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At least 73 records · Page 4

Channels and valleys on Venus - Preliminary analysis of Magellan data

A preliminary survey of Magellan imagery reveals more than 200 newly discovered relic channel and valley landform complexes. For purposes of discussion the channels can be classed as simple, complex, and compound. Integrated valleys also occur. Simple channels include: (1) sinuous rilles that closely resemble their lunar counterparts and (2) a newly recognized long sinuous form of high width-to-depth ratio and remarkably constant width. Herein designated canali, the most spectacular of these channels is 6800 km long. One of the compound channels, an outflow complex in Lada Terra, extends over 1200 km and is up to 30 km wide. Streamlined hills and spill relationships at a cross-axial ridge are similar to features in flood channels. Venusian channels have a global distribution with most of the large canali-type channels developed on volcanic plains. Alternative hypotheses for the channel-forming processes include genesis by the following erosive fluids: ultramafic silicate melts, sulfur, and carbonate lavas. Each of these causative agents has profound implications for Venusian planetology. The remote possibility of an aqueous origin, indicated by apparent regime behavior of the active channeling process, cannot be excluded with absolute certainty.

Baker, V. R.↗

West-Antarctic Ice Streams: Analog to Ice Flow in Channels on Mars

Sounding of the sea floor in front of the Ross Ice Shelf in Antarctica recently revealed large persistent patterns of longitudinal megaflutes and drumlinoid forms, which are interpreted to have formed at the base of ice streams during the list glacial advance. The flutes bear remarkable resemblance to longitudinal grooves and highly elongated streamlined islands found on the floors of some large martian channels, called outflow channels. ln addition, other similarities exist between Antarctic ice streams and outflow channels. Ice streams are 30 to 80 km wide and hundreds of kilometers long, as are the martian channels. Ice stream beds are below sea level. Floors of many martian outflow channels lie below martian datum, which may have been close to or below past martian sea levels. The Antarctic ice stream bed gradient is flat and locally may go uphill, and surface slopes are exceptionally low. So are gradients of martian channels. The depth to the bed in ice streams is 1 to 1.5 km. At bankful stage, the depth of the fluid in outflow channels would have been 1 to 2 km. These similarities suggest that the martian outflow channels, whose origin is commonly attributed to gigantic catastrophic floods, were locally filled by ice that left a conspicuous morphologic imprint. Unlike the West-Antarctic-ice streams, which discharge ice from an ice sheet, ice in the martian channels came from water erupting from the ground. In the cold martian environment, this water, if of moderate volume, would eventually freeze. Thus it may have formed icings on springs, ice dams and jams on constrictions in the channel path, or frozen pools. Given sufficient thickness and downhill surface gradient, these ice masses would have moved; and given the right conditions, they could have moved like Antarctic ice streams.

Lucchitta, B. K.↗

Channel-wing System for Thrust Deflection and Force/Moment Generation

An aircraft comprising a Channel Wing having blown c h - ne1 circulation control wings (CCW) for various functions. The blown channel CCW includes a channel that has a rounded or near-round trailing edge. The channel further has a trailing-edge slot that is adjacent to the rounded trailing edge of the channel. The trailing-edge slot has an inlet connected to a source of pressurized air and is capable of tangentially discharging pressurized air over the rounded trailing edge. The aircraft further has a propeller that is located in the channel and ahead of the rounded trailing edge of the channel. The propeller provides a propeller thrust exhaust stream across the channel wing to propel the aircraft through the air and to provide high lift. The pressurized air being discharged over the rounded trailing edge provides a high lift that is obtained independent of an aircraft angle of attack, thus preventing the asymmetry. separated flow, and stall experienced by the CC wing at the high angle of attack it required for high lift generation. The aircraft can further include blown outboard circulation control wings (CCW) that are synergistically connected to the blown channel CCWs. The blown outboard CCWs provide additional high lift, control thrust/drag interchange, and can provide all three aerodynamic moments when differential blowing is applied front-to-rear or left-to-right. Both the blown channel CCW and the outboard CCW also have leading-edge blowing slots to prevent flow separation or to provide aerodynamic moments for control.

