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At least 73 records · Page 4

Pros and Cons of Using Water Immersion to Simulate Physiological Responses to Microgravity

Head-out water immersion (HOI) has been employed as a remedial treatment for various ills and ailments for many millennia, and total body immersion even longer as protective encapsulation for the mammalian fetus. Two discrete differences between stimuli induced by true microgravity (10(exp -4) g) and HOI are readily apparent. External water pressure on the skin and accompanying negative pressure breathing cause blood to shift headward. Secondly, the gravitational force is ever present during immersion and microgravity, but its effect is essentially neutralized during Earth orbital flight. Thus, the physiological responses to immersion should not be expected to match those during microgravity. Immersion has been used mainly to study and understand kidney function and associated cardiovascular responses for control of body fluid volume and osmotic content, with some application to and simulation of microgravity responses. There is a plethora of data from human HOI studies, but relatively few controlled data from microgravity studies. In general, it appears that physiological responses occur more quickly with water immersion than in microgravity, but this may be due to less rigorous control (voluntary and involuntary) of the preflight state of crew members. The central venous pressure-vasopressin (Gauer-Henry) reflex control for fluid balance may not be of prime importance in microgravity. Gross functions such as reduced body weight and water, level of hypovolemia, decreased isokinetic strength, and lower nitrogen balance found during immersion are qualitatively similar in microgravity, but the mechanisms controlling these and other functions are, for the most part, unclear. Only acquisition of data from well-controlled microgravity experiments will resolve this discrepancy.

Greenleaf, J. E.↗

Autonomic physiological data associated with simulator discomfort

The development of a physiological monitoring capability for the Army's advanced helicopter simulator facility is reported. Additionally, preliminary physiological data is presented. Our objective was to demonstrate the sensitivity of physiological measures in this simulator to self-reported simulator sickness. The data suggested that heart period, hypergastria, and skin conductance level were more sensitive to simulator sickness than were vagal tone and normal electrogastric activity.

Miller, James C.↗

Autonomic physiological data associated with simulator discomfort

A physiological monitoring capability was developed for the Army's Crew Station Research and Development Facility (CSRDF), a research simulator for advanced rotorcraft. Preliminary physiological data are reported from studies of simulator-induced sickness. Our objective was to demonstrate sensitivity of physiological measures relative to self-reports of simulator sickness severity. The data suggested that heart period, tachygastria, and skin conductance level were more sensitive to simulator sickness than were vagal tone and normal myoelectrical gastric activity.

Miller, James C.↗

Proposed law of nature linking impacts, plume volcanism, and Milankovitch cycles to terrestrial vertebrate mass extinctions via greenhouse-embryo death coupling

A greenhouse-physiological coupling killing mechanism active among mammals, birds, and reptiles has been identified. Operating via environmental thermal effects upon the maternal core-skin blood flow critical to the survival and development of embryos, it reduces the flow of blood to the uterine tract. Today, during hot summers, this phenomena kills embryos on a vast, global scale. Because of sensitivity of many mammals to modern heat, a major modern greenhouse could reduce population numbers on a global scale, and potentially trigger population collapses in the more vulnerable parts of the world. In the geological past, the killing mechanism has likely been triggered into action by greenhouse warming via impact events, plume volcanism, and Earth orbital variations (Milankovitch cycles). Earth's biosphere is maintained and molded by the flow of energy from the solar energy source to Earth and on to the space energy sink (SES). This SES energy flow maintains Earth's biosphere and its living components, as open, intermediate, dissipative, nonequilibrium systems whose states are dependent upon the rate of energy flowing through them. Greenhouse gases such as CO2 in the atmosphere influence the SES energy flow rate. Steady-state flow is necessary for global ecological stability (autopoiesis). Natural fluctuations of the C cycle such as rapid releases of CO2 from the mantle, or oceans, disrupt steady-state SES flow. These fluctuations constantly challenge the biosphere; slowdown of SES energy flow drives it toward thermodynamical equilibrium and stagnation. Fluctuations induced by impact event, mantle plume volcanism, and Milankovitch cycles can grow into structure-breaking waves triggering major perturbations of Earth's C cycle and mass extinctions. A major C cycle perturbation involves readjustment of the outer physiochemical spheres of the Earth: the atmosphere, hydrosphere, and lithosphere; and by necessity, the biosphere. A greenhouse, one manifestation of a major C cycle perturbation, is the most dangerous natural phenomenon that life on Earth can experience. Greenhouse conditions existed during the KT mass extinctions of 65 m.y. ago, and the Pleistocene-Holocene (P-H) mammalian extinctions of 10,000-12,000 yr ago. Coupling climatology to reproductive physiology via effects of ambient air temperature upon uterine blood flow to developing embryos accounts for the extinctions via established physiological principles.

