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At least 73 records · Page 4

All sources NASA NTRS DOE OSTI

NASA NTRS1980

Chemical release module facility

The chemical release module provides the capability to conduct: (1) thermite based metal vapor releases; (2) pressurized gas releases; (3) dispersed liquid releases; (4) shaped charge releases from ejected submodules; and (5) diagnostic measurements with pi supplied instruments. It also provides a basic R-F and electrical system for: (1) receiving and executing commands; (2) telemetering housekeeping data; (3) tracking; (4) monitoring housekeeping and control units; and (5) ultrasafe disarming and control monitoring.

Reasoner, D. L.↗

NASA NTRS1985

Residual thermal and moisture influences on the strain energy release rate analysis of edge delamination

A laminated plate theory analysis is developed to calculate the strain energy release rate associated with edge delamination growth in a composite laminate. The analysis includes the contribution of residual thermal and moisture stresses to the strain energy released. The strain energy release rate, G, increased when residual thermal effects were combined with applied mechanical strains, but then decreased when increasing moisture content was included. A quasi-three-dimensional finite element analysis indicated identical trends and demonstrated these same trends for the individual strain energy release rate components, G sub I and G sub II, associated with interlaminar tension and shear. An experimental study indicated that for T300/5208 graphite-epoxy composites, the inclusion of residual thermal and moisture stresses did not significantly alter the calculation of interlaminar fracture toughness from strain energy release rate analysis of edge delamination data taken at room temperature, ambient conditions.

Obrien, T. K.↗

NASA NTRS1985

Self-locking double retention redundant full pin release

A double retention redundant pull pin release system is disclosed. The system responds to a single pull during an intentional release operation. A spiral threaded main pin is seated in a mating bore in a housing, which main pin has a flange fastened thereon at the part of the main pin which is exterior to the housing. Accidental release tends to rotate the main pin. A secondary pin passes through a slightly oversized opening in the flange and is seated in a second bore in the housing. The pins counteract against one another to prevent accidential release. A frictional lock is shared between the main and secondary pins to enhance further locking of the system. The secondary pin, in response to a first pull, is fully retracted from its bore and flange hole. Thereafter the pull causes the main pin to rotate free of the housing to release, for example, a parachute mechanism.

Killgrove, T. O.↗

NASA NTRS1986

Residual thermal and moisture influences on the strain energy release rate analysis of edge delamination

Obrien, T. K.↗

NASA NTRS1988

Toggle release

The invention relates to a pyrotechnic actuated release mechanism which is mechanically two fault tolerant for effecting release. It is particularly well suited for releasably connecting structures to be used in the space environment or in other aerospace applications. The device comprises a fastener plate and fastener body, each attachable to either one of a pair of structures to be joined. The fastener plate and the body are fastenable by a toggle supported at one end on the fastener plate and mounted for universal pivotal movement thereon. At its other end, which is received in a central opening in the fastener body and adapted for limited pivotal movement therein, the toggle is restrained by three retractable latching pins. Each pin is individually retractable by combustion of a pyrotechnic charge. While retraction of all three pins releases the toggle, the fastener is mechanically two fault tolerant since the failure of any single or pair of the latch pins to retract results in an asymmetrical loading on the toggle and its pivotal movement to effect a release. An annular bolt is mounted on the fastener plate as a support for the socket mounting of the toggle whereby its selective axial movement provides a means for pre-loading the toggle.

Graves, Thomas Joseph↗

NASA NTRS1989

Transport of ions injected by AMPTE magnetotail releases

The BA and Li ions released in the magnetotail by the AMPTE IRM satellite were not observed in the inner magnetosphere with the AMPTE CCE satellite. In an effort to understand these results, Cladis and Francis (1988) modeled the expansion and ionization of the released atoms and computed several hundred guiding-center trajectories of the ions to sample the motion of each ion cloud. Here, the transport calculations are improved, principally by computing the full gyration motion of the ions in a more realistic model of the geomagnetic tail. The results indicate that the Ba(+) ions were convected inward along a narrow corridor, which was at least 2 earth radii away from the satellite in the case of the first Ba release and at least 3 earth radii away in the case of the second Ba release. Even if the ions had reached the satellite, their energies would have been too low to be detected. The Li(+) ions from both releases drifted inward over broad regions which overlapped the satellite in space and time. However, their fluxes at the satellite were somewhat too low to be detected.

