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Results for “Hypogravity”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 73 records · Page 4
All sourcesNASA NTRSDOE OSTI
NASA NTRS1974

Prevention of bone mineral changes induced by bed rest: Modification by static compression simulating weight bearing, combined supplementation of oral calcium and phosphate, calcitonin injections, oscillating compression, the oral diophosphonatedisodium etidronate, and lower body negative pressure

The phenomenon of calcium loss during bed rest was found to be analogous to the loss of bone material which occurs in the hypogravic environment of space flight. Ways of preventing this occurrence are investigated. A group of healthy adult males underwent 24-30 weeks of continuous bed rest. Some of them were given an exercise program designed to resemble normal ambulatory activity; another subgroup was fed supplemental potassium phosphate. The results from a 12-week period of treatment were compared with those untreated bed rest periods. The potassium phosphate supplements prevented the hypercalciuria of bed rest, but fecal calcium tended to increase. The exercise program did not diminish the negative calcium balance. Neither treatment affected the heavy loss of mineral from the calcaneus. Several additional studies are developed to examine the problem further.

Schneider, V. S.↗
NASA NTRS1974

Long-Term Regulation in the Cardiovascular System - Cornerstone in the Development of A Composite Physiological Model

The present work discusses a model of the cardiovascular system and related subsystems capable of long-term simulations of the type desired for in-space hypogravic human physiological performance prediction. The discussion centers around the model of Guyton and modifications of it. In order to draw attention to the fluid handling capabilities of the model, one of several transfusion simulations performed is presented, namely, the isotonic saline transfusion simulation.

R J White↗
NASA NTRS1978

Gravity as a biochemical determinant

Hypogravity effects on the biochemistry of living organisms are surveyed, and the differences found under orbital, clinostat, and flotation conditions are examined. Changes can be transient - such as altered serum hormone and electrolyte levels in man - and disappear shortly after return to earth, or changes can be more persistent or permanent, as seems to be the case for changes in the skeletal system mineral and protein constituents for humans who have been in space. While plant ethylene and peroxidase both increase under orbital, clinostat, or flotation conditions, 3-PGA-dehydrogenase increases under orbital but not clinostat conditions and cytochrome C reductase and malic dehydrogenase are affected by clinostat but not actual free fall conditions. Reasons for these discrepancies are considered.

Siegel, S. M.↗
NASA NTRS1980

Retinal changes in rats flown on Cosmos 936 - A cosmic ray experiment

Ten rats, five centrifuged during flight to simulate gravity and five stationary in flight and experiencing hypogravity, orbited the Earth. No differences were noted between flight-stationary and flight-centrifuged animals, but changes were seen between these two groups and ground controls. Morphological alterations were observed comparable to those in the experiment flown on Cosmos 782 and to the retinal cells exposed to high-energy particles at Berkeley. Affected cells in the outer nuclear layer showed swelling, clearing of cytoplasm, and disruption of the membranes. Tissue channels were again found, similar to those seen on 782. After space flight, preliminary data indicated an increase in cell size in montages of the nuclear layer of both groups of flight animals. This experiment shows that weightlessness and environmental conditions other than cosmic radiation do not contribute to the observed damage of retinal cells.

Philpott, D. E.↗
NASA NTRS1980

Experiment operations in Spacelab

A review is presented of laboratory procedures which are expected to be used in Life Sciences experiments on Spacelab. The impact of hypogravity on these procedures is discussed. Specimen treatments with solutions, 'snap' freezing, and micro-mass measurements are explored in detail. Potential solutions for these operational problems are offered.

Giannovario, J. A.↗
NASA NTRS1981

Experiment K-308: Automatic analysis of muscle fibers from rats subjected to spaceflight

The morphology of histochemically prepared muscle sections from the gastrocnemius and plantaris muscles of flight and vivarium control rats was studied quantitatively. Both fast-twitch and slow-twitch fibers were significantly smaller in flight groups than in control groups. Fibers in group 4F were somewhat larger than in 1F, presumably due to growth after recovery. Fibers in 4V were slightly larger than in 1V, presumably due to age. The slow fibers showed more spaceflight induced size loss than fast fibers, suggesting they suffered more from hypogravity. The proportion of slow fibers was also lower in the flight groups, suggesting spaceflight induced fiber type conversion from slow to fast.

