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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 703 records · Page 39

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DOE OSTI2022

Conceptual core design of the molten metal fueled microreactor with self-regulating capability

The microreactor concept has received significant attention in the United States for its lower capital investment, siting flexibility and high mobility. A microreactor aims to provide reliable electricity in remote communities, mining areas, or isolated islands, which will save the high fuel transportation cost. Thus, minimizing the staff level for operating and maintaining a microreactor is desirable. The objective of the study is to design a self-regulated Molten Metal fueled microReactor core (MMR) and to demonstrate the self-regulating capability of the MMR core. The control of the reactor is solely relying on reactivity feedbacks from fuel temperature perturbation. Molten UMn (liquid form at the temperature over 720°C) was utilized as the fuel material in MMR due to the larger thermal expansion coefficient compared to the conventional solid fuel. The MMR core has a fast neutron spectrum, which corresponds to a small burnup reactivity swing. The core design parameters were selected based on DAKOTA, REBUS, and ANLHTP calculations. The MMR is designed to run for 10 years at a power level of 15 MWth. Furthermore, no refueling is needed during the reactor lifetime. The system dynamic analyses were performed, and it was found that the reactor can be self-regulating within a temperature range of 800 ± 80°C for a loss of heat sink transient.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

DOE OSTI2017

Cellobiose Consumption Uncouples Extracellular Glucose Sensing and Glucose Metabolism in Saccharomyces cerevisiae

Glycolysis is central to energy metabolism in most organisms and is highly regulated to enable optimal growth. In the yeast Saccharomyces cerevisiae, feedback mechanisms that control flux through glycolysis span transcriptional control to metabolite levels in the cell. Using a cellobiose consumption pathway, we decoupled glucose sensing from carbon utilization, revealing new modular layers of control that induce ATP consumption to drive rapid carbon fermentation. Alterations of the beta subunit of phosphofructokinase-1 (PFK2), H + -plasma membrane ATPase (PMA1), and glucose sensors (SNF3 and RGT2) revealed the importance of coupling extracellular glucose sensing to manage ATP levels in the cell. Controlling the upper bound of cellular ATP levels may be a general mechanism used to regulate energy levels in cells, via a regulatory network that can be uncoupled from ATP concentrations under perceived starvation conditions.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2018

Foot-and-mouth disease virus non-structural protein 2B negatively regulates the RLR-mediated IFN-β induction

Highlights: • FMDV 2B is a negatively regulator of type I interferon induction. • FMDV 2B can inhibit the phosphorylation of TBK1 and IRF3. • FMDV 2B inhibited the expression of the RIG-I and MDA5. Foot-and-mouth disease virus (FMDV) is the causative agent of Foot-and-mouth disease (FMD), which is an acute and highly contagious disease affecting pigs, cattle and other cloven-hoofed animals. Several studies have shown that FMDV has evolved multiple strategies to evade the host innate immune response, but the underlying mechanisms for immune evasion are still not fully understood. In the current research, we have demonstrated that FMDV utilizes its non-structural protein 2B to sabotage the host immune response. Over-expression of the FMDV 2B inhibited Poly(I:C)-induced or SeV-triggered up-regulation of IFN-β, IL-6 as well as ISG15. When HEK293T cells were transfected with FMDV 2B, the phosphorylation of TBK1 and IRF3 was inhibited. Co-immunoprecipitation and pull-down experiments indicated that FMDV 2B protein could interact with host RIG-I and MDA5. Moreover, FMDV 2B also inhibited the expression of the RIG-I and MDA5. Thus, FMDV 2B negatively regulates the RLR-mediated IFN-β induction by targeting RIG-I and MDA5.