Mclean, D. M.↗

Non-invasive (non-contact) measurements of human thermal physiology signals and thermal comfort/discomfort poses -A review

Heating, ventilation and air-conditioning (HVAC) systems have been adopted to create comfortable, healthy and safe indoor environments. In the control loop, the technical feature of the human demand-oriented supply can help operate HVAC effectively. Among many technical options, real time monitoring based on feedback signals from end users has been frequently reported as a critical technology to confirm optimizing building performance. Recent studies have incorporated human thermal physiology signals and thermal comfort/discomfort status as real-time feedback signals. A series of human subject experiments used to be conducted by primarily adopting subjective questionnaire surveys in a lab-setting study, which is limited in the application for reality. With the help of advanced technologies, physiological signals have been detected, measured and processed by using multiple technical formats, such as wearable sensors. Nevertheless, they mostly require physical contacts with the skin surface in spite of the small physical dimension and compatibility with other wearable accessories, such as goggles, and intelligent bracelets. Most recently, a low cost small infrared camera has been adopted for monitoring human facial images, which could detect the facial skin temperature and blood perfusion in a contactless way. Also, according to latest pilot studies, a conventional digital camera can generate infrared images with the help of new methods, such as the Euler video magnification technology. Human thermal comfort/discomfort poses can also be detected by video methods without contacting human bodies and be analyzed by the skeleton keypoints model. Here, new sensing technologies were summarized, their cons and pros were discussed, and extended applications for the demand-oriented ventilation were also reviewed as potential development and applications.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Autonomic Responses to Microgravity

The purpose of this report is to describe how changes in autonomic nervous system responses may be used as an index of individual differences in adaptational capacity to space flight. During two separate Spacelab missions, six crewmembers wore an ambulatory monitoring system which enabled continuous recording of their physiological responses for up to twelve hours a day for 3 to 5 mission days. The responses recorded were electrocardiography, respiration wave form, skin conductance level, hand temperature, blood flow to the hands and triaxial accelerations of the head and upper body. Three of these subjects had been given training, before the mission, in voluntary control of these autonomic responses as a means of facilitating adaptation to space. Three of these subjects served as Controls, i.e., did not receive this training but took anti-motion sickness medication. Nearly 300 hours of flight data are summarized. These data were examined using time-series analyses, spectral analyses of heart rate variability, and analyses of variance. Information was obtained on responses to space motion sickness, inflight medications, circadian rhythm, workload and fatigue. Preliminary assessment was made on the effectiveness of self-regulation training as a means of facilitating adaptation, with recommendations for future flights.

