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2025 Review and Revision of Federal Guidance Report 15

Federal Guidance Report No. 15 (FGR 15), External Exposure to Radionuclides in Air, Water and Soil, published in 2019 and referred to below as FGR 2019, provides age-specific effective dose rate coefficients for reference persons externally exposed to each of 1252 radionuclides homogenously distributed in environmental media. Soon after completion of FGR 2019, the International Commission on Radiological Protection (ICRP) published a similar report (ICRP Publication 144, 2020) addressing the same radionuclides and many of the external exposure scenarios addressed in FGR 2019. In 2023 Argonne National Laboratory (ANL) published a review of dose coefficients in FGR 2019, concluding that “The external effective dose from beta radiation is not appropriately accounted for in FGR 15 for both low- and high-energy beta emitters in air, in soil, and on soil surfaces.” That conclusion was based largely on comparisons of dose coefficients in FGR 2019 with values in ICRP Publication 144 but also on consideration of some unexpected patterns of equivalent dose rate coefficients across tissues and of effective dose rate coefficients across different soil depths, for a selected set of low-energy beta emitters. In response to the ANL report, the Center for Radiation Protection Knowledge (CRPK) at Oak Ridge National Laboratory (ORNL) performed an extensive reexamination of the methods and published values of FGR 2019. CRPK found that coding errors had resulted in inaccurate estimates, primarily overestimates, in many of the dose coefficients tabulated in FGR 2019 but that many of the differences between results in FGR 2019 and ICRP Publication 144 could be traced to differences in methodology. CRPK has corrected all errors in FGR 2019 associated with the coding errors and has taken the opportunity to improve a major portion of the remaining dose coefficients in FGR 2019, primarily through additional Monte Carlo calculations resulting in improved statistics for tissue equivalent dose rate coefficients for exposure to monoenergetic sources. This has eliminated the need for extrapolation of results from high and medium energies to low energies, as was done in FGR 2019. In addition, inconsistencies in the methodology identified in the review, such as computational representation of the adult female, were eliminated. The revised effective dose rate coefficients are consistent with values in ICRP Publication 144 except for differences in values clearly arising from differences in methodology; and differences in values for a relatively small set of very low-energy radionuclides with highly uncertain dose coefficients regardless of methodology.

54 ENVIRONMENTAL SCIENCES

Generation of shear flows induced by AE / EPM in LHD plasma

The generation of shear flows (SFs) by Alfven Eigenmodes (AEs) and energetic particle modes (EPMs) have important effects on the operation of future nuclear fusion reactors, because SFs regulate the saturation of the AEs/EPMs, the transport of EPs and thermal plasma, as well as the formation of transport barriers among other consequences. The aim of this study is the analysis of SFs generation during the saturation phase of AEs and EPMs in LHD plasma. Experiments performed in the 23rd and 24th LHD experimental campaigns are dedicated to explore the destabilization of AEs/EPMs in discharges with different heating patterns, thermal plasma and magnetic field configurations. In particular, the shots 176490 and 179697 show the destabilization of MHD bursts and energetic-ion-driven resistive interchange modes (EIC), respectively. Charge exchange spectroscopy measurements in both discharges indicate that the generation of SFs by AE/EPM is uncorrelated with the perturbation induced by the neutral beam injector (NBI). Nonlinear simulations performed using the gyro-fluid code FAR3d show the generation of zonal structures, especially SFs, induced during the saturation phase of Toroidal Alfven Eigenmodes (TAEs) triggered in the MHD burst as well as by the 1/1 EIC in the bursting phase. The simulations indicate that SFs are caused by the radial electric fields powered by energy transfers from the unstable AE/EPM towards the thermal plasma. The strongest SFs are measured during the EIC bursting phase once the 1/1 EPM overlaps with nearby resonances at the plasma periphery. Likewise, the largest SFs during the MHD burst are observed once TAEs radially overlap in the inner-middle plasma region.

