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NASA NTRS2021

Combining Satellite Data and Spatial Analysis to Assess the UHI Amplitude and Structure within Urban Areas: The Case of Moroccan Cities

Landsat-8 surface temperature and the European Space Agency land cover are used to assess the impact of land cover on the Urban Heat Island (UHI) and Urban Heat Sink (UHS). We analyzed five Moroccan cities selected for their different local climate, size, and typology during summer at three different spatial scales. The results show multiple causes defining the different forms and amplitudes of the UHI, namely: the ambient climate, the proximity to the sea, the presence of landscaped areas, and the color of building roofs and walls. Contrary to what was expected, the vegetation was not systematically an island of coolness, either because of its typology or its irrigation status. In the coastal cities of Tangier and Casablanca, UHIs around 20°C are observed on the seaside, whereas a UHS of up to 11°C is observed between the city center and the southern periphery of Casablanca. A moderate amplitude UHI of 7°C is formed in the mountainous city of Ifrane. For cities built in desert-like environments, well-defined UHSs between 9°C and 12°C are observed in Smara and Marrakech, respectively. At a finer scale, towns recorded lower temperatures than their immediate surroundings, which are attributed to evaporation from irrigated plants.

Laila El Ghazouani↗

DOE OSTI2016

HFIR Core Modeling and Analysis for the PROSPECT Reactor Antineutrino Experiment

Nuclear reactors have been employed as a copious source of antineutrinos for over six decades. Research initially directed at the study of antineutrino physics has led to applications of these highly penetrating particles to reactor safeguards because the antineutrino flux and spectrum can be related to the state of the reactor core, including burnup evolution. One of the main challenges of antineutrino-based safeguards is operation of the detectors near surface (within the reactor containment or in the close proximity). Lack of overburden results in increased contribution to the detector noise from cosmic radiation. Similarly to safeguards, experiments to definitively confirm or exclude the existence of sterile neutrino oscillations require detector technologies capable of operating at short baselines (tens of meters) at the surface. The Precision Reactor Oscillation and Spectrum Experiment (PROSPECT) at the High Flux Isotope Reactor (HFIR) at Oak Ridge National Laboratory (ORNL) is an experiment with a main objective to make a precision measurement of the flux and energy spectrum of antineutrinos emitted from nuclear reactors in order to search for the oscillation signature of sterile neutrinos. Fissions of highly-enriched uranium of HFIR will serve as a source of antineutrinos. (authors)

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

DOE OSTI2024

What to expect when you're expecting engagement: Delivering procedural justice in large-scale solar energy deployment

Community engagement in the planning process to build large-scale solar (LSS) projects can win local support and advance procedural justice. However, an understanding of community engagement in current LSS development is lacking. Using responses from a U.S. nationwide survey (n = 979) of residential neighbors living within 3 miles (4.8 km) of completed LSS projects (i.e. “solar neighbors”) and project details from the U.S. Large-Scale Solar Photovoltaic Database (USPVDB), this study seeks to answer the following questions: How are solar neighbors' perceptions of community engagement associated with their attitudes toward their LSS projects? How do solar neighbors' perceptions of community engagement compare to their expectations? And, how do neighbors explain what they perceived about the planning process? We answer these questions using mixed methods, including regression modeling, a new gap analysis technique, and qualitative coding. We find that higher perceived engagement is associated with more positive attitudes toward the project, even when controlling for respondents who acted in opposition. Supporters and opponents alike expect more engagement than they perceived and information about projects both before construction and after operation is lacking. Awareness and engagement expectations increase at certain project size and proximity thresholds. However, most neighbors expect the public to offer input during engagement, but not make decisions. We contextualize these findings with explanatory comments from respondents.

14 SOLAR ENERGY↗

DOE OSTI2024

Two-dimensional-lattice-confined single-molecule-like aggregates

Intermolecular distance largely determines the optoelectronic properties of organic matter. Conventional organic luminescent molecules are commonly used either as aggregates or as single molecules that are diluted in a foreigner matrix. They have garnered great research interest in recent decades for a variety of applications, including light-emitting diodes, lasers and quantum technologies, among others. However, there is still a knowledge gap on how these molecules behave between the aggregation and dilution states. Here we report an unprecedented phase of molecular aggregate that forms in a two-dimensional hybrid perovskite superlattice with a near-equilibrium distance, which we refer to as a single-molecule-like aggregate (SMA). By implementing two-dimensional superlattices, the organic emitters are held in proximity, but, surprisingly, remain electronically isolated, thereby resulting in a near-unity photoluminescence quantum yield, akin to that of single molecules. Moreover, the emitters within the perovskite superlattices demonstrate strong alignment and dense packing resembling aggregates, allowing for the observation of robust directional emission, substantially enhanced radiative recombination and efficient lasing. Molecular dynamics simulations together with single-crystal structure analysis emphasize the critical role of the internal rotational and vibrational degrees of freedom of the molecules in the two-dimensional lattice for creating the exclusive SMA phase. Furthermore, this two-dimensional superlattice unifies the paradoxical properties of single molecules and aggregates, thus offering exciting possibilities for advanced spectroscopic and photonic applications.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

