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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 703 records · Page 39
All sourcesNASA NTRSDOE OSTI
DOE OSTI2016

Isolation, structural analysis, and expression characteristics of the maize nuclear factor Y gene families

NUCLEAR FACTOR-Y (NF-Y) has been shown to play an important role in growth, development, and response to environmental stress. A NF-Y complex, which consists of three subunits, NF-YA, NF-YB, and, NF-YC, binds to CCAAT sequences in a promoter to control the expression of target genes. Although NF-Y proteins have been reported in Arabidopsis and rice, a comprehensive and systematic analysis of ZmNF-Y genes has not yet been performed. To examine the functions of ZmNF-Y genes in this family, we isolated and characterized 50 ZmNF-Y (14 ZmNF-YA, 18 ZmNF-YB, and 18 ZmNF-YC) genes in an analysis of the maize genome. The 50 ZmNF-Y genes were distributed on all 10 maize chromosomes, and 12 paralogs were identified. Multiple alignments showed that maize ZmNF-Y family proteins had conserved regions and relatively variable N-terminal or C-terminal domains. The comparative syntenic map illustrated 40 paralogous NF-Y gene pairs among the 10 maize chromosomes. Microarray data showed that the ZmNF-Y genes had tissue-specific expression patterns in various maize developmental stages and in response to biotic and abiotic stresses. The results suggested that ZmNF-YB2, 4, 8, 10, 13, and 16 and ZmNF-YC6, 8, and 15 were induced, while ZmNF-YA1, 3, 4, 6, 7, 10, 12, and 13, ZmNF-YB15, and ZmNF-YC3 and 9 were suppressed by drought stress. ZmNF-YA3, ZmNF-YA8 and ZmNF-YA12 were upregulated after infection by the three pathogens, while ZmNF-YA1 and ZmNF-YB2 were suppressed. These results indicate that the ZmNF-Ys may have significant roles in the response to abiotic and biotic stresses. - Highlights: • We indicated a total of 50 members of ZmNF-Y gene family in maize genome. • We analyzed gene structure, protein architecture of ZmNF-Y genes. • Evolution pattern and phylogenic relationships were analyzed among 50 ZmNF-Y genes. • Expression pattern of ZmNF-Ys were detected in various maize tissues. • Transcript levels of ZmNF-Ys were measured under various abiotic and biotic stresses.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2025

Harnessing the Power of Machine Learning and Omics to Identify Environmental Regulation on Microbial Functional Composition for Soil C, N, and P Cycling

Microbial enzyme-mediated soil organic matter (SOM) decomposition regulates many key ecosystem functions, such as elemental cycling, soil carbon sequestration, and soil fertility. However, representing microbial processes in Earth system models (ESMs) remains challenging due to a limited understanding of the spatial patterns of diverse microbial functions responsible for soil carbon (C), nitrogen (N), and phosphorus (P) cycling as well as the underlying mechanisms regulating their relative abundances across various environments. We collected published metagenomics data across the continental US (CONUS) to identify hundreds of microbial genes involved in soil C, N, and P cycling and grouped them into eight enzyme functional classes (EFCs). Each EFC represented a group of gene-encoded potential enzymes that decompose similar soil compounds. By integrating the abundances of omics-informed EFCs with the corresponding environmental information, we trained a machine learning (ML) model to identify key edaphic, climate, and vegetation factors regulating the abundances of each EFC. Quantitative analysis of effects of these factors revealed that the spatial distribution of eight EFCs for soil C, N, and P cycling across CONUS reflected potential resource optimization strategies of microbial communities under nutrient limitation, preferential organic-mineral associations, and climatological stresses. This insight, together with the interpreted ML tool and the CONUS-level benchmark for EFCs abundances, paves the way for parameterizing environmental-regulated microbial functional dynamics in biogeochemical models.

machine learning↗
DOE OSTI2020

Hanford Site Composite Analysis Data Package: Exposure Scenarios and Radionuclide Specific Dose Conversion Factors

This data package summarizes the exposure assumptions, equations, and methods used to calculate radionuclide-specific unit dose factors and the radiological doses for both groundwater and atmospheric pathways as a part of the updated Hanford Site Composite Analysis (CA). An All Pathways Representative Person exposure scenario is considered to evaluate exposure via both groundwater and atmospheric transport pathways. The radiological dose assessments for both groundwater and atmospheric pathways are included in the performance assessments (PAs) for various Waste Management Areas at the Hanford Site. This data package calculates exposure route-specific and total unit dose factors for CA-specific radionuclides of concern based on the exposure assumptions used in the CA and PAs. This data package also presents the results and comparison of the radionuclide-specific unit dose factors based on the exposure assumptions used in the revised Hanford Site Composite Analysis and Hanford Site performance assessments for low-level waste disposal facilities.

