical models are validated against experimental data obtained from testing the breadboard oven in a terrestrial laboratory environment. It is anticipated that the validation will produce math models capable of predicting the thermal performance of the furnace over a wide range of operating conditions, including those for which no experimental data is available. Of particular interest is the furnace core temperature versus heater power parametric and the transient thermal response of the furnace. Application to a microgravity environment is not considered, although it is conjectured that the removal of any gravity dependent terms from the math models developed for the terrestrial application should yield adequate results in a microgravity environment. The UAH Isothermal Diffusion Oven is designed to provide a thermal environment that is conducive to measuring the diffusion of high temperature liquid metals. In addition to achieving the temperatures required to melt a sample placed within the furnace, reducing or eliminating convective motions within the melt is an important design consideration [1]. Both of these influences are reflected in the design of the furnace. Reducing unwanted heat losses from the furnace is achieved through the use of low conductivity materials and reflective shielding. As evidenced by the highly conductive copper core used to house the sample within the furnace, convective motions can be greatly suppressed by providing an essentially uniform thermal environment. An oven of this design could ultimately be utilized in a microgravity environment, presumably as a experiment payload. Such an application precipitates other design requirements that limit the resources available to the furnace such as power, mass, volume, and possibly even time. Through the experimental and numerical results obtained, the power requirements and thermal response time of the breadboard furnace are quantified.

Schunk, Richard Gregory↗

Modelling of Blast Furnace with Respective Chemical Reactions in Coke and Ore Burden Layers

The ironmaking blast furnace (BF) is an efficient chemical reactor for producing liquid iron from solid iron ore, where the solids of coke and iron ore are charged in alternative layers and different chemical reactions occur in the two solid layers as they descend. Such respective reacting burden layers have not been considered explicitly in the previous BF models. In this article, a mathematical model based on multi-fluid theory is developed for describing the multiphase reacting flows considering the respective reacting burden layers. Then, this model is applied to a BF, covering the area from the burden surface at the furnace top to the liquid surface above the hearth, to describe the inner states of a BF in terms of the multiphase flows, temperature distribution and reduction process. The results show that some key important features in the layered burden with respective chemical reactions are captured, including fluctuating iso-lines in terms of gas flow and thermochemical behaviours; particularly the latter cannot be well captured in the previous BF models. The temperature difference between gas–solid phases is found to be larger near the raceway, at the cohesive zone and at the furnace top, and the thermal reserved zone can be identified near the shaft. Three chemical reserve zones of hematite, magnetite and wustite can also be observed near the stockline, in the shaft near the wall and near centre, respectively. Inside each reserve zone, the corresponding ferrous oxides stay constantly high in alternative layers; the overall performance indicators including gas utilization efficiency and reduction degree also stay stable in an alternative-layered structure. This model provides a cost-effective tool to investigate the BF in-furnace process and optimize BF operation.

36 MATERIALS SCIENCE↗

Understanding Hepatitis B Virus Dynamics and the Antiviral Effect of Interferon Alpha Treatment in Humanized Chimeric Mice

Whereas the mode of action of lamivudine (LAM) against hepatitis B virus (HBV) is well established, the inhibition mechanism(s) of interferon alpha (IFN-α) is less completely defined. To advance our understanding, we, for this study, mathematically modeled HBV kinetics during 14-day pegylated IFN-α-2a (pegIFN), LAM, or pegIFN-plus-LAM (pegIFN+LAM) treatment of 39 chronically HBV-infected humanized uPA/SCID chimeric mice. Serum HBV DNA and intracellular HBV DNA were measured frequently. We developed a multicompartmental mathematical model and simultaneously fit it to the serum and intracellular HBV DNA data. Unexpectedly, even in the absence of an adaptive immune response, a biphasic decline in serum HBV DNA and intracellular HBV DNA was observed in response to all treatments. Kinetic analysis and modeling indicate that the first phase represents inhibition of intracellular HBV DNA synthesis and secretion, which was similar under all treatments with an overall mean efficacy of 98%. In contrast, there were distinct differences in HBV decline during the second phase, which was accounted for in the model by a time-dependent inhibition of intracellular HBV DNA synthesis, with the steepest decline observed during pegIFN+LAM treatment (1.28/day) and the slowest (0.1/day) during pegIFN monotherapy. Reminiscent of observations in patients treated with pegIFN and/or LAM, a biphasic HBV decline was observed in treated humanized mice in the absence of an adaptive immune response. Interestingly, combination treatment did not increase the initial inhibition of HBV production but rather enhanced second-phase decline, providing insight into the dynamics of HBV treatment response and the mode of action of IFN-α against HBV.

