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NASA NTRS1998

The Toll pathway is required in the epidermis for muscle development in the Drosophila embryo

The Toll signaling pathway functions in several Drosophila processes, including dorsal-ventral pattern formation and the immune response. Here, we demonstrate that this pathway is required in the epidermis for proper muscle development. Previously, we showed that the zygotic Toll protein is necessary for normal muscle development; in the absence of zygotic Toll, close to 50% of hemisegments have muscle patterning defects consisting of missing, duplicated and misinserted muscle fibers (Halfon, M.S., Hashimoto, C., and Keshishian, H., Dev. Biol. 169, 151-167, 1995). We have now also analyzed the requirements for easter, spatzle, tube, and pelle, all of which function in the Toll-mediated dorsal-ventral patterning pathway. We find that spatzle, tube, and pelle, but not easter, are necessary for muscle development. Mutations in these genes give a phenotype identical to that seen in Toll mutants, suggesting that elements of the same pathway used for Toll signaling in dorsal-ventral development are used during muscle development. By expressing the Toll cDNA under the control of distinct Toll enhancer elements in Toll mutant flies, we have examined the spatial requirements for Toll expression during muscle development. Expression of Toll in a subset of epidermal cells that includes the epidermal muscle attachment cells, but not Toll expression in the musculature, is necessary for proper muscle development. Our results suggest that signals received by the epidermis early during muscle development are an important part of the muscle patterning process.

Non-NASA Center↗

NASA NTRS1995

Evaluation testing of a portable vapor detector for Part-Per-Billion (PPB) level UDMH and N2H4

Trace level detection of hydrazine (N2H4), monomethyl hydrazine (MMH) and unsymmetrical dimethylhydrazine (UDMH) has been receiving increased attention over the past several years. In May 1995 the American Conference of Government Industrial Hygienists (ACGIH) lowered their acceptable threshold limit value (TLV) from 100 parts-per-billion (ppb) to 10 ppb. Several types of ppb-level detectors are being developed by the United States Air Force (USAF) Space and Missile Systems Center (SMSC). A breadboard version of a portable, lightweight hydrazine detection sensor was developed and produced by Giner Corp. for the USAF. This sensor was designed for ppb level UDMH and N2H4 vapor detection in near real-time. This instrument employs electrochemical sensing, utilizing a three electrode cell with an anion-exchange polymer electrolyte membrane as the only electrolyte in the system. The sensing, counter and reference electrodes are bonded to the membrane forming a single component. The only liquid required to maintain the sensor is deionized water which hydrates the membrane. At the request of the USAF SMSC, independent testing and evaluation of the breadboard instrument was performed at NASA's Toxic Vapor Detection Laboratory (TVDL) for response to ppb-level N2H4 and UDMH and MMH. The TVDL, located at Kennedy Space Center (KSC) has the unique ability to generate calibrated sample vapor streams of N2H4, UDMH, and MMH over a range from less than 10 ppb to thousands of parts per million (ppm) with full environmental control of relative humidity (0-90%) and temperature (0-50 C). The TVDL routinely performs these types of tests. Referenced sensors were subjected to extensive testing, including precision, linearity, response/recovery times, zero and span drift, humidity and temperature effects as well as ammonia interference. Results of these tests and general operation characteristics are reported.