61 RADIATION PROTECTION AND DOSIMETRY↗
DOE OSTI2023

Estimation of Participation Factors Using the Synchrosqueezed Wavelet Transform

This paper proposes a data-driven approach for estimating participation factors for a power system using only simulation results on selected disturbances. The approach is purely response-based and does not need a linearized system model for eigen-analysis, which makes it applicable to systems whose detailed, complete mathematical models are not available. Considering the unavoidable nonlinearity as exhibited in the transient period of a system response, the Synchrosqueezed Wavelet Transform is applied to simulated responses for modal analysis to obtain participation factors. Based on simulations of Kundur's two-area system using both the electromagnetic transient model and phasor model, the participation factors estimated by the proposed approach are compared with two other signal processing tools, the Prony analysis and continuous wavelet transform, and are also benchmarked with conventional model-based participation factors.

participation factor↗
DOE OSTI2016

High E6 Gene Expression Predicts for Distant Metastasis and Poor Survival in Patients With HPV-Positive Oropharyngeal Squamous Cell Carcinoma

Purpose: Patients with human papillomavirus (HPV)–positive oropharyngeal squamous cell carcinoma (OPSCC) have a favorable prognosis. As a result, de-escalation clinical trials are under way. However, approximately 10% of patients will experience distant recurrence even with standard-of-care treatment. Here, we sought to identify novel biomarkers to better risk-stratify HPV-positive patients with OPSCC. Methods and Materials: Gene expression profiling by RNA sequencing (RNA-seq) and quantitative polymerase chain reaction was performed on HPV-positive OPSCC primary tumor specimens from patients with and without distant metastasis (DM). Results: RNA-seq analysis of 39 HPV-positive OPSCC specimens revealed that patients with DM had 2-fold higher E6 gene expression levels than did patients without DM (P=.029). This observation was confirmed in a validation cohort comprising 93 patients with HPV-positive OPSCC. The mean normalized E6 expression level in the 17 recurring primary specimens was 13 ± 2 compared with 8 ± 1 in the remaining 76 nonrecurring primaries (P=.001). Receiver operating characteristic analysis established an E6 expression level of 7.3 as a cutoff for worse recurrence-free survival (RFS). Patients from this cohort with high E6 gene expression (E6-high) (n=51, 55%) had more cancer-related deaths (23% vs 2%, P<.001) and DM (26% vs 5%, P<.001) than did patients with low E6 gene expression (E6-low) (n=42, 45%). Kaplan-Meier survival analysis revealed that E6-high had worse RFS (95% vs 69%, P=.004) and cancer-specific survival (97% vs 79%, P=.007). E6-high maintained statistical significance in multivariate regression models balancing surgery, chemotherapy, nodal stage, and smoking status. Gene set enrichment analysis demonstrated that tumors with high E6 expression were associated with P53, epidermal growth factor receptor, activating transcription factor-2, and transforming growth factor-β signaling pathways. Conclusion: High E6 gene expression level identifies HPV-positive OPSCC patients with 5-fold greater risk of distant disease recurrence and worse cancer-specific survival. Validation in a multi-institutional prospective clinical trial is required to assess the utility of E6 gene expression as a clinically useful prognostic biomarker.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2019

$B\to D^\ast\ell\nu$ at Non-Zero Recoil

The current status of the lattice-QCD calculations of the form factors of the $B\to D^\ast\ell\nu$ semileptonic decay is reviewed. Particular emphasis is given to the most mature calculation at non-zero recoil coming from the Fermilab Lattice and MILC collaborations. Blinded, preliminary results for the form factors are shown, including a preliminary, but detailed error budget. The lattice results seem to favor a large slope at small recoil, in contrast to the latest untagged results coming from the Belle collaboration. A comprehensive comparison between the latest BGL $z$ expansions of Belle, Babar, the lattice and a joint BGL fit including lattice and Belle data is presented, and a roadmap to improve the current calculation is discussed. The current implications for $V_{cb}$ and $R(D^\ast)$ are discussed.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2017