Toscano, W. B.↗

The "Space Activity Suit" - A Historical Perspective and A Primer on the Physiology of Mechanical Counter-Pressure

Since the 1950s, mechanical counter-pressure (MCP) has been investigated as a possible alternative design concept to traditional extra-vehicular activity (EVA) space suits. While traditional gas-pressurized EVA suits provide physiological protection against the ambient vacuum by means of pressurized oxygen to at least 3.1 pounds per square inch absolute (160 millimeters of mercury), MCP provides protection by direct application of pressure on the skin by a fabric. In reviewing the concept, MCP offers distinct potential advantages to traditional EVA suits: lower mass, reduced consumables, increased mobility, increased comfort, less complexity, and improved failure modes. In the mid 1960s to early 1970s, Dr. Paul Webb of Webb Associates developed and tested such a suit under funding from NASA Langley Research Center. This "Space Activity Suit" (SAS) was improved many times while testing in the laboratory and an altitude chamber to as low as 0.3 pounds per square inch absolute (15 millimeters of mercury). This testing, and the reports by Webb documenting it, are often presented as evidence of the feasibility of MCP. In addition, the SAS reports contain a wealth of information regarding the physiological requirements to make MCP work at the time, which is still accurate today. This paper serves to document the Space Activity Suit effort and analyze it in today's context.

McFarland, Shane M.↗

Medical Devices Assess, Treat Balance Disorders

You may have heard the phrase as difficult as walking and chewing gum as a joking way of referring to something that is not difficult at all. Just walking, however, is not all that simple physiologically speaking. Even standing upright is an undertaking requiring the complex cooperation of multiple motor and sensory systems including vision, the inner ear, somatosensation (sensation from the skin), and proprioception (the sense of the body s parts in relation to each other). The compromised performance of any of these elements can lead to a balance disorder, which in some form affects nearly half of Americans at least once in their lifetimes, from the elderly, to those with neurological or vestibular (inner ear) dysfunction, to athletes with musculoskeletal injuries, to astronauts returning from space. Readjusting to Earth s gravity has a significant impact on an astronaut s ability to balance, a result of the brain switching to a different "model" for interpreting sensory input in normal gravity versus weightlessness. While acclimating, astronauts can experience headaches, motion sickness, and problems with perception. To help ease the transition and study the effects of weightlessness on the body, NASA has conducted many investigations into post-flight balance control, realizing this research can help treat patients with balance disorders on Earth as well. In the 1960s, the NASA-sponsored Man Vehicle Laboratory at the Massachusetts Institute of Technology (MIT) studied the effects of prolonged space flight on astronauts. The lab s work intrigued MIT doctoral candidate Lewis Nashner, who began conducting NASA-funded research on human movement and balance under the supervision of Dr. Larry Young in the MIT Department of Aeronautics and Astronautics. In 1982, Nashner s work resulted in a noninvasive clinical technique for assessing the cooperative systems that allow the body to balance, commonly referred to as computerized dynamic posturography (CDP). CDP employs a series of dynamic protocols to isolate and assess balance function deficiencies. The technology was based on Nashner s novel, engineering-inspired concept of balance as an adaptable collaboration between multiple sensory and motor systems. CDP proved useful not only for examining astronauts, but for anyone suffering from balance problems. Today, CDP is the standard medical tool for objectively evaluating balance control.

Source record↗

Mechanical Counter-Pressure EVA Suits: NASA Outlook and Development Strategy

Since the 1950s, mechanical counter-pressure (MCP) has been investigated as a possible alternative architecture to traditional extra-vehicular activity (EVA) suits. While traditional gas-pressurized EVA suits provide physiological protection against the ambient vacuum environment by means of pressurized oxygen to at least 3.1 psid, MCP provides protection by direct application of pressure on the skin by a fabric. In reviewing the concept, MCP offers distinct potential advantages to traditional EVA suits: lower mass, reduced consumables, increased mobility, increased comfort, less complexity, and improved failure modes. In addition, as basic feasibility was established in the 1960s with the successful testing of the Space Activity Suit, MCP seems poised to inevitably supplant traditional EVA architectures with a modest degree of concentrated development. However, as they say, "The devil is in the details". This paper serves as a comprehensive summary of the technical work that has been completed related to MCP from 1960 to 2019, the technical gaps that need to be closed to facilitate a flight-capable design, and outlines an overall development strategy that NASA feels would best address these gaps moving forward.

mechanical counter-pressure↗

Improved temperature control of liquid cooling garments

Skin and auditory meatus temperature readings supply control signal for temperature control valve in fluid temperature control system which provides increased subject comfort and responds to directly measured physiological cooling needs. System applications include medical care and thermal protection garment manufacturing.