AE

Exploring genetic diversity, population structure, and subgenome differences in the allopolyploid Camelina sativa : implications for future breeding and research studies

Abstract Camelina (Camelina sativa), an allohexaploid species, is an emerging aviation biofuel crop that has been the focus of resurgent interest in recent decades. To guide future breeding and crop improvement efforts, the community requires a deeper comprehension of subgenome dominance, often noted in allopolyploid species, “alongside an understanding of the genetic diversity” and population structure of material present within breeding programs. We conducted population genetic analyses of a C. sativa diversity panel, leveraging a new genome, to estimate nucleotide diversity and population structure, and analyzed for patterns of subgenome expression dominance among different organs. Our analyses confirm that C. sativa has relatively low genetic diversity and show that the SG3 subgenome has substantially lower genetic diversity compared to the other two subgenomes. Despite the low genetic diversity, our analyses identified 13 distinct subpopulations including two distinct wild populations and others putatively representing founders in existing breeding populations. When analyzing for subgenome composition of long non-coding RNAs, which are known to play important roles in (a)biotic stress tolerance, we found that the SG3 subgenome contained significantly more lincRNAs compared to other subgenomes. Similarly, transcriptome analyses revealed that expression dominance of SG3 is not as strong as previously reported and may not be universal across all organ types. From a global analysis, SG3 “was only significant higher expressed” in flower, flower bud, and fruit organs, which is an important discovery given that the crop yield is associated with these organs. Collectively, these results will be valuable for guiding future breeding efforts in camelina.

Agriculture

Unsupervised Segmentation and Clustering Workflow for Efficient Processing of 4D-STEM and 5D-STEM Data

Four-dimensional scanning transmission electron microscopy (4D-STEM) enables mapping of diffraction information with nanometer-scale spatial resolution, offering detailed insight into local structure, orientation, and strain. However, as data dimensionality and sampling density increase, particularly for in situ scanning diffraction experiments (5D-STEM), robust segmentation of structurally consistent behavior across sequential measurements becomes essential for efficient and physically meaningful analysis. Here, we introduce a clustering framework that identifies crystallographically distinct domains from 4D-STEM datasets. By using local diffraction-pattern similarity as a metric, the method extracts closed contours delineating spatially contiguous regions. This approach produces cluster-averaged diffraction patterns that improve signal quality while reducing data volume by orders of magnitude, enabling rapid and accurate orientation, phase, and strain mapping. We demonstrate the applicability of this approach to in situ liquid-cell 4D-STEM data of gold nanoparticle growth. Our method provides a scalable and generalizable route for spatially coherent segmentation, data compression, and quantitative structure–strain mapping across diverse 4D-STEM modalities. The full analysis code and example workflows are publicly available to support reproducibility and reuse.

4D-STEM

Decision Making Under Uncertainty Human Subjects Data - Fire Evacuation Task

This dataset contains de-identified data from human subjects experiments, along with the images and code that were used to run the experiments (as a crowdsourced online study). In this study, participants were shown the probability of a house being in the burn zone of a wildfire. They were asked if they would stay in the house or evacuate in that scenario. The probability information was presented in different ways, including text and maps. The studies tested the impact of different visual cues on the participants' patterns of decisions.

Matzen, Laura E. [Sandia National Laboratories (SN

Notice of Illegal Foreign Pesticides Entering the United States: Information Bulletin v.01

This information bulletin is intended to generate a heightened awareness of illicit pesticide importation, distribution, and use in the United States. This bulletin focuses on solid, fumigant materials which are primarily used in the production of marijuana growth and cultivation. Exposure to illicit pesticides, fumigant fumes, or residual materials may pose a public health and officer safety concern. Many illegal fumigant pesticide products have been seized and determined to consist of a mixture of several pesticides and is often in contrast with the pesticide labelling. This information bulletin is not a complete account of all illegal pesticides found in country; it serves to highlight frequently encountered materials and present patterns in product presentation, packaging, and shipment containment which are intended to aid in identification and intervention. Other varieties of illegal pesticide fumigants are known to exist, and additional variations are expected to be encountered in policing intervention. This bulletin includes information on the presentation of illegal pesticides, label review recommendations, a field reference guide, which includes example photographs of seized pesticide/fumigants and their labels, and related United States federal regulation information, including relevant tariff code information for reference.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH

Assessing plasma face component thermal response to rotating 3D magnetic fields for SPARC tokamak

Thermal response simulations of plasma-facing components (PFCs) in the SPARC tokamak, performed with the HEAT code, show that three-dimensional (3D) heat loads resulting from stationary n=1 perturbations require highly radiative scenarios, with up to 95% of the power crossing the separatrix (P SOL ) being radiated, to maintain PFC temperatures within acceptable operational limits, whereas the application of slowly rotating 3D fields substantially reduces the thermal loads. The HEAT module, developed to predict heat loads from non-axisymmetric plasmas, is extended to model time-dependent heat flux patterns generated by rotating 3D fields, and a comprehensive thermal analysis is performed on PFCs subjected to both the maximum and minimum power loads, as well as to rotating heat flux distributions, to evaluate the temperature evolution for varying perturbation amplitudes and rotation frequencies. The extension of this analysis to 3D fields with toroidal mode number n=2 shows that this configuration leads to weaker localized heat flux peaks relative to the n=1 case, enabling safe operation with less than 80% of the power radiated when static 3D fields of low amplitude are applied, while using slowly rotating fields at higher amplitudes. These results indicate that n=2 perturbations are generally less detrimental to divertor power exhaust, emphasizing the strong dependence of divertor power exhaust on the characteristics of the applied 3D fields.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY

