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At least 73 records · Page 4

Biochemical properties of glycerol kinase from the hypersaline-adapted archaeon Haloferax volcanii

ABSTRACT Extremophilic microorganisms are promising candidates for industrial and analytical biocatalysis.Haloferax volcanii, a halophilic archaeon that prefers glycerol over glucose, channels this substrate into central metabolism through glycerol kinase (GK). Here, we report the biochemical properties ofH. volcaniiGK and its potential for biotechnological applications. An N-terminal His-tagged GK was functionalin vivoand yielded 3 mg/L culture—4.5 times more enzyme than a C-terminal StrepII-tagged version. Size exclusion chromatography revealed a glycerol-induced oligomeric shift from homodimer to a dimer-dominant state with detectable tetramer. The purified enzyme showed robust activity across broad pH and salinity ranges, with optimal activity at 100 mM NaCl and 50°C–60°C. It retained catalytic activity in 5%–10% dimethyl sulfoxide (DMSO) and crude glycerol containing methanol. His-GK was freeze-thaw stable and thermotolerant in 2 M NaCl buffers. In the absence of ligands, the enzyme’s melting temperature (T m ) was 80°C. Glycerol increased the T m to 85°C, and combinations with MgCl₂ (84°C) or ATP (88°C) provided further stabilization. The highest T m (89°C) occurred with all three ligands, suggesting a cumulative stabilizing effect. Kinetic analyses revealed positive cooperativity for glycerol, ATP, and Mg² + ; Mn² + and Co² + also supported the activity.H. volcaniiGK is the first known GK to exhibit positive cooperativity with glycerol and ATP. Its high stability and substrate flexibility support its use in biodiesel waste valorization,in vitrobiocatalysis, and biosensor development—applications demanding robust, specific, and stable enzymes. IMPORTANCE This study reveals thatH. volcaniiGK exhibits positive cooperativity for glycerol, ATP, and Mg² + , a kinetic feature not previously reported for glycerol kinases. This behavior enables steep, switch-like responses to small substrate changes, offering unique advantages for biosensor design. Importantly,H. volcaniiGK also maintains high activity under extreme salinity, temperature, broad pH, and solvent conditions that typically limit enzyme use in industrial and environmental applications. These traits make this GK an ideal candidate for enzyme-based biosensors, which often suffer from poor tolerance to pH, solvent, and thermal stress. Its robustness supports its use in cross-linked enzyme crystals, an immobilization method that enhances enzyme stability and reusability under harsh conditions. Moreover, GKs are already employed in Mg² + detection kits; however,H. volcaniiGK’s ability to tolerate and respond to diverse divalent cations (e.g., Co² + , Mn² + ) broadens their potential for pollutant detection and environmental monitoring. These features collectively positionH. volcaniiGK as a valuable biocatalyst for biosensing,in vitrodiagnostics, and biotechnological applications requiring both precision and durability.

Biotechnology & Applied Microbiology↗

Pressure Transient Analyses and Poroelastic Modeling of Hydraulic Fracture Dilation for Multiple Injections at the Devine Fracture Pilot Site

Our team has conducted electromagnetic (EM) surveys for the past six years to monitor hydraulic-fracture behavior at the Devine Fracture Pilot Site (DFPS). The sub-horizontal orientation of a shallow hydraulic fracture at the DFPS provides uniform access to the fracture area for interrogation and data collection. Ahmadian et al. (2023) suggested a possible correlation between spatiotemporal changes in the flow rate, bottomhole pressure (BHP), and the observed surface recorded electric field at the DFPS. In this paper, we present the development of poroelastic forward models and pressure transient analyses (PTAs) to support the development of a multiphysics inverse model for these EM surveys. First, we conducted PTAs of the shut-in periods after six injections out of 10 to determine the fracture closure pressure (FCP) or the overburden pressure used in a poroelastic fracture reopening model. Second, we developed a finite-element poroelastic model throughout five injection cycles to include the effect of the cumulative injected volumes due to the previous injections on current fracture dilation in the presence of highly permeable unpropped and propped zones adjacent to the cohesive layer that models fracture reopening. Fracture reopening in this poroelastic model is based on a calibrated traction-separation response using the bottomhole pressure collected in two injection campaigns in 2020 and 2022. We used the outcomes of a previous simulation study of the primary hydraulic-fracturing stimulation to define the dimension of an unpropped fracture zone ahead of the propped fracture area. The PTAs led to FCPs consistent with those obtained using the injection data collected at the DFPS in 2020. Further, these analyses showed that at later injections, the fracture closure occurred at a later time with respect to the shut-in time, inferring the effect of cumulative injected volumes in previous injections. The simulation results show that considering the propped and unpropped fracture zones improves our poroelastic model in predicting the injection-well BHP. The numerical simulation results demonstrate a significant excess pore pressure near the fracture because of the preceding formation loadings by the previous injections. The obtained fracture dilation area and fluid pressure distribution provide a basis to improve the development of a multiphysics inverse model. Furthermore, in an iteratively coupled scheme, this pressure distribution can be introduced into EM models to render a holistic view of the causative mechanisms for the surface signal anomalies.