Englar, Robert J.↗

Ion Channels – From Structure to Electrophysiology and Back

A reliable way to establish whether our understanding of a channel is satisfactory is to reproduce its measured ionic conductance over a broad range of applied voltages in computer simulations. In molecular dynamics (MD), this can be done by way of applying an external electric field to the system and counting the number of ions that traverse the channel per unit time. Since this approach is computationally very expensive, we have developed a markedly more efficient alternative in which MD is combined with the electrodiffusion (ED) equation. In this approach, the assumptions of the ED equation can be rigorously tested, and the precision and consistency of the calculated conductance can be determined. We have demonstrated that the full current/voltage dependence and the underlying free energy profile for a simple channel can be reliably calculated from equilibrium or non-equilibrium MD simulations at a single voltage. Free energy profiles can be obtained from non-equilibrium simulations without a loss of accuracy even without the knowledge of diffusion coefficient. To carry out MD simulations, a structural model of a channel has to be assumed, which is an important constraint, considering that high-resolution structures are available for only very few simple channels. If the comparison of calculated ionic conductance with electrophysiological data is satisfactory, it greatly increases our confidence that the structure and the function are described sufficiently accurately. We examined the validity of the ED for several channels embedded in phospholipid membranes - four naturally occurring channels: trichotoxin, alamethicin, p7 from hepatitis C virus (HCV) and Vpu from the HIV-1 virus, a synthetic, hexameric channel, formed by a 21-residue peptide that contains only leucine and serine and a bacterial pentameric ligand-gated ion channel, GLIC. All these channels mediate transport of potassium and chloride ions. It was found that the ED equation is satisfactory for these systems. In some of them, experimental and calculated electrophysiological properties are in good agreement, whereas in others there are strong indications that the structural models are incorrect.

Pohorille, Andrew↗

Technology Advancements for Channel Wall Nozzle Manufacturing In Liquid Rocket Engines

A regeneratively-cooled or dump-cooled nozzle is a critical component for expansion of hot gases to enable high temperature and performance in liquid rocket engines systems. Regeneratively-cooled channel wall nozzles are a design solution used across the propulsion industry as a simplified method to fabricate the nozzle structure with internal coolant passages. The scale and complexity of the channel wall nozzle (CWN) design can be challenging to fabricate which results in extended lead times and higher costs. Some of these challenges include: 1) Unique and high temperature materials, 2) Tight tolerances on large parts during manufacturing and assembly to contain high pressure propellants, 3) Thin-walled features to maintain adequate wall temperatures, and 4) Unique manufacturing process operations and complex tooling. The United States (U.S.) National Aeronautics and Space Administration (NASA) and U.S. specialty manufacturing vendors are maturing modern fabrication techniques to reduce complexity and decrease costs associated with channel wall nozzle manufacturing technology. Additive Manufacturing (AM) is one of the key technology advancements under evaluation for channel wall nozzles. Much of additive manufacturing for propulsion components has focused on laser powder bed fusion (L-PBF), but the scale is not yet feasible for application to large scale nozzles. NASA is evolving directed energy deposition (DED) techniques for nozzles including arc-based deposition, blown powder deposition, and Laser Wire Direct Closeout (LWDC). There are different approaches being considered for fabrication of the nozzle, and each of these DED processes offer unique process steps for rapid fabrication. The arc-based and blown powder deposition techniques are used for the forming of the CWN liner. A variety of materials are being demonstrated including Inconel 625, Haynes 230, JBK-75, and NASA HR-1. The blown powder DED process is also being demonstrated for forming an integral channel nozzle in a single operation in similar materials. The LWDC process is a method for closing out the channels within the liner and forming the structural jacket using a localized laser wire deposition technique. Identical materials mentioned above have been used for this process in addition to bimetallic closeout (C-18150–SS347, and C-18150–Inconel 625). NASA has completed process development, material characterization, and hot-fire testing on a variety of these channel wall nozzle fabrication technique. This publication presents an overview of the various channel wall nozzle manufacturing processes and materials under evaluation including results from the hot-fire testing. Future development and technology focus areas is also discussed relative to channel wall nozzle manufacturing.

