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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 73 records · Page 4
All sourcesNASA NTRSDOE OSTI
NASA NTRS2003

Stressed to death: implication of lymphocyte apoptosis for psychoneuroimmunology

Psychological and physical stressors best exemplify the intercommunication of the immune and the nervous systems. It has been shown that stress significantly impacts leukocyte cellularity and immune responses and alters susceptibility to various diseases. While acute stress has been shown to enhance immune responses, chronic stress often leads to immunosuppression. Among many criteria examined upon exposure to chronic stress, the reduction in lymphocyte mitogenic response and lymphocyte cellularity are commonly assessed. We have reported that chronic restraint stress could induce lymphocyte reduction, an effect dependent on endogenous opioids. Interestingly, the effect of endogenous opioids was found to be exerted through increasing the expression of a cell death receptor, Fas, and an increased sensitivity of lymphocytes to apoptosis. Stress-induced lymphocyte reduction was not affected by adrenalectomy. In this review, based on available literature and our recent data, we will discuss the role of the hypothalamic-pituitary-adrenal axis and endogenous opioids and examine the mechanisms by which chronic stress modulates lymphocyte apoptosis.

Review Literature↗
NASA NTRS2000

IR spectroscopic characteristics of cell cycle and cell death probed by synchrotron radiation based Fourier transform IR spectromicroscopy

Synchrotron radiation based Fourier transform IR (SR-FTIR) spectromicroscopy allows the study of individual living cells with a high signal to noise ratio. Here we report the use of the SR-FTIR technique to investigate changes in IR spectral features from individual human lung fibroblast (IMR-90) cells in vitro at different points in their cell cycle. Clear changes are observed in the spectral regions corresponding to proteins, DNA, and RNA as a cell changes from the G(1)-phase to the S-phase and finally into mitosis. These spectral changes include markers for the changing secondary structure of proteins in the cell, as well as variations in DNA/RNA content and packing as the cell cycle progresses. We also observe spectral features that indicate that occasional cells are undergoing various steps in the process of cell death. The dying or dead cell has a shift in the protein amide I and II bands corresponding to changing protein morphologies, and a significant increase in the intensity of an ester carbonyl C===O peak at 1743 cm(-1) is observed. Copyright John Wiley & Sons, Inc. Biopolymers (Biospectroscopy) 57: 329-335, 2000.

Non-NASA Center↗
NASA NTRS2000

An early ethylene up-regulated gene encoding a calmodulin-binding protein involved in plant senescence and death

35S-Labeled calmodulin (CaM) was used to screen a tobacco anther cDNA library. A positive clone (NtER1) with high homology to an early ethylene-up-regulated gene (ER66) in tomato, and an Arabidopsis homolog was isolated and characterized. Based on the helical wheel projection, a 25-mer peptide corresponding to the predicted CaM-binding region of NtER1 (amino acids 796-820) was synthesized. The gel-mobility shift assay showed that the peptide formed a stable complex with CaM only in the presence of Ca(2+). CaM binds to NtER1 with high affinity (K(d) approximately 12 nm) in a calcium-dependent manner. Tobacco flowers at different stages of development were treated with ethylene or with 1-methylcyclopropene for 2 h before treating with ethylene. Northern analysis showed that the NtER1 was rapidly induced after 15 min of exposure to ethylene. However, the 2-h 1-methylcyclopropene treatment totally blocked NtER1 expression in flowers at all stages of development, suggesting that NtER1 is an early ethylene-up-regulated gene. The senescing leaves and petals had significantly increased NtER1 induction as compared with young leaves and petals, implying that NtER1 is developmentally regulated and acts as a trigger for senescence and death. This is the first documented evidence for the involvement of Ca(2+)/CaM-mediated signaling in ethylene action.

Non-NASA Center↗
NASA NTRS1993

The Shape of Trail Canyon Alluvial Fan, Death Valley

A modified conic equation has been fit to high-resolution digital topographic data for Trail Canyon alluvial fan in Death Valley, California. Fits were accomplished for 3 individual fan units of different age.

Trail Canyon↗
NASA NTRS2009

From Research to Flight: Surviving the TRL Valley of Death for Robotic and Human Space Exploration

There must be a plan or opportunities for flight validation: a) To reduce the bottleneck of new technologies at the TRL Valley of Death; b) To allow frequent infusion of new technologies into flight missions. Risk must be tolerated for new technology flight experiments. Risk must also be accepted on early-adopting missions to enable new capabilities. Fundamental research is critical to taking the next giant leap in the scientific exploration of space. Technology push is often required to meet current mission requirements. Technology management requires more than issuing NRAs and overseeing contracts.