Peripheral transverse densities of the baryon octet from chiral effective field theory and dispersion analysis

The baryon electromagnetic form factors are expressed in terms of two-dimensional densities describing the distribution of charge and magnetization in transverse space at fixed light-front time. In this paper, we calculate the transverse densities of the spin-1/2 flavor-octet baryons at peripheral distances b=O(M$-1\atop{π}$) using methods of relativistic chiral effective field theory (χ EFT) and dispersion analysis. The densities are represented as dispersive integrals over the imaginary parts of the form factors in the timelike region (spectral functions). The isovector spectral functions on the two-pion cut t > 4 M$2\atop{π}$ are calculated using relativistic χEFT including octet and decuplet baryons. The χEFT calculations are extended into the ρ meson mass region using an N/D method that incorporates the pion electromagnetic form factor data. The isoscalar spectral functions are modeled by vector meson poles. We compute the peripheral charge and magnetization densities in the octet baryon states, estimate the uncertainties, and determine the quark flavor decomposition. Finally, the approach can be extended to baryon form factors of other operators and the moments of generalized parton distributions.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
NASA NTRS1994

On Bi-Grid Local Mode Analysis of Solution Techniques for 3-D Euler and Navier-Stokes Equations

A procedure is presented for utilizing a bi-grid stability analysis as a practical tool for predicting multigrid performance in a range of numerical methods for solving Euler and Navier-Stokes equations. Model problems based on the convection, diffusion and Burger's equation are used to illustrate the superiority of the bi-grid analysis as a predictive tool for multigrid performance in comparison to the smoothing factor derived from conventional von Neumann analysis. For the Euler equations, bi-grid analysis is presented for three upwind difference based factorizations, namely Spatial, Eigenvalue and Combination splits, and two central difference based factorizations, namely LU and ADI methods. In the former, both the Steger-Warming and van Leer flux-vector splitting methods are considered. For the Navier-Stokes equations, only the Beam-Warming (ADI) central difference scheme is considered. In each case, estimates of multigrid convergence rates from the bi-grid analysis are compared to smoothing factors obtained from single-grid stability analysis. Effects of grid aspect ratio and flow skewness are examined. Both predictions are compared with practical multigrid convergence rates for 2-D Euler and Navier-Stokes solutions based on the Beam-Warming central scheme.

Ibraheem, S. O.↗
DOE OSTI2017

CCN activity and organic hygroscopicity of aerosols downwind of an urban region in central Amazonia: Seasonal and diel variations and impact of anthropogenic emissions

During the Observations and Modeling of the Green Ocean Amazon (GoAmazon2014/5) campaign, size-resolved cloud condensation nuclei (CCN) spectra were characterized at a research site (T3) 60km downwind of the city of Manaus, Brazil, in central Amazonia for one year (12 March 2014 to 3 March 2015). Particle hygroscopicity (κCCN) and mixing state were derived from the size-resolved CCN spectra, and the hygroscopicity of the organic component of the aerosol (κorg) was then calculated from κCCN and concurrent chemical composition measurements. The annual average κCCN increased from 0.13 at 75 nm to 0.17 at 171&thinsp;nm, and the increase was largely due to an increase in sulfate volume fraction. Also, during both wet and dry seasons, κCCN, κorg, and particle composition under background conditions exhibited essentially no diel variations. The constant κorg of ~0.15 is consistent with the largely uniform and high O:C value (~0.8), indicating that the aerosols under background conditions are dominated by the aged regional aerosol particles consisting of highly oxygenated organic compounds. For air masses strongly influenced by urban pollution and/or local biomass burning, lower values of κorg and organic O:C atomic ratio were observed during night, due to accumulation of freshly emitted particles, dominated by primary organic aerosol (POA) with low hygroscopicity, within a shallow nocturnal boundary layer. The O:C, κorg, and κCCN increased from the early morning hours and peaked around noon, driven by the formation and aging of secondary organic aerosol (SOA) and dilution of POA emissions into a deeper boundary layer, while the development of the boundary layer, which leads to mixing with aged particles from the residual layer aloft, likely also contributed to the increases. The hygroscopicities associated with individual organic factors, derived from PMF analysis of AMS spectra, were estimated through multi-variable linear regression. For the SOA factors, the variation of the κ value with O:C agrees well with the linear relationship reported from earlier laboratory studies of SOA hygroscopicity. On the other hand, the variation in O:C of ambient aerosol organics is largely driven by the variation in the volume fractions of POA and SOA factors, which have very different O:C values. As POA factors have hygroscopicity values well below the linear relationship between SOA hygroscopicity and O:C, mixtures with different POA and SOA fractions exhibit a steeper slope for the increase of κorg with O:C, as observed during this and earlier field studies. Our finding helps better understand and reconcile the differences in the relationships between κorg and O:C observed in laboratory and field studies, therefore providing a basis for improved parameterization in global models, especially in a tropical context.

