Results for “Breakpoint” — Page 4

NASA NTRS1994

A computational approach to the relationship between radiation induced double strand breaks and translocations

A theoretical framework is presented which provides a quantitative analysis of radiation induced translocations between the ab1 oncogene on CH9q34 and a breakpoint cluster region, bcr, on CH 22q11. Such translocations are associated frequently with chronic myelogenous leukemia. The theory is based on the assumption that incorrect or unfaithful rejoining of initial double strand breaks produced concurrently within the 200 kbp intron region upstream of the second abl exon, and the 16.5 kbp region between bcr exon 2 and exon 6 interact with each other, resulting in a fusion gene. for an x-ray dose of 100 Gy, there is good agreement between the theoretical estimate and the one available experimental result. The theory has been extended to provide dose response curves for these types of translocations. These curves are quadratic at low doses and become linear at high doses.

NASA Discipline Radiation Health↗

NASA NTRS2005

Propagation Characteristics of International Space Station Wireless Local Area Network

This paper describes the application of the Uniform Geometrical Theory of Diffraction (UTD) for Space Station Wireless Local Area Networks (WLANs) indoor propagation characteristics analysis. The verification results indicate good correlation between UTD computed and measured signal strength. It is observed that the propagation characteristics are quite different in the Space Station modules as compared with those in the typical indoor WLANs environment, such as an office building. The existing indoor propagation models are not readily applicable to the Space Station module environment. The Space Station modules can be regarded as oversized imperfect waveguides. Two distinct propagation regions separated by a breakpoint exist. The propagation exhibits the guided wave characteristics. The propagation loss in the Space Station, thus, is much smaller than that in the typical office building. The path loss model developed in this paper is applicable for Space Station WLAN RF coverage and link performance analysis.

Sham, Catherine C.↗

NASA NTRS2006

Inspection and Verification of Domain Models with PlanWorks and Aver

When developing a domain model, it seems natural to bring the traditional informal tools of inspection and verification, debuggers and automated test suites, to bear upon the problems that will inevitably arise. Debuggers that allow inspection of registers and memory and stepwise execution have been a staple of software development of all sorts from the very beginning. Automated testing has repeatedly proven its considerable worth, to the extent that an entire design philosophy (Test Driven Development) has been developed around the writing of tests. Unfortunately, while not entirely without their uses, the limitations of these tools and the nature of the complexity of models and the underlying planning systems make the diagnosis of certain classes of problems and the verification of their solutions difficult or impossible. Debuggers provide a good local view of executing code, allowing a fine-grained look at algorithms and data. This view is, however, usually only at the level of the current scope in the implementation language, and the data-inspection capabilities of most debuggers usually consist of on-line print statements. More modem graphical debuggers offer a sort of tree view of data structures, but even this is too low-level and is often inappropriate for the kinds of structures created by planning systems. For instance, god or constraint networks are at best awkward when visualized as trees. Any any non-structural link between data structures, as through a lookup table, isn't captured at all. Further, while debuggers have powerful breakpointing facilities that are suitable for finding specific algorithmic errors, they have little use in the diagnosis of modeling errors.

Bedrax-Weiss, Tania↗

NASA NTRS2004

Model-Based Engineering Design for Trade Space Exploration throughout the Design Cycle

This paper presents ongoing work to standardize model-based system engineering as a complement to point design development in the conceptual design phase of deep space missions. It summarizes two first steps towards practical application of this capability within the framework of concurrent engineering design teams and their customers. The first step is standard generation of system sensitivities models as the output of concurrent engineering design sessions, representing the local trade space around a point design. A review of the chosen model development process, and the results of three case study examples, demonstrate that a simple update to the concurrent engineering design process can easily capture sensitivities to key requirements. It can serve as a valuable tool to analyze design drivers and uncover breakpoints in the design. The second step is development of rough-order- of-magnitude, broad-range-of-validity design models for rapid exploration of the trade space, before selection of a point design. At least one case study demonstrated the feasibility to generate such models in a concurrent engineering session. The experiment indicated that such a capability could yield valid system-level conclusions for a trade space composed of understood elements. Ongoing efforts are assessing the practicality of developing end-to-end system-level design models for use before even convening the first concurrent engineering session, starting with modeling an end-to-end Mars architecture.

