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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 73 records · Page 4

Pharmacotherapeutics of Intranasal Scopolamine: FDA Regulations and Procedures for Clinical Applications

Space Motion Sickness (SMS) is commonly experienced by astronauts and often requires treatment with medications during the early flight days of a space mission. Bioavailability of oral (PO) SMS medications is often low and highly variable; additionally, physiological changes in a microgravity environment exacerbate variability and decrease bioavailability. These factors prompted NASA to develop an intranasal dosage form of scopolamine (INSCOP) suitable for the treatment of SMS. However, to assure safety and efficacy of treatment in space, NASA physicians prescribe commercially available pharmaceutical products only. Development of a pharmaceutical preparation for clinical use must follow distinct clinical phases of testing, phase I through IV to be exact, before it can be approved by the FDA for approval for clinical use. After a physician sponsored Investigative New Drug (IND) application was approved by the FDA, a phase I clinical trial of INSCOP formulation was completed in normal human subjects and results published. The current project includes three phase II clinical protocols for the assessment of pharmacokinetics and pharmacodynamics (PK/PD), efficacy, and safety of INSCOP. Three clinical protocols that were submitted to FDA to accomplish the project objectives: 1) 002-A, a FDA Phase II dose ranging study with four dose levels between 0.1 and 0.4 mg in 12 subjects to assess PK/PD, 2) 002-B, a phase II clinical efficacy study in eighteen healthy subjects to compare efficacy of 0.2 (low dose) and 0.4 mg (high dose) INSCOP for prophylactic treatment of motion-induces (off-axis vertical rotation) symptoms, and (3) 002-C, a phase II clinical study with twelve subjects to determine bioavailability and pharmacodynamics of two doses (0.2 and 0.4 mg) of INSCOP in simulated microgravity, antiorthostatic bedrest. All regulatory procedures were competed that include certification for Good laboratory Procedures by Theradex , clinical documentation, personnel training, selection of clinical research operations contractor, data capturing and management, and annual reporting of results to FDA were successfully completed. Protocol 002-A was completed and sample and data analysis is currently in progress. Protocol 002-B is currently in progress at Dartmouth Hitchcock Medical Center and Protocol 002-C has been submitted to the FDA and will be implemented at the same contractor site as 002-A. An annual report was filed as required by FDA on the results of Protocol 002-A. Once all the three Phase II protocols are completed, a New Drug Administration application will be filed with FDA for Phase III clinical assessment and approval for marketing of the formulation. A commercial vendor will be identified for this phase. This is critical for making this available for treatment of SMS in astronauts and military personnel on duty. Once approved by FDA, INSCOP can be also used by civilian population for motion sickness associated with recreational travel and other ailments that require treatment with anticholinergic drugs.

Das, H.↗

Helmet-Mounted Display Technology for Eva Training in NASA's Neutral Buoyancy Lab

Currently, during extravehicular activity (EVA) on the International Space Station (ISS), astronauts are in constant communication with mission control; however, this paradigm will significantly change during future NASA exploration missions due to limited and time-delayed communications. As exploration missions will thereby require an increase in crew autonomy, it is hypothesized that heads-up display (HUD) technology can supplement communications with mission control. Before introducing novel display technology to EVA operations, it must first be demonstrated and evaluated in an EVA training environment. The UC Davis Center for Spaceflight Research, in collaboration with NASA Johnson Space Center’s Human Physiology, Performance, Protection, and Operations (H-3PO) Lab has developed a low-cost and rapid development helmet-mounted display (HMD) for EVA training at NASA’s Neutral Buoyancy Lab (NBL). The first two phases of HMD testing (Phase I and II) at the NBL focused on technology and capability development and demonstration. Crew member feedback was obtained that evaluated aspects of HMD including its user satisfaction, visibility, readability, and usefulness. Overall, feedback indicated HMD was readable, un-obtrusive, and the available display modes had potential to be useful and enhance EVA training. HMD display modes currently available include: real-time biofeedback (metabolic rate), phase elapsed time (PET), ability to set timers, task procedural aids (e.g. Pistol Grip Tool settings) and custom messages. The goal for Phase III, which is currently underway, is to evaluate the effects that access to bioinformatics through HMD has on astronaut training and performance at the NBL. For this phase of testing, crewmembers will be asked to perform a go/no-go task while wearing HMD throughout the NBL run to characterize crew member state of situational awareness with respect to HMD. This information could be used to inform how best to display relatively important or supplemental, but not critical, data in the future.