Cladis, J. B.↗

NASA NTRS1990

An outgassing release factor for nonradiogenic volatiles on Mars

The outgassing release factor for nonradiogenic volatiles (such as water) on Mars since the end of accretion is calculated using the current value of the Ar-40 release factor and a correction coefficient derived from the history of volcanism on Mars. The Ar-40 release factor is calculated from the bulk K content of the planet and its current atmospheric inventory of Ar-40. The correction coefficient compensates for the variable abundance of Ar-40 in the Martian mantle through time versus the relatively constant nonradiogenic volatile abundance, and for the variable rate at which outgassing has occurred on Mars. The results yield a nonradiogenic release coefficient between 1.4 and 2.8. The outgassing release factor for nonradiogenic volatiles is calculated to be between 0.017 and 0.112.

Scambos, Ted A.↗

NASA NTRS1990

Ionospheric chemical releases

Ionospheric plasma density irregularities can be produced by chemical releases into the upper atmosphere. F-region plasma modification occurs by: (1) chemically enhancing the electron number density; (2) chemically reducing the electron population; or (3) physically convecting the plasma from one region to another. The three processes (production, loss, and transport) determine the effectiveness of ionospheric chemical releases in subtle and surprising ways. Initially, a chemical release produces a localized change in plasma density. Subsequent processes, however, can lead to enhanced transport in chemically modified regions. Ionospheric modifications by chemical releases excites artificial enhancements in airglow intensities by exothermic chemical reactions between the newly created plasma species. Numerical models were developed to describe the creation and evolution of large scale density irregularities and airglow clouds generated by artificial means. Experimental data compares favorably with theses models. It was found that chemical releases produce transient, large amplitude perturbations in electron density which can evolve into fine scale irregularities via nonlinear transport properties.

Bernhardt, Paul A.↗

NASA NTRS1991

Method and apparatus for releasably connecting first and second objects

The apparatus and method are disclosed for releasably connecting first and second objects, where a magnetic end effector may include at least one elongated pin number, a proximal end of which is connected to the first object and the distal end of which may be inserted into a receiving portion in the second object. Latch members are carried by the pin member for radial movement between retracted and expanded positions for releasing and locking, respectively, first and second objects. A plunger member carried by the pin member is axially moveable between first and second positions. In the first plunger position, the latch members are located in the expanded (locked) position and in the second plunger position the latch members are released for movement to retracted or unlocked position. The magnetic end effector is provided for releasable attachment to the first object and for moving the plunger member to the second position, releasing the first object.

Monford, Leo G., Jr.↗

NASA NTRS1992

Xenon critical velocity releases from the ACTIVNY satellite - Discussion of attempted optical observations

The ACTIVNY satellite launched on Sept. 30, 1989 was a platform for a suite of active plasma experiments, including releases of Xe gas to test Alfven's critical velocity effect. Three releases were done over Alaska and three over Utah, all fully illuminated by sunlight. We attempted optical observations from ground stations in the dark, using various low light level imagers and spectrographs, with narrow bandpass filters on XeI and XeII lines and also in white light. Viewing conditions were very good on several releases, the satellite could tracked easily, but we saw no optical evidence of the releases from any wavelength. We discuss the reasons why optical diagnostics in the visible and near infrared failed to detect emissions from the releases.

Wescott, E. M.↗

NASA NTRS1996

Understanding and Predicting the Process of Software Maintenance Releases

One of the major concerns of any maintenance organization is to understand and estimate the cost of maintenance releases of software systems. Planning the next release so as to maximize the increase in functionality and the improvement in quality are vital to successful maintenance management. The objective of this paper is to present the results of a case study in which an incremental approach was used to better understand the effort distribution of releases and build a predictive effort model for software maintenance releases. This study was conducted in the Flight Dynamics Division (FDD) of NASA Goddard Space Flight Center(GSFC). This paper presents three main results: 1) a predictive effort model developed for the FDD's software maintenance release process; 2) measurement-based lessons learned about the maintenance process in the FDD; and 3) a set of lessons learned about the establishment of a measurement-based software maintenance improvement program. In addition, this study provides insights and guidelines for obtaining similar results in other maintenance organizations.

Basili, Victor↗

NASA NTRS2003

Quantification of Energy Release in Composite Structures

Energy release rate is usually suggested as a quantifier for assessing structural damage tolerance. Computational prediction of energy release rate is based on composite mechanics with micro-stress level damage assessment, finite element structural analysis and damage progression tracking modules. This report examines several issues associated with energy release rates in composite structures as follows: Chapter I demonstrates computational simulation of an adhesively bonded composite joint and validates the computed energy release rates by comparison with acoustic emission signals in the overall sense. Chapter II investigates the effect of crack plane orientation with respect to fiber direction on the energy release rates. Chapter III quantifies the effects of contiguous constraint plies on the residual stiffness of a 90 deg ply subjected to transverse tensile fractures. Chapter IV compares ICAN and ICAN/JAVA solutions of composites. Chapter V examines the effects of composite structural geometry and boundary conditions on damage progression characteristics.

