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Results for “neuromuscular systems”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 73 records · Page 4
All sourcesNASA NTRSDOE OSTI
DOE OSTI2023

Neck Muscle Coactivation Response to Varied Levels of Mental Workload During Simulated Flight Tasks

Objective To evaluate neck muscle coactivation across different levels of mental workload during simulated flight tasks. Background Neck pain (NP) is highly prevalent among military aviators. Given the complex nature within the flight environment, mental workload may be a risk factor for NP. This may induce higher levels of neck muscle coactivity, which over time may accelerate fatigue, increase neck discomfort, and affect flight task performance. Method Three counterbalanced mental workload conditions represented by simulated flight tasks modulated by interstimulus frequency and complexity were investigated using the Modifiable Multitasking Environment (ModME). The primary measure was a neck coactivation index to describe the neuromuscular effort of the neck muscles as a system. Additional measures included perceived workload (NASA TLX), subjective discomfort, and task performance. Participants ( n = 60; 30M, 30F) performed three test conditions over 1 hr each while seated in a simulated seating environment. Results Neck coactivation indices (CoA) and subjective neck discomfort corresponded with increasing level of mental workload. Average CoAs for low, medium, and high workloads were: .0278(SD = .0232), .0286(SD = .0231), and .0295(SD = .0228), respectively. NASA TLX mental, temporal, effort, and overall scores also increased with the level of mental workload assigned. For ModME task performance, the overall performance score, monitoring accuracy, and resource management accuracy decreased while reaction times increased with the increasing level of mental workload. Communication accuracy was lowest with the low mental workload but had higher reaction times relative to increasing workload. Conclusion Mental workload affects neck muscle coactivation during combinations of simulated flight tasks within a simulated helicopter seating environment. Application The results of this study provide insights into the physical response to mental workload. With increasing multisensory modalities within the work environment, these insights may assist the consideration of physical effects from cognitive factors.

Behavioral Sciences↗
NASA NTRS1988

Effect of manipulator and feel system characteristics on pilot performance in roll tracking

The control system features of force vs displacement stick command, feel/force displacement gradient, 'feel' system vs command prefilter dynamic lag, and flight control system effective time delay, have been investigated by a fixed-base simulation employing both joysticks and side-sticks in order to ascertain their effect on pilot opinion, pilot performance, and their hand/arm neuromuscular subsystem interaction. The results obtained indicate that the use of displacement sensing added the feel system dynamic lag to the command path and increased effective system flight delay, thereby lowering pilot opinion and performance but reducing the possibility of roll instability; the use of force sensing as stick command to exclude feel system dynamic lag had the obverse effect.

Aponso, Bimal L.↗
NASA NTRS1971

Medically related activities of application team program

Application team methodology identifies and specifies problems in technology transfer programs to biomedical areas through direct contact with users of aerospace technology. The availability of reengineering sources increases impact of the program on the medical community and results in broad scale application of some bioinstrumentation systems. Examples are given that include devices adapted to the rehabilitation of neuromuscular disorders, power sources for artificial organs, and automated monitoring and detection equipment in clinical medicine.

Source record↗
DOE OSTI2021

CRISPR/Cas correction of muscular dystrophies

Muscular dystrophies are a heterogeneous group of monogenic neuromuscular disorders which lead to progressive muscle loss and degeneration of the musculoskeletal system. The genetic causes of muscular dystrophies are well characterized, but no effective treatments have been developed so far. The discovery and application of the CRISPR/Cas system for genome editing offers a new path for disease treatment with the potential to permanently correct genetic mutations. The post-mitotic and multinucleated features of skeletal muscle provide an ideal target for CRISPR/Cas therapeutic genome editing because correction of a subpopulation of nuclei can provide benefit to the whole myofiber. In this review, we provide an overview of the CRISPR/Cas system and its derivatives in genome editing, proposing potential CRISPR/Cas-based therapies to correct diverse muscular dystrophies, and we discuss challenges for translating CRISPR/Cas genome editing to a viable therapy for permanent correction of muscular dystrophies.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1996