Curran, Dan↗

NASA NTRS1994

New Computer Simulations of Macular Neural Functioning

We use high performance graphics workstations and supercomputers to study the functional significance of the three-dimensional (3-D) organization of gravity sensors. These sensors have a prototypic architecture foreshadowing more complex systems. Scaled-down simulations run on a Silicon Graphics workstation and scaled-up, 3-D versions run on a Cray Y-MP supercomputer. A semi-automated method of reconstruction of neural tissue from serial sections studied in a transmission electron microscope has been developed to eliminate tedious conventional photography. The reconstructions use a mesh as a step in generating a neural surface for visualization. Two meshes are required to model calyx surfaces. The meshes are connected and the resulting prisms represent the cytoplasm and the bounding membranes. A finite volume analysis method is employed to simulate voltage changes along the calyx in response to synapse activation on the calyx or on calyceal processes. The finite volume method insures that charge is conserved at the calyx-process junction. These and other models indicate that efferent processes act as voltage followers, and that the morphology of some afferent processes affects their functioning. In a final application, morphological information is symbolically represented in three dimensions in a computer. The possible functioning of the connectivities is tested using mathematical interpretations of physiological parameters taken from the literature. Symbolic, 3-D simulations are in progress to probe the functional significance of the connectivities. This research is expected to advance computer-based studies of macular functioning and of synaptic plasticity.

Ross, Muriel D.↗

NASA NTRS2014

A Radiation Chemistry Code Based on the Green's Function of the Diffusion Equation

Stochastic radiation track structure codes are of great interest for space radiation studies and hadron therapy in medicine. These codes are used for a many purposes, notably for microdosimetry and DNA damage studies. In the last two decades, they were also used with the Independent Reaction Times (IRT) method in the simulation of chemical reactions, to calculate the yield of various radiolytic species produced during the radiolysis of water and in chemical dosimeters. Recently, we have developed a Green's function based code to simulate reversible chemical reactions with an intermediate state, which yielded results in excellent agreement with those obtained by using the IRT method. This code was also used to simulate and the interaction of particles with membrane receptors. We are in the process of including this program for use with the Monte‐Carlo track structure code Relativistic Ion Tracks (RITRACKS). This recent addition should greatly expand the capabilities of RITRACKS, notably to simulate DNA damage by both the direct and indirect effect.

Plante, Ianik↗

NASA NTRS2014

Performance of Water Recirculation Loop Maintenance Components for the Advanced Spacesuit Water Membrane Evaporator

Water loop maintenance components to maintain the water quality of the Advanced Spacesuit Water Membrane Evaporation (SWME) water recirculation loop have undergone a comparative performance evaluation with a recirculating control loop which had no water quality maintenance. Results show that periodic water maintenance can improve performance of the SWME. The SWME is a heat rejection device under development at the NASA Johnson Space Center to perform thermal control for advanced spacesuits. One advantage of this technology is the potential for a significantly greater degree of tolerance to contamination when compared to the existing sublimator technology. The driver for the evaluation of water recirculation maintenance components was to enhance the robustness of the SWME through the leveraging of fluid loop management lessons learned from the International Space Station (ISS). A patented bed design that was developed for a United Technologies Aerospace System military application provided a low pressure drop means for water maintenance in the SWME recirculation loop. The bed design is coupled with high capacity ion exchange resins, organic adsorbents, and a cyclic methodology developed for the Extravehicular Mobility Unit (EMU) Transport Water loop. The maintenance cycle included the use of a biocide delivery component developed for the ISS to introduce a biocide in a microgravity compatible manner for the Internal Active Thermal Control System (IATCS). The leveraging of these water maintenance technologies to the SWME recirculation loop is a unique demonstration of applying the valuable lessons learned on the ISS to the next generation of manned spaceflight Environmental Control and Life Support System (ECLSS) hardware.

Rector, Tony↗

NASA NTRS2019

Fabrication of Phononic-Isolated Kinetic Inductance Detectors

Kinetic inductance detectors (KID) have received increased interest due to their relative ease of fabrication, low noise, and scalability to large format arrays required by next generation of astronomical telescopes. The development of KIDs has progressed rapidly, with very low noise equivalent power demonstrated by several groups and KIDs arrays implemented in several ground-based and air-borne instruments. In this paper, we describe a new fabrication process which consists of a membrane isolated KID incorporating a phononic bandgap structure tuned to block recombination phonons from escaping to the thermal bath. This architecture is designed to increase the quasi-particle lifetime and results in increased responsivity to signal photons and lower noise. These devices have been fabricated as lumped-element resonators with hafnium inductors and Nb capacitors on low stress silicon nitride and silicon-on-insulator membranes. We discuss the fabrication process, which uses a combination of sub-micron laser based direct write lithography and nanoscale electron beam lithography.

