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At least 73 records · Page 4

Mitigation of Beam Losses in LANSCE Linear Accelerator

Suppression of beam losses is essential for successful operation of high-intensity accelerator facility. The LANSCE accelerator started routine operation in 1972 as a 0.8 MW average proton beam power facility for meson physics research, and delivered highpower beam for a quarter century. The accelerator currently delivers 100 MeV proton beam to Isotope Production Facility (IPF) and 800 MeV H- beams to various experimental areas. The accelerator is equipped with two independent injectors for H + and H - beams, merging at the entrance of a 201.25 MHz Drift Tube Linac (DTL). The DTL performs acceleration up to the energy of 100 MeV. After the DTL, the Transition Region beamline directs a 100 MeV proton beam to the Isotope Production Facility, while the H - beam is accelerated up to the final energy of 800 MeV in an 805- MHz Coupled Cavity Linac. The H - beams, created with different time structure by a lowenergy chopper, are distributed in the Switch Yard (SY) to four experimental areas: the Lujan Neutron Scattering Center equipped with a Proton Storage Ring (PSR), the Weapons Neutron Research facility (WNR), the Proton Radiography facility (pRad), and the Ultra-Cold Neutron facility (UCN). Multi-beam operation requires careful control of accelerator tune to minimize beam losses. In this paper we review main effects affecting beam losses in LANSCE linear accelerator and discuss methods to reduce them.

43 PARTICLE ACCELERATORS↗

Charged Microdroplets in Air: Characterization and Use in Surface Functionalization and Nanomaterials Preparation (Final Technical Report)

The major theme of this project is the exploration of ions and charged droplets in the open air. The specific goals are (1) focusing ions in the open air, (2) separating and measuring the sizes of charged droplets, (3) examining chemical reactions occurring within droplets, (4) examining chemical reactions occurring between charged droplets and chemical vapors, and (5) characterizing surfaces post droplet deposition. The analysis of ions in the open air greatly simplifies instrumentation as it removes the need for large, costly vacuum pumps. Major strides in this project include the sizing of electrospray droplets using structured illumination microscopy, 3D printed drift tube ion mobility (both standalone and coupled with mass spectrometry), and accelerated Suzuki reactions in Leidenfrost droplets.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

LAMP Manufacturing Survey (Final Report)

This report presents the results of a market manufacturing survey performed for fabricating radiofrequency quadrupoles (RFQ) and Drift Tube Linear Accelerator (DTL) components needed for the Los Alamos Neutron Science Center (LANSCE) Modernization Project (LAMP). A review on existing RFQs and DTLs with their parameters, a summary of specific capabilities needed to manufacture them, the common issues during the fabrication process, their consequences, and resolutions to these problems is presented in this report. The goal of this study is to identify potential collaborators and companies capable of manufacturing the necessary accelerator equipment, while minimizing cost and schedule risks that could impact the future modernization of the LANSCE facility.

43 PARTICLE ACCELERATORS↗

Agilent AgileBioFoundry CRADA (Final Report)

The mission of this CRADA with Agilent was to couple powerful MS platforms (QQQ, IM-QTOF-MS) with Agilent’s novel Ultra-High-Performance Liquid Chromatography (UHPLC) fast metabolomic workflows and perform ABF Machine Learning (ML) to generated datasets. Agilent transferred UHPLC methods to PNNL and LBNL and methods were implemented and demonstrated in both labs, achieving total acquisition times of < 10 min. Metabolites analyzed using Agilent’s shared methods included metabolites from central carbon metabolism, common across hosts, and metabolites unique to engineered strains. Standards were acquired in an UHPLC-Drift Tube Ion Mobility Mass Spectrometer (DTIMS) system for the first time within the context of ABF and methods were optimized based on Agilent’s protocols. Samples from ABF hosts Pseudomonas putida, Aspergillus pseudoterreus, Aspergillus niger and Rhodosporidium toruloides were analyzed using the UHPLC-DTIMS platform for a total of 276 runs. A data analysis workflow compatible with the Experimental Data Depot (EDD) and completely shareable was developed for the acquired UHPLC-DTIMS data. Samples were analyzed using a Data Independent Acquisition Approach (DIA), which for most of the standards provided more transitions therefore increasing detection confidence. Using the data acquired by PNNL, LBNL, and Agilent’s specifications from previous ML projects, SNL applied an ensemble ML strategy to pick the best performing model for automated LC-method selection. Finally, with the contribution of the participant labs and Agilent, SNL developed an Automated Method Selection (AMS) software tool to predict the best liquid chromatography method for analysis of any new molecules of interest. Samples with novel pathways and new metabolite targets of interest are generated at a high pace in the ABF. Therefore, our accomplishment in this CRADA improved the efficiency and accuracy of strain testing by developing and implementing fast analytical methods, robust processing tools, and software for predicting the best methods for UHPLC analysis.

