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At least 73 records · Page 4
All sourcesNASA NTRSDOE OSTI
DOE OSTI2025

Bayesian estimation of HIV acquisition dates for prevention trials

Accurate timing estimates of when participants acquire HIV in HIV prevention trials are necessary for determining antibody levels at acquisition. The Antibody-Mediated Prevention (AMP) Studies showed that a passively administered broadly neutralizing antibody can prevent the acquisition of HIV from a neutralization-sensitive virus. We developed a pipeline for estimating the date of detectable HIV acquisition (DDA) in AMP Study participants using diagnostic and viral sequence data. Using a Bayesian strategy that combines three streams of data (REN [rev/vpu/env/Δnef] sequence, GP [gag/Δpol] sequence, and diagnostic) where their 95% credible intervals overlap based on pre-specified criteria and decision rules. We evaluated the performance of our AMP pipeline using PacBio viral sequence data from 41 participants across two prospective acute HIV acquisition cohort studies, FRESH and RV217, with twice-weekly sampling. These cohort studies enrolled young women in South Africa and men and women in Kenya and Thailand, respectively, with a high likelihood of HIV acquisition. In evaluating performance, “true DDA” was the center of bounds between last-negative and first-positive RNA diagnostic tests (median time 4 days, range 2–7 days); bias was the mean difference between estimated and true DDA. Using diagnostic data alone yielded timing estimates with a bias of 2.4 days and root mean square error (RMSE) of 7.9 days. These results were improved using sequence + diagnostic data (bias 1.5 days, RMSE 6.9 days), as well as by restricting sequence-based estimation to samples from ≤5 weeks post-DDA (bias 0.2 days, RMSE 7.8 days).

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2021

Chemical compositions, pharmacological activities, quality control studies of Erycibes plants, and the development of their substitutes

Erycibes are members of the Convolvulaceae family, including more than 10 species worldwide that are distributed in tropical Asia. Some Erycibes species have long been used as traditional remedies for rheumatoid arthritis, fever, hepatitis, and liver injury in China and Thailand. A total of 152 compounds from Erycibes plants have been isolated and identified, categorized as flavonoids, coumarins, quinic acid derivatives, lignans, and alkaloids. Coumarins are the characteristic and active constituents of this species, including scopoletin and scopolin. Modern pharmacological studies have shown that the extracts and bioactive components of Erycibes plants exhibit several biological activities, including antiinflammatory, analgesic, hepatoprotective, anti‐gout, antitumor, antioxidation, and other therapeutic effects. However, in recent years, due to destructive exploitation and utilization, some Erycibes plants' natural resources have become rare or endangered. Developing substitutes is a strategy to alleviate the pressure on those endangered medicinal plant resources. To provide a scientific basis for the development and protection of those threatened Erycibes species, this review summarized the current status of the chemical compositions, pharmacological activities, quality control studies, and the development of substitutes for Erycibes plants. In particular, the rationale for use of Porana sinensis currently on the market is discussed.

Peng, Yu↗
DOE OSTI2021

Dendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes

During early HIV-1 infection, immunodominant T cell responses to highly variable epitopes lead to the establishment of immune escape virus variants. Here we assessed a type 1-polarized monocyte-derived dendritic cell (MDC1)-based approach to selectively elicit cytotoxic T lymphocyte (CTL) responses against highly conserved and topologically important HIV-1 epitopes in HIV-1-infected individuals from the Thailand RV254/SEARCH 010 cohort who initiated antiretroviral therapy (ART) during early infection (Fiebig stages I-IV). Autologous MDC1 were used as antigen presenting cells to induce in vitro CTL responses against HIV-1 Gag, Pol, Env, and Nef as determined by flow cytometry and ELISpot assay. Ultra-conserved or topologically important antigens were respectively identified using the Epigraph tool and a structure-based network analysis approach and compared to overlapping peptides spanning the Gag proteome. MDC1 presenting either the overlapping Gag, Epigraph, or Network 14-21mer peptide pools consistently activated and expanded HIV-1-specific T cells to epitopes identified at the 9-13mer peptide level. Interestingly, some CTL responses occurred outside known or expected HLA associations, providing evidence of new HLA-associated CTL epitopes. Comparative analyses demonstrated more sequence conservation among Epigraph antigens but a higher magnitude of CTL responses to Network and Gag peptide groups. Importantly, CTL responses against topologically constrained Gag epitopes contained in both the Network and Gag peptide pools were selectively enhanced in the Network pool-initiated cultures. Our study supports the use of MDC1 as a therapeutic strategy to induce and focus CTL responses toward putative fitness-constrained regions of HIV-1 to prevent immune escape and control HIV-1 infection.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2024