Flucher, C. W. G.↗

Noninvasive Sensor for Measuring Muscle Metabolism During Exercise

The measurement of oxygen uptake (VO2) and lactate threshold (LT) are utilized to assess changes in aerobic capacity and the efficacy of exercise countermeasures in astronauts. During extravehicular activity (EVA), real-time knowledge of VO2 and relative work intensity can be used to monitor crew activity levels and organize tasks to reduce the cumulative effects of fatigue. Currently VO2 and LT are determined with complicated measurement techniques that require sampling of expired ventilatory gases, which may not be accurate in enclosed, oxygen-rich environments such as the EVA suit. The UMMS team has developed a novel near infrared spectroscopic (NIRS) system which noninvasively, simultaneously and continuously measures muscle oxygen tension, oxygen saturation, pH (pHm), and hematocrit from a small sensor placed on the leg. This system is unique in that it allows accurate, absolute measurement of these parameters in the thigh muscle by correcting spectra for the interference from skin pigment and fat. These parameters can be used to estimate VO2 and LT. A preliminary evaluation of the system s capabilities was performed in the NASA JSC Exercise Physiology Lab.

Soller, B. R.↗

Exercise thermoregulation in men after 1 and 24-hours of 6 degrees head-down tilt

BACKGROUND: Exercise thermoregulation is dependent on heat loss by increased skin blood flow (convective and conductive heat loss) and through enhanced sweating (evaporative heat loss). Reduction of plasma volume (PV), increased plasma osmolality, physical deconditioning, and duration of exposure to simulated and actual microgravity reduces the ability to thermoregulate during exercise. HYPOTHESIS: We hypothesized that 24 h of head down tilt (HDT24) would alter thermoregulatory responses to a submaximal exercise test and result in a higher exercise rectal temperature (Tre) when compared with exercise Tre after 1 h of head down tilt (HDT1). METHODS: Seven men (31+/-SD 6 yr, peak oxygen uptake (VpO2peak) of 44+/-6 ml x kg(-1) x min(-1)) were studied during 70 min of supine cycling at 58+/-SE 1.5% VO2peak at 22.0 degrees C Tdb and 47% rh. RESULTS: Relative to pre-tilt sitting chair rest data, HDT1 resulted in a 6.1+/-0.9% increase and HDT24 in a 4.3+/-2.3% decrease in PV (delta = 10.4% between experiments, p<0.05) while plasma osmolality remained unchanged (NS). Pre-exercise Tre was elevated after HDT24 (36.71 degrees C +/-0.06 HDT1 vs. 36.93 degrees C+/-0.11 HDT24, p<0.05). The 70 min of exercise did not alter this relationship (p<0.05) with respective end exercise increases in Tre to 38.01 degrees C and 38.26 degrees C (degrees = 1.30 degrees C (HDT1) and 1.33 degrees C (HDT24)). While there were no pre-exercise differences in mean skin temperature (Tsk), a significant (p<0.05) time x treatment interaction occurred during exercise: after min 30 in HDT24 the Tsk leveled off at 31.1 degrees C, while it continued to increase reaching 31.5 degrees C at min 70 in HDT1. A similar response (NS) occurred in skin blood velocity. Neither local sweating rates nor changes in body weight during exercise of -1.63+/-0.24 kg (HDT1) or - 1.33+/-0.09 kg (HDT24) were different (NS) between experiments. CONCLUSION: While HDT24 resulted in elevated pre-exercise Tre, reduced PV, attenuation of Tsk and skin blood velocity during exercise, the absolute increase in exercise Tre was not altered. But if sweat rate and cutaneous vascular responses were similar at different core temperatures (unchanged thermoregulation), the Tre offset could have been caused by the HDT-induced hypovolemia.

