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Boundary Layer Stability and Laminar-Turbulent Transition Analysis with Thermochemical Nonequilibrium Applied to Martian Atmospheric Entry

As Martian atmospheric entry vehicles increase in size to accommodate larger payloads, transitional ow may need to be taken into account in the design of the heat shield in order to reduce heat shield mass. The mass of the Thermal Protection System (TPS) comprises a significant portion of the vehicle mass, and a reduction of this mass would result in fuel savings. The current techniques used to design entry shields generally assume fully turbulent flow when the vehicle is large enough to expect transitional flow, and while this worst-case scenario provides a greater factor of safety it may also result in overdesigned TPS and unnecessarily high vehicle mass. Greater accuracy in the prediction of transition would also reduce uncertainty in the thermal and aerodynamic loads. Stability analysis, using e(sup⁡ N) -based methods including Linear Stability Theory (LST) and the Parabolized Stability Equations (PSE), offers a physics-based method of transition prediction that has been thoroughly studied and applied in perfect gas flows, and to a more limited extent in reacting and nonequilibrium flows. These methods predict the amplification of a known disturbance frequency and allow identification of the most unstable frequency. Transition is predicted to occur at a critical amplification or N Factor, frequently determined through experiment and empirical correlations. The LAngley Stability and TRansition Analysis Code (LASTRAC), with modifications for thermochemically reacting flows and arbitrary gas mixtures, will be presented with LST results on a simulation of a high enthalpy CO2 gas wind tunnel test relevant to Martian atmospheric entry. The results indicate transition caused by modified Tollmien-Schlichting waves on the leeward side, which are predicted to be more stable and cause transition slightly downstream when thermochemical nonequilibrium is included in the stability analysis for the same mean flow solution.

Transition↗

Convolutional Neural Network for Transition Modeling Based on Linear Stability Theory

Transition prediction is an important aspect of aerodynamic design because of its impact on skin friction and potential coupling with flow separation characteristics. Traditionally, the modeling of transition has relied on correlation-based empirical formulas based on integral quantities such as the shape factor of the boundary layer. However, in many applications of computational fluid dynamics, the shape factor is not straightforwardly available or not well-defined. We propose using the complete velocity profile along with other quantities (e.g., frequency, Reynolds number) to predict the perturbation amplification factor. While this can be achieved with regression models based on a classical fully connected neural network, such a model can be computationally more demanding. We propose a novel convolutional neural network inspired by the underlying physics as described by the stability equations. Specifically, convolutional layers are first used to extract integral quantities from the velocity profiles, and then fully connected layers are used to map the extracted integral quantities, along with frequency and Reynolds number, to the output (amplification ratio). Numerical tests on classical boundary layers clearly demonstrate the merits of the proposed method. More importantly, we demonstrate that, for Tollmien-Schlichting instabilities in two-dimensional, low-speed boundary layers, the proposed network encodes information in the boundary layer profiles into an integral quantity that is strongly correlated to a well-known, physically defined parameter – the shape factor.

Laminar-turbulent transition↗

Transition Analysis for the CRM-NLF Wind Tunnel Configuration

This paper reports the results of a comprehensive linear stability analysis of the boundary layer flow over the common research model with natural laminar flow (CRM-NLF) aircraft configuration. The flow conditions match selected test conditions from a recent wind tunnel experiment in the National Transonic Facility at the NASA Langley Research Center. Previous work has shown that the measured onset of laminar-turbulent transition during the experiments can be correlated with the linear amplification of Tollmien-Schlichting (TS) and stationary crossflow (CF) instabilities in the swept wing boundary layer. However, a significant scatter ( N ∈ (4,9)) was observed in the values of the logarithmic amplification factor along the measured transition front. This previous analysis was based on an approximate basic state (based on a boundary layer code with conical flow approximation) and parallel stability computations without surface curvature effects. Here, we examine the effects of these various approximations with the goal of quantifying the resulting changes in the N-factor correlations. Specifically, both linear stability theory (LST) and the parabolized stability equations (PSE)are used in conjunction with an accurate definition of the laminar boundary layer flow as computed with a Navier-Stokes solver with a Reynolds-Averaged-Navier-Stokes (RANS) based turbulence model within the turbulent parts of the flow. Furthermore, the effects of instability wave propagation within a fully three-dimensional boundary layer are also evaluated by integrating the disturbance growth rates along suitably chosen, curvilinear (i.e., nonplanar) propagation trajectories. The results of this analysis are also used in an accompanying paper by Venkatachari et al. to develop improved, physics based transition predictions for the same CRM-NLF configuration.