Denis, Kevin L.↗

NASA NTRS2010

Colorimetric Solid Phase Extraction (CSPE): Using Color to Monitor Spacecraft Water Quality

In August 2009, an experimental water quality monitoring kit based on Colorimetric Solid Phase Extraction (CSPE) technology was delivered to the International Space Station (ISS). The kit, called the Colorimetric Water Quality Monitoring Kit (CWQMK), was launched as a Station Development Test Objective (SDTO) experiment to evaluate the suitability of CSPE technology for routine use monitoring water quality on the ISS. CSPE is a sorption-spectrophotometric technique that combines colorimetric reagents, solid-phase extraction, and diffuse reflectance spectroscopy to quantify trace analytes in water samples. In CSPE, a known volume of sample is metered through a membrane disk that has been impregnated with an analyte-specific colorimetric reagent and any additives required to optimize the formation of the analyte-reagent complex. As the sample flows through the membrane disk, the target analyte is selectively extracted, concentrated, and complexed. Formation of the analyte-reagent complex causes a detectable change in the color of the membrane disk that is proportional to the amount of analyte present in the sample. The analyte is then quantified by measuring the color of the membrane disk surface using a hand-held diffuse reflectance spectrophotometer (DRS). The CWQMK provides the capability to measure the ionic silver (Ag +) and molecular iodine (I2) in water samples on-orbit. These analytes were selected for the evaluation of CSPE technology because they are the biocides used in the potable water storage and distribution systems on the ISS. Biocides are added to the potable water systems on spacecraft to inhibit microbial growth. On the United States (US) segment of the ISS molecular iodine serves as the biocide, while the Russian space agency utilizes silver as a biocide in their systems. In both cases, the biocides must be maintained at a level sufficient to control bacterial growth, but low enough to avoid any negative effects on crew health. For example, the presence of high levels of iodine in water can cause taste and odor issues that result in decreased water consumption by the crew. There are also concerns about potential impacts on thyroid function following exposure to high levels of iodine. With silver, there is a risk of developing argyria, an irreversible blue-gray discoloration of the skin, associated with long term consumption of water containing high concentrations of silver. The need to ensure that safe, effective levels of biocide are maintained in the potable water systems on the ISS provides a perfect platform for evaluating the suitability of CSPE technology for in-flight water quality monitoring. This paper provides an overview of CSPE technology and details on the silver and iodine methods used in the CWQMK. It also reports results obtained during in-flight analyses performed with the CWQMK and briefly discusses other potential applications for CSPE technology in both the spacecraft and terrestrial environments.

Gazda, Daniel B.↗

NASA NTRS1988

Performance of high spatial frequency X-ray transmission gratings

The performance of high spatial frequency 'phased' X-ray transmission gratings developed for the High Energy Transmission Grating Spectrometer on the Advanced X-ray Astrophysics FAcility (AXAF) is examined. The gratings tested here nominally consist of 1-micron-thick gold lines of 0.2 micron period covering approximately 5 sq cm of a polyimide membrane. A table-top setup at MIT employs the gratings in reflection to diffract UV (325 nm) laser light. It is used to measure grating periods and indicates that period variations within and between gratings are a few parts in 10,000. Tests performed at the Marshall Space Flight Center 304 m X-ray Facility using 1.5 keV X-rays in transmission corroborate the UV measurements and demonstrate geometrically-limited resolving powers of E/Delta E about 750. Finally, X-ray transmission tests performed in the MIT 25 m X-ray facility provide measurements of period, line thickness, space-to-period ratio, tilt of grating lines, and efficiency.