Additive manufacturing↗

Heat transfer performance comparisons of five different rectangular channels with parallel angled ribs

This paper systematically presents the results of heat transfer and friction factor data measured in five short rectangular channels with turbulence promoters. The project investigated the combined effects of the channel aspect ratio, rib angle-of-attack, and flow Reynolds number on heat transfer and pressure drop in rectangular channels with two opposite ribbed walls. The channel aspect ratio (width-to-height, W/H, ribs on side W) varied from 1/4 to 1/2, to 1, 2, and 4, while the corresponding rib angles-of-attack alpha were 90 deg, 60 deg, 45 deg, and 30 deg, respectively. The Reynolds number range was 10,000-60,000. The results suggest that the narrow aspect ratio channels (W/H less than 1) give much better heat transfer performance than the wide aspect ratio channels (W/H greater than 1). For the square channel (W/H = 1), the 60 deg/45 deg angled ribs provide the best heat transfer performance. For the narrow aspect ratio channel (W/H = 1/4 or 1/2), the 45 deg/60 deg angled ribs are recommended, while the 30 deg/45 deg angled ribs are better for wide aspect ratio channels (W/H = 4 or 2).

Park, J. S.↗

Calibration of the AVHRR visible and near IR channels using radiances measured over remote ocean areas

An inflight absolute calibration method has been adapted and applied to channel 1 of the AVHRR. The approach is based on AVHRR observations in channels 1, 2 and 4. A rigorous cloud screening is performed, based on the homogeneity of the data in channel 1 and 2 and on the temperature in channel 4. In a combined approach, the off-nadir view satellite count in channel 2 is used to detect the aerosol optical thickness and loading and the count of channel 1 is used to calibrate this channel, based on the predictable Rayleigh scattering component. Water vapor data are used, and the channels are intercalibrated using the ratio between channels 1 and 2 over the glint region.

Vermote, Eric F.↗

Channels and Valleys

More than 200 channels and valleys have been identified on the Magellan images of Venus. These are classified, on the basis of morphology. as simple channels (including sinuous rilles, simple channels with flow margins. and canali), complex channels (with or without flow margins), compound channels, and valley networks (including rectangular, labyrinthic, and pitted or irregular networks). Sinuous rilles closely resemble their lunar counterparts. Canali are exceptional for their remarkably constant width along very extenuated flow paths, exceeding 500 km. One of the compound channels, the outflow complex of Kallistos Vallis. extends over 1200 km and is up to 30 km wide. Venusian channels are globally distributed, but each class has a preferential topographic association. The canali are developed on the volcanic plains. while sinuous rilles occur at higher elevations, associated with volcanic complexes and coronae. Both canali and sinuous rilles have been deformed by post-emplacement tectonism. Highly fluid lavas, erupted at sustained, high discharges seem best to explain many of the channel features, particularly for the canali and the compound channels. Explanation of the canali morphologies may also involve unusual low-viscosity lavas, perhaps of exotic composition.

Baker, Victor R.↗

Water transport by the bacterial channel alpha-hemolysin

This study is an investigation of the ability of the bacterial channel alpha-hemolysin to facilitate water permeation across biological membranes. alpha-Hemolysin channels were incorporated into rabbit erythrocyte ghosts at varying concentrations, and water permeation was induced by mixing the ghosts with hypertonic sucrose solutions. The resulting volume decrease of the ghosts was followed by time-resolved optical absorption at pH 5, 6, and 7. The average single-channel permeability coefficient of alpha-hemolysin for water ranged between 1.3x10-12 cm/s and 1.5x10-12 cm/s, depending on pH. The slightly increased single-channel permeability coefficient at lower pH-values was attributed to an increase in the effective pore size. The activation energy of water transport through the channel was low (Ea=5.4 kcal/mol), suggesting that the properties of water inside the alpha-hemolysin channel resemble those of bulk water. This conclusion was supported by calculations based on macroscopic hydrodynamic laws of laminar water flow. Using the known three-dimensional structure of the channel, the calculations accurately predicted the rate of water flow through the channel. The latter finding also indicated that water permeation data can provide a good estimate of the pore size for large channels.