Minnetyan, Levon↗

NASA NTRS2003

Quantification of Energy Release in Composite Structures

Energy release rate is usually suggested as a quantifier for assessing structural damage tolerance. Computational prediction of energy release rate is based on composite mechanics with micro-stress level damage assessment, finite element structural analysis and damage progression tracking modules. This report examines several issues associated with energy release rates in composite structures as follows: Chapter I demonstrates computational simulation of an adhesively bonded composite joint and validates the computed energy release rates by comparison with acoustic emission signals in the overall sense. Chapter II investigates the effect of crack plane orientation with respect to fiber direction on the energy release rates. Chapter III quantifies the effects of contiguous constraint plies on the residual stiffness of a 90 ply subjected to transverse tensile fractures. Chapter IV compares ICAN and ICAN/JAVA solutions of composites. Chapter V examines the effects of composite structural geometry and boundary conditions on damage progression characteristics.

Minnetyan, Levon↗

NASA NTRS2001

Regulation of PGE(2) and PGI(2) release from human umbilical vein endothelial cells by actin cytoskeleton

Disruption of microfilaments in human umbilical vein endothelial cells (HUVEC) with cytochalasin D (cytD) or latrunculin A (latA) resulted in a 3.3- to 5.7-fold increase in total synthesis of prostaglandin E(2) (PGE(2)) and a 3.4- to 6.5-fold increase in prostacyclin (PGI(2)) compared with control cells. Disruption of the microtubule network with nocodazole or colchicine increased synthesis of PGE(2) 1.7- to 1.9-fold and PGI(2) 1.9- to 2.0-fold compared with control cells. Interestingly, however, increased release of PGE(2) and PGI(2) from HUVEC into the media occurred only when microfilaments were disrupted. CytD treatment resulted in 6.7-fold more PGE(2) and 3.8-fold more PGI(2) released from HUVEC compared with control cells; latA treatment resulted in 17.7-fold more PGE(2) and 11.2-fold more PGI(2) released compared with control cells. Both increased synthesis and release of prostaglandins in response to all drug treatments were completely inhibited by NS-398, a specific inhibitor of cyclooxygenase-2 (COX-2). Disruption of either microfilaments using cytD or latA or of microtubules using nocodazole or colchicine resulted in a significant increase in COX-2 protein levels, suggesting that the increased synthesis of prostaglandins in response to drug treatments may result from increased activity of COX-2. These results, together with studies demonstrating a vasoprotective role for prostaglandins, suggest that the cytoskeleton plays an important role in maintenance of endothelial barrier function by regulating prostaglandin synthesis and release from HUVEC.

Non-NASA Center↗

NASA NTRS2001

Hypertonic enhancement of transmitter release from frog motor nerve terminals: Ca2+ independence and role of integrins

Hyperosmotic solutions cause markedly enhanced spontaneous quantal release of neurotransmitter from many nerve terminals. The mechanism of this enhancement is unknown. We have investigated this phenomenon at the frog neuromuscular junction with the aim of determining the degree to which it resembles the modulation of release by stretch, which has been shown to be mediated by mechanical tension on integrins.The hypertonicity enhancement, like the stretch effect, does not require Ca2+ influx or release from internal stores, although internal release may contribute to the effect. The hypertonicity effect is sharply reduced (but not eliminated) by peptides containing the RGD sequence, which compete with native ligands for integrin bonds.There is co-variance in the magnitude of the stretch and osmotic effects; that is, individual terminals exhibiting a large stretch effect also show strong enhancement by hypertonicity, and vice versa. The stretch and osmotic enhancements also can partially occlude each other.There remain some clear-cut differences between osmotic and stretch forms of modulation: the larger range of enhancement by hypertonic solutions, the relative lack of effect of osmolarity on evoked release, and the reported higher temperature sensitivity of osmotic enhancement. Nevertheless, our data strongly implicate integrins in a significant fraction of the osmotic enhancement, possibly acting via the same mechanism as stretch modulation.