02 PETROLEUM↗

Global net climate effects of anthropogenic reactive nitrogen

Anthropogenic activities have substantially enhanced the loadings of reactive nitrogen (Nr) in the Earth system since pre-industrial times, contributing to widespread eutrophication and air pollution. Increased Nr can also influence global climate through a variety of effects on atmospheric and land processes but the cumulative net climate effect is yet to be unravelled. Here we show that anthropogenic Nr causes a net negative direct radiative forcing of –0.34 [–0.20, –0.50] W m –2 in the year 2019 relative to the year 1850. This net cooling effect is the result of increased aerosol loading, reduced methane lifetime and increased terrestrial carbon sequestration associated with increases in anthropogenic Nr, which are not offset by the warming effects of enhanced atmospheric nitrous oxide and ozone. Future predictions using three representative scenarios show that this cooling effect may be weakened primarily as a result of reduced aerosol loading and increased lifetime of methane, whereas in particular N 2 O-induced warming will probably continue to increase under all scenarios. Our results indicate that future reductions in anthropogenic Nr to achieve environmental protection goals need to be accompanied by enhanced efforts to reduce anthropogenic greenhouse gas emissions to achieve climate change mitigation in line with the Paris Agreement.

54 ENVIRONMENTAL SCIENCES↗

Convolutional Non-Homogeneous Poisson Process and its Application to Wildfire Ignition Risk Quantification for Power Delivery Networks

To quantify wildfire ignition risks on power delivery networks, the current practice predominantly relies on the empirically calculated fire danger indices, which may not well capture the effects of dynamically changing environmental factors. This article proposes a spatio-temporal point process model, known as the Convolutional Non-homogeneous Poisson Process (cNHPP), and applies the model to quantify wildfire ignition risks for power delivery networks. The proposed model captures both the current (i.e., instantaneous) and cumulative (i.e., historical) effects of key environmental processes (i.e., covariates) on wildfire risks, as well as the spatio-temporal dependency among different segments of the power delivery network. The computation and interpretation of the intensity function are thoroughly investigated. We apply the proposed approach to estimate wildfire ignition risks on major transmission lines in California, using historical fire data, meteorological and vegetation data obtained from the National Oceanic and Atmospheric Administration and National Aeronautics and Space Administration. Here, a comprehensive comparison study is performed to show the applicability and predictive capability of the proposed approach.

Non-homogeneous Poisson Process↗

Hotter droughts alter resource allocation to chemical defenses in piñon pine

Abstract Heat and drought affect plant chemical defenses and thereby plant susceptibility to pests and pathogens. Monoterpenes are of particular importance for conifers as they play critical roles in defense against bark beetles. To date, work seeking to understand the impacts of heat and drought on monoterpenes has primarily focused on young potted seedlings, leaving it unclear how older age classes that are more vulnerable to bark beetles might respond to stress. Furthermore, we lack a clear picture of what carbon resources might be prioritized to support monoterpene synthesis under drought stress. To address this, we measured needle and woody tissue monoterpene concentrations and physiological variables simultaneously from mature piñon pines ( Pinus edulis ) from a unique temperature and drought manipulation field experiment. While heat had no effect on total monoterpene concentrations, trees under combined heat and drought stress exhibited ~ 85% and 35% increases in needle and woody tissue, respectively, over multiple years. Plant physiological variables like maximum photosynthesis each explained less than 10% of the variation in total monoterpenes for both tissue types while starch and glucose + fructose measured 1-month prior explained ~ 45% and 60% of the variation in woody tissue total monoterpene concentrations. Although total monoterpenes increased under combined stress, some key monoterpenes with known roles in bark beetle ecology decreased. These shifts may make trees more favorable for bark beetle attack rather than well defended, which one might conclude if only considering total monoterpene concentrations. Our results point to cumulative and synergistic effects of heat and drought that may reprioritize carbon allocation of specific non-structural carbohydrates toward defense.