Genomic factors shaping codon usage across the Saccharomycotina subphylum

Codon usage bias, or the unequal use of synonymous codons, is observed across genes, genomes, and between species. It has been implicated in many cellular functions, such as translation dynamics and transcript stability, but can also be shaped by neutral forces. We characterized codon usage across 1,154 strains from 1,051 species from the fungal subphylum Saccharomycotina to gain insight into the biases, molecular mechanisms, evolution, and genomic features contributing to codon usage patterns. We found a general preference for A/T-ending codons and correlations between codon usage bias, GC content, and tRNA-ome size. Codon usage bias is distinct between the 12 orders to such a degree that yeasts can be classified with an accuracy >90% using a machine learning algorithm. We also characterized the degree to which codon usage bias is impacted by translational selection. We found it was influenced by a combination of features, including the number of coding sequences, BUSCO count, and genome length. Our analysis also revealed an extreme bias in codon usage in the Saccharomycodales associated with a lack of predicted arginine tRNAs that decode CGN codons, leaving only the AGN codons to encode arginine. Analysis of Saccharomycodales gene expression, tRNA sequences, and codon evolution suggests that avoidance of the CGN codons is associated with a decline in arginine tRNA function. Consistent with previous findings, codon usage bias within the Saccharomycotina is shaped by genomic features and GC bias. However, we find cases of extreme codon usage preference and avoidance along yeast lineages, suggesting additional forces may be shaping the evolution of specific codons.

59 BASIC BIOLOGICAL SCIENCES

Decoding substance use disorder severity from clinical notes using a large language model

Substance use disorder (SUD) poses a major concern due to its detrimental effects on health and society. SUD identification and treatment depend on a variety of factors such as severity, co-determinants (e.g., withdrawal symptoms), and social determinants of health. Existing diagnostic coding systems used by insurance providers, like the International Classification of Diseases (ICD-10), lack granularity for certain diagnoses, but American clinicians will add this granularity (as that found within the Diagnostic and Statistical Manual of Mental Disorders classification or DSM-5) as supplemental unstructured text in clinical notes. Traditional natural language processing (NLP) methods face limitations in accurately parsing such diverse clinical language. Large language models (LLMs) offer promise in overcoming these challenges by adapting to diverse language patterns. This study investigates the application of LLMs for extracting severity-related information for various SUD diagnoses from clinical notes. We propose a workflow employing zero-shot learning of LLMs with carefully crafted prompts and post-processing techniques. Through experimentation with Flan-T5, an open-source LLM, we demonstrate its superior recall compared to the rule-based approach. Focusing on 11 categories of SUD diagnoses, we show the effectiveness of LLMs in extracting severity information, contributing to improved risk assessment and treatment planning for SUD patients.

60 APPLIED LIFE SCIENCES

Regional specialization in prefrontal cortex manifests in the reliability of task progression codes

The brain has the remarkable ability to guide the performance of complex tasks. Distinct prefrontal cortical areas make specific contributions to this ability, with the orbitofrontal cortex (OFC) critical for processing information related to trial outcomes and the dorsomedial prefrontal cortex (dmPFC) critical for sustained effort and selecting the right action at the right time. Yet, in both areas, neural activity represents both outcome- and action-related quantities. How similar neural representations support different functions remains unclear. Here, we compared OFC and dmPFC activity in rats performing a spatial alternation task. We show that, in contrast to other task-related variables, task progression is represented in both areas, but with distinct patterns of across-trial reliability that match each area’s previously documented functional specialization. Our results indicate that the engagement of reliable, task-phase-specific activity patterns differs across prefrontal regions in a manner well suited to engage different computations at different times.