Biofuel production from palm oil deoxygenation using nickel-molybdenum on zirconia catalyst using glycerol as a hydrogen donor

The growing demand for renewable energy has generated interest in biofuels as alternatives to fossil fuels. Second-generation biofuels, derived from deoxygenating fats and oils, have garnered a higher level of interest from industry and academia due to their potential for direct replacement of diesel and jet fuels. Palm oil, mostly cultivated in Thailand and composed of C16 and C18 fatty acids, is a primary feedstock sought for biofuel production. Palm oil deoxygenation contains several pathways that may or may not require hydrogen gas. This study aimed to produce biofuels in different fuel ranges, such as gasoline, jet fuel, and diesel, through palm oil deoxygenation using glycerol as a hydrogen source. Glycerol, a low-value byproduct, was used as a hydrogen donor, whereas nickel-molybdenum-supported catalysts were chosen for their high efficiency in deoxygenation and cost-effectiveness. The study investigated the impact of reaction time, temperature, and catalyst activation method on palm oil deoxygenation. Catalyst characterization methods, including XRD, SEM, TEM, XPS, FTIR, TGA, and nitrogen-sorption, were employed to understand the role of catalysts’ activity during palm oil upgrading. Findings indicated that alkane hydrocarbons are the major components in liquid products. The presence of excess hydrogen in post reaction gaseous phase proves the hydrogen donation capability of glycerol. Increased reaction time and temperature facilitated the removal of oxygen from palm oil. Nickel-molybdenum on zirconia activated by sulfidation demonstrated higher stability than by reduction activation.

09 BIOMASS FUELS↗
DOE OSTI2024

Case study on climate change effects and food security in Southeast Asia

Agriculture, a cornerstone of human civilization, faces rising challenges from climate change, resource limitations, and stagnating yields. Precise crop production forecasts are crucial for shaping trade policies, development strategies, and humanitarian initiatives. This study introduces a comprehensive machine learning framework designed to predict crop production. We leverage CMIP5 climate projections under a moderate carbon emission scenario to evaluate the future suitability of agricultural lands and incorporate climatic data, historical agricultural trends, and fertilizer usage to project yield changes. Our integrated approach forecasts significant regional variations in crop production across Southeast Asia by 2028, identifying potential cropland utilization. Specifically, the cropland area in Indonesia, Malaysia, Philippines, and Viet Nam is projected to decline by more than 10% if no action is taken, and there is potential to mitigate that loss. Moreover, rice production is projected to decline by 19% in Viet Nam and 7% in Thailand, while the Philippines may see a 5% increase compared to 2021 levels. Our findings underscore the critical impacts of climate change and human activities on agricultural productivity, offering essential insights for policy-making and fostering international cooperation.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2023

A global phylogenomic analysis of the shiitake genus Lentinula

Lentinula is a broadly distributed group of fungi that contains the cultivated shiitake mushroom, L. edodes . We sequenced 24 genomes representing eight described species and several unnamed lineages of Lentinula from 15 countries on four continents. Lentinula comprises four major clades that arose in the Oligocene, three in the Americas and one in Asia–Australasia. To expand sampling of shiitake mushrooms, we assembled 60 genomes of L. edodes from China that were previously published as raw Illumina reads and added them to our dataset. Lentinula edodes sensu lato (s. lat.) contains three lineages that may warrant recognition as species, one including a single isolate from Nepal that is the sister group to the rest of L. edodes s. lat., a second with 20 cultivars and 12 wild isolates from China, Japan, Korea, and the Russian Far East, and a third with 28 wild isolates from China, Thailand, and Vietnam. Two additional lineages in China have arisen by hybridization among the second and third groups. Genes encoding cysteine sulfoxide lyase ( lecsl ) and γ-glutamyl transpeptidase ( leggt ), which are implicated in biosynthesis of the organosulfur flavor compound lenthionine, have diversified in Lentinula . Paralogs of both genes that are unique to Lentinula ( lecsl 3 and leggt 5b) are coordinately up-regulated in fruiting bodies of L. edodes . The pangenome of L. edodes s. lat. contains 20,308 groups of orthologous genes, but only 6,438 orthogroups (32%) are shared among all strains, whereas 3,444 orthogroups (17%) are found only in wild populations, which should be targeted for conservation.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2023