97 MATHEMATICS AND COMPUTING↗

Delivery of H - / H + Beams to Area A

We explore the relative merits of transporting the beam from the H + ion source and from the H - ion source to Area-A for low current applications. Transporting the H - beam to Area-A using the laser neutralization approach has some risk associated with it and will require some development. Alternative method of delivering H - beam to Area-A includes replacing LDBM00 bending magnet with kicker for sharing beam between Line D and modified Line A. Transporting the H + beam to Area-A will have significant impact on the operation the IPF facility and maintaining high pulse rate to IPF will require major modifications to the transition region of the accelerator and Drift Tube Linac.

43 PARTICLE ACCELERATORS↗

LAMP Technical Readiness Evaluation Report (Rev. 1)

An internal preliminary evaluation of Critical Technology Elements (CTEs) for the LANSCE Modernization Project (LAMP) was completed. Corresponding Technical Readiness Levels (TRLs) were also determined for all subsystems using the criteria of DOE G 413.3-4A, Technical Readiness Assessment Guide. The scope of the evaluation was limited to the project Work Breakdown Structure (WBS) elements as defined for the RFQ Injector and Drift Tube Linac (DTL) systems only. Integration of Instrumentation and Controls (I&C) and Safety Systems was not considered, although specific technologies as related to the RFQ and DTL systems were included. Other elements of the project such as Shielding, System Design, Technical Management, and additional facility integration needed to enable off-line testing and pre-installation commissioning were also not evaluated. Each technical subsystem element was evaluated for technical readiness, however, not all were found to meet the criteria for a CTE. Only two subsystem elements were determined to meet the CTE criteria. Their associated TRLs are summarized in the table below. These subsystem elements of the project have the lowest technical readiness due to either being new, novel or modified, requiring additional R&D before being capable of meeting the project Key Performance Parameters (KPPs) and subsystem requirements, or present technology exists but has not yet been demonstrated in a relevant environment. All other subsystems were determined to have a TRL of 8, indicating that actual operating systems exist having similar performance requirements as needed for LAMP. Details of the technical readiness evaluation for each subsystem is given in the following sections of this report.

43 PARTICLE ACCELERATORS↗

Ion Beam Propagation Through the FNAL LEBT

The Fermilab 750keV injector sends 25mA H- beam for 30µs at a rep-rate of 15Hz. The beam transmission through the FNAL injector is currently less than 50% from the ion source to the entrance of the drift tube linac. Recently it was uncovered that the primary loss point is within the region prior to the RFQ which houses the solenoid focal elements that match the beam to the RFQ. Recent diagnostic measurements indicate that the cause of the transmission efficiency could be the non-linear effects of the solenoid elements on the beam. An aperture restriction was placed just upstream of the first solenoid element to restrict the beam size and reduce the non-linear effects of the solenoid element.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Agilent AgileBioFoundry CRADA

NTESS, LBNL, PNNL, and Agilent are collaborating to expand a prototype system that processes hundreds of samples per day by UHPLC-QTOF mass spectrometric-based target methods for both metabolomic and proteomic application sin support the needs of strain optimization. Extending this technology to targeted triple quadrupole and drift tube ion mobility spectrometry mass spectrometric analyses offers direct advantages.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Performance of the Fermilab Linac Injector