60 APPLIED LIFE SCIENCES↗

DOE OSTI2018

Synergistic Effect of Graphene Oxide for Impeding the Dendritic Plating of Li

Dendritic growth of lithium (Li) has severely impeded the practical application of Li-metal batteries. Herein, a 3D conformal graphene oxide nanosheet (GOn) coating, confined into the woven structure of a glass fiber separator, is reported, which permits facile transport of Li-ions thought its structure, meanwhile regulating the Li deposition. Electrochemical measurements illustrate a remarkably enhanced cycle life and stability of the Li-metal anode, which is explained by various microscopy and modeling results. Utilizing scanning electron microscopy, focused ion beam, and optical imaging, the formation of an uniform Li film on the electrode surface in the case of GO-modified samples is revealed. Ab initio molecular dynamics (AIMD) simulations suggest that Li-ions initially get adsorbed to the lithiophilic GOn and then diffuse through defect sites. This delayed Li transfer eliminates the “tip effect” leading to a more homogeneous Li nucleation. Meanwhile, C-C bonds rupture observed in the GO during AIMD simulations creates more pathways for faster Li-ions transport. In addition, phase-field modeling demonstrates that mechanically rigid GOn coating with proper defect size (smaller than 25 nm) can physically block the anisotropic growth of Li. This new understanding is a significant step toward the employment of 2D materials for regulating the Li deposition

25 ENERGY STORAGE↗

DOE OSTI2018

Deletion of the GCW13 gene derepresses Gap1-dependent uptake of amino acids in Pichia pastoris grown on methanol as the sole carbon source

Highlights: • Deletion of GCW13 results in an increased growth rate in P. pastoris GS115 on methanol as the sole carbon source. • The intracellular concentrations of various amino acids are increased in the GCW13-deletion P. pastoris strain. • Gcw13 facilitates the endocytosis of Gap1 in P. pastoris GS115 on methanol as the sole carbon source. In Pichia pastoris, most of the Glycosylphosphatidylinositol (GPI)-anchored proteins are of unknown function. Gcw13, one of these GPI-anchored proteins, was found to exert an inhibitory effect on the growth of the histidine auxotrophic P. pastoris strain GS115 on methanol as the sole carbon source. To investigate the biological function of Gcw13, RNA sequencing (RNA-Seq) was performed to compare the difference of gene expression between GS115 and GCW13-deletion strain D13. RNA-Seq analysis showed that, in strain D13, the expression of genes involved in the methanol utilization pathway or peroxisome biogenesis was not changed, and a high proportion of genes involved in the biosynthesis of amino acids were down-regulated, whereas GAP1, which encodes a general amino acid permease, was significantly up-regulated. Besides, the intracellular concentrations of various amino acids were significantly higher in D13 than that in GS115. We also observed that deletion of GCW13 resulted in more Gap1 presented on the cell surface and more active uptake of the toxic proline analogue l-azetidine-2-carboxylate acid (AzC). These results suggest that Gcw13 suppresses the expression of GAP1 and facilitates the endocytosis of Gap1 on methanol, resulting in decreasing Gap1-dependent uptake of amino acids in P. pastoris, which might contribute to the poor growth of GS115 on methanol.

60 APPLIED LIFE SCIENCES↗

DOE OSTI2018

The ADP-ribose reactive NUDIX hydrolase isoforms can modulate HIF-1α in cancer cells

Highlights: • Knockdown of some ADP-ribose reactive NUDIX hydrolases enhances HIF-1α accumulation. • Neither HIF-1 α mRNA expression nor protein degradation is affected by NUDT9 knockdown. • Knockdown of NUDT9 enhances HIF-1α translation via TRPM2-CaMKKβ-AMPK pathway. The human nucleoside-diphosphate linked moiety–X (NUDIX) hydrolases that utilize ADP-ribose and NADH/NAD{sup +} are overexpressed in cancer cells, but their roles in hypoxia inducible factor-1α (HIF-1α) regulation have not yet been revealed. Here, we showed that these NUDIX hydrolases negatively regulated HIF-1α accumulation by modulating the Ca{sup 2+} dependent AMP-activated protein kinase (AMPK) signaling pathway. In specific, knockdown of NUDT9 resulted in accumulation of free ADP-ribose that triggered Ca{sup 2+} influx mediated by transient receptor potential cation channel subfamily M member 2 and subsequent activation of Ca{sup 2+}/calmodulin-dependent protein kinase kinase β (CaMKKβ). In addition, AMPK activation by CaMKKβ was shown to enhance HIF-1α accumulation. Our findings provide insights into the action of NUDIX hydrolases as an additional, discrete modulator of HIF-1α accumulation.