Conference Report on the 7th International Symposium on Liquid metals Applications for fusion (ISLA-7)

Supported by the world magnetic fusion research community, a series of International Symposia on Liquid metals Applications for fusion (ISLA) have been held biannually since 2010. The 7th edition (ISLA-7) was held for the period from 12 December through 16 December 2022, at Chubu University located in Kasugai, Aichi, Japan. For the first time in the history of this series of symposia, ISLA-7 was held in a hybrid fashion, due to the COVID-19 situation. The total number of the participants was 60, 34 out of whom attended the symposium in person, and the rest participated online. As to the presentation statistics, 29 papers were presented in person, whereas 21 presentations were delivered online but real-time by the presenters in China, Spain, the UK, and the USA. Both of the presentations delivered in person and online were recorded, and the video has been shared by all participants. These participants represent 11 countries: China, Czech, Italy, Japan, Latvia, Netherlands, Russia, Thailand, the UK, and the USA. All these numbers are among the largest in this series of symposia. Covered by these presentations are; in session-2, program overviews and liquid metal research review; in session-3, liquid metal flows, and MHD issues; in session-4, liquid metal facilities; in sessions-5 and 6, liquid metal experiments and modeling; in session-7, divertor physics and heat flux mitigation; in session-8, plasma and liquid metals interactions; in session-9 liquid metal plasma-facing components, erosion, and wettability. In addition, there were an opening session whereby several opening addresses were delivered and also a closing session where all technical session summaries were presented by the respective session chairs.

divertor↗
DOE OSTI2025

Conference Report on the 8th International Symposium on Liquid Metals Applications for Fusion (ISLA-8)

The International Symposium on Liquid Metals Applications for Fusion (ISLA) aims to assemble scientists and engineers engaged in research on lithium and liquid metal applications for fusion devices, facilitating discussions on recent advancements and challenges in an open forum to support the development of viable fusion reactors. The 8th International Symposium on Liquid Metals Applications for Fusion (ISLA-8) was organized by the Institute of Plasma Physics, Chinese Academy of Sciences, from 8 to 12 September 2024, in Hefei, China. The symposium was attended by over 70 participants, marking one of the highest attendance figures in the series. A total of 68 presentations were delivered, including 59 presented on-site, while the remainder were conducted online. The participants represented 10 countries, namely China, Japan, the Netherlands, Russia, the USA, the Czech Republic, Italy, Thailand, Spain, and Germany. The symposium covered 10 topics, structured into 13 sessions. Additionally, an opening session provided an overview of the current symposium, while a closing session summarized reports from each session chair.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2020

Effectiveness of Electric Vehicle Policies and Implications for Pakistan

This report explores evidence from several key countries regarding the impacts to electric vehicle (EV) market penetration from financial incentives, road access policies, EV mandates, fuel taxes, discounted electricity rates, charging infrastructure, and government investment in the domestic automotive industry. It reviews EV promotional policies in countries that have demonstrated success deploying EVs, focusing on Norway, China, the United States, India, and Korea. It also provides anecdotal examples from select ASEAN countries trying to promote domestic auto industry EV activity, such as Thailand, Indonesia, Philippines, and Vietnam. It provides applicability to policy efforts for growing the EV industry in Pakistan.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗
DOE OSTI2021

Bifacial Photovoltaic Modules and Systems: Experience and Results from International Research and Pilot Applications

