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Results for “SUPPRESSOR”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 73 records · Page 4
All sourcesNASA NTRSDOE OSTI
DOE OSTI2021

sMicroRNA-28-5p acts as a metastasis suppressor in gastric cancer by targeting Nrf2

The transcription factor nuclear factor (erythroid-2)-related factor 2 (Nrf2) can principally serve a mode of protection for both the normal cells and cancer cells from cellular stress, and elevates cancer cell survival. microRNA-28 (miR-28) has been involved in the regulation of Nrf2 expression in breast epithelial cells. However, no comprehensive analysis has been conducted regarding the function of miR-28-5p regulating Nrf2 in gastric cancer (GC). In this study, we aimed to evaluate their interaction and biological roles in the migration and invasion of GC cells. The expression of Nrf2 in the cancer tissues harvested from 42 patients with GC was examined by an array of molecular techniques comprising of Immunohistochemical staining, RT-qPCR and Western blot analysis. Kaplan-Meier method was adopted for analysis of the correlation of Nrf2 with the prognosis of GC patients. Interaction between miR-28-5p and Nrf2 was determined using the bioinformatics analysis and dual luciferase reporter gene assay. Gain- and loss-of-function studies of miR-28-5p and Nrf2 were conducted to elucidate their effects on GC cell migration, invasion and metastasis, as well as expression pattern of several epithelial-mesenchymal transition (EMT)-related proteins. Results indicated that the expression pattern of Nrf2 was significantly upregulated in GC tissues and indicative of poor prognosis of GC patients. miR-28-5p was verified to target Nrf2 and downregulate its expression. GC cells with overexpression of miR-28-5p or Nrf2 knockdown exhibited a marked reduction in the migrated and invasive abilities, along with the N-cadherin expression yet an increase of E-cadherin expression. Furthermore, miR-28-5p exerted an inhibitory function on the metastatic and tumorigenicity of GC cells. In conclusion, miR-28-5p is a comprehensive tumor suppressor that inhibits GC cell migration and invasion through repressing the Nrf2 expression. Therefore, miR-28-5p may serve as a potential biomarker for the prognosis of GC and a novel therapeutic target in advanced GC.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2020

Early-Time (E1) High-Altitude Electromagnetic Pulse Effects on Transient Voltage Surge Suppressors

Determining the effectiveness of surge and pulse protection devices in the United States power grid against effects of a High-Altitude Electromagnetic Pulse (HEMP) is crucial in determining the present state of grid resilience. Transient Voltage Surge Suppressors (TVSS) are used to protect loads in substations from transient overvoltages. Designed to mitigate the effects of lightning, their response to a HEMP event is unknown and was determined. TVSSs were tested in two unique configurations using a pulser that generates pulses in the tens of nanoseconds scale to determine their protective capability as well as to determine their self-resilience against HEMP pulses. Testing concluded that TVSS devices adequately protect against microsecond scale pulses like lightning but do not protect against pulses resembling HEMP events. It suggests that TVSS devices should not be relied upon to mitigate the effects of HEMP pulses.

24 POWER TRANSMISSION AND DISTRIBUTION↗
DOE OSTI2023

Oncogenic Ras and ΔNp63α cooperate to recruit immunosuppressive polymorphonuclear myeloid-derived suppressor cells in a mouse model of squamous cancer pathogenesis