54 ENVIRONMENTAL SCIENCES↗
NASA NTRS1974

A review of surface-crack fracture testing

A brief historical review of surface-crack testing and analysis is given together with some examples of service failures due to surface cracks. The factors which complicate the analysis and interpretation of surface-crack fracture data are discussed. Current efforts to develop consensus recommendations for tensile testing of surface-crack specimens are summarized.

Orange, T. W.↗
NASA NTRS1974

A review of surface-crack fracture testing

A brief historical review of surface-crack testing and analysis is given together with some examples of service failures due to surface cracks. The factors which complicate the analysis and interpretation of surface-crack fracture data are discussed. Current efforts to develop consensus recommendations for tensile testing of surface-crack specimens are summarized.

Orange, T. W.↗
DOE OSTI2019

I Asked 30,000 People in the Nuclear Industry About Safety Culture; This is What I Learned - 19204

Organizations in the nuclear industry place a high value on maintaining the safety of the workforce and community. Some of these organizations do a better job than others when it comes to developing and sustaining a healthy safety culture. We spent six years studying nuclear organizations to better understand the factors that influence safety culture. We used mixed methods to evaluate perceptions of safety culture in these organizations including administering a valid and reliable safety culture survey, conducting one-on-one interviews with managers, and facilitating focus groups with members of the workforce. We analyzed the quantitative and qualitative data collected from more than 30,000 workers in U.S. based organizations. All of the organizations had a nuclear component to their operations. They operated nuclear reactors, processed nuclear materials, decontaminated and decommissioned buildings with radiological contamination, cleaned-up hazardous/mixed waste, and conducted basic science research and development. We talked to craft workers, technicians, engineers, scientific professionals, support personnel, production workers, supervisors and managers. We conducted extensive statistical analysis and learned that, with rare exception, there is a gap between the perceptions of managers and the workforce that they manage. Managers almost always have a more positive perception of safety culture than the people that are actually performing the work. It is not a question of whether there will be a gap; it is simply a matter of the magnitude of the gap. We also learned through exploratory factor analysis that there is one dominant factor that accounted for almost all (75%) of the variance in the perceptions of safety culture. It was the behavior of the leaders, the decisions they made, and the systems they implemented that most influenced the workforce's perception of safety culture. Personal accountability for safety accounted for 14% of the variance, communication and reporting accounted for another 6%. Everything else accounted for the remaining 5%. Management systems, decision making and behavior is the dominant factor and managers almost always have a more positive perception than the people that work for them. People that work in organizations where management exhibits positive decision-making and safety-related behaviors tend to have more positive perceptions of safety culture. Based upon these results, we developed a theory that there were a few important factors on which management could focus on if they sought to influence the safety culture in their organization. Our experience and research suggests that management often fails to recognize five root causes of employee discontent. Employees seek: - To be recognized as an individual; - To be respected; - A sense of stability; - Fairness; - To make a difference. Understanding the perceptions of the workforce is critical because perceptions influence attitudes, which contribute to behaviors that determine individual performance. An organisation's performance is simply the sum of the performance of all of the members of that organization. To change an organisation's safety culture, interventions should target management behavior and decision making for the greatest return on investment. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
NASA NTRS1996

Factorial Design: An Eight Factor Experiment Using Paper Helicopters

The goal of this paper is to present the analysis of the multi-factor experiment (factorial design) conducted in EG490, Junior Design at Loyola College in Maryland. The discussion of this paper concludes the experimental analysis and ties the individual class papers together.