Castleman, K. R.↗
NASA NTRS1982

Computer simulations of postural change, water immersion and bedrest - An integrative approach for understanding the spaceflight response

Mathematical modeling techniques were used to simulate the fluid electrolyte (F-E) responses during gravity unloading. It is shown that the response to weightlessness can best be understood by separately examining the acute (hours to days) and chronic (days to weeks) phases, and assuming the presence of normal, although complex, feedback regulatory processes. Headward shifts of fluid are shown to be primarily responsible for acute body losses of extracellular F-E. Losses of body water are closely related to the volume of fluid shifts from the legs. A diuresis is predicted within the first several hours of hypogravity, and this may be obscured by a reduced F-E intake; on Skylab, early F-E losses occurred primarily by deficit intake.

Leonard, J. I.↗
NASA NTRS1983

The significance of gravity on biological systems

Ground based and spaceborne (Biosatellite) research into the effects of hypogravity on biological systems is summarized. A concept of sensitivity to gravity is defined: sensitivity = dR/dQ x 1/standard deviation of R, where R is the measured biological response to a quantitative stimulus, Q. Detection and transformation of gravity information by the organism are discussed. The role of an uncommon gravity force environment as stimulus for physiologic adaptations, rather than stress, is introduced.

Brown, A. H.↗
NASA NTRS1983

Effect of confinement in small space flight size cages on insulin sensitivity of exercise-trained rats

The effect of confinement in small cages (simulating the size to be used in future space Shuttle missions) on insulin sensitivity was studied in rats having an increased insulin sensitivity due to exercise training prior to confinement. Oral glucose tolerance tests (OGTT) were given to both control and exercise-trained rats before and after placement in the small cages for 7 days. The insulin resistance was assessed by the product of the area of the insulin and glucose curves of the OGTT (IG index). Results show that the values obtained before confinement were one-half as high in exercise-trained rats as those in control rats, reflecting an increased sensitivity to insulin with exercise training. After 7 days confinement, the IG index was found to be not significantly different from initial values for both control and exercise-trained rats. These findings suggest that increased insulin sensitivity in exercise-trained rats persists 7 days after cessation of running activity. The data also indicate that exercise training, before flight, may be beneficial in minimizing the loss of insulin sensitivity expected with decreased use of gravity dependent muscles during exposure to hypogravity in space flight.

Mondon, C. E.↗
NASA NTRS1983

Developing Higher Plant Systems in Space

The effects of hypogravity and microgravity environments on plant cells are discussed. Experiments on embryos of carrots are discussed. Simulation and spacecraft environments were used in experiments.

Krikorian, A. D.↗
NASA NTRS1984

Importance of gravity for plant growth and behavior

Accomplishments during the past fiscal year consisted of (1) completion of research on a study of the kinetics of damping out of circummutation when the axially directed g-force was abruptly eliminated (Research Task NULYRL). (2) Further experiments were accomplished on a comprehensive study, underway for several years, to validate (or invalidate) the use of clinostat rotation as a hypogravity simulation device. (3) Some of our earlier (unpublished) observations on plant seedlings resistance to g-loading were evaluated, interpreted, and a paper was submitted for publication (Research Task HYGEFF). (4) In what has been called ""Shuttle middeck locker ecology" an attempt to acquire reliable empirical information on the thermal profile experienced by test packages housed in middeck lockers (MDDL) during shuttle flights at long last seems to be yielding some results.

Brown, A. H.↗
NASA NTRS1983

Human cellular immune responsiveness following space flight

Peripheral circulating lymphocytes were separated from astronaut blood samples three times before and two times after the first four US Space Shuttle flights. The ability of the in vitro T lymphocytes to respond to Phytohemagglutinin by blastogenesis was found to be reduced for each crewmember following spaceflight. In addition, the astronauts experienced a postflight increase in neutrophils and a decrease in eosinophils. These postflight changes in leukocytes are shown to increase with subjectively-evaluated increases in the incidence of inflight stress, indicating that stress, and not hypogravity, is likely to be the major effector of these changes.