Biological and medical sciences

Two deeply conserved non-coding sequences control PLETHORA1/2 expression and coordinate embryo and root development

Conserved non-coding sequences (CNSs) are integral elements of transcriptional regulation. Transcriptional tuning of PLETHORA (PLT) genes that encode master regulators of plant development is vital for embryogenesis and meristematic function. However, how the expression of PLT genes is modulated through CNSs remains unclear. Through motif-based mining of upstream sequences in 120 angiosperm genomes, we identified 21 conserved and lineage-specific CNSs, two of which are unusually long, similar, and colinear within eudicots. Using Arabidopsis thaliana, we demonstrate that these two deeply conserved elements, which we named BOX1 and BOX2, control PLT1 and PLT2 expression. CRISPR mutants within these elements specifically reduced PLT expression levels, and reporter lines revealed that deletion of either or both BOXes altered and/or abrogated the PLT2 expression pattern in the root tip, affecting the ability to rescue the plt1 plt2 double mutant. We further show that the influence of these elements on expression patterns is already exerted during embryogenesis and functional in the context of the early embryo. Finally, we reveal the existence of a BOX-mediated autoregulatory feedback loop that, in large part, explains CNS influence on expression patterns. We thus uncover a transcriptional mechanism by which genes encoding master regulators of embryo and root meristem development are regulated.

PLETHORA

Numerical simulation of involute-plate research reactor flow behavior using RANS, LES and DNS

This paper investigates the flow behavior of involute-plate research reactors by performing Reynolds-Averaged Navier Stokes simulation (RANS), Large Eddy Simulation (LES) and Direct Numerical Simulation (DNS) of the channel flow between fuel plates. By modeling turbulence with different numerical approaches, this study provides data with three levels of fidelity. For the RANS simulation, three widely used turbulence models, i.e., k-ε, k-ω, Reynolds Stress Turbulence model (RST) are applied by using the commercial CFD code STAR-CCM +. For LES and DNS, the open-source CFD code, Nek5000, is used given its outstanding scalability on High Performance Computer (HPC) and high-order technique. The results from RANS simulations are compared with that from LES and DNS for benchmarking. Both macroscale parameters and turbulence statistics, such as velocity magnitude, lateral velocity and turbulence kinetic energy, are presented and analyzed. The results from RANS simulation achieve good agreement with LES and DNS on velocity and turbulence kinetic energy prediction. The RST turbulence model predicts the most similar flow pattern of lateral velocity as compared to LES and DNS. The Lambda-2 (λ2) criterion with a reasonable threshold is used to demonstrate the instantaneous vortices distribution in the involute channel from both LES and DNS calculation. The DNS simulation captures more detailed turbulence especially near the corner, which explains the discrepancy between LES and DNS results near the corner. The normalized RMS error are defined and calculated to assess the performance of those turbulence models. The RST model captures the anisotropic feature of turbulence, which enable it to outperform other turbulence models for predicting the flow behavior in an involute channel. Although some discrepancies are found between LES and DNS results in the corner, the overall deviations between LES and DNS are found to be small. In conclusion, given that the computational cost of DNS calculation is an order of magnitude higher, using LES data for benchmarking RANS model is a cost-effective approach.

DNS

Understanding the Costs and Barriers of Residential Electrical Panel and Service Upgrades

Upgrading electrical panels and services in U.S. homes represents a significant barrier to building modernization, imposing considerable costs, delays, and procedural uncertainties on homeowners, contractors, utilities, and building departments. Although cost databases document individual infrastructure activities, they rarely capture the integrated, whole-project perspective required to understand how electrical upgrades are planned, executed, and regulated. Existing research is often geographically constrained, narrowly scoped, or derived from limited samples, leaving significant knowledge gaps unaddressed. This study examines the timelines and costs associated with residential electrical panel and service upgrades using data from a national cross- sectional survey conducted in summer 2025. The survey captured responses from 140 stakeholders across 34 states, including building industry professionals, utility staff, and building department staff. Findings indicate that project duration and cost increase substantially with building size though patterns vary by infrastructure type. Most single-family and small multifamily projects were completed within 30 days, whereas medium and large multifamily buildings show longer and less predictable timelines. Service rating increases modestly extend project duration, but building type and size were the primary determinants of delays. Cost patterns were similar: customer-side equipment and panel replacements scale predictably with building size, while utility-side costs are highly variable, often triggered by threshold-driven infrastructure upgrades such as transformer replacements. Permit fees vary considerably between jurisdictions but generally represent a minor proportion of total project costs. These findings identify electrical upgrades as a significant barrier to residential building costs and highlight the need for improved stakeholder coordination, streamlined permitting, and strategies that reduce upgrade requirements while maintaining safety and code compliance.