Non-NASA Center↗

Contribution of the AIRS Shortwave Sounding Channels to Retrieval Accuracy

AIRS contains 2376 high spectral resolution channels between 650/cm and 2665/cm, including channels in both the 15 micron (near 667/cm) and 4.2 micron (near 2400/cm) COP sounding bands. Use of temperature sounding channels in the 15 micron CO2 band has considerable heritage in infra-red remote sensing. Channels in the 4.2 micron CO2 band have potential advantages for temperature sounding purposes because they are essentially insensitive to absorption by water vapor and ozone, and also have considerably sharper lower tropospheric temperature sounding weighting functions than do the 15 micron temperature sounding channels. Potential drawbacks with regard to use of 4.2 micron channels arise from effects on the observed radiances of solar radiation reflected by the surface and clouds, as well as effects of non-local thermodynamic equilibrium on shortwave observations during the day. These are of no practical consequences, however, when properly accounted for. We show results of experiments performed utilizing different spectral regions of AIRS, conducted with the AIRS Science Team candidate Version 5 algorithm. Experiments were performed using temperature sounding channels within the entire AIRS spectral coverage, within only the spectral region 650/cm to 1614 /cm; and within only the spectral region 1000/cm-2665/cm. These show the relative importance of utilizing only 15 micron temperature sounding channels, only the 4.2 micron temperature sounding channels, and both, with regards to sounding accuracy. The spectral region 2380/cm to 2400/cm is shown to contribute significantly to improve sounding accuracy in the lower troposphere, both day and night.

Susskind, Joel↗

Symmetrization for redundant channels

A plurality of redundant channels in a system each contain a global image of all the configuration data bases in each of the channels in the system. Each global image is updated periodically from each of the other channels via cross channel data links. The global images of the local configuration data bases in each channel are separately symmetrized using a voting process to generate a system signal configuration data base which is not written into by any other routine and is available for indicating the status of the system within each channel. Equalization may be imposed on a suspect signal and a number of chances for that signal to heal itself are provided before excluding it from future votes. Reconfiguration is accomplished upon detecting a channel which is deemed invalid. A reset function is provided which permits an externally generated reset signal to permit a previously excluded channel to be reincluded within the system. The updating of global images and/or the symmetrization process may be accomplished at substantially the same time within a synchronized time frame common to all channels.

Tulplue, Bhalchandra R.↗

Slopes To Prevent Trapping of Bubbles in Microfluidic Channels

The idea of designing a microfluidic channel to slope upward along the direction of flow of the liquid in the channel has been conceived to help prevent trapping of gas bubbles in the channel. In the original application that gave rise to this idea, the microfluidic channels are parts of micro-capillary electrophoresis (microCE) devices undergoing development for use on Mars in detecting compounds indicative of life. It is necessary to prevent trapping of gas bubbles in these devices because uninterrupted liquid pathways are essential for sustaining the electrical conduction and flows that are essential for CE. The idea is also applicable to microfluidic devices that may be developed for similar terrestrial microCE biotechnological applications or other terrestrial applications in which trapping of bubbles in microfluidic channels cannot be tolerated. A typical microCE device in the original application includes, among other things, multiple layers of borosilicate float glass wafers. Microfluidic channels are formed in the wafers, typically by use of wet chemical etching. The figure presents a simplified cross section of part of such a device in which the CE channel is formed in the lowermost wafer (denoted the channel wafer) and, according to the present innovation, slopes upward into a via hole in another wafer (denoted the manifold wafer) lying immediately above the channel wafer. Another feature of the present innovation is that the via hole in the manifold wafer is made to taper to a wider opening at the top to further reduce the tendency to trap bubbles. At the time of reporting the information for this article, an effort to identify an optimum technique for forming the slope and the taper was in progress. Of the techniques considered thus far, the one considered to be most promising is precision milling by use of femtosecond laser pulses. Other similar techniques that may work equally well are precision milling using a focused ion beam, or a small diamond-tipped drill bit.