Introduction Amplification of human chromosome 3q26-29, which encodes oncoprotein ΔNp63 among other isoforms of the p63 family, is a feature common to squamous cell carcinomas (SCCs) of multiple tissue origins. Along with overexpression of ΔNp63, activation of the protooncogene, RAS , whether by overexpression or oncogenic mutation, is frequently observed in many cancers. In this study, analysis of transcriptome data from The Cancer Genome Atlas (TCGA) demonstrated that expression of TP63 mRNA , particularly ΔNp63 isoforms, and HRAS are significantly elevated in advanced squamous cell carcinomas of the head and neck (HNSCCs), suggesting pathological significance. However, how co-overexpressed ΔNp63 and HRAS affect the immunosuppressive tumor microenvironment (TME) is incompletely understood. Methods Here, we established and characterized an immune competent mouse model using primary keratinocytes with retroviral-mediated overexpression of ΔNp63α and constitutively activated HRAS (v-ras Ha G12R) to evaluate the role of these oncogenes in the immune TME. Results In this model, orthotopic grafting of wildtype syngeneic keratinocytes expressing both v-ras Ha and elevated levels of ΔNp63α consistently yield carcinomas in syngeneic hosts, while cells expressing v-ras Ha alone yield predominantly papillomas. We found that polymorphonuclear (PMN) myeloid cells, experimentally validated to be immunosuppressive and thus representing myeloid-derived suppressor cells (PMN-MDSCs), were significantly recruited into the TME of carcinomas arising early following orthotopic grafting of ΔNp63α/v-ras Ha -expressing keratinocytes. ΔNp63α/v-ras Ha -driven carcinomas expressed higher levels of chemokines implicated in recruitment of MDSCs compared to v-ras Ha -initiated tumors, providing a heretofore undescribed link between ΔNp63α/HRAS-driven carcinomas and the development of an immunosuppressive TME. Conclusion These results support the utilization of a genetic carcinogenesis model harboring specific genomic drivers of malignancy to study mechanisms underlying the development of local immunosuppression.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1966

Suppressor plate eliminates undesired arcing during electron beam welding

Suppressor grid eliminates undesired arcing during electron beam welding in one of two ways. A grid at ground potential collects secondary emission of ions and electrons produced by the beam as it strikes the workpiece, or a negatively energized grid repels the plasma arc back to the workpiece. This eliminates ground screens used to cover view ports.

Hanchey, K. K.↗
NASA NTRS1972

Subsonic and supersonic jet flow and acoustic characteristics and supersonic suppressors

To study the similarities and differences between subsonic and supersonic jets, velocity and impact pressure fluctuations were determined along the axis over a jet Mach number range of 0.6 to 1.4 for a 2 in. diameter convergent nozzle and for a one inch diameter jet flow. Static pressure distribution fluctuations due to shear and turbulence in the jet flow for subsonic and supersonic jets were related to acoustic radiation to the far field. Also determined were flow and acoustic characteristics of a single shroud, and multiple shroud tube and shroud suppressors for supersonic and subsonic exhaust velocities. A compressor consisting of 191 tubes and 191 shrouds decreased the primary Mach number drastically for both jet Mach numbers of 1.4 and 0.7; rms impact and static pressure fluctuations on the axis were also reduced from values existing for an equivalent area single nozzle.

Nagamatsu, H. T.↗
NASA NTRS1972

Flight velocity influence on jet noise of conical ejector, annular plug and segmented suppressor nozzles

An F106 aircraft with a J85-13 engine was used for static and flight acoustic and aerodynamic tests of a conical ejector, an unsuppressed annular plug, and three segmented suppressor nozzles. Static 100 ft. arc data, corrected for influences other than jet noise, were extrapolated to a 300 ft. sideline for comparison to 300 ft. altitude flyover data at M = 0.4. Data at engine speeds of 80 to 100% (max dry) static and 88 to 100% flight are presented. Flight velocity influence on noise is shown on peak OASPL and PNL, PNL directivity, EPNL and chosen spectra. Peak OASPL and PNL plus EPNL suppression levels are included showing slightly lower flight than static peak PNL suppression but greater EPNL than peak PNL suppression. Aerodynamic performance was as anticipated and closely matched model work for the 32-spoke nozzle.

Brausch, J. F.↗
NASA NTRS1972

Flyover and static tests to investigate external flow effect on jet noise from nonsuppressor and suppressor exhaust nozzles

The effect of external air flowing across exhaust nozzles on the jet noise characteristics of supersonic transport aircraft at high takeoff speeds was investigated. A series of flyover and static tests were conducted using an F-106B aircraft modified with two underwing nacelles each containing a calibrated J85-GE-13 turbojet engine. Comparison of flyover and static data indicated that external flow reduces the noise of an auxiliary inlet ejector nozzle. An unsuppressed plug nozzle was not affected while the plug suppressor configurations were not as effective in flight.