The Fermilab Linac injection line consists of a 35 keV magnetron-type H- ion source, two-solenoid Low Energy Beam Transport (LEBT), 201 MHz 4-rod 750 keV Radio Frequency Quadrupole (RFQ), and a Medium Energy Transport (MEBT) containing 4 quadrupoles and a bunching cavity. The injector delivers 25 mA, 48 s pulses to drift-tube Linac at a repetition rate of 15Hz. The transmission efficiency has been lower than expected since commissioning. Recent beam current measurements suggest that the beam is primarily lost upstream of the RFQ exit. Numerical simulations indicate that ions passing through the non-linear field region of the solenoids could produce a beam with an increased emittance resulting in up to 50 % of the LEBT beam current failing to meet the RFQ acceptance. An aperture restriction was installed upstream of the first solenoid to remove these ions. This report describes the results of measurements and simulations as well as the LEBT tuning.

Jones, Daniel C.↗

LAMP Technical Readiness Evaluation Report

An internal preliminary evaluation of Critical Technology Elements (CTEs) for the LANSCE Modernization Project (LAMP) was completed in 2023. This included determining corresponding Technical Readiness Levels (TRLs) for all subsystems using the criteria of DOE G 413.3-4A, Technical Readiness Assessment Guide. This revised report includes a summary of the recent design modifications required to meet the project Key Performance Requirements (KPPs), some of which may reduce technical risk to the project. These recent design modifications include: • Further optimization of the low-energy and medium-energy beam transport regions (LEBT and MEBT, respectively), including relocation of various functional elements (ie choppers, kickers, and bunchers). • An additional H - ion source to separate ion-source function based on beam delivery requirements. • A high-repetition-rate pulsed kicker magnet to select/merge the two H ion beams into a common low-energy beam transport. • Modification and further optimization to a more conventional RFQ design. Performance of the RFQ has been optimized to deliver the required three types of beams while meeting the project KPPs. • The addition of a second chopper in the medium-energy beam transport (MEBT) line to reduce the required pulser voltages. The scope of the evaluation was limited to the project Work Breakdown Structure (WBS) elements as defined for the RFQ Injector and Drift Tube Linac (DTL) systems only. Integration of Instrumentation and Controls (I&C) and Safety Systems was not considered, although specific technologies as related to the RFQ and DTL systems were included. Other elements of the project such as Shielding, System Design, Technical Management, and additional facility integration needed to enable off-line testing and pre-installation commissioning were also not evaluated. Each technical subsystem element was evaluated for technical readiness, however, not all were found to meet the criteria for a CTE. Three subsystem elements were determined to meet the CTE criteria. Their associated TRLs are summarized in the table below. These subsystem elements of the project have the lowest technical readiness due to either being new, novel or modified, requiring additional R&D before being capable of meeting the project Key Performance Parameters (KPPs) and subsystem requirements, or present technology exists but has not yet been demonstrated in a relevant environment. All other subsystems were determined to have a TRL of 8, indicating that actual operating systems exist having similar performance requirements as needed for LAMP. Details of the technical readiness evaluation for each subsystem is given in the following sections of this report.

43 PARTICLE ACCELERATORS↗

MEBT Bunchers: System Design Document (SDD)

The LAMP Medium Energy Beam Transport (MEBT) transfers bunched beam at the energy 3 MeV from RFQ to the Drift-Tube Linac (DTL) entrance. The beam particles (protons or H- ) in the LAMP MEBT have velocity β = v/c = 0.08, where v is the beam velocity, c is the speed of light. The MEBT bunchers keep beam bunches from spreading longitudinally as they propagate through the MEBT, where some unwanted bunches are removed by a chopper to create a required beam pattern. The MEBT bunchers are RF cavities operating at the frequency 201.25 MHz; possible design options were considered in.

43 PARTICLE ACCELERATORS↗

MEBT Chopper System: System Design Document (SDD)

The Medium Energy Beam Transport (MEBT) chopper removes unwanted beam bunches by deflecting them to a target from a bunched beam transported through the MEBT from RFQ to the Drift-Tube Linac (DTL) entrance. The unchopped bunches propagate through the MEBT to DTL, while the deflected bunches are deposited on a target downstream of chopper. The chopper system consists of a deflecting structure, where the beam-deflecting fields are created, and a pulse generator (pulser) that feeds this structure with voltage pulses having the required time pattern. Ideally, the system should turn deflection on and off in the time interval between the bunches to prevent partially chopped / deflected bunches. This usually requires traveling slow-wave chopper structures where the field propagates with the same velocity as the beam, as illustrated in Fig. 1.