Johnson, Les↗
NASA NTRS2011

An Unusual Stellar Death on Christmas Day

Long Gamma-Ray Bursts (GRBs) are the most dramatic examples of massive stellar deaths, usually associated with supernovae. They release ultra-relativistic jets producing non-thermal emission through synchrotron radiation as they interact with the surrounding medium. Here we report observations of the peculiar GRB 101225A (the "Christmas burst"). Its gamma-ray emission was exceptionally long and followed by a bright X-ray transient with a hot thermal component and an unusual optical couuterpart. During the first 10 days, the optical emission evolved as an expanding, cooling blackbody after which an additional component, consistent with a faint supernova, emerged. We determine its distance to 1.6 Gpc by fitting the spectral-energy distribution and light curve of the optical emission with a GRB-supernova template. Deep optical observations may have revealed a faint, unresolved host galaxy. Our proposed progenitor is a helium star-neutron star merger that underwent a common envelope phase expelling its hydrogen envelope. The resulting explosion created a GRB-like jet which gets thermalized by interacting with the dense, previously ejected material and thus creating the observed black-body, until finally the emission from the supernova dominated. An alternative explanation is a minor body falling onto a neutron star io the Galaxy

Thone, C. C.↗
NASA NTRS2014

Transforming the "Valley of Death" into a "Valley of Opportunity"

Transitioning technology from research to operations (23 R2O) is difficult. The problem's importance is exemplified in the literature and in every failed attempt to do so. Although the R2O gap is often called the "valley of death", a recent a Space Weather editorial called it a "Valley of Opportunity". There are significant opportunities for space weather organizations to learn from the terrestrial experience. Dedicated R2O organizations like those of the various NOAA testbeds and collaborative "proving ground" projects take common approaches to improving terrestrial weather forecasting through the early transition of research capabilities into the operational environment. Here we present experience-proven principles for the establishment and operation of similar space weather organizations, public or private. These principles were developed and currently being demonstrated by NASA at the Applied Meteorology Unit (AMU) and the Short-term Prediction Research and Transition (SPoRT) Center. The AMU was established in 1991 jointly by NASA, the U.S. Air Force (USAF) and the National Weather Service (NWS) to provide tools and techniques for improving weather support to the Space Shuttle Program (Madura et al., 2011). The primary customers were the USAF 45th Weather Squadron (45 WS) and the NWS Spaceflight Meteorology Group (SMG who provided the weather observing and forecast support for Shuttle operations). SPoRT was established in 2002 to transition NASA satellite and remote-sensing technology to the NWS. The continuing success of these organizations suggests the common principles guiding them may be valuable for similar endeavors in the space weather arena.

Jedlovec, Gary J.↗
NASA NTRS2009

SAR Imagery Applied to the Monitoring of Hyper-Saline Deposits: Death Valley Example (CA)

The present study aims at understanding the influence of salinity on the dielectric constant of soils and then on the backscattering coeff cients recorded by airborne/spaceborne SAR systems. Based on dielectric measurements performed over hyper-saline deposits in Death Valley (CA), as well as laboratory electromagnetic characterization of salts and water mixtures, we used the dielectric constants as input parameters of analytical IEM simulations to model both the amplitude and phase behaviors of SAR signal at C, and L-bands. Our analytical simulations allow to reproduce specif c copolar signatures recorded in SAR data, corresponding to the Cottonball Basin saltpan. We also propose the copolar backscattering ratio and phase difference as indicators of moistened and salt-affected soils. More precisely, we show that these copolar indicators should allow to monitor the seasonal variations of the dielectric properties of saline deposits.

evaporites↗
NASA NTRS2015

Bridging the Technology Readiness "Valley of Death" Utilizing Nanosats

Incorporating new technology is a hallmark of space missions. Missions demand ever-improving tools and techniques to allow them to meet the mission science requirements. In Earth Science, these technologies are normally expressed in new instrument capabilities that can enable new measurement concepts, extended capabilities of existing measurement techniques, or totally new detection capabilities, and also, information systems technologies that can enhance data analysis or enable new data analyses to advance modeling and prediction capabilities. Incorporating new technologies has never been easy. There is a large development step beyond demonstration in a laboratory or on an airborne platform to the eventual space environment that is sometimes referred to as the "technology valley of death." Studies have shown that non-validated technology is a primary cause of NASA and DoD mission delays and cost overruns. With the demise of the New Millennium Program within NASA, opportunities for demonstrating technologies in space have been rare. Many technologies are suitable for a flight project after only ground testing. However, some require validation in a relevant or a space flight environment, which cannot be fully tested on the ground or in airborne systems. NASA's Earth Science Technology Program has initiated a nimble program to provide a fairly rapid turn-around of space validated technologies, and thereby reducing future mission risk in incorporating new technologies. The program, called In-Space Validation of Earth Science Technology (InVEST), now has five tasks in development. Each are 3U CubeSats and they are targeted for launch opportunities in the 2016 time period. Prior to formalizing an InVEST program, the technology program office was asked to demonstrate how the program would work and what sort of technologies could benefit from space validation. Three projects were developed and launched, and have demonstrated the technologies that they set out to validate. This paper will provide a brief status of the pre-InVEST CubeSats, and discuss the development and status of the InVEST program. Figure