59 BASIC BIOLOGICAL SCIENCES↗

Tidal Circularization of Binaries by Resonance Locking. I. The Importance of the Pre-main Sequence

Although tidal dissipation in binary stars has been studied for over a century, theoretical predictions have yet to match the observed properties of binary populations. This work quantitatively examines the recent proposal of tidal circularization by resonance locking, where tidal dissipation arises from resonances between the star’s natural oscillation frequencies and harmonics of the orbital frequency, and where resonances are “locked” for an extended period of time due to concurrent stellar evolution. We focus on tidal resonances with axi-symmetric gravity modes, and examine binaries with primary masses from one to two solar masses. We find that orbital evolution via resonance locking occurs primarily during the star’s pre-main-sequence phase, with the main-sequence phase contributing negligibly. Resonance locking, ignoring nonlinearity, can circularize binaries with peri-center distances out to ∼10 stellar radii, corresponding to circular periods of ∼4–6 days. However, we find resonantly excited gravity modes will become nonlinear in stellar cores, which prevents them from reaching their full, linear amplitudes. We estimate that such a “saturated resonance lock” reduces the circularization period by about a third, but resonance locking remains much more effective than the cumulative actions of equilibrium tides. In a companion paper, we examine recent binary data to compare against theory.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Investigating the p--π ± and p--p--π ± dynamics with femtoscopy in pp collisions at $\sqrt{s}$ = 13 TeV

The interaction between pions and nucleons plays a crucial role in hadron physics. It represents a fundamental building block of the low-energy QCD dynamics and is subject to several resonance excitations. This work studies the p--π ± dynamics using femtoscopic correlations in high-multiplicity pp collisions at $\sqrt{s}$ = 13 TeV measured by ALICE at the LHC. As the final-state interaction between protons and pions is well constrained by scattering experiments and the study of pionic hydrogen, the results give access to information on the particle-emitting source in pp collisions using the femtoscopy methods. The scaling of the source size of primordial protons and pions against their pair transverse mass is extracted. The results are compared with the source sizes studied with p–p, p--K + , and π ± –π ± pairs by ALICE in the same collision system and are found to be in agreement for the different particle pairs. This reinforces recent findings by ALICE of a common emission source for all hadron-pairs in pp collisions at LHC energies. Furthermore, the p--p--π ± systems are studied using three-particle femtoscopy in pp collisions at TeV. The presence of three-body effects is analyzed utilizing the cumulant expansion method. In this formalism, the known two-body interactions are subtracted in order to isolate the three-body effects. For both, p--p--π + and p--p--π – , a non-zero cumulant is found, indicating effects beyond pairwise interactions. These results give information on the coupling of the pion to multiple nucleons.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Toluene adsorption and capacity regeneration using zeolite-based monolith and activated carbon fiber felt

Common adsorbents studied to remove volatile organic compounds (VOCs) from indoor air can release previously adsorbed VOCs back into the indoor space when the adsorbent is saturated or if the VOC concentration fluctuates. A durable adsorbent with a continuous regeneration strategy could prevent this recontamination of the indoor air and reduce adsorbent disposal waste. A deeper understanding of the adsorption and desorption behavior of VOC adsorbents is needed to create an efficient regeneration strategy. This study investigated the adsorption and thermal desorption behavior of toluene on two different adsorbents, (1) a zeolite-based adsorbent and (2) an activated carbon fiber (ACF) felt. Consistent adsorption behavior across a series of toluene concentrations was used to experimentally determine effective adsorption capacity. When the cumulative adsorption between thermal regeneration steps was maintained below the maximum effective capacity with 0% breakthrough, the zeolite-based adsorbent was found to effectively minimize passive desorption. The impact of regeneration feed conditions, such as inert, oxidizing, humidified air, on thermal desorption was examined. These conditions influenced desorption of the zeolite-based adsorbent but had minimal impact on the ACF felt adsorbent, which would lead to different regeneration schedules and methods for applications in buildings' heating, ventilation, and air conditioning (HVAC) systems.