Casquero-Modrego, Nuria

Simulating Marine Ecosystem Dynamics and Biogeochemical Cycling With Multiple Plankton Functional Types

Current representations of marine ecosystems in Earth System Models are greatly simplified, neglecting key interactions between dynamic food webs, biogeochemistry, and climate change. We use the Marine Biogeochemistry Library code base within the Community Earth System Model 2.2.2 to create an expanded ecosystem model with eight phytoplankton groups and four zooplankton size classes (MARBL-8P4Z). Incorporating more specific plankton types and size classes has the potential to capture a wider range of possible behaviors of the ecosystem, its complex interactions with biogeochemistry, and its feedback to climate change. It also permits stronger observational constraints, including in situ group-specific biomass and various observational estimates of plankton community composition. MARBL-8P4Z broadly captures observed global-scale patterns in biomass and community composition for both phytoplankton and zooplankton, with a good performance in simulating broad biogeochemistry fields. The model shows comparable spatial patterns and magnitudes to the observed picophytoplankton biomass (Prochlorococcus, Synechococcus, picoeukaryotes), and captures the seasonal cycle of mesozooplankton biomass. Picophytoplankton groups and microzooplankton dominate biomass and production in oligotrophic, subtropical regions, while nano-phytoplankton, diatoms and the larger zooplankton groups prevail at higher latitudes and within upwelling zones. The model simulates reasonable energy transfer efficiency through the food web, with tight linkages between the phytoplankton community composition, zooplankton grazing, and carbon export, with the potential to link to fisheries models. Thus, MARBL-8P4Z has the potential to account for key climate-driven ecological shifts in the plankton that will modify ocean biogeochemistry in the future.

54 ENVIRONMENTAL SCIENCES

Tetranucleotide frequencies differentiate genomic boundaries and metabolic strategies across environmental microbiomes

Microbiomes are constrained by physicochemical conditions, nutrient regimes, and community interactions across diverse environments, yet genomic signatures of this adaptation remain unclear. Metagenome sequencing is a powerful technique to analyze genomic content in the context of natural environments, establishing concepts of microbial ecological trends. Here, we developed a data discovery tool-a tetranucleotide-informed metagenome stability diagram-that is publicly available in the integrated microbial genomes and microbiomes (IMG/M) platform for metagenome ecosystem analyses. We analyzed the tetranucleotide frequencies from quality-filtered and unassembled sequence data of over 12,000 metagenomes to assess ecosystem-specific microbial community composition and function. We found that tetranucleotide frequencies can differentiate communities across various natural environments and that specific functional and metabolic trends can be observed in this structuring. Our tool places metagenomes sampled from diverse environments into clusters and along gradients of tetranucleotide frequency similarity, suggesting microbiome community compositions specific to gradient conditions. Within the resulting metagenome clusters, we identify protein-coding gene identifiers that are most differentiated between ecosystem classifications. We plan for annual updates to the metagenome stability diagram in IMG/M with new data, allowing for refinement of the ecosystem classifications delineated here. This framework has the potential to inform future studies on microbiome engineering, bioremediation, and the prediction of microbial community responses to environmental change. IMPORTANCE: Microbes adapt to diverse environments influenced by factors like temperature, acidity, and nutrient availability. We developed a new tool to analyze and visualize the genetic makeup of over 12,000 microbial communities, revealing patterns linked to specific functions and metabolic processes. This tool groups similar microbial communities and identifies characteristic genes within environments. By continually updating this tool, we aim to advance our understanding of microbial ecology, enabling applications like microbial engineering, bioremediation, and predicting responses to environmental change.

Kellom, Matthew

$\mathrm{SageNet}$: Fast Neural Network Emulation of the Stiff-amplified Gravitational Waves from Inflation