models↗

NASA NTRS2009

A Monte-Carlo Model for the Formation of Radiation-induced Chromosomal Aberrations

Purpose: To simulate radiation-induced chromosome aberrations in mammalian cells (e.g., rings, translocations, and dicentrics) and to calculate their frequency distributions following exposure to DNA double strand breaks (DSBs) produced by high-LET ions. Methods: The interphase genome was assumed to be comprised of a collection of 2 kbp rigid-block monomers following the random-walk geometry. Additional details for the modeling of chromosomal structure, such as chromosomal domains and chromosomal loops, were included. A radial energy profile for heavy ion tracks was used to simulate the high-LET pattern of induced DSBs. The induced DSB pattern depended on the ion charge and kinetic energy, but always corresponded to the DSB yield of 25 DSBs/cell/Gy. The sum of all energy contributions from Poisson-distributed particle tracks was taken to account for all possible one-track and multi-track effects. The relevant output of the model was DNA fragments produced by DSBs. The DSBs, or breakpoints, were defined by (x, y, z, l) positions, where x, y, z were the Euclidian coordinates of a DSB, and where l was the relative position along the genome. Results: The code was used to carry out Monte Carlo simulations for DSB rejoinings at low doses. The resulting fragments were analyzed to estimate the frequencies of specific types of chromosomal aberrations. Histograms for relative frequencies of chromosomal aberrations and P.D.F.s (probability density functions) of a given aberration type were produced. The relative frequency of dicentrics to rings was compared to empirical data to calibrate rejoining probabilities. Of particular interest was the predicted distribution of ring sizes, irrespective of their frequencies relative to other aberrations. Simulated ring sizes were . 4 kbp, which are far too small to be observed experimentally (i.e., by microscopy) but which, nevertheless, are conjectured to exist. Other aberrations, for example, inversions, translocations, as well as multi-centrics were also recorded. Conclusion: High-LET DNA damage affects the frequencies of chromosomal aberrations. The ratio of rings to dicentrics is correct for the genomic size cut-offs corresponding to available experimental data. The present work predicts a relative abundance of small rings following irradiation by heavy ions.

Ponomarev, Artem L.↗

NASA NTRS2010

Thermal Stability Testing of a Fischer-Tropsch Fuel and Various Blends with Jet A

Fischer-Tropsch (F-T) jet fuel composition differs from petroleum-based, conventional commercial jet fuel because of differences in feedstock and production methodology. Fischer-Tropsch fuel typically has a lower aromatic and sulfur content and consists primarily of iso and normal parafins. The ASTM D3241 specification for Jet Fuel Thermal Oxidation Test (JFTOT) break point testing method was used to test the breakpoint of a baseline conventional Jet A, a commercial grade F-T jet fuel, and various blends of this F-T fuel in Jet A. The testing completed in this report was supported by the NASA Fundamental Aeronautics Subsonics Fixed Wing Project.

Klettlinger, Jennifer Suder↗

NASA NTRS2013

Thermal Stability Results of a Fischer-Tropsch Fuel With Various Blends of Aromatic Solution

Fischer-Tropsch (F-T) jet fuel composition differs from petroleum-based, conventional commercial jet fuel because of differences in feedstock and production methodology. F-T fuel typically has a lower aromatic and sulfur content and consists primarily of iso and normal paraffins. The ASTM D3241 specification for Jet Fuel Thermal Oxidation Test (JFTOT) break point testing method was used to test the breakpoint of a baseline commercial grade F-T jet fuel, and various blends of this F-T fuel with an aromatic solution. The goal of this research is to determine the effect of aromatic content on the thermal stability of F-T fuel. The testing completed in this report was supported by the NASA Fundamental Aeronautics Subsonic Fixed Wing Project. Two different aromatic content fuels from Rentech, as well as these fuels with added aromatic blend were analyzed for thermal stability using the JFTOT method. Preliminary results indicate a reduction in thermal stability occurs upon increasing the aromatic content to 10% by adding an aromatic blend to the neat fuel. These results do not specify a failure based on pressure drop, but only on tube color. It is unclear whether tube color correlates to more deposition on the tube surface or not. Further research is necessary in order to determine if these failures are true failures based on tube color. Research using ellipsometry to determine tube deposit thickness rather than color will be continued in follow-up of this study.