60 APPLIED LIFE SCIENCES↗

DOE OSTI2023

Optimal Binding Affinity for Sieving Separation of Propylene from Propane in an Oxyfluoride Anion-Based Metal–Organic Framework

Highly efficient adsorptive separation of propylene from propane offers an ideal alternative method to replace the energy-intensive cryogenic distillation technology. Molecular sieving-type separation via high-performance adsorbents is targeted for superior selectivity, but the limit in adsorption capacity remains a great challenge. Here, we report an oxyfluoride-based ultramicroporous metal–organic framework UTSA-400, [Ni(WO 2 F 4 )(pyz) 2 ] (pyz = pyrazine), featuring one-dimensional pore channels that can accommodate the propylene molecules with optimal binding affinity while specifically excluding the propane molecules. The exposed oxide/fluoride pairs in UTSA-400 serve as strong functional sites for strengthened propylene–host interactions, accounting for a significantly enhanced propylene uptake, while the propane molecules are excluded due to the regulated host framework dynamics. The strong propylene binding enables near-saturation of propylene in the pore confinement at ambient conditions, leading to full utilization of pore space and superior packing density. Combined in situ infrared spectroscopy measurements and dispersion-corrected density functional theory calculations clearly unveil the nature of boosted host–guest binding. Direct production of polymer-grade (>99.5%) propylene with remarkable dynamic productivity is demonstrated by column breakthrough experiments. Furthermore, this work presents an example of pore engineering with atomic precision to break the trade-off in adsorptive separation through guest binding optimization.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

DOE OSTI2025

The role of chromatin state in intron retention: A case study in leveraging large scale deep learning models

Complex deep learning models trained on very large datasets have become key enabling tools for current research in natural language processing and computer vision. By providing pre-trained models that can be fine-tuned for specific applications, they enable researchers to create accurate models with minimal effort and computational resources. Large scale genomics deep learning models come in two flavors: the first are large language models of DNA sequences trained in a self-supervised fashion, similar to the corresponding natural language models; the second are supervised learning models that leverage large scale genomics datasets from ENCODE and other sources. We argue that these models are the equivalent of foundation models in natural language processing in their utility, as they encode within them chromatin state in its different aspects, providing useful representations that allow quick deployment of accurate models of gene regulation. We demonstrate this premise by leveraging the recently created Sei model to develop simple, interpretable models of intron retention, and demonstrate their advantage over models based on the DNA language model DNABERT-2. Our work also demonstrates the impact of chromatin state on the regulation of intron retention. Using representations learned by Sei, our model is able to discover the involvement of transcription factors and chromatin marks in regulating intron retention, providing better accuracy than a recently published custom model developed for this purpose.

Biochemistry & Molecular Biology↗

DOE OSTI2021

Voltage Control Strategy for Energy Storage System in Sustainable Distribution System Operation

Due to the increasing penetration of distributed energy resources (DERs) required for the sustainable distribution system, new voltage control strategy is needed by utilities. Traditional voltage control strategy can not support the increasing number of DERs in a coordinated and scalable manner to meet the operational voltage regulation requirement. Supported by the power electronics converter, the energy storage system can provide fast, smooth, and flexible voltage control services. In this paper, an effective and easy to implement sensitivity-based voltage control strategy is developed for the energy storage system. The developed control strategy is validated using an industrial feeder data in Northwest Washington. The proposed strategy can mitigate the voltage unbalance issue, improve the voltage profile, and correct power factors while supporting sustainable distribution system operation.