60 APPLIED LIFE SCIENCES↗

The Oxidation Mechanism of Pure Magnesium Powder Particles: A Mathematical Approach

In this study, the mechanism of nonisothermal oxidation of magnesium powder was determined using a tension analysis, which was performed by mathematical modeling and the finite element method. The results revealed that phase transformation of magnesium hydroxide to magnesium oxide in the oxide layer plays an important role in this process so that formation of magnesium hydroxide in the early stages of oxidation (< 450 °C) leads to the formation of compressive stresses through the oxide layer, and as a result, the beginning of measurable oxidation is delayed. The results obtained by the mathematical model and finite element method were validated by the experimental results.

36 MATERIALS SCIENCE↗

A comparison of the results of dynamic wind-tunnel tests with theoretical predictions for an aeromechanical gust-alleviation system for light airplanes

Dynamic wind tunnel tests have been conducted on a 1/6-scale model of a general aviation airplane equipped with an all-mechanical gust alleviation system which uses auxiliary aerodynamic surfaces to drive the flaps. The longitudinal short period motions were studied under simulated gust conditions in order to verify the mathematical model used in a previous study to predict the performance of the full scale system and determine the amount of normal acceleration alleviation which could be attained. The model responses were measured for different configurations with the system active and without the system active for comparison. The tests confirmed the general relationships between the experimental variables and the model responses predicted by the mathematical model, but there were significant differences in the magnitudes of the responses. The experimental results for the model were used to estimate a reduction of 30 percent in the rms normal acceleration response of a similar full scale airplane in atmospheric turbulence.

Stewart, E. C.↗

Wind shear modeling for aircraft hazard definition

Mathematical models of wind profiles were developed for use in fast time and manned flight simulation studies aimed at defining and eliminating these wind shear hazards. A set of wind profiles and associated wind shear characteristics for stable and neutral boundary layers, thunderstorms, and frontal winds potentially encounterable by aircraft in the terminal area are given. Engineering models of wind shear for direct hazard analysis are presented in mathematical formulae, graphs, tables, and computer lookup routines. The wind profile data utilized to establish the models are described as to location, how obtained, time of observation and number of data points up to 500 m. Recommendations, engineering interpretations and guidelines for use of the data are given and the range of applicability of the wind shear models is described.

Frost, W.↗

Thermodynamic Modeling and Optimization of the Copper Flash Converting Process Using the Equilibrium Constant Method

Based on the principle of multiphase equilibrium, a mathematical model of the copper flash converting process was established by the equilibrium constant method, and a computational system was developed with the use of MetCal software platform. The mathematical model was validated by comparing simulated outputs, industrial data, and published data. To obtain high-quality blister copper, a low copper content in slag, and increased impurity removal rate, the model was then applied to investigate the effects of the operational parameters [oxygen/feed ratio (R{sub OF}), flux rate (R{sub F}), and converting temperature (T)] on the product weights, compositions, and the distribution behaviors of impurity elements. The optimized results showed that R{sub OF}, R{sub F}, and T should be controlled at approximately 156 Nm{sup 3}/t, within 3.0 pct, and at approximately 1523 K (1250 °C), respectively.

36 MATERIALS SCIENCE↗