Non-NASA Center↗

NASA NTRS2000

Release of kinesin from vesicles by hsc70 and regulation of fast axonal transport

The nature of kinesin interactions with membrane-bound organelles and mechanisms for regulation of kinesin-based motility have both been surprisingly difficult to define. Most kinesin is recovered in supernatants with standard protocols for purification of motor proteins, but kinesin recovered on membrane-bound organelles is tightly bound. Partitioning of kinesin between vesicle and cytosolic fractions is highly sensitive to buffer composition. Addition of either N-ethylmaleimide or EDTA to homogenization buffers significantly increased the fraction of kinesin bound to organelles. Given that an antibody against kinesin light chain tandem repeats also releases kinesin from vesicles, these observations indicated that specific cytoplasmic factors may regulate kinesin release from membranes. Kinesin light tandem repeats contain DnaJ-like motifs, so the effects of hsp70 chaperones were evaluated. Hsc70 released kinesin from vesicles in an MgATP-dependent and N-ethylmaleimide-sensitive manner. Recombinant kinesin light chains inhibited kinesin release by hsc70 and stimulated the hsc70 ATPase. Hsc70 actions may provide a mechanism to regulate kinesin function by releasing kinesin from cargo in specific subcellular domains, thereby effecting delivery of axonally transported materials.

Non-NASA Center↗

NASA NTRS1999

Steady and transient fluid shear stress stimulate NO release in osteoblasts through distinct biochemical pathways

Fluid flow has been shown to be a potent stimulus in osteoblasts and osteocytes and may therefore play an important role in load-induced bone remodeling. The objective of this study was to investigate the characteristics of flow-activated pathways. Previously we reported that fluid flow stimulates rapid and continuous release of nitric oxide (NO) in primary rat calvarial osteoblasts. Here we demonstrate that flow-induced NO release is mediated by shear stress and that this response is distinctly biphasic. Transients in shear stress associated with the onset of flow stimulated a burst in NO production (8.2 nmol/mg of protein/h), while steady flow stimulated sustained NO production (2.2 nmol/mg of protein/h). Both G-protein inhibition and calcium chelation abolished the burst phase but had no effect on sustained production. Activation of G-proteins stimulated dose-dependent NO release in static cultures of both calvarial osteoblasts and UMR-106 osteoblast-like cells. Pertussis toxin had no effect on NO release. Calcium ionophore stimulated low levels of NO production within 15 minutes but had no effect on sustained production. Taken together, these data suggest that fluid shear stress stimulates NO release by two distinct pathways: a G-protein and calcium-dependent phase sensitive to flow transients, and a G-protein and calcium-independent pathway stimulated by sustained flow.

Non-NASA Center↗

NASA NTRS1992

Effects of methiothepin on changes in brain serotonin release induced by repeated administration of high doses of anorectic serotoninergic drugs

We previously observed, using in vivo microdialysis, that the potassium-evoked release of frontocortical serotonin (5-HT) is suppressed after rats receive high doses (30 mg/kg, i.p., daily for 3 days) of fluoxetine, a selective blocker of 5-HT reuptake. We now describe similar impairments in 5-HT release after repeated administration of two other 5-HT uptake blockers, zimelidine and sertraline (both at 20 mg/kg, i.p. for 3 days) as well as after dexfenfluramine (7.5 mg/kg, i.p. daily for 3 days), a drug which both releases 5-HT and blocks its reuptake. Doses of these indirect serotonin agonists were about 4-6 times the drug's ED50 in producing anorexia, a serotonin-related behavior. In addition, methiothepin (20 microM), a non-selective receptor antagonist, locally perfused through the dialysis probe 24 h after the last drug injection, enhanced K(+)-evoked release of 5-HT at serotoninergic nerve terminals markedly in control rats and slightly in rats treated with high doses of dexfenfluramine or fluoxetine. On the other hand, pretreatment with methiothepin (10 mg/kg, i.p.) one hour before each of the daily doses of fluoxetine or dexfenfluramine given for 3 days, totally prevented the decrease in basal and K(+)-evoked release of 5-HT. Finally, when methiothepin was injected systemically the day before the first of 3 daily injections of dexfenfluramine, it partially attenuated the long-term depletion of brain 5-HT and 5-HIAA levels induced by repeated administration of high doses of dexfenfluramine. These data suggest that drugs which bring about the prolonged blockade of 5-HT reuptake - such as dexfenfluramine and fluoxetine - can, by causing prolonged increases in intrasynaptic 5-HT levels as measured by in vivo microdialysis, produce receptor-mediated long-term changes in the processes controlling serotonin levels and dynamics.

NASA Discipline Regulatory Physiology↗