DOE OSTI2022

Microhydration of the metastable N -Protomer of 4-Aminobenzoic acid by condensation at 80 K: H/D exchange without conversion to the more stable O- protomer

4-Aminobenzoic acid (4ABA) is a model scaffold for studying solvent-mediated proton transfer. Although protonation at the carboxylic group (O-protomer) is energetically favored in the gas phase, the N-protomer, where the proton remains on the amino group, can be kinetically trapped by electrospray ionization of 4ABA in an aprotic solvent such as acetonitrile. Here we report the formation of the hydrated deuterium isotopologues of the N-protomers, RND 3 + ·(H 2 O) n=1-3 , (R=C 6 H 4 COOD), which are generated by condensing water molecules onto the bare N-protomers in a liquid nitrogen cooled, radiofrequency octopole ion trap at 80 K. The product clusters are then transferred to a 20 K cryogenic ion trap where they are tagged with weakly bound D 2 molecules. The structures of these clusters are determined by analysis of their vibrational patterns obtained by resonant IR photodissociation. The resulting patterns confirm that the metastable N-protomer configuration remains intact even when warmed by sequential condensation of water molecules. Attachment of H 2 O molecules onto the RND 3 + head group also affords the opportunity to explore the possibility of H/D exchange between the acid scaffold and the proximal water network. The spectroscopic results establish that although the RND 3 + ·(H 2 O) n=1,2 clusters are formed without H/D exchange, the n = 3 cluster exhibits about 10% H/D exchange as evidenced by the appearance of the telltale HOD bands. Furthermore, the site of exchange on the acid is determined to be the acidic OH by the emergence of the OH stretching fundamental in the -COOH motif.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

DOE OSTI2021

Whole-Genome SNP Analysis Identifies Putative Mycobacterium bovis Transmission Clusters in Livestock and Wildlife in Catalonia, Spain

The high-resolution WGS analyses of MTBC strains have provided useful insight for determining sources of infection for animal tuberculosis. In Spain, tuberculosis in livestock is caused by Mycobacterium bovis and Mycobacterium caprae, where wildlife reservoirs play an important role. We analyzed a set of 125 M. bovis isolates obtained from livestock and wildlife from Catalonia to investigate strain diversity and identify possible sources and/or causes of infection. Whole-genome SNP profiles were used for phylogenetic reconstruction and pairwise SNP distance analysis. Additionally, SNPs were investigated to identify virulence and antimicrobial resistance factors to investigate clade-specific associations. Putative transmission clusters (≤12 SNPs) were identified, and associated epidemiological metadata were used to determine possible explanatory factors for transmission. M. bovis distribution was heterogeneous, with 7 major clades and 21 putative transmission clusters. In order of importance, the explanatory factors associated were proximity and neighborhood, residual infection, livestock-wildlife interaction, shared pasture, and movement. Genes related to lipid transport and metabolism showed the highest number of SNPs. All isolates were pyrazinamide resistant, and five were additionally resistant to isoniazid, but no clade-specific associations could be determined. Our findings highlight the importance of high-resolution molecular surveillance to monitor bovine tuberculosis dynamics in a low-prevalence setting.

59 BASIC BIOLOGICAL SCIENCES↗

NASA NTRS1973

Feasibility test of a solid state spin-scan photo-imaging system

The feasibility of using a solid-state photo-imaging system to obtain resolution imagery from a Pioneer-type spinning spacecraft in future exploratory missions to the outer planets is discussed. Evaluation of the photo-imaging system performance, based on electrical video signal analysis recorded on magnetic tape, shows that the signal-to-noise (S/N) ratios obtained at low spatial frequencies exceed the anticipated performance and that measured modulation transfer functions exhibited some degradation in comparison with the estimated values, primarily owing to the difficulty in obtaining a precise focus of the optical system in the laboratory with the test patterns in close proximity to the objective lens. A preliminary flight model design of the photo-imaging system is developed based on the use of currently available phototransistor arrays. Image quality estimates that will be obtained are presented in terms of S/N ratios and spatial resolution for the various planets and satellites. Parametric design tradeoffs are also defined.