Boundary layer transition↗

A Computational Analysis of Boundary Layer Instability over the BOLT Configuration

The complex boundary layer flow over the BOLT flight configuration is known to exhibit multiple and potentially interacting instability mechanisms. This paper represents a continuation of our numerical investigation of the flow instabilities over the main test surface of the BOLT configuration by using state-of-the-art tools in multidimensional instability analysis. Specifically, the paper extends our previous computations by considering the separate effects of a nonzero angle of attack and a nonzero yaw on the modal instability characteristics of the boundary layer streaks adjacent to the minor-axis symmetry plane, specifically near both ends of the azimuthal region of a thick boundary layer in the middle, where this region rapidly changes to a thinner boundary layer on either side. At the t = 28.8767 s condition from the ascent part of the anticipated flight trajectory with a flight Mach number of M ∞ = 5.53 and unit Reynolds number of 4.25 x 10 6 /m, either type of departure from the design condition is shown to have a considerable impact on the structure of the basic state rollup within the region of interest and, hence, also on the amplification characteristics of instability waves within the resulting streaks. Yet, for a yaw angle of β = 4 degrees, the computations indicate only a slight reduction with respect to the peak N-factor of nearly 11 at the design condition of zero degrees yaw and zero degrees angle of attack. In contrast, an angle of attack equal to α = 4 degrees, the peak N-factor decreases to nearly 6 on the leeward side and increases above 16 on the windward side, making the onset of transition highly likely on the windward side. Computations also highlight the role of streak instabilities that originate as Mack mode disturbances and also demonstrate the potential pitfalls in using surface pressure sensors alone to gauge the magnitude of instability amplification.

Boundary layer transition↗

Transition Analysis for the CRM-NLF Wind Tunnel Configuration

This paper presents the results of an ongoing study into the linear stability characteristics of the boundary layer flow over the common research model with natural laminar flow (CRMNLF) aircraft configuration. The flow conditions match selected test conditions from a recent wind tunnel experiment in the National Transonic Facility at the NASA Langley Research Center. Previous work involving parallel stability computations of a boundary layer flow based on the conical flow approximation has shown that the measured onset of laminar-turbulent transition during the experiments can be correlated with the linear amplification of Tollmien- Schlichting (TS) and stationary crossflow (CF) instabilities in the swept wing boundary layer. Here, we examine the effects of the simplifying approximations in both basic state computation and the stability analysis, with the goal of quantifying the resulting changes in the N-factor correlations. Specifically, the basic states are computed by using full Navier-Stokes equations and the stability analysis is performed by using a nonorthogonal coordinate system that allows a clear distinction between planar TS and CF instabilities. Furthermore, the effects of curvature and nonparallel mean flow have been included in the stability computations based on the parabolized stability equations (PSE). The fully turbulent Reynolds-Averaged-Navier-Stokes (RANS) mean flow solutions show good agreement with the measured wall pressure distribution. Viscous-inviscid interactive effects are observed to be important because the shock fronts along the suction surface are influenced by the imposed transition front. The stability results confirm the previous findings related to TS amplification within the inboard region of the wing and the dominance of stationary CF modes in the outboard region. However, given the close proximity of the measured transition front and the dual shock system within the outer part of the wing, the onset of transition may well be shock limited within the outboard region. In general, the transition criterion based on the dual N-factor method with N TS = N CF = 6 is reasonably successful at correlating with the measured transition fronts at Re MAC = 15 million and AoA = 1.5, 2 degrees; however, the low values of the correlating N-factors at Re MAC = 17.5 million support the hypothesis that the measured transition at the higher Reynolds number may have been strongly influenced by the merging of turbulent wedges that originate from surface imperfections near the leading edge.

