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At least 685 records · Page 38

Platte River Water Resources: Assessing Urban Flood Vulnerability to Select Restoration Sites for Urban Woods and Prairies in the Great Plains

In the Platte River Basin, wetlands provide ecosystem services such as flood mitigation and wildlife habitat. However, increasing urban development in the area has impacted natural floodplain processes, leading to a decline in wildlife habitat and an elevated flood risk for nearby communities. To address this issue, Audubon Great Plains’ Urban Woods and Prairies (UWP) Initiative focuses on restoring vital habitats within urban areas to protect bird species and reduce flood hazards. Our project used remotely sensed data, including Landsat 8 Operational Land Imagery (OLI), Sentinel-2 Multispectral Instrument (MSI), and Sentinel-1 Synthetic Aperture Radar (SAR), to assess land use and land cover from 2013 to 2023, as well as flood extent. Broad-scale analysis of the LULC showed some changes in land use patterns across the Central Platte River Basin, with the most notable being a decrease in Agricultural land coverage and an increase in Vegetation and Grassland coverage. Land use changes varied across 13 focal cities across the entire basin. In particular, developed land in Grand Island, NE, nearly tripled from 2019 to 2023, making it a good possible candidate for restoration efforts. We overlaid a flood extent map with the LULC classifications in Grand Island to identify possible restoration sites under UWP. This data will inform Audubon Great Plains in identifying potential restoration sites in key cities.

Jennifer Mathis↗

Digitally Calibrated TR Modules Enabling Real-Time Beamforming SweepSAR Architectures

SweepSAR, a novel radar architecture that depends on a DBF (digital beamforming) array, requires calibration accuracies that are order(s) of magnitude greater than is possible with traditional techniques, such as a priori characterization of TR (transmit/receive) modules in thermal vacuum chambers, or simple loop-back of the calibration signal. The advantages of a SweepSAR architecture are so great that it is worth applying significant resources to calibration efforts. Due to the nature of the DBF, each channel contains a digitizer and very powerful digital processor. Each channel can independently digitize (with the digitizer) and analyze (with the processor) its channel's unique calibration signal, and extract the relevant calibration parameters, namely channel gain and channel phase delay commonly referred to as the gain (or amplitude) and phase of the channel. Using the processor, each channel's gain and phase can theoretically be estimated with arbitrary precision through averaging a sufficiently large number of samples. Systematic errors and the changing gain and phase of the channels, typically due to temperature drifts, limits how long the averaging can occur, which limits the precision of the calibration estimate. However, results indicate that calibration knowledge of both the transmit and receive chains of each TR module can be improved by one or two orders of magnitude. Due to the digital nature of the receiver data, the channel's gain and phase may be corrected by a similar amount, while the transmit chain can only be corrected in a traditional manner. To implement Sweep SAR, the order of magnitude improvement in the knowledge of the channel's gain and phase is needed, and the control of the receiver to a similar level is required. Inherent to the DBF array is the individual digitization of each of the array's receiver channels. Current systems typically combine all of the analog signals in the array into one or two analog channels, which are then digitized and processed. All signal conditioning performed prior to digitization is done using analog hardware (which is less precise than digital signal conditioning and dependent on temperature). The DBF digitizes every signal prior to combining, and can therefore analyze and correct received signals, as well as analyze signals that are being transmitted through analog hardware (by sampling a copy and digitizing). Each channel of a DBF also has a powerful processor. With this combination, one is able to digitize, analyze, and correct each channel prior to its being combined. A unique factor is the ability to digitize and analyze (in real time) each of the array's channels independently, allowing one to achieve unprecedented knowledge of each channel's performance (gain and phase), and since the combining is done digitally, each receive channel can be corrected prior to combining. This enables an unprecedented level of accuracy and control through onboard processing. SweepSAR promises significant increases in instrument capability for solid earth and biomass remote sensing, while reducing mission mass and cost. This new instrument concept requires new methods for calibrating the multiple channels, which must be combined onboard, in real time. New methods are being developed for digitally calibrating digital beam-forming arrays to reduce development time, risk, and cost of precision calibrated TR modules for array architectures by accurately tracking modules' characteristics through closed-loop digital calibration, thus tracking systematic changes regardless of temperature.-

Hoffman, James P.↗

Effects of Atmosphere and Ocean Horizontal Model Resolution on Tropical Cyclone and Upper-Ocean Response Forecasts in Four Major Hurricanes