Heads up display↗

Acoustic Detection of Faults and Degradation in a High-Bypass Turbofan Engine during VIPR Phase III Testing

The Vehicle Integrated Propulsion Research (VIPR) Phase III project was executed at Edwards Air Force Base, California, by the National Aeronautics and Space Administration and several industry, academic, and government partners in the summer of 2015. One of the research objectives was to use external radial acoustic microphone arrays to detect changes in the noise characteristics produced by the research engine during volcanic ash ingestion and seeded fault insertion scenarios involving bleed air valves. Preliminary results indicate the successful acoustic detection of suspected degradation as a result of cumulative exposure to volcanic ash. This detection is shown through progressive changes, particularly in the high-frequency content, as a function of exposure to greater cumulative quantities of ash. Additionally, detection of the simulated failure of the 14th stage stability bleed valve and, to a lesser extent, the station 2.5 stability bleed valve, to their fully-open fail-safe positions was achieved by means of spectral comparisons between nominal (normal valve operation) and seeded fault scenarios.

noise spectra↗

HESTIA Phase I Test Results: The Air Revitalization System

In any human spaceflight mission, a number of Environmental Control & Life Support System (ECLSS) technologies work together to provide the conditions astronauts need to live healthily, productively, and comfortably in space. In a long-duration mission, many of these ECLSS technologies may use materials supplied by In-Situ Resource Utilization (ISRU), introducing more interactions between systems. The Human Exploration Spacecraft Test-bed for Integration & Advancement (HESTIA) Project aims to create a test-bed to evaluate ECLSS and ISRU technologies and how they interact in a high-fidelity, closed-loop, human-rated analog habitat. Air purity and conditioning are essential components within any ECLSS and for HESTIA's first test they were achieved with the Air Revitalization System (ARS) described below. The ARS provided four essential functions to the test-bed chamber: cooling the air, removing humidity from the air, removing trace contaminants, and scrubbing carbon dioxide (CO2) from the air. In this case, the oxygen supply function was provided by ISRU. In the current configuration, the ARS is a collection of different subsystems. A fan circulates the air, while a condensing heat exchanger (CHX) pulls humidity out of the air. A Trace Contaminant Removal System (TCRS) filters the air of potentially harmful contaminants. Lastly, a Reactive Plastic Lithium Hydroxide (RP-LiOH) unit removes CO2 from the breathing air. During the HESTIA Phase I test in September 2015, the ARS and its individual components each functioned as expected, although further analysis is underway. During the Phase I testing and in prior bench-top tests, the energy balance of heat removed by the CHX was not equal to the cooling it received. This indicated possible instrument error and therefore recalibration of the instruments and follow-up testing is planned in 2016 to address the issue. The ARS was tested in conjunction with two other systems: the Human Metabolic Simulator (HMS) and the Electrolyzer. They behaved as anticipated as well. The HMS added humidity, CO2, and heat to the chamber while removing oxygen, and the Electrolyzer (an ISRU technology) added oxygen. The objective for HESTIA in 2015 was achieved: the creation of a high-fidelity test-bed for ECLSS and ISRU technologies. With the 'backbone' technologies installed, more technologies will be added to increase the analog habitat's fidelity over the next few years. The ARS was designed with this in mind, and as new technologies develop and mature, the strategic installation of the existing components will allow for them to be replaced with the new technologies.

Wright, Sarah E.↗

Identification and Active Disturbance Rejection for the JPL Phase B Test Bed

Active disturbance rejection to minimize optical path length error is illustrated by experimental results from the JPL Phase B Test Bed, which incorporates an interferometric sensor and a controllable trolley mounted on a flexible truss structure. The controller actively isolates the optical instruments from structural vibrations induced by external disturbances consisting of linear combinations of sinusoidal signals.