Earth Science↗
NASA NTRS2017

Planetary Crater Detection and Registration Using Marked Point Processes, Multiple Birth and Death Algorithms, and Region-Based Analysis

Because of the large variety of sensors and spacecraft collecting data, planetary science needs to integrate various multi-sensor and multi-temporal images. These multiple data represent a precious asset, as they allow the study of targets spectral responses and of changes in the surface structure; because of their variety, they also require accurate and robust registration. A new crater detection algorithm, used to extract features that will be integrated in an image registration framework, is presented. A marked point process-based method has been developed to model the spatial distribution of elliptical objects (i.e. the craters) and a birth-death Markov chain Monte Carlo method, coupled with a region-based scheme aiming at computational efficiency, is used to find the optimal configuration fitting the image. The extracted features are exploited, together with a newly defined fitness function based on a modified Hausdorff distance, by an image registration algorithm whose architecture has been designed to minimize the computational time.

Image Processing; Pattern Recognition↗
NASA NTRS2018

Planetary Crater Detection and Registration Using Marked Point Processes, Multiple Birth and Death Algorithms, and Region-Based Analysis

Because of the large variety of sensors and spacecraft collecting data, planetary science needs to integrate various multi-sensor and multi-temporal images. These multiple data represent a precious asset, as they allow the study of targets spectral responses and of changes in the surface structure; because of their variety, they also require accurate and robust registration. A new crater detection algorithm, used to extract features that will be integrated in an image registration framework, is presented. A marked point process-based method has been developed to model the spatial distribution of elliptical objects (i.e. the craters) and a birth-death Markov chain Monte Carlo method, coupled with a region-based scheme aiming at computational efficiency, is used to find the optimal configuration fitting the image. The extracted features are exploited, together with a newly defined fitness function based on a modified Hausdorff distance, by an image registration algorithm whose architecture has been designed to minimize the computational time.

Image Processing:Pattern Recognition↗
NASA NTRS2020

The Fast Radio Burst Luminosity Function and Death Line in the Low-Twist Magnetar Model

We explore the burst energy distribution of fast radio bursts(FRBs)in the low-twist magnetar model ofWadiasingh & Timokhin(WT19). Motivated by the power-lawfluence distributions of FRB121102, we proposean elementary model for the FRB luminosity function of individual repeaters with an inversion protocol thatdirectly relates the power-law distribution index of magnetar short burstfluences to that for FRBs. The protocolindicates that the FRB energy scales virtually linearly with crust/field dislocation amplitude, if magnetar shortbursts prevail in the magnetoelastic regime. Charge starvation in the magnetosphere during bursts(required inWT19)for individual repeaters implies the predicted burstfluence distribution is narrow,3 decades for yieldingstrains and oscillation frequencies feasible in magnetar crusts. Requiring magnetic confinement and chargestarvation, we obtain a death line for FRBs, which segregates magnetars from the normal pulsar population,suggesting only the former will host recurrent FRBs. We convolve the burst energy distribution for individualmagnetars to define the distribution of luminosities in evolved magnetar populations. The broken power-lawluminosity function’s low-energy character depends on the population model, while the high-energy index tracesthat of individual repeaters. Independent of the evolved population, the broken power-law isotropic-equivalentenergy/luminosity function peaks at∼1037–1040erg with a low-energy cutoff at∼1037erg. Lastly, we considerthe localfluence distribution of FRBs andfind that it can constrain the subset of FRB-producing magnetarprogenitors. Our model suggests that improvements in sensitivity may reveal aflattening of the global FRBfluencedistribution and saturation in FRB rates.

Cosmology↗
NASA NTRSDate not supplied

Large Scale Volcanism: An Explanation for the Heat-death of Venus-like Worlds

Large scale volcanism has played a critical role in the long-term habitability of Earth and possibly Venus. Large Igneous Provinces (LIPs) are in fact the cause of most major extinction events in Earth’s history, contrary to the popular belief about the devastation from large bolides. We examine the timing of Large Igneous Provinces (LIPs) through Earth’s history [1] to estimate the likelihood of nearly simultaneous events that could drive a planet into an extreme moist or runaway greenhouse, quenching subductive plate tectonics. Such events would end volatile cycling and may have driven Venus from a cool temperate state into the heat-death we see today. Using the Earth's LIP record [1] we have found that LIP events are distributed randomly throughout the past 3 billion years. A conservative estimate of the rate of LIPs in a random history statistically the same as Earth’s, pairs and triplets of LIPs closer in time than 0.1-1 million years are likely. This simultaneity threshold is significant to the extent that it is less than the time over which environmental effects have been shown to persist, for example in the Siberian Traps record [2,3]. With the recent mission selections of VERITAS and EnVision it may be possible for their high resolution radar maps to distinguish LIPs in the surface record we can see today on Venus.