A coupled atmosphere–ocean model is necessary for tropical cyclone (TC) prediction to accurately characterize ocean feedback on atmospheric processes within the TC environment. Here, the ECMWF coupled global model is run at horizontal resolutions from 9 to 1.4 km in the atmosphere, as well as 25 and 8 km in the ocean, to identify how resolution impacts forecast accuracy of four observed major TCs in the Atlantic: Irma, Florence, Teddy, and Ida. Most of the resolutions used here are unprecedented for global models. GOES-16 and synthetic aperture radar (SAR) satellite images and best track data are used for atmospheric validation. Salinity and temperature observations from Air-Launched Autonomous Micro-Observer (ALAMO) floats are used to validate modeled upper-ocean response, including mixed layer deepening, sea surface cooling, and near-inertial waves in the wakes of TCs. Increasing atmospheric resolution leads to more realistic TC structure and stronger winds, significantly improving TC intensity forecasts and modestly improving track errors. Ocean resolution impacts the upper-ocean response but does not influence atmospheric forecasts for the fast-moving TCs considered here. Stronger mixing, sea surface cooling, and near-inertial oscillations are found for both higher atmosphere and ocean resolutions, provided the initial upper-ocean state is the same for the two ocean resolutions. Whether this agrees better with the ALAMO observations also depends on the realism of the initial upper-ocean state in the model, emphasizing the importance of ocean initialization for the accurate upper-ocean response. Overall, the model at all resolutions correctly predicts stronger mixing, surface cooling, and near-inertial oscillation amplitudes to the right of a TC center, as observed by ALAMO floats.

Atmosphere-ocean interaction↗

Computational Modeling To Adapt Neutralizing Antibody

Monoclonal antibodies (mAbs) is the leading therapy for viral infections because it provides immediate protection and can be administered at higher levels than in a natural immune response. Finding mAbs that neutralize a broad spectrum of viral targets has proven difficult because many species and strains exist and blanket targeting is a slow and laborious process to experimentally screen 108 variants. A new method is needed to rapidly redesign mAbs for homologous targets. This project speeds up redesign using structure-based computational design to reduce the mAbs search space to a manageable level and screen mutants at a much higher rate than in experiments. Computation will also provide critical knowledge about the fundamental interactions. The project will adapt S230, a human antibody that neutralizes SARS-CoV, to neutralize SARS-COV-2.

60 APPLIED LIFE SCIENCES↗

Sandia's Research in Support of COVID-19 Pandemic Response: Materials Science

Sandia Materials Science Investment Area contributed to the SARS-CoV-2 virus and COVID-19 disease which represent the most significant pandemic threat in over 100 years. We completed a series of 7, short duration projects to provide innovative materials science research and development in analytical techniques to aid the neutralization of COVID-19 on multiple surfaces, approaches to rapidly decontaminate personal protective equipment, and pareto assessment of construction materials for manufacturing personal protective equipment. The developed capabilities and processes through this research can help US medical personnel, government installations and assets, first responders, state and local governments, and multiple federal agencies address the COVID-19 Pandemic.

36 MATERIALS SCIENCE↗

Digital Beamforming Based RFI Mitigation for Synthetic Aperture Radar

An increasing challenge for P-band Synthetic Aperture Radar (SAR) is Radio Frequency Interference (RFI). RFI results in image distortions and degrades the derived science products. This makes it critical to apply RFI removal techniques to restore the image quality. New advanced techniques can be achieved with Digital Beamforming (DBF) radars such as EcoSAR. In this paper, we present a Range-Dependent Time Minimum Variance Distortionless Response (RDTMVDR) Beamformer and apply it to EcoSAR flight data during post-processing. The antenna pattern (AP) is adaptively changed for each range line which increases the RFI suppression compared to a fixed AP for each pulse. The interferometric image quality is assessed before and after RFI suppression.