Lindsey, Jennifer↗

NASA NTRS2012

Effect of Aromatic Concentration of a Fischer-Tropsch Fuel on Thermal Stability

Fischer-Tropsch (F-T) jet fuel composition differs from petroleum-based, conventional commercial jet fuel because of differences in feedstock and production methodology. Fischer Tropsch fuel typically has a lower aromatic and sulfur content and consists primarily of iso and normal parafins. The ASTM D3241 specification for Jet Fuel Thermal Oxidation Test (JFTOT) break point testing method was used to test the breakpoint of a baseline commercial grade F-T jet fuel, and various blends of this F-T fuel with an aromatic solution. The goal of this research is to determine the effect of aromatic content on the thermal stability of Fischer-Tropsch fuel. The testing completed in this report was supported by the NASA Fundamental Aeronautics Subsonics Fixed Wing Project.

Klettlinger, Jennifer Lindsey Suder↗

NASA NTRS2011

Thermal Stability Testing of Fischer-Tropsch Fuel and Various Blends with Jet A, as Well as Aromatic Blend Additives

Fischer-Tropsch (F-T) jet fuel composition differs from petroleum-based, conventional commercial jet fuel because of differences in feedstock and production methodology. Fischer-Tropsch fuel typically has a lower aromatic and sulfur content and consists primarily of iso and normal parafins. The ASTM D3241 specification for Jet Fuel Thermal Oxidation Test (JFTOT) break point testing method was used to test the breakpoint of a baseline conventional Jet A, a commercial grade F-T jet fuel, and various blends of this F-T fuel in Jet A. The testing completed in this report was supported by the NASA Fundamental Aeronautics Subsonics Fixed Wing Project.

Klettlinger, J.↗

NASA NTRS2016

Extreme Water Deficit in Brazil Detected from Space

Extreme droughts have caused significant socioeconomic and environmental damage worldwide. In Brazil, ineffective energy development and water management policies have magnified the impacts of recent severe droughts, which include massive agricultural losses, water supply restrictions, and energy rationing. Spaceborne remote sensing data advance our understanding of the spatiotemporal variability of large-scale droughts and enhance the detection and monitoring of extreme water-related events. In this study, data derived from the Gravity Recovery and Climate Experiment (GRACE) mission are used to detect and quantify an extended major drought over eastern Brazil and provide estimates of impacted areas and region-specific water deficits. Two structural breakpoint detection methods were applied to time series of GRACE-based terrestrial water storage anomalies (TWSA), determining when two abrupt changes occurred. One, in particular, defines the beginning of the current drought. Using TWSA, a water loss rate of 26.1 cmyr21 over southeastern Brazil was detected from 2012 to 2015. Based on analysis of Global Land Data Assimilation System(GLDAS) outputs, the extreme drought is mostly related to lower-than-usual precipitation rates, resulting in high soil moisture depletion and lower-than-usual rates of evapotranspiration. A reduction of 2023 of precipitation over an extended period of 3 years is enough to raise serious water scarcity conditions in the country. Correlations between monthly time series of both grid-based TWSA and ground-based water storage measurements at 16 reservoirs located within southeastern Brazil varied from 0.42 to 0.82. Differences are mainly explained by reservoir sizes and proximity to the drought nucleus.

terrestrial↗

NASA NTRS2017

Sensitivity Analysis of Hybrid Propulsion Transportation System for Human Mars Expeditions