Greer, Harold E.↗

Molecular Dynamics Simulation of the Antiamoebin Ion Channel: Linking Structure and Conductance

Molecular dynamics simulations were carried out in order to ascertain which of the potential multimeric forms of the transmembrane peptaibol channel, antiamoebin, is consistant with its measured conductance. Estimates of the conductance obtained through counting ions that cross the channel and by solving the Nernst-Planck equation yield consistent results, indicating that the motion of ions inside the channel can be satisfactorily described as diffusive.The calculated conductance of octameric channels is markedly higher than the conductance measured in single channel recordings, whereas the tetramer appears to be non-conducting. The conductance of the hexamer was estimated to be 115+/-34 pS and 74+/-20 pS, at 150 mV and 75 mV, respectively, in satisfactory agreement with the value of 90 pS measured at 75 mV. On this basis we propose that the antiamoebin channel consists of six monomers. Its pore is large enough to accommodate K(+) and Cl(-) with their first solvation shells intact. The free energy barrier encountered by K(+) is only 2.2 kcal/mol whereas Cl(-) encounters a substantially higher barrier of nearly 5 kcal/mol. This difference makes the channel selective for cations. Ion crossing events are shown to be uncorrelated and follow Poisson statistics. keywords: ion channels, peptaibols, channel conductance, molecular dynamics

Wilson, Michael A.↗

The Origins of Transmembrane Ion Channels

Even though membrane proteins that mediate transport of ions and small molecules across cell walls are among the largest and least understood biopolymers in contemporary cells, it is still possible to shed light on their origins and early evolution. The central observation is that transmembrane portions of most ion channels are simply bundles of -helices. By combining results of experimental and computer simulation studies on synthetic models and natural channels, mostly of non-genomic origin, we show that the emergence of -helical channels was protobiologically plausible, and did not require highly specific amino acid sequences. Despite their simple structure, such channels could possess properties that, at the first sight, appear to require markedly larger complexity. Specifically, we explain how the antiamoebin channels, which are made of identical helices, 16 amino acids in length, achieve efficiency comparable to that of highly evolved channels. We further show that antiamoebin channels are extremely flexible, compared to modern, genetically coded channels. On the basis of our results, we propose that channels evolved further towards high structural complexity because they needed to acquire stable rigid structures and mechanisms for precise regulation rather than improve efficiency. In general, even though architectures of membrane proteins are not nearly as diverse as those of water-soluble proteins, they are sufficiently flexible to adapt readily to the functional demands arising during evolution.

Pohorille, Andrew↗

Conductance of Ion Channels - Theory vs. Experiment

Transmembrane ion channels mediate a number of essential physiological processes in a cell ranging from regulating osmotic pressure to transmission of neural signals. Kinetics and selectivity of ion transport is of critical importance to a cell and, not surprisingly, it is a subject of numerous experimental and theoretical studies. In this presentation we will analyze in detail computer simulations of two simple channels from fungi - antiamoebin and trichotoxin. Each of these channels is made of an alpha-helical bundle of small, nongenomically synthesized peptides containing a number of rare amino acids and exhibits strong antimicrobial activity. We will focus on calculating ionic conductance defined as the ratio of ionic current through the channel to applied voltage. From molecular dynamics simulations, conductance can be calculated in at least two ways, each involving different approximations. Specifically, the current, given as the number of charges transferred through the channel per unit of time, can be obtained from the number of events in which ions cross the channel during the simulation. This method works well for large currents (high conductance values and/or applied voltages). If the number of crossing events is small, reliable estimates of current are difficult to achieve. Alternatively, conductance can be estimated assuming that ion transport can be well approximated as diffusion in the external potential given by the free energy profile. Then, the current can be calculated by solving the one-dimensional diffusion equation in this external potential and applied voltage (the generalized Nernst-Planck equation). To do so three ingredients are needed: the free energy profile, the position-dependent diffusion coefficient and the diffusive flux of ions into the channel. All these quantities can be obtained from molecular dynamics simulations. An important advantage of this method is that it can be used equally well to estimating large and small currents. In addition, once the free energy profile becomes available the full current-voltage dependence can be readily obtained. For both channels we carried out calculations using both approaches. We also tested the main assumptions underlying the diffusive model, such as uncorrelated nature of individual crossing events and Fickian diffusion. The accuracy and consistency of different methods will be discussed. Finally we will discuss how comparisons between calculated and measured ionic conductance and selectivity of transport can be used for determining structural models of the channels.