Kozma, Michael↗
DOE OSTI2017

An in situ USAXS–SAXS–WAXS study of precipitate size distribution evolution in a model Ni-based alloy

Intermetallic γ' precipitates typically strengthen nickel-based superalloys. The shape, size and spatial distribution of strengthening precipitates critically influence alloy strength, while their temporal evolution characteristics determine the high-temperature alloy stability. Combined ultra-small-, small- and wide-angle X-ray scattering (USAXS–SAXS–WAXS) analysis can be used to evaluate the temporal evolution of an alloy's precipitate size distribution (PSD) and phase structure during in situ heat treatment. Analysis of PSDs from USAXS–SAXS data employs either least-squares fitting of a preordained PSD model or a maximum entropy (MaxEnt) approach, the latter avoiding a priori definition of a functional form of the PSD. However, strong low- q scattering from grain boundaries and/or structure factor effects inhibit MaxEnt analysis of typical alloys. Lastly, this work describes the extension of Bayesian–MaxEnt analysis methods to data exhibiting structure factor effects and low- q power law slopes and demonstrates their use in an in situ study of precipitate size evolution during heat treatment of a model Ni–Al–Si alloy.

36 MATERIALS SCIENCE↗
DOE OSTI2019

The Efficacy of Paclitaxel Drug-Eluting Balloon Angioplasty Versus Standard Balloon Angioplasty in Stenosis of Native Hemodialysis Arteriovenous Fistulas: An Analysis of Clinical Success, Primary Patency and Risk Factors for Recurrent Dysfunction

Purpose: To investigate the efficacy of paclitaxel drug-eluting balloons (PEB) versus standard balloon angioplasty (BA) in stenosis of native hemodialysis arteriovenous fistulas (AVFs). Materials and Methods: A total of 96 patients with ESRD (mean ± SD age 57.0 ± 9.1 years, 63.5% were males) who underwent endovascular treatment with PEB angioplasty (n = 32) and BA (n = 64) for a dysfunctional native AVF were included. Clinical success, complications, primary patency and postoperative recurrence parameters were recorded in each group. Results: Primary patency rate at 6 months was significantly higher in PEB than in BA group (96.9 vs. 20.3%, p < 0.001), while the two groups had similar primary patency rates at 9 months (66.8 vs. 50.0%) and 12 months (6.3% for each). No significant difference was noted between PEB and BA groups in terms of the rate (21.9% and. 31.3%), time (median 220 vs. 152.5 days) and reasons (reocclusion in 18.8 vs. 28.1%) for dysfunction recurrence as well as the number of recurrent treatments. AVF dysfunction recurrence was more likely in younger age AVF (median 4 vs. 23 months, p < 0.001 in PEB, and 8.5 vs. 20.5 months p = 0.001 in SBA) and in AVF ≤ 6 months in both SBA and PEB groups (71.4 vs. 12.0%, p = 0.005 in PEB, 40.0 vs. 2.3%, p < 0.001). Conclusion: In conclusion, our findings emphasize favorable safety and efficacy of PEB and BA in the management of dysfunctional hemodialysis AVFs with similar rates of post-PTA recurrence of AVF dysfunction. Nonetheless, there was a nonsignificant tendency for lower rate and a delay for recurrent dysfunction in patients treated with PEB and a significant association younger AVF age with an increased risk of post-PTA recurrence of AVF dysfunction. Level of Evidence: 3, Retrospective cohort study.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
NASA NTRS1972

Statistical analysis of several terminal area traffic collision hazard factors.

An 11 hr sample of air traffic, comprising 584 tracks recorded at Atlanta during peak periods of August 1967, is analyzed to examine the statistical characteristics of range-guard intrusions and airspace conflicts in a terminal area. The number of intrusions (of an imaginary 3-naut mile, 500-ft range guard surrounding each aircraft) and number of conflicts (of the projected airspace for two aircraft) for a track exhibit Poisson variations with track duration. The hourly rate of intrusions follows the gas model square-law variation with traffic density, but the hourly conflict rate, contrary to the gas model, decreases with greater traffic density.

Ruetenik, J. R.↗
NASA NTRS2004

Analysis of Adverse Events in Identifying GPS Human Factors Issues

The purpose of this study was to analyze GPS related adverse events such as accidents and incidents (A/I), Aviation Safety Reporting System (ASRS) reports and Pilots Deviations (PDs) to create a framework for developing a human factors risk awareness program. Although the occurrence of directly related GPS accidents is small the frequency of PDs and ASRS reports indicated there is a growing problem with situational awareness in terminal airspace related to different types of GPs operational issues. This paper addresses the findings of the preliminary research and a brief discussion of some of the literature on related GPS and automation issues.

Adams, Catherine A.↗