The National Aeronautics and Space Administration continues to develop and refine various transportation options to successfully field a human Mars campaign. One of these transportation options is the Hybrid Transportation System which utilizes both solar electric propulsion and chemical propulsion. The Hybrid propulsion system utilizes chemical propulsion to perform high thrust maneuvers, where the delta-V is most optimal when ap- plied to save time and to leverage the Oberth effect. It then utilizes solar electric propulsion to augment the chemical burns throughout the interplanetary trajectory. This eliminates the need for the development of two separate vehicles for crew and cargo missions. Previous studies considered single point designs of the architecture, with fixed payload mass and propulsion system performance parameters. As the architecture matures, it is inevitable that the payload mass and the performance of the propulsion system will change. It is desirable to understand how these changes will impact the in-space transportation system's mass and power requirements. This study presents an in-depth sensitivity analysis of the Hybrid crew transportation system to payload mass growth and solar electric propulsion performance. This analysis is used to identify the breakpoints of the current architecture and to inform future architecture and campaign design decisions.

Chai, Patrick R.↗

NASA NTRS2019

Changes in Vegetation Cover of Yukon River Drainages in Interior Alaska Estimated from MODIS Greenness Trends, 2000 to 2018

Trends and transitions in the growing season MODerate resolution Imaging Spectroradiometer (MODIS) Normalized Difference Vegetation Index (NDVI) time-series at 250-m resolution were analyzed for the period from 2000 to 2018 to understand recent patterns of vegetation change in ecosystems of the Yukon River basin in interior Alaska. Statistical analysis of changes in the NDVI time series was conducted using the "Breaks for Additive Seasonal and Trend" method (BFAST). This structural change analysis indicated that NDVI breakpoints and negative 18-yr trends in vegetation greenness over the years since 2000 could be explained in large part by the impacts of severe wildfires, commonly affecting shrubland and forested ecosystems at relatively low elevations (< 300 m).

Potter, Christopher↗

NASA NTRS2004

Nuclear systems for Mars exploration

This paper identifies breakpoints for various power and propulsion technologies, with a special focus on fission-based sources in support of NASA's Mars exploration program.

NEP↗

NASA NTRSDate not supplied

Informing the Space Launch System Booster Separation Initial CFD Run Matrix with Observed Parametric Sensitivity

It currently requires significant computational cost to simulate the flow physics of the booster separation event on the Space Launch System. This comes from the large parametric space in which the event occurs, as pre-separation flight conditions and separated booster core-relative trajectories can vary. Functionally removing the risk of core-booster collision mandates careful assessment of the fluid dynamics in terms of several trajectory parameters. However, simulating the entire trajectory envelope is computationally intractable given the high parametric dimension. In order to reduce the uncertainty in the resulting low-parametric-resolution aerodynamic booster separation database, a data-driven approach was developed to select which breakpoints should be studied by simulations and experiments and which should be relegated to a regression-based interpolation procedure. This technique works by simulating cases where the flow physics are most sensitive to changes in the parameters and leaving the less parametrically sensitive regions for interpolation. The result is a booster separation run matrix whose computational cost is comparable to that of previous database generations but has lower interpolation errors.

SLS↗

NASA NTRSDate not supplied

Informing the Space Launch System Booster Separation Initial CFD Run Matrix with Observed Parametric Sensitivity

It currently requires significant computational cost to simulate the flow physics of the booster separation event on the Space Launch System. This comes from the large parametric space in which the event occurs, as pre-separation flight conditions and separated booster core-relative trajectories can vary. Functionally removing the risk of core-booster collision mandates careful assessment of the fluid dynamics in terms of several trajectory parameters. However, simulating the entire trajectory envelope is computationally intractable given the high parametric dimension. In order to reduce the uncertainty in the resulting low-parametric-resolution aerodynamic booster separation database, a data-driven approach was developed to select which breakpoints should be studied by simulations and experiments and which should be relegated to a regression-based interpolation procedure. This technique works by simulating cases where the flow physics are most sensitive to changes in the parameters and leaving the less parametrically sensitive regions for interpolation. The result is a booster separation run matrix whose computational cost is comparable to that of previous database generations but has lower interpolation errors.