Boundary layer transition↗

Evaluation of Arctic Warming in Mid-Pliocene Climate Simulations

Palaeoclimate simulations improve our understanding of the climate, inform us about the performance of climate models in a different climate scenario, and help to identify robust features of the climate system. Here, we analyse Arctic warming in an ensemble of 16 simulations of the mid-Pliocene Warm Period (mPWP), derived from the Pliocene Model Intercomparison Project Phase 2 (PlioMIP2). The PlioMIP2 ensemble simulates Arctic (60–90∘ N) annual mean surface air temperature (SAT) increases of 3.7 to 11.6 ∘C compared to the pre-industrial period, with a multi-model mean (MMM) increase of 7.2 ∘C. The Arctic warming amplification ratio relative to global SAT anomalies in the ensemble ranges from 1.8 to 3.1 (MMM is 2.3). Sea ice extent anomalies range from −3.0 to −10.4×106 km2, with a MMM anomaly of −5.6×106 km2, which constitutes a decrease of 53 % compared to the pre-industrial period. The majority (11 out of 16) of models simulate summer sea-ice-free conditions (≤1×106 km2) in their mPWP simulation. The ensemble tends to underestimate SAT in the Arctic when compared to available reconstructions, although the degree of underestimation varies strongly between the simulations. The simulations with the highest Arctic SAT anomalies tend to match the proxy dataset in its current form better. The ensemble shows some agreement with reconstructions of sea ice, particularly with regard to seasonal sea ice. Large uncertainties limit the confidence that can be placed in the findings and the compatibility of the different proxy datasets. We show that while reducing uncertainties in the reconstructions could decrease the SAT data–model discord substantially, further improvements are likely to be found in enhanced boundary conditions or model physics. Lastly, we compare the Arctic warming in the mPWP to projections of future Arctic warming and find that the PlioMIP2 ensemble simulates greater Arctic amplification than CMIP5 future climate simulations and an increase instead of a decrease in Atlantic Meridional Overturning Circulation (AMOC) strength compared to pre-industrial period. The results highlight the importance of slow feedbacks in equilibrium climate simulations, and that caution must be taken when using simulations of the mPWP as an analogue for future climate change.

Palaeoclimate simulations↗

Transition Analysis for the CRM-NLF Wind Tunnel Configuration

This paper presents the results of an ongoing study into the linear stability characteristics of the boundary layer flow over the common research model with natural laminar flow (CRMNLF) aircraft configuration. The flow conditions match selected test conditions from a recent wind tunnel experiment in the National Transonic Facility at the NASA Langley Research Center. Previous work involving parallel stability computations of a boundary layer flow based on the conical flow approximation has shown that the measured onset of laminar-turbulent transition during the experiments can be correlated with the linear amplification of Tollmien- Schlichting (TS) and stationary crossflow (CF) instabilities in the swept wing boundary layer. Here, we examine the effects of the simplifying approximations in both basic state computation and the stability analysis, with the goal of quantifying the resulting changes in the N-factor correlations. Specifically, the basic states are computed by using full Navier-Stokes equations and the stability analysis is performed by using a nonorthogonal coordinate system that allows a clear distinction between planar TS and CF instabilities. Furthermore, the effects of curvature and nonparallel mean flow have been included in the stability computations based on the parabolized stability equations (PSE). The fully turbulent Reynolds-Averaged-Navier-Stokes (RANS) mean flow solutions show good agreement with the measured wall pressure distribution. Viscous-inviscid interactive effects are observed to be important because the shock fronts along the suction surface are influenced by the imposed transition front. The stability results confirm the previous findings related to TS amplification within the inboard region of the wing and the dominance of stationary CF modes in the outboard region. However, given the close proximity of the measured transition front and the dual shock system within the outer part of the wing, the onset of transition may well be shock limited within the outboard region. In general, the transition criterion based on the dual N-factor method with N TS = N CF = 6 is reasonably successful at correlating with the measured transition fronts at Re MAC = 15 million and AoA = 1.5, 2 degrees; however, the low values of the correlating N-factors at Re MAC = 17.5 million support the hypothesis that the measured transition at the higher Reynolds number may have been strongly influenced by the merging of turbulent wedges that originate from surface imperfections near the leading edge.