Bollian, Tobias↗

Plasma proteomics of SARS-CoV-2 infection and severity reveals impact on Alzheimer’s and coronary disease pathways

Identification of proteins dysregulated by COVID-19 infection is critically important for better understanding of its pathophysiology, building prognostic models, and identifying new targets. Plasma proteomic profiling of 4,301 proteins was performed in two independent datasets and tested for the association for three COVID-19 outcomes (infection, ventilation, and death). We identified 1,449 proteins consistently associated in both datasets with any of these three outcomes. We subsequently created highly accurate models that distinctively predict infection, ventilation, and death. These proteins were enriched in specific biological processes including cytokine signaling, Alzheimer’s disease, and coronary artery disease. Mendelian randomization and gene network analyses identified eight causal proteins and 141 highly connected hub proteins including 35 with known drug targets. Our findings provide distinctive prognostic biomarkers for two severe COVID-19 outcomes, reveal their relationship to Alzheimer’s disease and coronary artery disease, and identify potential therapeutic targets for COVID-19 outcomes.

60 APPLIED LIFE SCIENCES↗

Optimization of Spirulina for biomanufacturing and the delivery of protein therapeutics

Lumen Bioscience has developed a novel cyanobacterial platform that enormously decreases the cost of pharmaceuticals used to prevent and treat illnesses. Arthrospira platensis (spirulina), is a photosynthetic microorganism that has been consumed as a dietary supplement for centuries in part because of its high protein content. Commercial cultivation operations have matured over the last 50 years to allow large-scale cultivation in outdoor ponds. Lumen recently discovered methods that transform this commercially important cyanobacterium into a genetically tractable platform for bioengineering. The high protein accumulation in spirulina makes it an ideal chassis for heterologous protein expression, and centuries of safe human consumption suggest its utility as an administration vehicle for biologic drugs. Lumen can express a broad range of recombinant proteins in spirulina and has developed manufacturing processes and strains to mucosally deliver bioactive proteins to treat and/or prevent disease. For example, Lumen has produced an oral cocktail of dried whole-cell spirulina biomass, containing 3 toxin-neutralizing antibodies and 1 endolysin, that is efficacious in a preclinical in vivo models of C. difficile infection. Lumen has also demonstrated that intranasal administration of a spirulina-manufactured neutralizing antibody can prevent disease by a respiratory pathogen, SARS-CoV-2, in a hamster model. Lumen’s current pipeline includes therapeutics to treat or prevent C. difficile infection, COVID-19, inflammatory bowel disease, cardiometabolic disease, and traveler’s diarrhea. Lumen deploys strategies to maximize the expression of these therapeutics for optimal dose sizing, a key limiting factor with past food crop-based expression systems. Spirulina can express exogenous proteins at unusually high levels (>15% of dry weight) but reaching this maximum value requires optimization of multiple interacting factors. We describe our current statistics design of experiments approach that optimizes these factors with minimal replicates. This maximizes exogenous protein expression allowing Lumen to generate spirulina-based therapeutics for a rapidly expanding range of medical uses.

Heinnickel, Mark↗

Radar image processing for rock-type discrimination

Image processing and enhancement techniques for improving the geologic utility of digital satellite radar images are reviewed. Preprocessing techniques such as mean and variance correction on a range or azimuth line by line basis to provide uniformly illuminated swaths, median value filtering for four-look imagery to eliminate speckle, and geometric rectification using a priori elevation data. Examples are presented of application of preprocessing methods to Seasat and Landsat data, and Seasat SAR imagery was coregistered with Landsat imagery to form composite scenes. A polynomial was developed to distort the radar picture to fit the Landsat image of a 90 x 90 km sq grid, using Landsat color ratios with Seasat intensities. Subsequent linear discrimination analysis was employed to discriminate rock types from known areas. Seasat additions to the Landsat data improved rock identification by 7%.

Blom, R. G.↗

Modulation of Magnetic Heating via Dipolar Magnetic Interactions in Monodisperse and Crystalline Iron Oxide Nanoparticles

Here, we report on the study of heat dissipation power in monodisperse and crystalline magnetite nanoparticles as function of particle and aggregate sizes, magnetic field frequencies (up to 435 kHz) and amplitudes (up to 50 mT), media viscosity and particle concentration. These nanoparticles display specific absorption rate values of few hundreds of Wg Fe -1 at moderate frequencies (~100 kHz), increasing up to 3632 Wg Fe -1 at more extreme field conditions (430 kHz and 40 mT) for the largest size. We have found that Néelian relaxation processes are dominant for all nanoparticle sizes, whereas Brownian contribution dominates only for the largest size (22 nm) at high particle concentrations when dipolar interactions enhance the effective magnetic anisotropy. Besides, the particle concentration dependence of the specific absorption rate reflects the importance of magnetic dipolar interactions which strongly depend on aggregate and particle size. Our results show that dipolar interactions tune the effective magnetic anisotropy determining the Néelian and Brownian contributions into SAR values. The possibility of switching between heating mechanisms via dipolar interactions is of great importance towards controlling the heat exposure supplied by IONP as intracellular heating mediators.