Pohorille, Andrew↗

Simple Ion Channels: From Structure to Electrophysiology and Back

A reliable way to establish whether our understanding of a channel is satisfactory is to reproduce its measured ionic conductance over a broad range of applied voltages in computer simulations. In molecular dynamics (MD), this can be done by way of applying an external electric field to the system and counting the number of ions that traverse the channel per unit time. Since this approach is computationally very expensive, we have developed a markedly more efficient alternative in which MD is combined with the electrodiffusion (ED) equation. In this approach, the assumptions of the ED equation can be rigorously tested, and the precision and consistency of the calculated conductance can be determined. We have demonstrated that the full current/voltage dependence and the underlying free energy profile for a simple channel can be reliably calculated from equilibrium or non-equilibrium MD simulations at a single voltage. To carry out MD simulations, a structural model of a channel has to be assumed, which is an important constraint, considering that high-resolution structures are available for only very few simple channels. If the comparison of calculated ionic conductance with electrophysiological data is satisfactory, it greatly increases our confidence that the structure and the function are described sufficiently accurately. We examined the validity of the ED for several channels embedded in phospholipid membranes - four naturally occurring channels: trichotoxin, alamethicin, p7 from hepatitis C virus (HCV) and Vpu from the HIV-1 virus, and a synthetic, hexameric channel, formed by a 21-residue peptide that contains only leucine and serine. All these channels mediate transport of potassium and chloride ions. It was found that the ED equation is satisfactory for these systems. In some of them experimental and calculated electrophysiological properties are in good agreement, whereas in others there are strong indications that the structural models are incorrect.

molecular dynamics (MD↗

A Communication Channel Density Estimating Generative Adversarial Network

Autoencoder-based communication systems use neural network channel models to backwardly propagate message reconstruction error gradients across an approximation of the physical communication channel. In this work, we develop and test a new generative adversarial network (GAN) architecture for the purpose of training a stochastic channel approximating neural network. In previous research, investigators have focused on additive white Gaussian noise (AWGN) channels and/or simplified Rayleigh fading channels, both of which are linear and have well defined analytic solutions. Given that training a neural network is computationally expensive, channel approximation networks— and more generally the autoencoder systems—should be evaluated in communication environments that are traditionally difficult. To that end, our investigation focuses on channels that contain a combination of non-linear amplifier distortion, pulse shape filtering, intersymbol interference, frequency-dependent group delay, multipath, and non-Gaussian statistics. Each of our models are trained without any prior knowledge of the channel. We show that the trained models have learned to generalize over an arbitrary amplifier drive level and constellation alphabet. We demonstrate the versatility of our GAN architecture by comparing the marginal probability density function of several channel simulations with that of their corresponding neural network approximations

Smith, Aaron↗

Model for the Increase in Thruster Efficiency from Cross-Channel Coupling in Nested Hall Thrusters

Multi-channel operation in nested Hall thrusters has been experimentally shown to enhance thruster efficiency compared to single-channel operation at constant power. This is the result of higher local neutral density due to the flow from adjacent channels, leading to two effects: neutral ingestion and decreased plume divergence. Analytical expressions for the impact of these cross-channel effects on efficiency are derived for a nested Hall thruster based on the flow of neutrals between channels. These expressions are dependent on the geometry and operation of a given thruster, as well as its performance in single-channel operation. The mass utilization efficiency increase from cross-channel neutrals is found to be primarily driven by the distance between adjacent channels. A comparison of the model predictions of efficiency to experiment also shows agreement within uncertainty. These results are discussed in the context of best practices for nested Hall thruster channel testing and optimal thruster design.

Nested Hall Thruster↗