Boundary layer transition↗

A Computational Analysis of Boundary Layer Instability over the BOLT Configuration (Effect of Nonzero AoA and Yaw)

The complex boundary layer flow over the BOLT flight configuration is known to exhibit multiple and potentially interacting instability mechanisms. This paper represents a continuation of our numerical investigation of the flow instabilities over the main test surface of the BOLT configuration by using state-of-the-art tools in multidimensional instability analysis. Specifically, the paper extends our previous computations by considering the separate effects of a nonzero angle of attack and a nonzero yaw on the modal instability characteristics of the boundary layer streaks adjacent to the minor-axis symmetry plane, specifically near both ends of the azimuthal region of a thick boundary layer in the middle, where this region rapidly changes to a thinner boundary layer on either side. At the t = 28.8767 s condition from the ascent part of the anticipated flight trajectory with a flight Mach number of M ∞ = 5.53 and unit Reynolds number of 4.25 x 10 6 /m, either type of departure from the design condition is shown to have a considerable impact on the structure of the basic state rollup within the region of interest and, hence, also on the amplification characteristics of instability waves within the resulting streaks. Yet, for a yaw angle of β = 4 degrees, the computations indicate only a slight reduction with respect to the peak N-factor of nearly 11 at the design condition of zero degrees yaw and zero degrees angle of attack. In contrast, an angle of attack equal to α = 4 degrees, the peak N-factor decreases to nearly 6 on the leeward side and increases above 16 on the windward side, making the onset of transition highly likely on the windward side. Computations also highlight the role of streak instabilities that originate as Mack mode disturbances and also demonstrate the potential pitfalls in using surface pressure sensors alone to gauge the magnitude of instability amplification.

Boundary layer transition↗

Transition Analysis for Isolated Trips on BOLT-II Wind-Tunnel and Flight Configuration

The BOLT-II configuration designed for an upcoming flight experiment exemplifies the complexities of hypersonic boundary layer transition in the presence of multiple and potentially interacting instability mechanisms. The present paper is related to the NASA-led roughness experiment on the secondary side of the BOLT-II configuration. First, computations are performed to aid mean-flow based correlations for the transition measurements acquired during an experimental campaign in the Ludwieg Tube facility at the United States Air Force Academy. To that end, both laminar and turbulent flow computations are performed for selected conditions of the experiment with a 1:3 scale model of the slightly shorter BOLT configuration. The variation in well-known correlation parameters for transition due to isolated roughness elements with respect to element position, height, and flow Reynolds number is delineated. Furthermore, the wake instability theory is used to examine the amplification of unstable disturbances behind the centerline trip at the design conditions of the BOLT-II flight experiment and for its dynamically scaled version on the 1:3 scale model of the wind tunnel experiment. To our knowledge, this study represents the first analysis of the wake instabilities in the presence of a prominent entropy layer outside the boundary layer. At the nominal flight design condition of Re ∞ ) = 5.44 and Re ∞ = 2.5 x 10 6 /m, a diamond planform (“pizza-box”) trip with k/δ = 0.70 and planform-halfwidth-to-height ratio of b/k = 3.0 at X/L = 0.254 induces a strong distortion of the boundary-layer flow in the vicinity of the symmetry plane, such that the wake structure includes a centerline streak produced by the flow retardation behind the trip along with multiple additional, prominent vorticity structures representing the necklace vortex system. Stability results reveal that each of these streaks can support a strong amplification of wake instabilities within a frequency band of 95 kHz–255 kHz, with a peak N-factor of greater than 15 beyond X/L ≈ 0.42. The dynamically scaled wind tunnel configuration with Re ∞ = 20.25 x 10 6 /m is also found to support N > 15 at similar axial stations.