43 PARTICLE ACCELERATORS↗

Preliminary Look at the LBEG & MPEG Beam Transmissions between HPSim and Operation Data

This report summarizes recent work on estimating the transmission of LANSCE H- beams from the end of the present DTL to both the PSR stripper foil (LBEG) and WNR target 4 (MPEG). The LBEG beam might be considered a more typical LINAC beam and lends itself to continuous monitoring of transmission through the various stages of the accelerator. For the MPEG, however, the widely-spaced micropulses and lack of the requisite sensitivity current monitors throughout the accelerator make these measurements extremely difficult and more uncertain. Therefore, to assist in estimating the MPEG beam transmission, beam-dynamics simulations using HPSim were employed. These beam transmission estimates from the end of the Drift Tube Linac (DTL) to Target 4 (MPEG) and the PSR stripper foil (LBEG) are vital to determine the charge requirements for LAMP’s front end. In this technote, we demonstrate three major efforts in determining the transmission: (1) Convert the WNR beamline lattice from TRANSPORT to HPSim for use in the simulation; (2) Simulate the optimization process in the Central Control Room (CCR) that brings down the losses by up to a factor of 4000 between the end of the initial physics-based tuneup phase and production beam operation; (3) Analyze operational data to deduce measured transmissions. Table 1 shows the estimated losses with HPSim and operational analysis. Finally, a better measurement and other improvements to refine the results are also proposed.

43 PARTICLE ACCELERATORS↗

LAMP Emittance Budget, Rev. 1

This report summarizes the performance limits of the LANSCE Coupled-Cavity Linac (CCL). These results are captured or summarized directly from the references cited. This report was written in support of the LANSCE Modernization Project (LAMP). This brief report summarizes the emittance budget for the LANSCE Modernization Project (LAMP). While the project Key Performance Parameters (KPPs) specify threshold and objective requirements for charge delivered to each experimental area, no upper limits on beam emittances are specified. To maintain low losses in the high-energy section of the LANSCE linac and hands-on maintenance, some upper limits on beam emittance need to be specified for the new LAMP front-end performance. The scope of the LAMP project replaces the injector section and drift-tube linac (DTL) up to 100 MeV of the existing LANSCE linac. This new design replacement will be integrated with the remaining coupled cavity linac (CCL) which makes up most of the accelerator at LANSCE and accelerates the beam to a final energy of 800 MeV. The initial approach that has been used to define an emittance budget for the new LAMP front end is based on recent and historical measured beam emittances at 100 MeV for the three beam types accelerated at LANSCE: H+ (protons for isotope production), LBEG (H- beam for delivery to proton radiography and to the Lujan neutron spallation target, and MPEG (H- beam for delivery to the Weapons Neutron Research facility). The emittance budget (upper limit) for each beam type has been selected to maintain the losses in the CCL to a level approximately equivalent to those observed in present operations to first order. However, the goal of the LAMP project is to improve the quality of the beams injected into the CCL, if possible, thus allowing for higher average current operation while also lowering beam losses and activation at high beam energies. The table below summarizes the beam measurements evaluated and used to establish a conservative emittance budget for LAMP based on known historical beam losses and activation. However, based on estimates of the CCL admittance and the Isotope Production Facility (IPF) beamline acceptance, a more relaxed transverse emittance upper limit of 0.095 π-cm-mrad, rms, normalized may be acceptable at 100 MeV while still meeting the LAMP performance requirements for charge delivery to each LANSCE experimental area and maintaining hands-on maintenance. This upper limit is supported by a recent analysis of operational data. Additionally, the present conceptual LAMP front-end design meets this requirement.