Within the framework of IEA PVPS, Task 13 aims to provide support to market actors working to improve the operation, the reliability and the quality of PV components and systems. Operational data from PV systems in different climate zones compiled within the project will help provide the basis for estimates of the current situation regarding PV reliability and performance. The general setting of Task 13 provides a common platform to summarize and report on technical aspects affecting the quality, performance, reliability and lifetime of PV systems in a wide variety of environments and applications. By working together across national boundaries we can all take advantage of research and experience from each member country and combine and integrate this knowledge into valuable summaries of best practices and methods for ensuring PV systems perform at their optimum and continue to provide competitive return on investment. Task 13 has so far managed to create the right framework for the calculations of various parameters that can give an indication of the quality of PV components and systems. The framework is now there and can be used by the industry who has expressed appreciation towards the results included in the high-quality reports. The IEA PVPS countries participating in Task 13 are Australia, Austria, Belgium, Canada, Chile, China, Denmark, Finland, France, Germany, Israel, Italy, Japan, the Netherlands, Norway, Spain, Sweden, Switzerland, Thailand, and the United States of America.

14 SOLAR ENERGY↗
DOE OSTI2021

Designing New Materials for Photovoltaics: Opportunities for Lowering Cost and Increasing Performance through Advanced Material Innovations

Within the framework of IEA PVPS, Task 13 aims to provide support to market actors working to improve the operation, the reliability and the quality of PV components and systems. Operational data from PV systems in different climate zones compiled within the project will help provide the basis for estimates of the current situation regarding PV reliability and performance. The general setting of Task 13 provides a common platform to summarize and report on technical aspects affecting the quality, performance, reliability and lifetime of PV systems in a wide variety of environments and applications. By working together across national boundaries we can all take advantage of research and experience from each member country and combine and integrate this knowledge into valuable summaries of best practices and methods for ensuring PV systems perform at their optimum and continue to provide competitive return on investment. Task 13 has so far managed to create the right framework for the calculations of various parameters that can give an indication of the quality of PV components and systems. The framework is now there and can be used by the industry who has expressed appreciation towards the results included in the high-quality reports. The IEA PVPS countries participating in Task 13 are Australia, Austria, Belgium, Canada, Chile, China, Denmark, Finland, France, Germany, Israel, Italy, Japan, the Netherlands, Norway, Spain, Sweden, Switzerland, Thailand, and the United States of America.

14 SOLAR ENERGY↗
DOE OSTI2021

Building Blocks of Electric Vehicle Deployment: A Guide for Developing Countries

Countries can use electric transportation to help fulfill numerous goals, including greenhouse gas (GHG) emissions targets, local air quality goals, mobility objectives, energy security, and transportation resiliency. Vehicle electrification is a promising pathway to achieving clean energy transitions in the transport sector at scale. As vehicles electrify, the traditionally siloed electricity and transport sectors increasingly converge to create technical, institutional, and economic opportunities and challenges. To navigate this transition effectively, we propose the following foundational pillars or “building blocks” that undergird effective electric vehicle (EV) deployment. Jurisdictions with experience and mature EV markets offer useful lessons learned that may enable developing countries to leapfrog over common roadblocks. Nonetheless, developing countries face distinct challenges collectively, and individually, from developed countries that require careful consideration. From our work around the world, the U.S. Agency for International Development (USAID) and National Renewable Energy Laboratory (NREL) have witnessed interest growing in EVs for a variety of reasons. Lao People’s Democratic Republic (PDR), for example, looks toward EVs as a way to use their surplus of hydropower to displace expensive oil. Thailand and Pakistan seek economic development opportunities in EV manufacturing. Cities including Mexico City, Surat, India, and Kingston, Jamaica see the potential of bus electrification to improve local air quality and reduce traffic congestion. Many USAID partner countries in Southeast Asia are trying to understand how to reach ambitious EV deployment targets and implement EV and transportation plans. This pursuit is prompting questions about EV supply equipment (EVSE) standards, tariff design, and business models that affirm the importance of the building blocks outlined in this report.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗
DOE OSTI2023