Moses-DeBusk, Melanie [Oak Ridge National Laborato↗

Addressing deep array effects and impacts to wake steering with the cumulative-curl wake model

Abstract. Wind farm design and analysis heavily rely on computationally efficient engineering models that are evaluated many times to find an optimal solution. A recent article compared the state-of-the-art Gauss-curl hybrid (GCH) model to historical data of three offshore wind farms. Two points of model discrepancy were identified therein: poor wake predictions for turbines experiencing a lot of wakes and wake interactions between two turbines over long distances. The present article addresses those two concerns and presents the cumulative-curl (CC) model. Comparison of the CC model to high-fidelity simulation data and historical data of three offshore wind farms confirms the improved accuracy of the CC model over the GCH model in situations with large wake losses and wake recovery over large inter-turbine distances. Additionally, the CC model performs comparably to the GCH model for single- and fewer-turbine wake interactions, which were already accurately modeled. Lastly, the CC model has been implemented in a vectorized form, greatly reducing the computation time for many wind conditions. The CC model now enables reliable simulation studies for both small and large offshore wind farms at a low computational cost, thereby making it an ideal candidate for wake-steering optimization and layout optimization.

17 WIND ENERGY↗

Tensor Network Path Integral Study of Dynamics in B850 LH2 Ring with Atomistically Derived Vibrations

The recently introduced multisite tensor network path integral (MS-TNPI) allows simulation of extended quantum systems coupled to dissipative media. We use MS-TNPI to simulate the exciton transport and the absorption spectrum of a B850 bacteriochlorophyll (BChl) ring. The MS-TNPI network is extended to account for the ring topology of the B850 system. Accurate molecular-dynamics-based description of the molecular vibrations and the protein scaffold is incorporated through the framework of Feynman–Vernon influence functional. To relate the present work with the excitonic picture, an exploration of the absorption spectrum is done by simulating it using approximate and topologically consistent transition dipole moment vectors. Comparison of these numerically exact MS-TNPI absorption spectra are shown with second-order cumulant approximations. Finally, the effect of temperature on both the exact and the approximate spectra is also explored.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Transient evolution of permeability and friction in a slowly slipping fault activated by fluid pressurization

The mechanisms of permeability and friction evolution in a natural fault are investigated in situ. During three fluid injection experiments at different places in a fault zone, we measured simultaneously the fluid pressure, fault displacements and seismic activity. Changes in fault permeability and friction are then estimated concurrently. Results show that fault permeability increases up to 1.58 order of magnitude as a result of reducing effective normal stress and cumulative dilatant slip, and 19-to-60.8% of the enhancement occurs without seismic emissions. When modeling the fault displacement, we found that a rate-and-state friction and a permeability dependent on both slip and slip velocity together reasonably fit the fault-parallel and fault-normal displacements. This leads to the conclusion that the transient evolution of fault permeability and friction caused by a pressure perturbation exerts a potentially dominant control on fault stability during fluid flow.

58 GEOSCIENCES↗

Flow-plane decorrelations in heavy-ion collisions with multiple-plane cumulants

The azimuthal correlations between local flow planes at different (pseudo)rapidities (η) may reveal important details of the initial nuclear matter density distributions in heavy-ion collisions. Extensive experimental measurements of a factorization ratio (r 2 ) and its derivative (F 2 ) have shown evidence of the longitudinal flow-plane decorrelation. However, nonflow effects also affect this observable and prevent a quantitative understanding of the phenomenon. In this paper, to distinguish decorrelation and nonflow effects, we propose a new cumulant observable, T 2 , which largely suppresses nonflow. Here, the technique sensitivity to different initial-state scenarios and nonflow effects are tested with a simple Monte Carlo model, and in the end, the method is applied to events simulated by a multiphase transport model (AMPT) for Au+Au collisions at $\sqrt{s_{NN}}$ = 200 GeV. We also emphasize that a distinct decorrelation signal requires not only the right sign of an observable but also its proper dependence on the η window of the reference flow plane to be consistent with the pertinent decorrelation picture.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Dose Summation Strategies for External Beam Radiation Therapy and Brachytherapy in Gynecologic Malignancy: A Review from the NRG Oncology and NCTN Medical Physics Subcommittees