Fischbach, K. F.↗

NASA NTRS1994

Mars power system concept definition study. Volume 1: Study results

A preliminary top level study was completed to define power system concepts applicable to Mars surface applications. This effort included definition of power system requirements and selection of power systems with the potential for high commonality. These power systems included dynamic isotope, Proton Exchange Membrane (PEM) regenerative fuel cell, sodium sulfur battery, photovoltaic, and reactor concepts. Design influencing factors were identified. Characterization studies were then done for each concept to determine system performance, size/volume, and mass. Operations studies were done to determine emplacement/deployment maintenance/servicing, and startup/shutdown requirements. Technology development roadmaps were written for each candidate power system (included in Volume 2). Example power system architectures were defined and compared on a mass basis. The dynamic isotope power system and nuclear reactor power system architectures had significantly lower total masses than the photovoltaic system architectures. Integrated development and deployment time phasing plans were completed for an example DIPS and reactor architecture option to determine the development strategies required to meet the mission scenario requirements.

Littman, Franklin D.↗

NASA NTRS2004

Curvature-Based Wavefront Sensor for Use on Extended, Arbitrary, Low-Contract Scenes Final Technical Report August 2004

A small amount of work has been done on this project; the strategy to be adopted has been better defined, though no experimental work has been started. 1) Wavefront error signals: The best choice appears use a lenslet array at a pupil image to produce defocused image pairs for each subaperture. Then use the method proposed by Molodij et al. to produce subaperture curvature signals. Basically, this method samples a moderate number of locations in the image where the value of the image Laplacian is high, then taking the curvature signal from the difference of the Laplacians of the extrafocal images at those locations. The tip-tilt error is obtained from the temporal dependence of the first spatial derivatives of an in-focus image, at selected locations where these derivatives are significant. The wavefront tilt can be obtained from the full-aperture image. 2) Extrafocal image generation: The important aspect here is to generate symmetrically defocused images, with dynamically adjustable defocus. The adjustment is needed because larger defocus is required before the feedback loop is closed, and at times when the seeing is worse. It may be that the usual membrane mirror is the best choice, though other options should be explored. 3) Detector: Since the proposed sensor is to work on solar granulation, rather than a point source, an array detector for each subaperture is required. A fast CMOS camera such as that developed by the National Solar Observatory would be a satisfactory choice. 4) Processing: Processing requirements have not been defined in detail, though significantly fewer operations per cycle are required than for a correlation tracker.

LaBonte, Barry J.↗

NASA NTRS2011

Development of Sample Verification System for Sample Return Missions

This paper describes the development of a proof of-concept sample verification system (SVS) for in-situ mass measurement of planetary rock and soil sample in future robotic sample return missions. Our proof-of-concept SVS device contains a 10 cm diameter pressure sensitive elastic membrane placed at the bottom of a sample canister. The membrane deforms under the weight of accumulating planetary sample. The membrane is positioned in proximity to an opposing substrate with a narrow gap. The deformation of the membrane makes the gap to be narrower, resulting in increased capacitance between the two nearly parallel plates. Capacitance readout circuitry on a nearby printed circuit board (PCB) transmits data via a low-voltage differential signaling (LVDS) interface. The fabricated SVS proof-of-concept device has successfully demonstrated approximately 1pF/gram capacitance change

Electrodes↗

NASA NTRS1975

Analytical displacements and vibrations of cantilevered unsymmetric fiber composite laminates

A fiber composite flat cantilever plate that has symmetric and nonsymmetric laminate configurations is theoretically investigated to determine its static and dynamic structural response. The finite element analysis method used includes a unique triangular finite element developed at Lewis for the analysis of fiber composite airfoils. The various responses investigated include tip displacements, natural frequencies, and fundamental mode shapes. The results show that the displacements and the natural frequencies can be in considerable error for nonsymmetric laminate configurations if the membrane-bending coupling is not taken into account. Structural response results obtained from ten laminate configurations are presented in tabular forms and may be used as an aid in selecting laminate configurations for composite airfoils.