43 PARTICLE ACCELERATORS↗

Record of Decision: MEBT Energy Change

The LAMP Conceptual Design (LCD), as described in the LAMP Conceptual Design Report incorporates a radiofrequency quadrupole (RFQ) with an output beam energy of 3.0-MeV; the medium energy beam transport line (MEBT) transports beam from the end of the RFQ into the first LAMP drift tube linac (DTL) tank. The MEBT contains components, such as rebunchers and beam choppers, designed for the specific output energy of the RFQ, and the DTL tank is designed to accept this beam energy.

43 PARTICLE ACCELERATORS↗

High-Power Amplifier Considerations for testing the LAMP RFQ and first DTL Cavity

As part of the LANSCE Accelerator Modernization Pro ject (LAMP), critical portions of the proposed accelerator will be tested as proof of concept and aid in planning the installation of LAMP at Los Alamos Neutron Science Cen ter. As part of this demonstration, the radio frequency quadrupole (RFQ) and the first drift-tube linac (DTL) cav ity will be tested with beam. For this purpose, high-power RF amplifiers are being designed to meet the testing de mands. This is a description of the requirements of these amplifiers and how the design is intended to meet them.

42 ENGINEERING↗

Configuration Management Plan

The Los Alamos Neutron Science Center (LANSCE) is located at Technical Area 53 (TA-53) at Los Alamos National Laboratory (LANL) in Los Alamos, New Mexico. LANSCE is driven by an 800 megaelectronvolt (MeV) proton accelerator that delivered its first beam in 1972. The LANSCE accelerator is unique in that it accelerates both H– (to full energy of 800 MeV) and H+ ions (up to 100 MeV currently but has accelerated high-power H+ beam to 800 MeV in the past) and supports five separate experimental areas that operate simultaneously, with each having different timing and beam current requirements. Many of the LANSCE accelerator front-end components date back to original commissioning in 1972, including the ion sources, Cockcroft-Walton (CW) generators, and the Drift Tube LINAC (DTL), which accelerates the beam up to 100 MeV.

43 PARTICLE ACCELERATORS↗

Development and implementation of high-throughput proteomic and metabolomics assays by using advanced chromatographic and mass spectrometric systems (CRADA Final Report)

The mission of this CRADA with Agilent was to couple powerful MS platforms (QQQ, IM-QTOFMS) with Agilent’s novel Ultra-High-Performance Liquid Chromatography (UHPLC) fast metabolomic workflows and perform ABF Machine Learning (ML) to generated datasets. Agilent transferred UHPLC methods to PNNL and LBNL and methods were implemented and demonstrated in both labs, achieving total acquisition times of < 10 min. Metabolites analyzed using Agilent’s shared methods included metabolites from central carbon metabolism, common across hosts, and metabolites unique to engineered strains. Standards were acquired in an UHPLC-Drift Tube Ion Mobility Mass Spectrometer (DTIMS) system for the first time within the context of ABF and methods were optimized based on Agilent’s protocols. Samples from ABF hosts Pseudomonas putida, Aspergillus pseudoterreus, Aspergillus niger and Rhodosporidium toruloides were analyzed using the UHPLC-DTIMS platform for a total of 276 runs. A data analysis workflow compatible with the Experimental Data Depot (EDD) and completely shareable was developed for the acquired UHPLC-DTIMS data. Samples were analyzed using a Data Independent Acquisition Approach (DIA), which for most of the standards provided more transitions therefore increasing detection confidence. Using the data acquired by PNNL, LBNL, and Agilent’s specifications from previous ML projects, SNL applied an ensemble ML strategy to pick the best performing model for automated LC-method selection. Finally, with the contribution of the participant labs and Agilent, SNL developed an Automated Method Selection (AMS) software tool to predict the best liquid chromatography method for analysis of any new molecules of interest. Samples with novel pathways and new metabolite targets of interest are generated at a high pace in the ABF. Overall, the project advanced rapid metabolomics by combining liquid chromatography, ion mobility spectrometry, and data-independent mass spectrometry with machine learning. This multidimensional approach uses retention time, collision cross-section, precursor mass, and fragment-ion information to distinguish chemically similar metabolites that can be difficult to resolve using conventional liquid- or gas-chromatography methods. The resulting workflow also provided automated metabolite-identification error estimates, addressing a recognized need for statistical confidence measures in metabolomics.

Petzold, Christopher [Lawrence Berkeley National L↗