Zhang, Yue (ORCID:0000000241469716)↗

DOE OSTI2019

Dust Polarization Maps from TIGRESS: E/B Power Asymmetry and TE Correlation

We present the first large set of all-sky synthetic dust polarization maps derived directly from a self-consistent magnetohydrodynamics simulation using the TIGRESS framework. Turbulence in this simulation is predominantly driven by supernova explosions, with rates that are self-consistently regulated by feedback loops. The simulation covers both the outer scale and inertial range of turbulence with uniformly high resolution. The shearing-box utilized in the simulation, in concert with resolved supernova-driven turbulence, enables the capturing of generation, growth, and saturation of both turbulent and mean magnetic fields. We construct polarization maps at 353 GHz, as seen by observers inside a model of the multiphase, turbulent, magnetized interstellar medium (ISM). To fully sample the simulated ISM state, we use 350 snapshots spanning over $\sim 350\,\mathrm{Myr}$ (more than six feedback loops) and nine representative observers. The synthetic skies show a prevalent E/B power asymmetry (${EE}\gt {BB}$) and positive TE correlation in broad agreement with observations by the Planck satellite. However, the ranges of ${EE}/{BB}\sim 1.4\mbox{-}1.7$ and ${TE}/{({TT}\cdot {EE})}^{1/2}\sim 0.2\mbox{-}0.3$ are generally lower than those measured by Planck. We find large fluctuations of E/B asymmetry and TE correlation depending on the observer's position and temporal fluctuations of ISM properties due to bursts of star formation. The synthetic maps are made publicly available to provide novel models of the microwave sky.

79 ASTRONOMY AND ASTROPHYSICS↗

NASA NTRS1992

Tidal evolution of globular clusters. I - Method

Tidal evolution of globular clusters is regulated by both Galactic tidal effects and internal relaxation processes. In order to investigate the tidal evolution of globular clusters, a numerical scheme which utilizes a Fokker-Planck approach as well as direct numerical integration of the restricted three-body problem is developed. In the inner regions of the cluster, stellar orbits are mapped with the cluster's gravitational potential and orbit-averaged diffusion coefficients. In the outer regions, the Galactic tidal field is explicitly included in the direct orbital integration. This method is presented here with some tests on King-Michie models.

Oh, K. S.↗

NASA NTRS2000

National Emission Standards for Hazardous Air Pollutants (NESHAP) Memorandum of Agreement (MOA) Between NASA Headquarters and MSFC (Marshall Space Flight Center) for NASA Principal Center for Review of Clean Air Regulations

This paper presents a memorandum of agreement on Clean Air Regulations. NASA headquarters (code JE and code M) has asked MSFC to serve as principle center for review of Clean Air Act (CAA) regulations. The purpose of the principle center is to provide centralized support to NASA headquarters for the management and leadership of NASA's CAA regulation review process and to identify the potential impact of proposed CAA reguations on NASA program hardware and supporting facilities. The materials and processes utilized in the manufacture of NASA's programmatic hardware contain HAPs (Hazardous Air Pollutants), VOCs (Volatile Organic Compounds), and ODC (Ozone Depleting Chemicals). This paper is presented in viewgraph form.

Caruso, Salvadore V.↗

NASA NTRS2003

Collective Intelligence

Many systems of self-interested agents have an associated performance criterion that rates the dynamic behavior of the overall system. This chapter presents an introduction to the science of such systems. Formally, collectives are defined as any system having the following two characteristics: First, the system must contain one or more agents each of which we view as trying to maximize an associated private utility; second, the system must have an associated world utility function that rates the possible behaviors of that overall system. In practice, collectives are often very large, distributed, and support little, if any, centralized communication and control, although those characteristics are not part of their formal definition. A naturally occurring example of a collective is a human economy. One can identify the agents and their private utilities as the human individuals in the economy and the associated personal rewards they are each trying to maximize. One could then identify the world utility as the time average of the gross domestic product. ("World utility" per se is not a construction internal to a human economy, but rather something defined from the outside.) To achieve high world utility it is necessary to avoid having the agents work at cross-purposes lest phenomena like liquidity traps or the Tragedy of the Commons (TOC) occur, in which agents' individually pursuing their private utilities lowers world utility. The obvious way to avoid such phenomena is by modifying the agents utility functions to be "aligned" with the world utility. This can be done via punitive legislation. A real-world example of an attempt to do this was the creation of antitrust regulations designed to prevent monopolistic practices.