BOLT↗

Transition Analysis for Isolated Trips on BOLT-II Wind-Tunnel and Flight Configuration

The BOLT-II configuration designed for an upcoming flight experiment exemplifies the complexities of hypersonic boundary layer transition in the presence of multiple and potentially interacting instability mechanisms. The present paper is related to the NASA-led roughness experiment on the secondary side of the BOLT-II configuration. First, computations are performed to aid mean-flow based correlations for the transition measurements acquired during an experimental campaign in the Ludwieg Tube facility at the United States Air Force Academy. To that end, both laminar and turbulent flow computations are performed for selected conditions of the experiment with a 1:3 scale model of the slightly shorter BOLT configuration. The variation in well-known correlation parameters for transition due to isolated roughness elements with respect to element position, height, and flow Reynolds number is delineated. Furthermore, the wake instability theory is used to examine the amplification of unstable disturbances behind the centerline trip at the design conditions of the BOLT-II flight experiment and for its dynamically scaled version on the 1:3 scale model of the wind tunnel experiment. To our knowledge, this study represents the first analysis of the wake instabilities in the presence of a prominent entropy layer outside the boundary layer. At the nominal flight design condition of Re ∞ ) = 5.44 and Re ∞ = 2.5 x 10 6 /m, a diamond planform (“pizza-box”) trip with k/δ = 0.70 and planform-halfwidth-to-height ratio of b/k = 3.0 at X/L = 0.254 induces a strong distortion of the boundary-layer flow in the vicinity of the symmetry plane, such that the wake structure includes a centerline streak produced by the flow retardation behind the trip along with multiple additional, prominent vorticity structures representing the necklace vortex system. Stability results reveal that each of these streaks can support a strong amplification of wake instabilities within a frequency band of 95 kHz–255 kHz, with a peak N-factor of greater than 15 beyond X/L ≈ 0.42. The dynamically scaled wind tunnel configuration with Re ∞ = 20.25 x 10 6 /m is also found to support N > 15 at similar axial stations.

BOLT↗

The Harmonic Linearized Navier-Stokes Equations for Transition Prediction in Three-Dimensional Flows

The conventional method to predict the onset of laminar-turbulent transition in convectively unstable boundary-layer flows is based on the logarithmic amplification ratio, the so-called N-factor, of the linear instability waves. To calculate the N-factor, the flow variables are decomposed into a laminar basic state solution and the linear disturbances, which are assumed to be harmonic in time. The most commonly used linear stability analysis approaches include the locally parallel linear stability theory (LST) and the nonlocal, weakly nonparallel parabolized stability equations (PSE). However, these methods do not account for strong streamwise gradients that are encountered in several configurations of interest, such as those in the vicinity of roughness elements, steps, gaps, or corners. To compute the linear evolution of disturbances along such strongly nonparallel regions, the harmonic linearized Navier-Stokes equations (HLNSE) need to be solved. The discretization of the HLNSE for spanwise/azimuthally inhomogeneous laminar basic states yields a linear system of complex arithmetic with a leading dimension of the order of 10^(7) to 10^(8) even in relatively simple flows. A combined multithread and multiprocessor algorithm is implemented for the direct solution of such linear systems. Results for a supersonic boundary layer over a three-dimensional roughness patch show good agreement with experimental measurements when the evolution of the instability waves over the roughness patch is included via the HLNSE. Additionally, inflow-resolvent analysis based on the HLNSE for discrete-roughness-induced disturbances in the nose tip of a blunt cone at Mach 6 demonstrates the importance of including the disturbance amplification along the near vicinity of the roughness element and separation region.