Definitive, nonsurgical management of gynecologic malignancies involves external beam radiation therapy (EBRT) and/or brachytherapy (BT). Summation of the cumulative dose is critical to assess the total biologic effective dose to targets and organs at risk. Cumulative dose calculation from EBRT and BT can be performed with or without image registration (IR) and biologic dose summation. Among these dose summation strategies, linear addition of dose-volume histogram (DVH) parameters without IR is the global standard for composite dose reporting. This approach stems from an era without image guidance and simple external beam and brachytherapy treatment approaches. With technological advances, EBRT and high-dose-rate BT have evolved to allow for volume-based treatment planning and delivery. Modern conformal therapeutic radiation involves volumetric or intensity modulated EBRT, capable of simultaneously treating multiple targets at different specified dose levels. Therefore, given the complexity of modern radiation treatment, the linear addition of DVH parameters from EBRT and high-dose-rate BT is challenging to represent the combined dose distribution. Deformable image registration (DIR) between EBRT and image guided brachytherapy (IGBT) data sets may provide a more nuanced calculation of multimodal dose accumulation. However, DIR is still nascent in this regard, and needs further development for accuracy and efficiency for clinical use. Biologic dose summation can combine physical dose maps from EBRT and each IGBT fraction, thereby generating a composite DVH from the biologic effective dose. However, accurate radiobiologic parameters are tissue-dependent and not well characterized. A combination of voxel-based DIR and biologic weighted dose maps may be the best approximation of dose accumulation but remains invalidated. The purpose of this report is to review dose summation strategies for EBRT and BT, including conventional equivalent dose in 2-Gy fractions dose summation without image registration, physical dose summation using 3-dimensional rigid IR and DIR, and biologic dose summation. We also provide general clinical workflows for IGBT with a focus on cervical cancer.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Measurement of the azimuthal anisotropy of charged particles in sNN=5.36TeV O16+O16 and Ne20+Ne20 collisions with the ATLAS detector

This paper presents the first measurements of the azimuthal anisotropy coefficients , which quantify the -order Fourier modulation of charged-particle azimuthal distributions, for in and collisions recorded with the ATLAS detector at the CERN Large Hadron Collider in 2025. The coefficients are measured as a function of transverse momentum ( ), collision centrality, and event multiplicity. They are extracted using two complementary methods: two-particle correlations with a template-fit subtraction of short-range nonflow contributions, and four-particle subevent cumulants, which intrinsically suppress nonflow effects and provide sensitivity to flow fluctuations. The results show a clear hierarchy and a nonmonotonic dependence on , reaching a maximum around , consistent with trends observed in heavy-ion collisions. Detailed comparisons between the two collision systems reveal an enhanced in central collisions, consistent with theory expectations based on the predicted prolate deformation of neon nuclei, in contrast to the slightly tetrahedral structure predicted for oxygen. The four-particle cumulant results highlight strong event-by-event fluctuations and provide the greatest sensitivity to nuclear shape effects. These measurements can place new constraints on the initial geometry and the hydrodynamic response in light-ion collisions, offering valuable input for models of nuclear structure.

Aad, G↗

Green’s function methods for excited states and x-ray spectra of functional materials

Many interesting properties of functional materials, such as dynamic response and thermodynamic behavior, depend on their excited state properties. These functional properties are often related to excitations in the system, such as phonons and plasmons, which lead to inelastic losses, lifetime, and other dynamic effects. The excitations are pure many-body correlation effects that are missing from independent particle theories. They are revealed in x-ray spectra such as photoemission and absorption, where they show up as satellites beyond the quasi-particle approximation. Our main focus in this work is the use of Green's function methods to describe these effects. In particular, we discuss how the cumulant Green's function provides a unified treatment of such dynamic correlation effects in many contexts. Besides a robust theoretical framework, these methods also yield widely applicable tools for practical calculations of many functional properties of materials. Furthermore, this methodology is illustrated with a number of applications ranging from optical and x-ray spectra to thermodynamic properties, and dynamic response. Some recent extensions for more correlated systems are also briefly discussed.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Nonlinear spectroscopy in the condensed phase: The role of Duschinsky rotations and third order cumulant contributions