Accurate modeling of the inflationary gravitational waves (GWs) requires time-consuming, iterative numerical integrations of differential equations to take into account their backreaction on the expansion history. To improve computational efficiency while preserving accuracy, we present the Stiff-amplified Gravitational-wave Emulator Network (SageNet), a deep learning framework designed to replace conventional numerical solvers (code available at https://github.com/YifangLuo/SageNet). SageNet employs a long short-term memory architecture to emulate the present-day energy density spectrum of the inflationary GWs with possible stiff amplification, Ω GW (f). Trained on a data set of 25,689 numerically generated solutions, SageNet allows accurate reconstructions of Ω GW (f) and generalizes well to a wide range of cosmological parameters; 90.9% of the test emulations with randomly distributed parameters exhibit errors of under 4%. In addition, SageNet demonstrates its ability to learn and reproduce the artificial, adaptive sampling patterns in numerical calculations, which implement denser sampling of frequencies around changes in spectral indices in Ω GW (f). The dual capability of learning both physical and artificial features of the numerical GW spectra establishes SageNet as a robust alternative to exact numerical methods. Finally, our benchmark tests show that SageNet reduces the computation time from tens of seconds to milliseconds, achieving a speedup of ∼10 4 times over standard CPU-based numerical solvers with the potential for further acceleration on GPU hardware. These capabilities make SageNet a powerful tool for accelerating Bayesian inference procedures for extended cosmological models. In a broad sense, the SageNet framework offers a fast, accurate, and generalizable solution to modeling cosmological observables whose theoretical predictions demand costly differential equation solvers.

Astronomy data modeling

Maps of growing season gross primary production and net ecosystem exchange for Council Road Mile Marker 71, Seward Peninsula, Alaska, [2017-2023]

This data archive is in support of the Next-Generation Ecosystem Experiments in the Arctic (NGEE Arctic) publication "Integrating Characteristic Arctic Vegetation in a Land Surface Model Improves Representation of Carbon Dynamics Across a Tundra Landscape", by Murphy et al. (2025a). Murphy et al. (2025a) evaluated whether incorporating observed Arctic vegetation heterogeneity into ELM, the land model of the Department of Energy’s Energy Exascale Earth System Model (E3SM), improved simulations of tundra carbon cycling. The associated model archive can be found at Murphy et al. (2025b). The study focused on the spatial patterns and net landscape-level growing season productivity and carbon uptake. As part of this evaluation, observationally derived maps of average growing season (June–August) net ecosystem exchange (NEE) and gross primary production (GPP) were developed for the same domain. These maps, which form the dataset described here, integrate eddy covariance flux tower, remote sensing, and vegetation community data to provide spatially explicit benchmarks for model evaluation. The maps provide spatially explicit estimates of average growing season NEE and GPP across 13 tundra vegetation communities within the study domain. By combining flux tower observations with Airborne Visible-Infrared Imaging Spectrometer-Next Generation (AVIRIS-NG) hyperspectral imagery and drone-based normalized difference vegetation index (NDVI), these maps capture the heterogeneity of carbon fluxes associated with different Arctic vegetation types. While they represent average seasonal conditions rather than interannual variability, the maps provide a unique dataset for evaluating model performance, comparing vegetation community contributions to landscape-scale carbon cycling, and supporting regional analyses of Arctic carbon dynamics. This data archive contains 5 m resolution maps of vegetation communities, vegetation community average growing season GPP, and vegetation community average growing season NEE (three *.tif files), a User’s Guide (*pdf file), and Table 1 of the User’s Guide displaying vegetation community coverage and average growing season NEE and GPP values (*.csv file).

Murphy, Bailey [ORNL] (ORCID:0000000203995221)

Power balance and divertor asymmetries in the Super-X divertors of MAST-U using SOLPS-ITER

Spherical tokamaks (STs) present unique challenges and opportunities in the area of particle and power exhaust, intensified due to their more compact sizes. Substantial efforts are underway in STs to determine the limits in dissipative operational regimes and advanced divertor solutions, including at MAST-U which provides access to the Super-X divertor configuration. Power balance, and upper/lower divertor asymmetries have been studied using SOLPS-ITER simulations of the MAST-U Super-X divertor. A set of simulations with experimentally inferred transport coefficients with E x B and diamagnetic drifts activated, consisting of density and power scans, and high field side vs low field side gas puff locations, have been used for code experimentation to uncover trends beyond the current experimental parameter space. The upper biased asymmetry (U:L > 1) of the ratio of the peaks of the plasma energy flux densities at the outer targets increases with heating power and decreases with gas puff strength, going from symmetric to up to a factor of 15. The upper target electron temperature has been found to be a good ordering quantity for the magnitude of this asymmetry for all heating powers, gas puff strength, and gas puff locations. The lower divertor biased asymmetry (U:L < 1) of the radiation patterns processed through SOLPS-based bolometry synthetic diagnostics is in qualitative agreement with resistive bolometry experimental results, and it is in quantitative agreement with the trend of the total volume radiation within the divertors of SOLPS. However, radiation measurements alone are not sufficient to infer the magnitude of the asymmetry of the peaks of the power loads at the targets.

MAST-U