77 NANOSCIENCE AND NANOTECHNOLOGY↗

TIME-SERIES SOIL MOISTURE RETRIEVAL USING S-BAND BACKSCATTER MEASUREMENTS FROM THE SMEX02 CAMPAIGN

S-band observations from NASA’s Passive/Active L/S Band (PALS) radar from theSMEX02 campaign were used to estimate soil moisture. The “alpha”method is applied for this process, in which a time series of ratios of normalized radar cross section values at successive measurements is used to infer the corresponding soil moisture time series given ancillary information on the minimum and maximum soil moisture values expected over the time series. Results are examined as a function of the polarization and crop type. The results show reasonable retrieval performance, indicating the potential of usingS-band observations from the future NASA/ISRO SAR(NISAR)mission.

Dustin Horton↗

Exploratory Modeling and Simulation of the Evolutionary Dynamics of Single-Stranded RNA Virus Populations

Infection, replication and mutation govern the population dynamics of viruses and are the key mechanisms driving their evolution. In particular, RNA viruses (such as the causative agents of Ebola, Dengue, Zika, West Nile, and SARS) have the highest mutation rates which enable them to form highly diverse populations within a single host, evade immune responses and develop resistances to drugs. Understanding the complexity of virus evolution is crucial for developing reliable countermeasures. We present an exploratory simulation model to study the evolution of heterogeneous virus populations in heterogeneous cell environments. This is a unique model that operates at three scales and captures the core mechanisms of the evolutionary process. To the best of our knowledge, this is the first HPC-based simulation of its kind.

60 APPLIED LIFE SCIENCES↗

A Cryogenic Readout IC with 100 KSPS in-Pixel ADC for Skipper CCD-in-CMOS Sensors

The Skipper CCD-in-CMOS Parallel Read-Out Circuit (SPROCKET) is a mixed-signal front-end design for the readout of Skipper CCD-in-CMOS image sensors. SPROCKET is fabricated in a 65 nm CMOS process and each pixel occupies a 50$\mu$m $\times$ 50$\mu$m footprint. SPROCKET is intended to be heterogeneously integrated with a Skipper-in-CMOS sensor array, such that one readout pixel is connected to a multiplexed array of nine Skipper-in-CMOS pixels to enable massively parallel readout. The front-end includes a variable gain preamplifier, a correlated double sampling circuit, and a 10-bit serial successive approximation register (SAR) ADC. The circuit achieves a sample rate of 100 ksps with 0.48 $\mathrm{e^-_{rms}}$ equivalent noise at the input to the ADC. SPROCKET achieves a maximum dynamic range of 9,000 $e^-$ at the lowest gain setting (or 900 $e^-$ at the lowest noise setting). The circuit operates at 100 Kelvin with a power consumption of 40 $\mu W$ per pixel. A SPROCKET test chip was submitted in September 2022, and test results will be presented at the conference.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Light-Induced Transformation of Virus-Like Particles on TiO 2

Titanium dioxide (TiO 2 ) shows significant potential as a self-cleaning material to inactivate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and prevent virus transmission. This study provides insights into the impact of UV-A light on the photocatalytic inactivation of adsorbed SARS-CoV-2 virus-like particles (VLPs) on a TiO 2 surface at the molecular and atomic levels. X-ray photoelectron spectroscopy, combined with density functional theory calculations, reveals that spike proteins can adsorb on TiO 2 predominantly via their amine and amide functional groups in their amino acids blocks. We employ atomic force microscopy and grazing-incidence small-angle X-ray scattering (GISAXS) to investigate the molecular-scale morphological changes during the inactivation of VLPs on TiO 2 under light irradiation. Notably, in situ measurements reveal photoinduced morphological changes of VLPs, resulting in increased particle diameters. These results suggest that the denaturation of structural proteins induced by UV irradiation and oxidation of the virus structure through photocatalytic reactions can take place on the TiO 2 surface. The in situ GISAXS measurements under an N 2 atmosphere reveal that the virus morphology remains intact under UV light. This provides evidence that the presence of both oxygen and UV light is necessary to initiate photocatalytic reactions on the surface and subsequently inactivate the adsorbed viruses. The chemical insights into the virus inactivation process obtained in this study contribute significantly to the development of solid materials for the inactivation of enveloped viruses.