SLS↗

NASA NTRS2021

Recovery: Fast and Slow—Vegetation Response During the 2012–2016 California Drought

The 2012–2016 California Drought severely impacted natural vegetation across a wide range of environmental gradient. Although several studies have reported an increase in plant water stress and mortality, the spatiotemporal variations of ecosystem productivity responses and the associated environmental and biological drivers remain unclear. Here, using Enhanced Vegetation Index from the Moderate resolution imaging spectrometer, we found that 45% of the natural ecosystems showed an abrupt change (breakpoint [BP]) in productivity during 2012–2016. There were three major contrasting temporal patterns of productivity responses: (i) a steady increase under higher temperature followed by a decline due to accumulated moisture depletion (high elevation forest) or temperature decrease (high elevation nonforest), (ii) gradual decline during the drought followed by a rapid recovery within 1 year after drought stress was partially relieved, and (iii) both a gradual decline and an abrupt decline. The magnitude of abrupt changes was negatively correlated (r = −0.80, p < 0.001) with initial gradual changes. Overall, changes during BP offset, on average, 57% of the preceding gradual responses. The spatial variability in ecosystem response patterns is driven by both environmental and biological factors. Particularly, for forests, positive BP was driven by increasing rainfall and decreasing temperature, while negative BP was mainly driven by the precipitation anomaly. By 2019, 33% of the natural vegetation have recovered to the level of EVI in 2010. Ecosystem responses to multiyear droughts can influence ecosystem dynamics in a complex pattern. Multiple ecohydrological factors should be considered to understand and predict the long-term drought impacts on ecosystems.

Xi Yang↗

NASA NTRSDate not supplied

Sensitivity Analysis of Heat Rejection and Propellant Management Technologies for Nuclear Thermal Propulsion Architectures

Cryogenic fluid management (CFM) technologies are very important for enabling a wider range of missions to utilize space nuclear propulsion (SNP) concepts such as nuclear thermal propulsion (NTP). Technologies for thermal and cryogenic propellant management allow for vehicles to take full advantage of the higher efficiency NTP systems for longer duration human interplanetary and deep space robotic missions. Currently, the CFM Portfolio Project at NASA’s Marshall Space Flight Center (MSFC) is developing thermal and propellant management technologies needed for SNP. When developing these technologies, it is important to understand the sensitivities of key performance parameters (KPPs) at the system and overall mission level due to the ways the technologies interact with each other, other subsystems, and influence the overall vehicle. The Advanced Concepts Office (ACO) at NASA-MSFC was tasked with building an integrated system model of a human Mars NTP mission to evaluate the impacts and sensitivities of CFM technologies on the overall vehicle and mission. This paper will cover the buildup of the model and highlight major sensitivities and breakpoints encountered, as well as future work in improving the existing models and sensitivities being evaluated.

Robert J. Hetterich↗

NASA NTRSDate not supplied

Sensitivity Analysis of Heat Rejection and Propellant Management Technologies for Nuclear Thermal Propulsion Architectures

Cryogenic fluid management (CFM) technologies are very important for enabling a wider range of missions to utilize space nuclear propulsion (SNP) concepts such as nuclear thermal propulsion (NTP). Technologies for thermal and cryogenic propellant management allow for vehicles to take full advantage of the higher efficiency NTP systems for longer duration human interplanetary and deep space robotic missions. Currently, the CFM Portfolio Project at NASA’s Marshall Space Flight Center (MSFC) is developing thermal and propellant management technologies needed for SNP. When developing these technologies, it is important to understand the sensitivities of key performance parameters (KPPs) at the system and overall mission level due to the ways the technologies interact with each other, other subsystems, and influence the overall vehicle. The Advanced Concepts Office (ACO) at NASA-MSFC was tasked with building an integrated system model of a human Mars NTP mission to evaluate the impacts and sensitivities of CFM technologies on the overall vehicle and mission. This paper will cover the buildup of the model and highlight major sensitivities and breakpoints encountered, as well as future work in improving the existing models and sensitivities being evaluated.

Robert J Hetterich↗