Active↗

Recent Loads Calibration Experience With a Delta Wing Airplane

Aircraft which are designed for supersonic and hypersonic flight are evolving with delta wing configurations. An integral part of the evolution of all new aircraft is the flight test phase. Included in the flight test phase is an effort to identify and evaluate the loads environment of the aircraft. The most effective way of examining the loads environment is to utilize calibrated strain gages to provide load magnitudes. Using strain gage data to accomplish this has turned out to be anything but a straightforward task. The delta wing configuration has turned out to be a very difficult type of wing structure to calibrate. Elevated structural temperatures result in thermal effects which contaminate strain gage data being used to deduce flight loads. The concept of thermally calibrating a strain gage system is an approach to solving this problem. This paper will address how these problems were approached on a program directed toward measuring loads on the wing of a large, flexible supersonic aircraft. Structural configurations typical of high-speed delta wing aircraft will be examined. The temperature environment will be examined to see how it induces thermal stresses which subsequently cause errors in loads equations used to deduce the flight loads.

Jenkins, Jerald M.↗

A Method for Calculating the Probability of Successfully Completing a Rocket Propulsion Ground Test

Propulsion ground test facilities face the daily challenges of scheduling multiple customers into limited facility space and successfully completing their propulsion test projects. Due to budgetary and schedule constraints, NASA and industry customers are pushing to test more components, for less money, in a shorter period of time. As these new rocket engine component test programs are undertaken, the lack of technology maturity in the test articles, combined with pushing the test facilities capabilities to their limits, tends to lead to an increase in facility breakdowns and unsuccessful tests. Over the last five years Stennis Space Center's propulsion test facilities have performed hundreds of tests, collected thousands of seconds of test data, and broken numerous test facility and test article parts. While various initiatives have been implemented to provide better propulsion test techniques and improve the quality, reliability, and maintainability of goods and parts used in the propulsion test facilities, unexpected failures during testing still occur quite regularly due to the harsh environment in which the propulsion test facilities operate. Previous attempts at modeling the lifecycle of a propulsion component test project have met with little success. Each of the attempts suffered form incomplete or inconsistent data on which to base the models. By focusing on the actual test phase of the tests project rather than the formulation, design or construction phases of the test project, the quality and quantity of available data increases dramatically. A logistic regression model has been developed form the data collected over the last five years, allowing the probability of successfully completing a rocket propulsion component test to be calculated. A logistic regression model is a mathematical modeling approach that can be used to describe the relationship of several independent predictor variables X(sub 1), X(sub 2),..,X(sub k) to a binary or dichotomous dependent variable Y, where Y can only be one of two possible outcomes, in this case Success or Failure. Logistic regression has primarily been used in the fields of epidemiology and biomedical research, but lends itself to many other applications. As indicated the use of logistic regression is not new, however, modeling propulsion ground test facilities using logistic regression is both a new and unique application of the statistical technique. Results from the models provide project managers with insight and confidence into the affectivity of rocket engine component ground test projects. The initial success in modeling rocket propulsion ground test projects clears the way for more complex models to be developed in this area.

Messer, Bradley P.↗

Phase II Testing of Liquid Cooling Garments Using a Sweating Manikin, Controlled by a Human Physiological Model

An Advanced Automotive Manikin (ADAM) developed at the National Renewable Energy Laboratory (NREL) is used to evaluate NASA's liquid cooling garments (LCGs) used in advanced space suits for extravehicular applications. The manikin has 120 separate heated/sweating zones and is controlled by a finite element physiological model of the human thermoregulatory system. Previous testing showed the thermal sensation and comfort followed the expected trends as the LCG inlet fluid temperature was changed. The Phase II test data demonstrates the repeatability of ADAM by retesting the baseline LCG. Skin and core temperature predictions using ADAM in an LCG/Arctic suit combination are compared to NASA physiological data to validate the manikin/model. Additional LCG configurations are assessed using the manikin and compared to the baseline LCG. Results can extend to other personal protective clothing, including HAZMAT suits, nuclear/biological/chemical protective suits, and fire protection suits.