NASA Program Biomedical Research and Countermeasur↗

Physiological measures and mental-state assessment

General considerations regarding monitoring of operators for alertness are discussed, including who should be monitored and what information should be collected. Measures that have been used to ascertain more general and persistent states of alertness are outlined, including cardiac activity, peripheral vascular activity, skin conductance, electroencephalography, pupillography, oculomotor activity, and body movements.

Stern, John A.↗

Stress Counter-Response Training Via Physiological Self-Regulation During Flight Simulation

This study provided the first evaluation of a new training concept and technology aimed at training pilots to maintain physiological equilibrium during circumstances in an airplane cockpit. Thirty healthy subjects (16 males and 14 females) between the ages of 18 and 35 were randomized into two study groups, A and B. Subjects participated individually in a sequence of four study sessions. In the first visit, subjects were taught to operate a desktop fighter jet flight simulation program. In the three sessions that followed, subjects in group A were trained to minimize their autonomic deviation from baseline values while operating the desktop flight simulation. This was done by making their skin conductance and hand temperature deviations from baseline impair the functionality of the aircraft controls. Subjects also received auditory and visual cues about their autonomic deviation, and were instructed to keep these within pre-set limits to retain full control of the aircraft. Subjects in group B were subjected to periods of impaired aircraft functionality independent of their physiologic activity, and thus served as a control group. No statistically significant group differences were found in the flight performance scores from the three training sessions, and post-training flight performance scores of the two groups were not different. We conclude that this study did not provide clear support for this training methodology in optimizing pilot performance. However, a number of shortcomings in the current status of this training methodology may account for the lack of demonstrable training benefit to the experimental group. Suggested future modifications for research on this training methodology include: Limiting the amount of instrument impairment resulting from physiological deviations; conducting a greater number of physiological training sessions per subject; using pre-post training performance tests which invoke a greater amount of stress in subjects; and developing a more detailed performance scoring system.

Palsson, Olafur S.↗

Bion-11 Spaceflight Mission

The Sensors 2000! Program, in support of the Space Life Sciences Payloads Office at NASA Ames Research Center developed a suite of bioinstrumentation hardware for use on the Joint US/Russian Bion I I Biosatellite Mission (December 24, 1996 - January 7, 1997). This spaceflight included 20 separate experiments that were organized into a complimentary and interrelated whole, and performed by teams of US, Russian, and French investigators. Over 40 separate parameters were recorded in-flight on both analog and digital recording media for later analysis. These parameters included; Electromyogram (7 ch), Electrogastrogram, Electrooculogram (2 ch), ECG/EKG, Electroencephlogram (2 ch), single fiber firing of Neurovestibular afferent nerves (7 ch), Tendon Force, Head Motion Velocity (pitch & yaw), P02 (in vivo & ambient), temperature (deep body, skin, & ambient), and multiple animal and spacecraft performance parameters for a total of 45 channels of recorded data. Building on the close cooperation of previous missions, US and Russian engineers jointly developed, integrated, and tested the physiologic instrumentation and data recording system. For the first time US developed hardware replaced elements of the Russian systems resulting in a US/Russian hybrid instrumentation and data system that functioned flawlessly during the 14 day mission.