Wolpert, David H.↗

NASA NTRS2006

Radiation Tolerant Intelligent Memory Stack (RTIMS)

The Radiation Tolerant Intelligent Memory Stack (RTIMS), suitable for both geostationary and low earth orbit missions, has been developed. The memory module is fully functional and undergoing environmental and radiation characterization. A self-contained flight-like module is expected to be completed in 2006. RTIMS provides reconfigurable circuitry and 2 gigabits of error corrected or 1 gigabit of triple redundant digital memory in a small package. RTIMS utilizes circuit stacking of heterogeneous components and radiation shielding technologies. A reprogrammable field programmable gate array (FPGA), six synchronous dynamic random access memories, linear regulator, and the radiation mitigation circuitries are stacked into a module of 42.7mm x 42.7mm x 13.00mm. Triple module redundancy, current limiting, configuration scrubbing, and single event function interrupt detection are employed to mitigate radiation effects. The mitigation techniques significantly simplify system design. RTIMS is well suited for deployment in real-time data processing, reconfigurable computing, and memory intensive applications.

Ng, Tak-kwong↗

DOE OSTI2023

Beyond PID Controllers: PPO with Neuralized PID Policy for Proton Beam Intensity Control in Mu2e

We introduce a novel Proximal Policy Optimization (PPO) algorithm aimed at addressing the challenge of maintaining a uniform proton beam intensity delivery in the Muon to Electron Conversion Experiment (Mu2e) at Fermi National Accelerator Laboratory (Fermilab). Our primary objective is to regulate the spill process to ensure a consistent intensity profile, with the ultimate goal of creating an automated controller capable of providing real-time feedback and calibration of the Spill Regulation System (SRS) parameters on a millisecond timescale. We treat the Mu2e accelerator system as a Markov Decision Process suitable for Reinforcement Learning (RL), utilizing PPO to reduce bias and enhance training stability. A key innovation in our approach is the integration of a neuralized Proportional-Integral-Derivative (PID) controller into the policy function, resulting in a significant improvement in the Spill Duty Factor (SDF) by 13.6%, surpassing the performance of the current PID controller baseline by an additional 1.6%. This paper presents the preliminary offline results based on a differentiable simulator of the Mu2e accelerator. It paves the groundwork for real-time implementations and applications, representing a crucial step towards automated proton beam intensity control for the Mu2e experiment.

43 PARTICLE ACCELERATORS↗

DOE OSTI2025

Grid Communications: Digital Assurance and Supply Chain Challenges and Emerging Regulation Session Two

The TADA Grid Communications Workshops are designed to strengthen cybersecurity and digital assurance across the energy sector by focusing on secure deployment and management of grid communications technologies. These workshops bring together state energy offices, utilities, and technology suppliers to explore the intersection of communications infrastructure, supply chain risks, and emerging regulatory requirements. Participants will apply Cyber-Informed Engineering (CIE) principles to reduce risks in communications systems, engage with INL’s procurement guidance, and explore future tools. Through scenario-based exercises and peer exchange, attendees will develop risk-based security strategies and actionable compliance roadmaps tailored to their grid communications projects. The workshops also help participants navigate evolving regulatory frameworks such as FEOC rules in the OBBB, NERC CIP-013, and NDAA 2024, while identifying compliance gaps in mixed-technology environments. A key outcome is the formation of a practitioner network with ongoing access to INL expertise and resources, fostering long-term resilience in the digital energy ecosystem. This is Session 2 of 3 (Full Version).

29 - ENERGY PLANNING, POLICY AND ECONOMY↗

DOE OSTI2025

Grid Communications: Cybersecurity and Supply Chain Challenges and Emerging Regulation Session Three

29 - ENERGY PLANNING, POLICY AND ECONOMY↗

DOE OSTI2016

Technologies to Increase PV Hosting Capacity in Distribution Feeders

This paper studies the distributed photovoltaic (PV) hosting capacity in distribution feeders by using the stochastic analysis approach. Multiple scenario simulations are conducted to analyze several factors that affect PV hosting capacity, including the existence of voltage regulator, PV location, the power factor of PV inverter and Volt/VAR control. Based on the conclusions obtained from simulation results, three approaches are then proposed to increase distributed PV hosting capacity, which can be formulated as the optimization problem to obtain the optimal solution. All technologies investigated in this paper utilize only existing assets in the feeder and therefore are implementable for a low cost. Additionally, the tool developed for these studies is described.

14 SOLAR ENERGY↗