First-principles modeling of nonlinear optical spectra in the condensed phase is highly challenging because both environment and vibronic interactions can play a large role in determining spectral shapes and excited state dynamics. In this work, we compute two dimensional electronic spectroscopy (2DES) signals based on a cumulant expansion of the energy gap fluctuation operator, with specific focus on analyzing mode mixing effects introduced by the Duschinsky rotation and the role of the third order term in the cumulant expansion for both model and realistic condensed phase systems. We show that for a harmonic model system, the third order cumulant correction captures effects introduced by a mismatch in curvatures of ground and excited state potential energy surfaces, as well as effects of mode mixing. We also demonstrate that 2DES signals can be accurately reconstructed from purely classical correlation functions using quantum correction factors. We then compute nonlinear optical spectra for the Nile red and methylene blue chromophores in solution, assessing the third order cumulant contribution for realistic systems. We show that the third order cumulant correction is strongly dependent on the treatment of the solvent environment, revealing the interplay between environmental polarization and the electronic-vibrational coupling.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Measurement of the galaxy-velocity power spectrum of DESI tracers with the kinematic Sunyaev-Zeldovich effect using DESI DR2 and ACT DR6

Joint analyses of high-resolution CMB temperature maps with galaxy surveys provide a unique way to reconstruct the radial velocity field of the underlying matter distribution via the kinematic Sunyaev-Zeldovich (kSZ) effect. Using data from the Atacama Cosmology Telescope (ACT) DR6 and the Dark Energy Spectroscopic Instrument (DESI) DR2, we present radial velocity reconstructions for luminous red galaxies (LRGs), emission-line galaxies (ELGs), and quasars (QSOs). Leveraging the spectroscopic data, we are able to reliably model the foreground contamination and report a negligible impact on our main observables. We detect the velocity-galaxy cross-correlation at $17.0σ$ for LRGs, and for the first time, at $8.3σ$ for ELGs and $6.8σ$ for QSOs. We further report the first detection of the velocity-velocity correlation using LRGs at $3.1σ$, as well as the highest cumulative detection of the kSZ effect to date at $20.8 σ$. Similarly to previous results, we find a lower amplitude of the kSZ signal compared to our fiducial halo model prediction and electron profile assuming a Battaglia profile. Combining these new observables, we obtain constraints on local-type primordial non-Gaussianity (PNG): $f_{\rm NL}^{\rm loc} = 15.9_{-34.4}^{+34.6}$ at 68% confidence, which represents the tightest constraint to date derived from the velocity field. The measurements presented here already exhibit lower noise on a per-mode basis than the galaxy auto-correlation on the largest scales, $k<0.004~\rm{Mpc^{-1}}$, highlighting the key role these observables will play in the context of future CMB experiments such as the Simons Observatory.

Chaussidon, Edmond [LBL, Berkeley] (ORCID:00000001↗

High-order cumulants and correlation functions near the critical point from molecular dynamics

We present a systematic investigation of particle-number fluctuations in the crossover region near the critical end point of a first-order phase transition using molecular dynamics simulations of the classical Lennard-Jones fluid. We extend our prior studies to third- and fourth-order cumulants in both coordinate- and momentum-space acceptances and integrated correlation functions (factorial cumulants). We find that, even near the critical point, non-Gaussian cumulants equilibrate on timescales comparable to those of the second-order cumulants, but show stronger finite-size effects. The presence of interactions and of the critical point leads to strong deviations of the cumulants from the ideal-gas baseline in coordinate space; these deviations are expected to persist in momentum space in the presence of collective expansion. In particular, the kurtosis becomes strongly negative, κσ 2 ≪ − 1 , on the crossover side of the critical point. However, this signal is significantly diluted once an efficiency cut used to distinguish protons from baryons is applied, leading to |κσ 2 | ≲ 1 even in the presence of the critical point. We discuss our results in the context of ongoing measurements of proton-number cumulants in heavy-ion collisions in RHIC-BES-II.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