36 MATERIALS SCIENCE↗

Porotomo: InSAR Data from San Emidio Geothermal Field, Nevada, 1992-2010

This submission contains tarred pair directories for interferometric synthetic aperture radar (InSAR) data covering San Emidio Geothermal Field in Nevada, USA as part of the porotomo project. Data included within this submission are the following: > ENVI_T120_GDR.tgz: Tarred directory containing 39 Envisat track 120 tarred, pair subdirectories spanning from 2003-Oct-29 to 2010-Jun-09. > ENVI_T27_GDR.tgz: Tarred directory containing 32 Envisat track 27 tarred, pair subdirectories spanning from 2004-Jun-23 to 2010-Apr-28. > ERS_T27_GDR.tgz: Tarred directory containing 35 ERS track 27 tarred, pair subdirectories spanning from 1992-Jun-07 to 2000-Sep-27. > ENVI_T27_SQR_drange_utm_cut.grd: SqueeSAR-derived data product for Enivsat track 27 from Eneva, et al. (2011) (provided by TRE Altamira) in terms of unwrapped range change rate. > MSTvsSQR_GDR.tgz: Tarred directory containing Easting gradient files for each satellite and track corresponding to the MST data products and the SqueeSAR data products. > sanem_dem_utm.grd: Digital elevation model (DEM) used in the creation of the interferograms. Explanation of pair subdirectories (contained within ENVI_T120_GDR, ENVI_T27_GDR, ERS_T27_GDR): Pairs are chosen based on a minimum spanning tree (MST) algorithm with image quality (as measured by the amount of phase noise within an interferometric pair) as the weighting criterion. Pairs are formed using the InSAR processing software GMT5SAR (Sandwell et al., 2011). Pair subdirectories are named by starting and ending epochs in YYYYMMDD_YYYYMMDD format. Each tarred pair directory contains GRD files for wrapped phase data (radians) and wrapped phase data after application of a modified Goldstein filter that depends on coherence (Goldstein & Werner, 1997; Baran et al., 2003; Sandwell et al., 2011). The data are given in both latitude/longitude and Universal Transverse Mercator (Zone 11N). Raw Synthetic Aperture Radar (SAR) data from the Envisat and ERS satellite missions operated by the European Space Agency (ESA) are copyrighted by ESA and were provided through the WInSAR consortium at the UNAVCO facility.

15 GEOTHERMAL ENERGY↗

A compilation system for Venus radar mission (Magellan)

A synthetic aperture radar (SAR) compilation system was developed for extraction of topographic information of Venus from stereoradar imagery to be obtained from the Magellan mission. The system was developed for an AS-11AM analytical stereoplotter. Extensive tests were made on this compilation software by using stereo images from various radar systems, both spaceborne and airborne. Maps were compiled and the precision of planimetry and contour measurement was evaluated. Digital data of some models were also collected for processing orthophoto or perspective views by using the original radar images.

Wu, Sherman S. C.↗

Numerical simulation of synthetic aperture radar image spectra for ocean waves

A numerical model for predicting the synthetic aperture radar (SAR) image of a moving ocean surface is described, and results are presented for two SIR-B data sets collected off the coast of Chile. Wave height spectra measured by the NASA radar ocean wave spectrometer (ROWS) were used as inputs to this model, and results are compared with actual SIR-B image spectra from orbits 91 and 106. Additional parametric variations are presented to illustrate the effects of nonlinearities in the imaging process.

Lyzenga, D. R.↗

Finding curvilinear features in speckled images

A method for finding curves in digital images with speckle noise is described. The solution method differs from standard linear convolutions followed by thresholds in that it explicitly allows curvature in the features. Maximum a posteriori (MAP) estimation is used, together with statistical models for the speckle noise and for the curve-generation process, to find the most probable estimate of the feature, given the image data. The estimation process is first described in general terms. Then, incorporation of the specific neighborhood system and a multiplicative noise model for speckle allows derivation of the solution, using dynamic programming, of the estimation problem. The detection of curvilinear features is considered separately. The detection results allow the determination of the minimal size of detectable feature. Finally, the estimation of linear features, followed by a detection step, is shown for computer-simulated images and for a SAR image of sea ice.

Samadani, Ramin↗