Taylor, G. R.↗
NASA NTRS1983

The effects of immobilization on cortical bone in monkeys (M. nemestrina)

Rhesus and pigtail monkeys were restrained for up to seven months in a hypogravic-hypodynamic environment for the purpose of studying the osteoporotic process and its reversibility, particularly in relation to humans. In vivo bending, radiography and tomography are among the techniques that were used. Bone deterioration within one month was detectable only in histological preparation, where resorption and subsequent cavity formation were demonstrated in addition to demineralization of the remaining hard tissue. Norland bone mineral analysis showed the greatest bone demineralization in the proximal tibia (23 percent to 31 percent after six months restraint), recovery did not even necessarily occur after 15 months. The largest bone stiffness decrease was 36 to 40 percent after a six months restraint; normal bending properties but not mineral content were restored after 8-1/2 months. Contrary to earlier studies, it is concluded that bone recovery, though a lengthy process, is possible: cortical bone in the tibia required 40 months.

Niklowitz, W. J.↗
NASA NTRS1985

Daylily as a System to Study Effects of Space Flight on Plant Development

The intent of the protoplast experimentation was to develop a system which would permit work with wall less counterparts of totipotent free cells as a model for a fertilized egg cell. It is clear that the daylily system is becoming a valuable tool with which to study any number of basic phases of higher plant development. The system can now be studied from a number of perspectives. A system amenable to rigorous experimentation was developed and can be used as a point of departure for studying problems of development in the space environment. This will be a prelude to the studying of the effect of hypogravity on higher plant development.

Krikorian, A. D.↗
NASA NTRS1985

Possible mechanism for changes in glycogen metabolism in unloaded soleus muscle

Carbohydrate metabolism has been shown to be affected in a number of ways by different models of hypokinesia. In vivo glycogen levels in the soleus muscle are known to be increased by short-term denervation and harness suspension. In addition, exposure to 7 days of hypogravity also caused a dramatic increase in glycogen concentration in this muscle. The biochemical alterations caused by unloading that may bring about these increases in glycogen storage in the soleus were sought.

Henriksen, E. J.↗
NASA NTRS1984

Life sciences and space research XXI(2); Proceedings of the Seventh and Eleventh Workshops, Graz, Austria, June 25-July 7, 1984

Space-based and space-related research in the life sciences is presented in reviews and reports. Topics examined include the long-term effects of weightlessness, cosmic chemistry and chemical and biological evolution, life-support systems for space travel, planetary protection, and the g-scale factor in gravitational biology. Consideration is given to the role of Ca ions in cytological effects of hypogravity, the organic aerosols of Titan, the role of meteorite impacts in the formation of organic molecules, prebiotic synthesis of purines and pyrimidines, atmosphere behavior of gas-closed mouse-algal systems, air and water regeneration in advanced regenerative environmental-control and life-support systems, and the influence of gravity on the development of animal systems.

Oser, H.↗
NASA NTRS1984

Tissue fluid shift, forelimb loading, and tail tension in tail-suspended rats

The tail suspension model (head-down tilt) simulates hypogravity in terms of musculoskeletal loss in the rat. However, little is known of tissue fluid shifts and body weight distribution in this model. Tissue fluid pressures were measured by wick catheters in 12 Munich-Wistar rats before, during, and after 48 hrs of tail suspension (about 30 deg head-down tilt). Subcutaneous tissue fluid pressure in the neck increased from -2.2 + or - 0.4 (normal horizontal position) to +4.0 + or - 1.5 cm H2O during tail suspension, indicating a cephalic fluid shift and significant edema during head-down tilt. In a separate study, six rats were suspended at 30-70 deg, and forelimb load and tail tension were measured by a balance and force transducer, respectively. Approximately 50 percent of body weight (BW) was loaded on forelimbs at a head-down tilt angle of 30 deg and forelimb load declined linearly to 10 percent BW at 70 deg. Furthermore, tail tension increased from 50 percent BW at 30 deg to 85 percent BW at 70 deg. These results indicate that less than normal loads are applied to forelimbs of rats suspended at angles of less than 30 deg and that the tail bears an increasing proportion of the rat's body weight at head-down tilt angles of less than 30 deg.

Hargens, A. R.↗