Minich, M. D.↗

NASA NTRS2007

Anti-radiation vaccine: Immunologically-based Prophylaxis of Acute Toxic Radiation Syndromes Associated with Long-term Space Flight

Protecting crew from ionizing radiation is a key life sciences problem for long-duration space missions. The three major sources/types of radiation are found in space: galactic cosmic rays, trapped Van Allen belt radiation, and solar particle events. All present varying degrees of hazard to crews; however, exposure to high doses of any of these types of radiation ultimately induce both acute and long-term biological effects. High doses of space radiation can lead to the development of toxicity associated with the acute radiation syndrome (ARS) which could have significant mission impact, and even render the crew incapable of performing flight duties. The creation of efficient radiation protection technologies is considered an important target in space radiobiology, immunology, biochemistry and pharmacology. Two major mechanisms of cellular, organelle, and molecular destruction as a result of radiation exposure have been identified: 1) damage induced directly by incident radiation on the macromolecules they encounter and 2) radiolysis of water and generation of secondary free radicals and reactive oxygen species (ROS), which induce chemical bond breakage, molecular substitutions, and damage to biological molecules and membranes. Free-radical scavengers and antioxidants, which neutralize the damaging activities of ROS, are effective in reducing the impact of small to moderate doses of radiation. In the case of high doses of radiation, antioxidants alone may be inadequate as a radioprotective therapy. However, it remains a valuable component of a more holistic strategy of prophylaxis and therapy. High doses of radiation directly damage biological molecules and modify chemical bond, resulting in the main pathological processes that drive the development of acute radiation syndromes (ARS). Which of two types of radiation-induced cellular lethality that ultimately develops, apoptosis or necrosis, depends on the spectrum of incident radiation, dose, dose rate, and functional conditions of impacted cells/organisms. The administration of an experimental anti-radiation vaccine may provide an immunologically based, adjunct method of prevention or prophylaxis against clinical ARS. The administration of experimental anti-radiation serum (ARS) and the use of the blood dialysis methods, such as immune plasma-sorption, may assist in the clearance of radiation-specific toxins and may enhance established strategies for the mitigation of the biological effects leading to ARS, and should be evaluated for use on exploration-class space missions.

Popov, Dmitri↗

NASA NTRS1992

STS-45 Space Shuttle mission report

The STS-45 Space Shuttle Program Mission Report contains a summary of the vehicle subsystem operations during the forty-sixth flight of the Space Shuttle Program and the eleventh flight of the Orbiter Vehicle Atlantis (OV-104). In addition to the Atlantis vehicle, the flight vehicle consisted of the following: an External Tank (ET) designated as ET-44 (LWT-37); three Space Shuttle main engines (SSME's), which were serial numbers 2024, 2012, and 2028 in positions 1, 2, and 3, respectively; and two Solid Rocket Boosters (SRB's) designated as BI-049. The lightweight redesigned Solid Rocket Motors (RSRM's) installed in each of the SRB's were designated as 360L021A for the left SRM and 360W021B for the right SRM. The primary objective of this mission was to successfully perform the planned operations of the Atmospheric Laboratory for Applications and Science-1 (ATLAS-1) and the Shuttle Solar Backscatter Ultraviolet Instrument (SSBUV) payloads. The secondary objectives were to successfully perform all operations necessary to support the requirements of the following: the Space Tissue Loss-01 (STL-01) experiment; the Radiation Monitoring Equipment-3 (RME-3) experiment; the Visual Function Tester-2 (VFT-2) experiment; the Cloud Logic to Optimize use of Defense System (CLOUDS-1A) experiment; the Shuttle Amateur Radio Experiment 2 (SAREX-2) Configuration B; the Investigation into Polymer Membranes Processing experiment; and the Get-Away Special (GAS) payload G-229. The Ultraviolet Plume Instrument (UVPI) was a payload of opportunity that required no special maneuvers. In addition to the primary and secondary objectives, the crew was tasked to perform as many as 10 Development Test Objectives (DTO'S) and 14 Detailed Supplementary Objectives (DSO's).