Large Igneous Provinces↗
NASA NTRSDate not supplied

Gene expression changes in peripheral blood mononuclear cells of ISS crewmembers suggest impacts of spaceflight on cell death

In space, living organisms are exposed to numerous stress factors including microgravity and space radiation. For humans, these harmful environmental factors have been known to cause negative health impacts such as immune dysfunction. Understanding the mechanisms by which spaceflight impacts human health at the molecular level is critical not only for accurately assessing the risks associated with spaceflight, but also for developing effective countermeasures. This study is part of the Functional Immune Project, intended to determine alterations in crewmembers` immunobiology before, during, and after spaceflight. For this project, blood samples were collected from International Space Station (ISS) crewmembers at the following time points: i) at two pre-flight time points of 180 days (L180) and 45 days (L45) before launch. ii) During flight, blood was drawn at approximately the midpoint (mid-flight, MF) of the mission, and shortly before egress from the ISS (late-flight, LF). iii) Post-flight blood samples were collected within 24 hrs (R0), 30 days (R30) and 90 days (R90) after landing. For each crewmember, blood was also drawn from a matching test subject on the ground at the corresponding time point. For both the ISS crewmembers and the ground control subjects, total RNA was isolated from peripheral blood mononuclear cells (PBMC) and mRNA was analysed using next generation RNA-sequencing (NGS). Differentially expressed genes were determined by performing contrast analysis. Using the data from all of the time points from the ground control subjects as a control, a number of dysregulated genes were identified in astronauts at MF, LF and R0, including downregulations of several cell cycle related genes including CDKN1A and VEGFA at MF and LF. Pathway analysis of these differentially expressed genes indicated that, in space, pathways associated with autophagy and senescence were affected. Our analysis also indicated that the genes related to metabolisms were downregulated in the microgravity environment. Taken together, our data suggests that PBMC in the ISS crewmembers may be starved, resulting in autophagy and delayed senescence in space. Such findings are in agreement with delayed cell death in PBMC under simulated microgravity conditions on the ground and offer an explanation for telomere lengthening that has been reported among the ISS astronauts in flight.

Maria Moreno-Villanueva↗
NASA NTRSDate not supplied

Gene Expression Changes in Peripheral Blood Mononuclear Cells of ISS Crewmembers Suggest Impacts of Spaceflight on Cell Death

In space, living organisms are exposed to numerous stress factors including microgravity and space radiation. For humans, these harmful environmental factors have been known to cause negative health impacts such as immune dysfunction. Understanding the mechanisms by which spaceflight impacts human health at the molecular level is critical not only for accurately assessing the risks associated with spaceflight, but also for developing effective countermeasures. This study is part of the Functional Immune Project, intended to determine alterations in crewmembers` immunobiology before, during, and after spaceflight. For this project, blood samples were collected from International Space Station (ISS) crewmembers at the following time points: i) at two pre-flight time points of 180 days (L180) and 45 days (L45) before launch. ii) During flight, blood was drawn at approximately the midpoint (mid-flight, MF) of the mission, and shortly before egress from the ISS (late-flight, LF). iii) Post-flight blood samples were collected within 24 hrs (R0), 30 days (R30) and 90 days (R90) after landing. For each crewmember, blood was also drawn from a matching test subject on the ground at the corresponding time point. For both the ISS crewmembers and the ground control subjects, total RNA was isolated from peripheral blood mononuclear cells (PBMC) and mRNA was analysed using next generation RNA-sequencing (NGS). Differentially expressed genes were determined by performing contrast analysis. Using the data from all of the time points from the ground control subjects as a control, a number of dysregulated genes were identified in astronauts at MF, LF and R0, including downregulations of several cell cycle related genes including CDKN1A and VEGFA at MF and LF. Pathway analysis of these differentially expressed genes indicated that, in space, pathways associated with autophagy and senescence were affected. Our analysis also indicated that the genes related to metabolisms were downregulated in the microgravity environment. Taken together, we hypothesize that PBMC in the ISS crewmembers may be starved, resulting in autophagy and delayed senescence in space. Such findings are in agreement with delayed cell death in PBMC under simulated microgravity conditions on the ground and offer an explanation for telomere lengthening that has been reported among the ISS astronauts in flight

Maria Moreno-Villanueva↗