Overview of LBNP Exercise as a Countermeasure for Long-Duration Space Flight

Theoretically, an integrated countermeasure for extended exposure to microgravity should combine high loads on the musculoskeletal system, normal regional distributions of transmural pressure across blood vessels and stimulation of normal neuromuscular locomotor patterns. Our strategy was to develop an exercise apparatus which induces cardiovascular and musculoskeletal strains equal to or greater than those on Earth without the need for a costly centrifugation apparatus. An LBNP chamber was designed to contain a treadmill upon which 8 male bed-rest subjects could exercise daily in supine posture for 40 min at cardiovascular and musculoskeletal loads up to 120% of those in upright posture on Earth. We undertook two 14 day bed-rest studies to investigate the mechanism of action and efficacy of our LBNP exercise concept. We examined the same 8 subjects in both 14 day bed rest (6 deg. head-down tilt, HDT) studies, assigning 4 subjects to 40 minutes of supine running exercise per day up to 1.2 BW of footward force, while the remaining 4 subjects constituted the non-exercise "control" group. Three months after the first 14 day HDT study, the two groups were reversed so that the previous non-exercise group received the same 40 min of supine jogging per day up to 1.2 BW, while the previously-exercised group did not exercise during the 14 days of HDT. This panel reviews the results obtained from an integrated, multiple system standpoint.

Hargens, Alan R.↗
NASA NTRS1974

Neurological applications of man-machine systems analysis

Quantitative descriptions of human control properties are formulated that take into account the dynamics of muscle actuation units, neuromuscular sensor units, and sensory feedback mechanics. Detailed dynamic measurements on neurologically disordered patients are correlated with clinical manifestations of various neurological syndromes to quantify operator behavior.

Mcruer, D. T.↗
NASA NTRS1973

Weightlessness

Weightlessness effects on physiological systems are summarized, including cardiovascular responses, hematological effects, work capacity (exercise tolerance), respiratory responses, skeletal responses, neuromuscular changes, vestibular responses, metabolism, endocrine and electrolyte responses, and weight loss. The nature of the adaptive response to space flight and microbial changes are also discussed. The effects of zero gravity upon performance are ascertained, and the physiological effects of weightlessness are counteracted.

Charles Berry↗
DOE OSTI2025

Characterization of Peripheral Neurophotonic Systems for High-Performance Human-Computer Interfaces (CRADA Final Report)

As part of the Cyclotron Road program, Morphosis Inc. sought to investigate a non-invasive neuromuscular sensing approach for use as an intuitive and secure human–computer interface. These highly miniaturized, wearable neural interfaces were completely non-invasive and maintained stable, high-bandwidth, long-term access to a user’s actions, intent, and identity, while offering an exceptionally high signal-to-noise ratio compared to contemporary neural recording technologies. The widespread adoption of neural interfaces had the potential to reshape how people interact with technology, with profound societal impacts. Millions worldwide suffered from movement and/or speech disabilities, and these tools had the potential to democratize access to technology to enhance autonomy and quality of life. More broadly, interfaces capable of accurately conveying intentions and safeguarding identities could serve as a cornerstone for privacy, trust, and personal authenticity in digital environments. The use of thought-driven control of digitally enabled devices and governance of digital identities had the potential to revolutionize relationships with technology, transforming how people learn, communicate, and interact with the world.

42 ENGINEERING↗
NASA NTRS1989

Exercise issues related to the neuromuscular function and adaptation to microgravity

Explored here is the question of whether astronauts can perform extravehicular activities effectively, efficiently, and productively. The loss of muscle mass, movement control, central nervous system function, muscle atrophy and fatigue, all consequent to weightlessness exposure, are discussed. The author recommends more research in these areas.

Edgerton, Reggie↗
NASA NTRS1973

Models of man as a suboptimal predictor

Models of man making predictions of future states of discrete linear dynamic systems are considered. The task is forced-pace, but the pace is slow enough to eliminate the effects of reaction time and neuromuscular lag. The best of the several models considered includes the constraints of limited memory and observation noise.