Paul, Heather↗

Flight Test of the F/A-18 Active Aeroelastic Wing Airplane

Successful flight-testing of the Active Aeroelastic Wing airplane was completed in March 2005. This program, which started in 1996, was a joint activity sponsored by NASA, Air Force Research Laboratory, and industry contractors. The test program contained two flight test phases conducted in early 2003 and early 2005. During the first phase of flight test, aerodynamic models and load models of the wing control surfaces and wing structure were developed. Design teams built new research control laws for the Active Aeroelastic Wing airplane using these flight-validated models; and throughout the final phase of flight test, these new control laws were demonstrated. The control laws were designed to optimize strategies for moving the wing control surfaces to maximize roll rates in the transonic and supersonic flight regimes. Control surface hinge moments and wing loads were constrained to remain within hydraulic and load limits. This paper describes briefly the flight control system architecture as well as the design approach used by Active Aeroelastic Wing project engineers to develop flight control system gains. Additionally, this paper presents flight test techniques and comparison between flight test results and predictions.

Clarke, Robert↗

Flight Test of the F/A-18 Active Aeroelastic Wing Airplane

Successful flight-testing of the Active Aeroelastic Wing airplane was completed in March 2005. This program, which started in 1996, was a joint activity sponsored by NASA, Air Force Research Laboratory, and industry contractors. The test program contained two flight test phases conducted in early 2003 and early 2005. During the first phase of flight test, aerodynamic models and load models of the wing control surfaces and wing structure were developed. Design teams built new research control laws for the Active Aeroelastic Wing airplane using these flight-validated models; and throughout the final phase of flight test, these new control laws were demonstrated. The control laws were designed to optimize strategies for moving the wing control surfaces to maximize roll rates in the transonic and supersonic flight regimes. Control surface hinge moments and wing loads were constrained to remain within hydraulic and load limits. This paper describes briefly the flight control system architecture as well as the design approach used by Active Aeroelastic Wing project engineers to develop flight control system gains. Additionally, this paper presents flight test techniques and comparison between flight test results and predictions.

Clarke, Robert↗

Design and Calibration of Custom Flowfield/Rake for the F-15B Propulsion Flight Test Fixture

The Propulsion Flight Test Fixture (PFTF) system at NASA Dryden Flight Research Center (DFRC) provides an innovative and cost effective method of flight testing advanced propulsion concepts and components in a relevant environment using DFRC's F-15B #836. The PFTF attaches to the centerline pylon of the aircraft and Has an integrated 6 axis force balance for flight testing of propulsion experiments The PTFF has undergone two previous flight validation test phases: (1)The Local Mach Investigation (LMT) flights, in which an air data boom was attached to a cylinder with a conical nose cap . This flight test phase quantified the local Mach number and the local flow angle at a single point under the F-155B/PFTF. (2) The Cone Drag Experiment (CDE), in which the cylinder / nosecap assembly was tested in order to validate the PFTF's integral 6-component force balance. The next test phase with the PFTF is the flight test of the channeled centerbody axisymmetric inlet. However, for the flight data from this test to be valid, more information must be gathered concerning the quality of the flow through the aerodynamic interface plane of the inlet. The flow angularity and Mach number must be known at multiple locations on the interface plane. Flight data will be gathered using a custom-design flowfield rake to probe the flow underneath the F-15B at the design flight conditions.