Boundary Layer Stability↗

Separation and Transition on the ROTEX-T Cone-Flare

As part of NATO STO AVT-346 “Predicting Hypersonic Boundary-Layer Transition on Complex Geometries,” coordinated experimental and computational studies were conducted on the ROTEX-T, a cone-flare geometry used in a successful flight-test experiment. At the as-flown conditions, a separation bubble existed at the compression corner. Separation, reattachment, and the multifaceted linear instability paths leading this bubble to transition to turbulence are challenging to predict, but have significant impact on surface pressure and heat flux. High-resolution background-oriented schlieren and infrared thermography measurements were made in the AFOSR–Notre Dame Large Mach-6 Quiet Tunnel at freestream unit Reynolds numbers from 5.8×10(exp 6) to 12.2×10(exp 6) m-1and nominally zero angle of attack. High-speed self-aligned focusing schlieren, infrared thermography, and focused laser differential interferometry measurements were made in the AFRL Mach-6 Ludwieg Tube from 2.2×10(exp 6) to 24.7×10(exp 6) m-1and nominally zero degrees angle of attack. The surface heat-flux and Stanton number distributions were computed. Separation and reattachment locations, as well as the flow state at each, were determined from the combination of surface and off-wall measurements. The convective and global boundary-layer instabilities of the axisymmetric laminar flow at the experimental conditions were investigated computationally. Amplification of Mack’s first and second modes were observed to have logarithmic amplification factors between 5 to 7.5 at the separation location, depending on conditions. The flow was found to be globally unstable to stationary three-dimensional disturbances concentrated in the reattachment region. Previous analysis of the ROTEX-T flight data had not assessed reattachment location or the flow state upon reattachment. Thanks to the insights gained from the coordinated, on- and off-wall ground-test measurements, these evaluations have now been made. The separation location indicated by laminar simulations is consistently numerically predicted to be upstream of the experimentally observed location for a transitional separation bubble. The cause of this difference is understood to lie in the steady-state and axisymmetric assumptions made by both solvers employed to compute the basic states analyzed, as flow topology considerations assert that unsteady two-dimensional or axisymmetric separation bubbles are structurally unstable and will become three-dimensional. Computed laminar heating rates prior to separation agreed well with experiment; transitional heating rates after reattachment were between laminar and turbulent computations.

CFD Validation↗

Ground Tests on the BOLT Geometry at Mach 7: Cross-Facility Comparison and Stability Analysis

Transition measurements have been obtained through two experimental campaigns conducted independently by the German Aerospace Center and the French Aerospace Lab with the French Alternative Energies and Atomic Energy Commission on subscale models of the BOLT-1 flight experiment geometry. This paper details a cross-facility comparison of measurements obtained at Mach 7, as well as subsequent computational analysis. Infrared (IR) thermography measurements obtained by both campaigns have facilitated a global comparison of the transition front across facilities at analagous conditions, which are found to be in good agreement. High-frequency surface pressure fluctuation data demonstrate significant amplification of instabilities with Mack-mode characteristics in the outboard regions of the acreage. These measurements are compared to stability analyses of varying fidelity. The computational methods employed to characterize the boundary-layer transition phenomena include the traditional line-marching implementation of the Parabolized Stability Equations (PSE), 2D eigenvalue analysis coupled with PSE, and Adaptive Mesh Refinement Wavepacket Tracking. While the 2D eigenvalue analysis is found to predict instabilities, which correlate in terms of frequency and acreage location to the experimental measurements, the predicted amplification for these instabilities is lower than would typically be expected for transition. Line-marching results for traveling crossflow produce the best match to the experimental transition front, with a consistent transition N factor of approximately 3-3.5.

