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With stacking and integration of the initial Block 1 Space Launch System (SLS) expected to begin in 2020, NASA’s powerful new launch vehicle is ready to take center stage in the agency’s Artemis program to return astronauts to the Moon. Combining the highest launch thrust and largest payload capacity ever developed, SLS also enables a new generation of high-C3 science missions to destinations such as the gas and ice giants, the Kuiper Belt, and even beyond the solar system. Block 1 is only the beginning, as the vehicle has a planned evolution path to progressively more powerful variants. In addition to these block upgrades providing increased lift capability, the vehicle can be configured to fly in crew configuration with the Orion spacecraft or in cargo configuration with payload fairings for launching science mission or large infrastructure, providing a flexible launch option. For Artemis I, the first SLS flight, the Block 1 vehicle in the crew configuration will send an uncrewed Orion spacecraft to lunar orbit for a thorough systems checkout before the crewed Artemis II flight. The Block 1 vehicle uses a proven propulsion system consisting of solid rocket boosters and RS-25 engines to lift more than 27 metric tons [t] to trans-lunar injection (TLI). In its cargo configuration, Block 1 can be fitted with a 5 m payload fairing. The second variant, Block 1B, uses a more powerful upper stage to increase payload mass to TLI to 38-42 t, depending on crew or cargo configuration. In the crew configuration, a co-manifested payload of up to 10 t can ride along in the Universal Stage Adapter (USA), which has as much volume for payloads as a 5 m-class payload fairing. The Block 2 evolved variant will lift 43-46 t to TLI, depending on crew or cargo configuration. The Block 1B and Block 2 vehicles can be outfitted with an 8.4 m-diameter payload fairing, available in 19.1 m and 27.4 m lengths, providing unprecedented volume for payloads. Larger-diameter 10 m fairings may also be an option in the future on the Block 2 vehicle. The unrivalled mass, volume and high-energy launches of SLS can provide significant mission flexibility for payloads and/or additional upper stages to open trade space for a new generation of exploration missions. SLS was designed to meet requirements for launching large-volume infrastructure as outlined in numerous studies of missions to cislunar space or Mars. Mission concept studies from the science community also point toward new possibilities enabled by SLS. Probes with more robust science packages can be sent to the gas giants. Dual spacecraft can be manifested for missions to Uranus and Neptune. Additional third or fourth payload stages can be encapsulated in the payload fairings to achieve missions to the Kuiper Belt or beyond. In addition, the large volume can be used to design and deploy wide-aperture mirrors on future space telescopes and to enable nuclear-thermal propulsion missions. At AIAA Ascend, the SLS Program will provide technical information on vehicle capabilities as well as descriptions of ongoing discussions with mission planners for utilizing the vehicle for an array of deep space missions.