Burley, R. R.↗
NASA NTRS1972

Subsonic and supersonic jets and supersonic suppressor characteristics

Convergent and parallel flow nozzles were used with room temperature air to investigate the flow and acoustic characteristics over a Mach number range of 0.6 to 1.5. For subsonic jets the maximum sound pressure levels occurred at 19.1 from the axis and the sound pressure level decreased monotonically with increasing angle. But for supersonic jets the sound pressure was nearly constant over most of angular positions. The power spectra for subsonic jets were similar with the peak occurring at 4 KHz and for a Mach 1.4 jet the peak occurred at 5 KHz. Near field sound pressure level distributions were quite similar for subsonic jets, but for supersonic jets the distributions were quite different. Mean and fluctuating velocity contours were determined for a convergent nozzle with the impact and piezoelectric impact pressure gage probes for Mach numbers of 0.6 to 1.4. A supersonic suppressor of 191 tubes and shrouds was investigated at Mach numbers of 1.4 and 0.7.

Nagamatsu, H. T.↗
NASA NTRS1973

Subsonic and supersonic jets and supersonic suppressor characteristics.

The flow and acoustic characteristics over a Mach number range of 0.6 to 1.5 were determined for convergent and parallel flow nozzles with room temperature air. Mean velocity and fluctuating impact and static pressure distributions were investigated. Near- and far-field acoustic measurements were obtained, and overall sound power levels were compared with subsonic theory of Lighthill and supersonic theory of Nagamatsu and Horvay. Flow and acoustic characteristics of single and multiple shroud supersonic suppressors were studied. With 191 tubes and shrouds the overall sound power level for a Mach 1.4 jet was reduced 15.3 and 20.5 db respectively.

Nagamatsu, H. T.↗
NASA NTRS1975

Noise suppressor

Suppressor reduces noise propagated through ducts. It provides high attenuation in given duct length. Entire device forms acoustic trap which utilizes reflective elements on ends to direct sound energy into sound-dissipating element in center. Device achieves large suppression by utilizing interactive effects of different suppression devices.

Zorumski, W. E.↗
NASA NTRS1974

Development of acoustically lined ejector technology for multitube jet noise suppressor nozzles by model and engine tests over a wide range of jet pressure ratios and temperatures

An experimental program comprising model nozzle and full-scale engine tests was undertaken to acquire parametric data for acoustically lined ejectors applied to primary jet noise suppression. Ejector lining design technology and acoustical scaling of lined ejector configurations were the major objectives. Ground static tests were run with a J-75 turbojet engine fitted with a 37-tube, area ratio 3.3 suppressor nozzle and two lengths of ejector shroud (L/D = 1 and 2). Seven ejector lining configurations were tested over the engine pressure ratio range of 1.40 to 2.40 with corresponding jet velocities between 305 and 610 M/sec. One-fourth scale model nozzles were tested over a pressure ratio range of 1.40 to 4.0 with jet total temperatures between ambient and 1088 K. Scaling of multielement nozzle ejector configurations was also studied using a single element of the nozzle array with identical ejector lengths and lining materials. Acoustic far field and near field data together with nozzle thrust performance and jet aerodynamic flow profiles are presented.

Atvars, J.↗
NASA NTRS1974

Suppressor nozzle and airframe noise measurements during flyover of a modified F106B aircraft with underwing nacelles

The effect of flight velocity on the jet noise and thrust of a 104-tube suppressor nozzle was investigated using an F-106B delta wing aircraft modified to carry two underwing nacelles each containing a turbojet engine. The nozzle was mounted behind one of the nacelles. Flight velocity had a large adverse effect on thrust and a small adverse effect on suppression when correlated with relative jet velocity. The clean airframe noise of the aircraft was measured at Mach 0.4 and was compared with that predicted from an empirical expression. The 83 db measured value was considerably below the predicted value.

Burley, R. R.↗