Skidmore, M.↗

Autogenic-Feedback Training Exercise (AFTE) Mitigates the Effects of Spatial Disorientation to Simulated Orion Spacecraft Re-Entry: Individual Differences

NASA has identified a potential risk of spatial disorientation to future astronauts during re-entry of the proposed Orion spacecraft. The purpose of this study was to determine if a 6-hour physiological training procedure, Autogenic-Feedback Training Exercise (AFTE), can mitigate these effects. Twenty subjects were assigned to two groups (AFTE and Control) matched for motion sickness susceptibility and gender. All subjects received a standard rotating chair test to determine motion sickness susceptibility; three training sessions on a manual performance task; and four exposures to a simulated Orion re-entry test in the rotating chair. Treatment subjects were given two hours of AFTE training before each Orion test. A diagnostic scale was used to evaluate motion sickness symptom severity. Results showed that 2 hours of AFTE significantly reduced motion sickness symptoms during the second Orion test. AFTE subjects were able to maintain lower heart rates and skin conductance levels and other responses than the control group subjects during subsequent tests. Trends show that performance was less degraded for AFTE subjects. The results of this study indicate that astronauts could benefit from receiving at least 2 hours of preflight AFTE. In addition, flight crews could benefit further by practicing physiologic self-regulation using mobile devices.

human performance↗

Temperature Measurement Aid

NASA's Ames Research Center has designed a simple but medically important device--one which holds temperature probes, called thermistors, to a person's skin without affecting the characteristics of the skin segment being measured. The device improves the accuracy of skin surface temperature measurements, valuable data in health evaluation. The need for such a device was recognized in the course of life science experiments at Ames. In earlier methods, the sensing head of the temperature probe was affixed to the patient's skin by tape or elastic bands. This created a heat variance which altered skin temperature readings. The Ames-developed thermistor holder is a plastic ring with tab extensions, shown in the upper photo on the chest, arm and leg of the patient undergoing examination. The ring holds the sensing head of the temperature probe and provides firm, constant pressure between the skin and the probe. The tabs help stabilize the ring and provide attachment points for the fastening tape or bands, which do not directly touch the sensor. With this new tool, it is possible to determine more accurately the physiological effects of strenuous exercise, particularly on the treadmill. The holder is commercially available from Yellow Springs Instrument Company, Inc., Yellow Springs, Ohio, which is producing the device under a NASA patent license.

Source record↗

Exercise thermoregulation after 6 h of chair rest, 6 degrees head-down bed-rest, and water immersion deconditioning in men

The purpose was to investigate the mechanism for the excessive exercise hyperthermia following deconditioning (reduction of physical fitness). Rectal (Tre) and mean skin (Tsk) temperatures and thermoregulatory responses were measured in six men [mean (SD) age, 32 (6) years; mass, 78.26 (5.80) kg; surface area, 1.95 (0.11) m2; maximum oxygen uptake (VO2max), 48 (6) ml.min-1.kg-1; whilst supine in air at dry bulb temperature 23.2 (0.6) degree C, relative humidity 31.1 (11.1)% and air speed 5.6 (0.1) m.min-1] during 70 min of leg cycle exercise [51 (4)% VO2max] in ambulatory control (AC), or following 6 h of chair rest (CR), 6 degree head-down bed rest (BR), and 20 degree (WI20) and 80 degree (WI80) foot-down water immersion [water temperature, 35.0 (0.1) degree C]. Compared with the AC exercise delta Tre [mean (SD) 0.77 (0.13) degree C (*P < 0.05), after WI80 0.96 (0.13) degree C*, and after WI20 1.03 (0.09) degree C*. All Tsk responded similarly to exercise: they decreased (NS) by 0.5-0.7 degree C in minutes 4-8 and equilibrated at +0.1 to +0.5 degree C at 60-70. Skin heat conductance was not different among the five conditions (range = 147-159 kJ.m-2.h-1.degree C-1). Results from an intercorrelation matrix suggested that total body sweat rate was more closely related to Tre at 70 min (Tre70) than limb sweat rate or blood flow. Only 36% of the variability in Tre70 could be accounted for by total sweating, and less than 10% from total body dehydration. It would appear that multiple factors are involved which may include change in sensitivity of thermo- and osmoreceptors.

NASA Discipline Regulatory Physiology↗