Rouse, W. B.↗
NASA NTRS2003

Cell Science and Cell Biology Research at MSFC: Summary

The common theme of these research programs is that they investigate regulation of gene expression in cells, and ultimately gene expression is controlled by the macromolecular interactions between regulatory proteins and DNA. The NASA Critical Path Roadmap identifies Muscle Alterations and Atrophy and Radiation Effects as Very Serious Risks and Severe Risks, respectively, in long term space flights. The specific problem addressed by Dr. Young's research ("Skeletal Muscle Atrophy and Muscle Cell Signaling") is that skeletal muscle loss in space cannot be prevented by vigorous exercise. Aerobic skeletal muscles (i.e., red muscles) undergo the most extensive atrophy during long-term space flight. Of the many different potential avenues for preventing muscle atrophy, Dr. Young has chosen to study the beta-adrenergic receptor (betaAR) pathway. The reason for this choice is that a family of compounds called betaAR agonists will preferentially cause an increase in muscle mass of aerobic muscles (i.e., red muscle) in animals, potentially providing a specific pharmacological solution to muscle loss in microgravity. In addition, muscle atrophy is a widespread medical problem in neuromuscular diseases, spinal cord injury, lack of exercise, aging, and any disease requiring prolonged bedridden status. Skeletal muscle cells in cell culture are utilized as a model system to study this problem. Dr. Richmond's research ("Radiation & Cancer Biology of Mammary Cells in Culture") is directed toward developing a laboratory model for use in risk assessment of cancer caused by space radiation. This research is unique because a human model will be developed utilizing human mammary cells that are highly susceptible to tumor development. This approach is preferential over using animal cells because of problems in comparing radiation-induced cancers between humans and animals.

Source record↗
NASA NTRS1992

Preliminary evidence for a postsynaptic action of beta-bungarotoxin in mammalian skeletal muscle

Two hours after treatment with beta-bungarotoxin (0.34-0.4 microM), when there was complete neuromuscular block, the peak contracture response to 50 microM succinylcholine was significantly reduced by about 35% in the mouse phrenic nerve-diaphragm preparation. Additionally, significant phospholipase A2 activity was detected on primary cell cultures from skeletal muscle which were incubated for 2 hr with concentrations of beta-bungarotoxin greater than or equal to 0.1 microM. Thus, beta-bungarotoxin appears to have pharmacologically and biochemically detectable postsynaptic actions in mammalian muscle systems.

Non-NASA Center↗
DOE OSTI2021

Sixty days of head-down tilt bed rest with or without artificial gravity do not affect the neuromuscular secretome

Highlights: • Long-term bed rest with/without artificial gravity does not affect the neuromuscular secretome. • Serum concentrations of markers of muscle wasting are not affected by bed rest/artificial gravity. • C-terminal Agrin Fragment serum concentrations are not affected by bed rest/artificial gravity. • Human centrifugation during bed rest does not have a negative impact on the neuromuscular secretome. Artificial gravity is a potential countermeasure to attenuate effects of weightlessness during long-term spaceflight, including losses of muscle mass and function, possibly to some extent attributable to disturbed neuromuscular interaction. The 60-day AGBRESA bed-rest study was conducted with 24 participants (16 men, 8 women; 33 ± 9 years; 175 ± 9 cm; 74 ± 10 kg; 8 control group, 8 continuous (cAG) and 8 intermittent (iAG) centrifugation) to assess the impact of bed rest with or without daily 30-min continuous/intermittent centrifugation with 1G at the centre of mass. Fasting blood samples were collected before and on day 6, 20, 40 and 57 during 6° head-down tilt bed rest. Concentrations of circulating markers of muscle wasting (GDF-8/myostatin; slow skeletal muscle troponin T; prostaglandin E2), neurotrophic factors (BDNF; GDNF) and C-terminal Agrin Fragment (CAF) were determined by ELISAs. Creatine kinase activity was assessed by colorimetric enzyme assay. Repeated-measures ANOVAs were conducted with TIME as within-subject, and INTERVENTION and SEX as between-subject factors. The analyses revealed no significant effect of bed rest or sex on any of the parameters. Continuous or intermittent artificial gravity is a safe intervention that does not have a negative impact of the neuromuscular secretome.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1973