Flynn, Darin C.↗

10.2 Thermal-Structural Testing

Objective: Test a C/SiC Ruddervator Subcomponent under relevant thermal, mechanical & dynamic loading a) Thermal-structural mission cycling for re-entry and hypersonic cruise conditions; b) High-temperature modal survey to study the effect of heating on mode shapes, natural frequencies and damping. Supports NASA ARMD Hypersonics Material & Structures Program. Partners: NASA Dryden / Langley / Glenn, Lockheed-Martin, Materials Research & Design, GE CCP Test Phases - Phase 1: Acoustic-Vibration Testing (LaRC) completed - Phase 2: Thermal-Mechanical Testing (DFRC) in assembly - Phase 3: Mechanical Testing (DFRC) in assembly

Hudson, Larry D.↗

Double Asteroid Redirection Test (DART) Phase D Mission Design & Navigation Analysis

NASA’s Double Asteroid Redirection Test (DART) mission is the first demonstration of kinetic deflection of an asteroid. DART uses terminal guidance to impact Dimorphos, which orbits Didymos, during its 2022 close-approach to Earth. The close range to Earth allows Earth-based observations to reconstruct the impact’s effect. Light-curve data will be used to measure the resulting change in orbit period of Dimorphos due to the momentum change associated with the impact experiment. This paper describes the current DART trajectory and recent Mission Design and Navigation analysis preparing for launch.

Velez, Dianna↗

The International Orion Spacecraft Is off Towards the Stars

Following a very successful year of manufacturing, assembly and testing in factories located around the globe, NASA and ESA are preparing to deliver the major Exploration Mission-1 (EM-1) Orion flight elements, including the Crew Module, ESA Service Module and Launch Abort System. This international effort to design and develop a deep space exploration capable human spacecraft is rapidly transitioning from the design, development and test phase to the early test flight and production phase. Two major flight tests, an Ascent Abort test and EM-1, Orion's first flight onboard NASA's new heavy lift Space Launch System, are planned for the near future. Further, Orion will play a crucial role in the ambitious new Deep Space Gateway human exploration Program. This paper gives a short overview of the system and subsystem configuration of the Orion spacecraft, including NASA and ESA contributions, a status of EM-1, AA-2 and EM-2 spacecraft production, and a look at Orion's role in the construction and operation of the Deep Space Gateway. The paper will also address the innovative international cooperation methods being employed to conduct Orion and Service Module integration.

Kirasich, Mark↗

Bithermal Low-Cycle Fatigue Behavior of a NiCoCrAlY-Coated Single Crystal Superalloy

Specimens of a single crystal superalloy, PWA 1480, both bare and coated with a NiCoCrAlY alloy, PWA 276, were tested in low-cycle fatigue at 650 and 1050 C, and in bithermal thermomechanical fatigue tests. In the two bithermal test types, tensile strain was imposed at one of the two temperatures and reversed in compression at the other. In the high-strain regime, lives for both bithermal test types approached that for the 650 C isothermal test on an inelastic strain basis, all being controlled by the low ductility of the superalloy at 650 C. In the low-strain regime, coating cracking reduced life in the 650 C isothermal test. The bithermal test imposing tension at 650 C, termed out-of-phase, also produced rapid surface cracking, but in both coated and bare specimens. Increased crack growth rates also occurred for the out-of-phase test. Increased lives in vacuum suggested that there is a large environmental contribution to damage in the out-of-phase test due to the 1050 C exposure followed by tensile straining at the low temperature.

Gayda, J.↗

Bithermal low-cycle fatigue behavior of a NiCoCrAlY-coated single crystal superalloy

Specimens of a single crystal superalloy, PWA 1480, both bare and coated with a NiCoCrAlY alloy, PWA 276, were tested in low-cycle fatigue at 650 and 1050 C, and in bithermal thermomechanical fatigue tests. In the two bithermal test types, tensile strain was imposed at one of the two temperatures and reversed in compression at the other. In the high-strain regime, lives for both bithermal test types approached that for the 650 C isothermal test on an inelastic strain basis, all being controlled by the low ductility of the superalloy at 650 C. In the low-strain regime, coating cracking reduced life in the 650 C isothermal test. The bithermal test imposing tension at 650 C, termed out-of-phase, also produced rapid surface cracking, but in both coated and bare specimens. Increased crack growth rates also occurred for the out-of-phase test. Increased lives in vacuum suggested that there is a large environmental contribution to damage in the out-of-phase test due to the 1050 C exposure followed by tensile straining at the low temperature.

Gayda, J.↗