Boundary Layer Transition↗

Separation and Transition on the ROTEX-T Cone-Flare

As part of NATO STO AVT-346 “Predicting Hypersonic Boundary-Layer Transition on Complex Geometries,” coordinated experimental and computational studies were conducted on the ROTEX-T, a cone-flare geometry used in a successful flight-test experiment. At the as-flown conditions, a separation bubble existed at the compression corner. Separation, reattachment, and the multifaceted linear instability paths leading this bubble to transition to turbulence are challenging to predict, but have significant impact on surface pressure and heat flux. High-resolution background-oriented schlieren and infrared thermography measurements were made in the AFOSR–Notre Dame Large Mach-6 Quiet Tunnel at freestream unit Reynolds numbers from 5.8×10(exp 6) to 12.2×10(exp 6) m-1and nominally zero angle of attack. High-speed self-aligned focusing schlieren, infrared thermography, and focused laser differential interferometry measurements were made in the AFRL Mach-6 Ludwieg Tube from 2.2×10(exp 6) to 24.7×10(exp 6) m-1and nominally zero degrees angle of attack. The surface heat-flux and Stanton number distributions were computed. Separation and reattachment locations, as well as the flow state at each, were determined from the combination of surface and off-wall measurements. The convective and global boundary-layer instabilities of the axisymmetric laminar flow at the experimental conditions were investigated computationally. Amplification of Mack’s first and second modes were observed to have logarithmic amplification factors between 5 to 7.5 at the separation location, depending on conditions. The flow was found to be globally unstable to stationary three-dimensional disturbances concentrated in the reattachment region. Previous analysis of the ROTEX-T flight data had not assessed reattachment location or the flow state upon reattachment. Thanks to the insights gained from the coordinated, on- and off-wall ground-test measurements, these evaluations have now been made. The separation location indicated by laminar simulations is consistently numerically predicted to be upstream of the experimentally observed location for a transitional separation bubble. The cause of this difference is understood to lie in the steady-state and axisymmetric assumptions made by both solvers employed to compute the basic states analyzed, as flow topology considerations assert that unsteady two-dimensional or axisymmetric separation bubbles are structurally unstable and will become three-dimensional. Computed laminar heating rates prior to separation agreed well with experiment; transitional heating rates after reattachment were between laminar and turbulent computations.

CFD Validation↗

Endpoint detection of amplified nucleic acids

The present invention relates to probes and primers beneficial for conducting amplification assays, such as those including loop-mediated isothermal amplification reactions. Also described herein are methods for detecting targets using such probes and/or primers.

59 BASIC BIOLOGICAL SCIENCES↗

Endpoint detection of amplified nucleic acids

The present invention relates to probes and primers beneficial for conducting amplification assays, such as those including loop-mediated isothermal amplification reactions. Also described herein are methods for detecting targets using such probes and/or primers.

Meagher, Robert↗

Higher-order dispersion compensating pulse shaper via amplitude spectral filtering and nonlinear phase accumulation

A method of pulse shaping using spectral filtering, positive chirp, and self-phase modulation to control the accumulated higher-order phase terms of the spectral phase. This pulse shaping method has particular advantage in fiber chirped pulse amplification (FCPA) systems, where there are two effects: (1) an offsetting of the fourth order phase via nonlinear phase accumulation, allowing for a higher Strehl ratio (i.e., a cleaner pulse), higher peak power pulse and (2) enabling power scaling to higher pulse energies without the increased nonlinear phase accumulation leading to pulse breakup. This technique can be used both in a passive system with no amplification to clean up an existing pulse, and in an amplifier system to enable higher performance operation (shorter pulses, cleaner pulses, higher energy pulses).

Domingue, Scott R.↗

Nonlinear Loss Engineering in Near‐Zero‐Index Bulk Materials

Transparent conducting oxides (TCOs) show unprecedented optical nonlinearities in the near infrared wavelength range, where the real part of their linear refractive index approaches zero. More specifically, the Kerr nonlinearities of these materials have sparked widespread attention due to their magnitude and speed. However, due to the absorptive nature of these nonlinear processes, it is of fundamental interest to further investigate the imaginary component of the nonlinear index. The present work studies the nonlinear optical absorption properties of aluminium‐doped zinc oxide (AZO) thin films in their near‐zero‐index (NZI) spectral window. It is found that the imaginary part of the refractive index is reduced under optical excitation such that the field penetration depth more than doubles. An optically induced shift of the NZI bandwidth of ≈120 nm for a pump intensity of 1.3 TW cm −2 is also demonstrated. Looking into the optically induced spectral redistribution of the probe signal, local net gain is recorded, which is ascribed to a nonlinear adiabatic energy transfer. The present study adds key information about the fundamental interplay between real and imaginary nonlinear indices in NZI media, while advancing parametric amplification as viable direction for loss compensation.

36 MATERIALS SCIENCE↗