Sensitivity of a critical tracking task to alcohol impairment

A first order critical tracking task is evaluated for its potential to discriminate between sober and intoxicated performances. Mean differences between predrink and postdrink performances as a function of BAC are analyzed. Quantification of the results shows that intoxicated failure rates of 50% for blood alcohol concentrations (BACs) at or above 0.1%, and 75% for BACs at or above 0.14%, can be attained with no sober failure rates. A high initial rate of learning is observed, perhaps due to the very nature of the task whereby the operator is always pushed to his limit, and the scores approach a stable asymptote after approximately 50 trials. Finally, the implementation of the task as an ignition interlock system in the automobile environment is discussed. It is pointed out that lower critical performance limits are anticipated for the mechanized automotive units because of the introduction of larger hardware and neuromuscular lags. Whether such degradation in performance would reduce the effectiveness of the device or not will be determined in a continuing program involving a broader based sample of the driving population and performance correlations with both BACs and driving proficiency.

Tennant, J. A.↗
DOE OSTI2026

Correlation of Surface Acoustic Wave (SAW) force myography sensor output with elbow joint torque

Accurate assessment of skeletal muscle forces and net joint torque is essential for preventing fatigue-related injuries, optimizing physical training, and monitoring disease progression in neuromuscular conditions. However, existing joint torque evaluation techniques are hindered by limited portability and high operational costs, confining their use to controlled laboratory or clinical settings. Despite substantial advances in wearable joint torque estimation systems, ongoing challenges such as power constraints, bulky wired setups, and susceptibility to environmental or motion artifacts underscore the urgent need for truly batteryless, wireless solutions deployable in real-world settings. This paper proposes a novel surface acoustic wave (SAW)-based force myography (FMG) system for noninvasive measurement of joint torque, validated against a gold-standard electromechanical dynamometer. The approach uses a single SAW sensor embedded in an armband to detect volumetric biceps brachii changes, with a second-order polynomial mapping sensor output and elbow angle to torque. Seven participants were tested in both isometric (15°–90°) and isokinetic (10°/s and 20°/s) supinated elbow flexion tasks. Under isometric conditions, subject-specific calibration achieved a normalized root-mean-square error (NRMSE) of 13.6% ± 6.0% and R 2 = 0.834 ± 0.180, while a group-level model yielded 14.4% ± 6.8% and 0.808 ± 0.208, respectively. For isokinetic trials, the group model produced an NRMSE of 24.1% ± 6.6% at 10°/s and 24.9% ± 08.9% at 20°/s, highlighting the feasibility of using a single-sensor SAW-FMG setup across different speeds. Because SAW devices support wireless, battery-free operation, the proposed system offers a pathway to portable, real-time monitoring for sports medicine, rehabilitation, and clinical diagnostics.

36 MATERIALS SCIENCE↗
DOE OSTI2021

Neuromuscular Junction Model Optimized for Electrical Platforms

Neuromuscular junctions (NMJs), specialized synapses between motor neurons and muscle fibers, are essential for muscle activity. A simple and reproducible cell-based in vitro NMJ platform is needed to test the impact of chemicals on the neuron-muscle communication. Our platform utilizes genetically modified neurons and muscle cells, optimized culture conditions, and commercially available multielectrode array system for recording action potentials. Neuronal cells (NSC34) were optogenetically modified with channelrhodopsin chimera to allow for simultaneous, light-mediated, millisecond-precise activation of neuronal population. This signal is propagated through functional synapses to the muscle fibers. Muscle cells (C2C12) were modified by incorporating gap junction protein (Connexin-43) to improve intracellular communication without affecting muscle differentiation. This communication between muscle fibers resulted in better signal propagation and signal strength. Optimized culture medium facilitated the growth and differentiation of both cell types together. Our system was validated using vecuronium, a muscle relaxant, which abolished the muscle response. This in vitro model provides a unique tool for establishing a NMJ platform that is easy to record and analyze. Potential applications include nondestructive long-term screening of drugs affecting the NMJ.

59 BASIC BIOLOGICAL SCIENCES↗