Fricke, Robert W.↗

NASA NTRS2003

The Interaction of Positively-charged Ions with Nucleic Acid Systems

The successful development of extremely low background sample cells for x-ray scattering studies has enabled experiments designed to elucidate some of the fundamental physical interactions involved in macromolecular folding. Microfabrication techniques were used to fabricate low volume (50 micro-liter) sample cells with silicon nitride membranes (sub micron in thickness) as x-ray windows. Scientifically, these studies focus on the interaction of negatively charged nucleic acid systems, RNA and DNA, with their surrounding (positively charged) ion atmospheres. Understanding the structure of the ion atmosphere and its influence on the shape/conformation of the macromolecule will help reveal the underlying physical forces employed by nature in the self-assembly of these important molecules.

Pollack, Lois↗

NASA NTRS2008

Collection of Infrasonic Sound From Sources of Military Importance

Extreme Endeavors is collaborating with NASA Langley Research Center (LaRC) in the development, testing and analysis of infrasonic detection system under a Space Act Agreement. Acoustic studies of atmospheric events like convective storms, shear-induced turbulence, acoustic gravity waves, microbursts, hurricanes, and clear air turbulence (CAT) over the past thirty years have established that these events are strong emitters of infrasound. Recently NASA Langley Research Center has designed and developed a portable infrasonic detection system which can be used to make useful infrasound measurements at locations where it was not possible previously, such as a mountain crag, inside a cave or on the battlefield. The system comprises an electret condenser microphone, having a 3-inch membrane diameter, and a small, compact windscreen. Extreme Endeavors will present the findings from field testing using this portable infrasonic detection system. Field testing of the infrasonic detection system was partly funded by Greer Industries and support provided by the West Virginia Division of Natural Resources. The findings from this work illustrate the ability to detect structure and other information about the contents inside the caves. The presentation will describe methodology for utilizing infrasonic to locate and portray underground facilities.

Masterman, Michael↗

NASA NTRS1999

Design and Development of a Composite Dome for Experimental Characterization of Material Permeability

This paper presents the design and development of a carbon fiber reinforced plastic dome, including a description of the dome fabrication, method for sealing penetrations in the dome, and a summary of the planned test series. This dome will be used for the experimental permeability characterization and leakage validation of composite vessels pressurized using liquid hydrogen and liquid nitrogen at the Cryostat Test Facility at the NASA Marshall Space Flight Center (MSFC). The preliminary design of the dome was completed using membrane shell analysis. Due to the configuration of the test setup, the dome will experience some flexural stresses and stress concentrations in addition to membrane stresses. Also, a potential buckling condition exists for the dome due to external pressure during the leak testing of the cryostat facility lines. Thus, a finite element analysis was conducted to assess the overall strength and stability of the dome for each required test condition. Based on these results, additional plies of composite reinforcement material were applied to local regions on the dome to alleviate stress concentrations and limit deflections. The dome design includes a circular opening in the center for the installation of a polar boss, which introduces a geometric discontinuity that causes high stresses in the region near the hole. To attenuate these high stresses, a reinforcement system was designed using analytical and finite element analyses. The development of a low leakage polar boss system is also investigated.

Estrada, Hector↗

NASA NTRS2000

Towards Development of Microcalorimeter Arrays of Mo/Au Transition-Edge Sensors with Bismuth Absorbers

We report on our progress towards the development of arrays of X-ray microcalorimeters as candidates for the high resolution x-ray spectrometer on the Constellation-X mission. The microcalorimeter arrays (30 x 30) with appropriate pixel sizes (0.25 mm. x 0.25 mm) and high packing fractions (greater than 96%) are being developed. Each individual pixel has a 10 micron thick Bi X-ray absorber that is shaped like a mushroom to increase the packing fraction, and a Mo/Au proximity effect superconducting transition edge sensor (TES). These are deposited on a 0.25 or 0.5 micron thick silicon nitride membrane with slits to provide a controllable weak thermal link to the sink temperature. Studies are underway to model, test and optimize the TES pixel uniformity, critical current, heat capacity and the membrane thermal conductance in the array structure. Fabrication issues and procedures, and results of our efforts based on these optimizations will be provided.

Tralshawala, Nilesh↗