COP28 Outcomes Report: Executive Summary

Net Zero World, launched at COP26, is a flagship U.S. effort to partner with countries in accelerating transitions to clean energy systems. This initiative brings together world-class experts and resources from 10 U.S. Department of Energy national laboratories and nine U.S. government agencies. Collaboratively, they work with technical and government representatives from Argentina, Chile, Egypt, Indonesia, Nigeria, Singapore, Thailand, and Ukraine to advance decarbonization in these economies.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗
DOE OSTI2024

Net Zero World 2024 Achievements

Net Zero World, launched at COP26, aims to expedite the transition to clean energy systems worldwide. This report details Net Zero World's achievements in 2024. Leveraging expertise from ten U.S. Department of Energy national laboratories and nine federal agencies, Net Zero World has provided specialized technical support and energy modeling to eight partner countries: Argentina, Chile, Egypt, Indonesia, Nigeria, Singapore, Thailand, and Ukraine.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗
DOE OSTI2024

Historical and projected future runoff over the Mekong River basin

The Mekong River (MR) crosses the borders and connects six countries, including China, Myanmar, Laos, Thailand, Cambodia, and Vietnam. It provides critical water resources and supports natural and agricultural ecosystems, socioeconomic development, and the livelihoods of the people living in this region. Understanding changes in the runoff of this important international river under projected climate change is critical for water resource management and climate change adaptation planning. However, research on long-term runoff dynamics for the MR and the underlying drivers of runoff variability remains scarce. Here, we analyse historical runoff variations from 1971 to 2020 based on runoff gauge data collected from eight hydrological stations along the MR. With these runoff data, we then evaluate the runoff simulation performance of five global hydrological models (GHMs) forced by four global climate models (GCMs) under the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP). Furthermore, based on the best simulation combination, we quantify the impact of future climate change on river runoff changes in the MR. The result shows that the annual runoff in the MR has not changed significantly in the past 5 decades, while the establishment of dams and reservoirs in the basin visibly affected the annual runoff distribution. The ensemble-averaged result of the Water Global Assessment and Prognosis version 2 (WaterGAP2; i.e. GHM) forced by four GCMs has the best runoff simulation performance. Under Representative Concentration Pathways (RCPs; i.e. RCP2.6, RCP6.0 and RCP8.5), the runoff of the MR is projected to increase significantly (p<0.05); e.g. 3.81 ± 3.47 m 3 s -1 a -1 (9 ± 8 % increase in 100 years) at the upper reach under RCP2.6 and 16.36 ± 12.44 m 3 s -1 a -1 (13 ±10 % increase in 100 years) at the lower reach under RCP6.0. In particular, under the RCP6.0 scenario, the increase in annual runoff is most pronounced in the middle and lower reaches, due to increased precipitation and snowmelt. Under the RCP8.5 scenario, the runoff distribution in different seasons varies obviously, increasing the risk of flooding in the wet season and drought in the dry season.

54 ENVIRONMENTAL SCIENCES↗
NASA NTRS1977

Remote sensing inputs to landscape models which predict future spatial land use patterns for hydrologic models

A tropical forest area of Northern Thailand provided a test case of the application of the approach in more natural surroundings. Remote sensing imagery subjected to proper computer analysis has been shown to be a very useful means of collecting spatial data for the science of hydrology. Remote sensing products provide direct input to hydrologic models and practical data bases for planning large and small-scale hydrologic developments. Combining the available remote sensing imagery together with available map information in the landscape model provides a basis for substantial improvements in these applications.

Miller, L. D.↗
NASA NTRS1978

International Symposium on Remote Sensing of Environment, 12th, Manila, Philippines, April 20-26, 1978, Proceedings. Volumes 1, 2 & 3

The papers outline the remote sensing activities being carried out in a number of countries throughout the world, and present details on a variety of individual projects. Topics studied include a worldwide approach to remote sensing and mineral exploration, a land use information system based on statistical inference, acoustic radar and remote sensing in the boundary layer, procedure for land-use analysis in developing countries, an airborne geochemical system, remote sensing of snowpack with microwave radiometers for hydrologic applications, wheat production forecasts based on Landsat data, airborne lidar aerosol measurements over the U.S. and Europe, Landsat inventory of agricultural and forest resources in Bangladesh, application of satellite imagery to flood plain mapping in Thailand, and vegetation mapping of Nigeria from radar.

Source record↗