Laverty, N. P.↗

NASA NTRS1992

Bone mineral density, muscle strength, and recreational exercise in men

Muscle strength has been shown to predict bone mineral density (BMD) in women. We examined this relationship in 50 healthy men who ranged in age from 28 to 51 years (average 38.3 years). BMD of the lumbar spine, proximal femur, whole body, and tibia were measured by dual-energy x-ray absorptiometry (Hologic QDR 1000W). Dynamic strength using one repetition maximum was assessed for the biceps, quadriceps, and back extensors and for the hip abductors, adductors, and flexors. Isometric grip strength was measured by dynamometry. Daily walking mileage was assessed by 9 week stepmeter records and kinematic analysis of video filming. Subjects were designated as exercisers and nonexercisers. Exercisers participated in recreational exercise at least two times each week. The results demonstrated that BMD at all sites correlated with back and biceps strength (p < 0.01 to p = 0.0001). Body weight correlated with tibia and whole-body BMD (p < 0.001); age negatively correlated with Ward's triangle BMD (p < 0.01). In stepwise multiple regressions, back strength was the only independent predictor of spine and femoral neck density (R2 = 0.27). Further, back strength was the most robust predictor of BMD at the trochanter, Ward's triangle, whole body, and tibia, although biceps strength, age, body weight, and leg strength contributed significantly to BMD at these skeletal sites, accounting for 35-52% of the variance in BMD. Exercisers and nonexercisers were similar for walking (3.97 versus 3.94 miles/day), age (37.8 versus 38.5) years, and weight (80.0 versus 77.7 kg). However, BMD and muscle strength were significantly greater in exercises than in nonexercisers.(ABSTRACT TRUNCATED AT 250 WORDS).

NASA Center ARC↗

NASA NTRS2015

NASA's International Space Station: A Testbed for Planetary Protection Protocol Development

Wherever humans go, they inevitably carry along the critters that live in and on them. Conventional wisdom has long held that it is unlikely those critters could survive the space environment, but in 2007 some microscopic aquatic animals called Tardigrades survived exposure to space and in 2008 Cyanobacteria lived for 548 days outside the ISS. Unlike the Mars rovers that were cleaned once and sent on their way, crew members will provide a constantly regenerating contaminant source. Are we prepared to certify that we can meet forward contamination protocols as we search for life at new destinations? What about the organisms we might reasonably expect a crewed spacecraft to leak or vent? Do we even know what they are? How long might our tiny hitch-hikers survive in close proximity to a warm spacecraft that periodically leaks/vents water or oxygen and how might they mutate with long-duration exposure? How will these contaminants migrate from their source in conditions encountered in space or on other planetary surfaces? This project aims to answer some of these questions by bringing together key stakeholder communities to develop a human forward contamination test, analysis, and integration plan. A system engineering approach to identify the experiments, analysis, and modeling needed to develop the contamination control protocols required will be used as a roadmap to integrate the many different parts of this problem - from launch to landing, living, and working on another planetary surface.

Bell, M. S.↗

NASA NTRS2015

Nasa's International Space Station: A Testbed for Planetary Protection Protocol Development

Bell, M. S.↗

NASA NTRS2018

Mars Planetary Network for Human Exploration Era – Potential Challenges and Solutions

During 2016-2017, a study was conducted under the sponsorship of the NASA’s Space Communications and Navigation (SCaN) Program to investigate the deep space communications capacity taking into account the needs of all the present and envisioned future missions toward 2030s. It was soon recognized that planning for human exploration to Mars would impose certain unprecedent challenges, both fiscal and technical, to the current space communications paradigm. Targeting the assumed missions concepts, i.e., Crewed Mission to Phobos (CMTP) and Mars Short Stay Mission (MSSM), a Mars Planetary Network for the human exploration era has been formulated. The activity modeling and network traffic simulation/modeling we performed gave some insight into the technical challenges in space communications for the envisioned human Mars exploration era. Chief among the potential challenges are: (1) the high demand on the deep space network (DSN) assets for achieving the high-rate links, both return and forward, from Mars farthest/farther distance (up to 2.67 AU); (2) the need for resilient, persistent communication coverage for crewed vehicles, on surface and in orbits; (3) the significant period of outage for the Mars-Earth link due to superior solar conjunction; (4) the need for on-demand, simultaneous access to the proximity link by multiple vehicles and astronauts in the exploration zone; (5) the capability of determining precise, real-time, positions of surface vehicles and astronauts by the deep space habitat and/or other tele-operations entities. Solution space to each of the above challenges has been explored and analyzed in the context of the individual problem domain and, more importantly, in conjunction with that for the other challenges. This has led to an end-to-end definition of a Mars Planetary Network that would feature: (1) the fusion of deep space Ka-band and optical communications for achieving Mars-Earth high-rate links taking advantage of the optical/RF hybrid 8m/34m antennas in DSN; (2) the integrated application of the Multiple Spacecraft Per Antenna (MSPA) technique, for return link data acquisition, and the Multiple Uplink Per Antenna (MUPA) technique, for forward link data trasnmission, to reduce the number of 34m beam-wave guide (BWG) antennas needed for the era; (3) the integration of three, arrayed, 34m beam-wave guide (BWG) antennas, to provide a high G/T aperture, with the MSPA/MUPA techniques, and a dual “trunk link”approach to cut down the needed G/T -- hence, reducing the number of 34m antennas, relative to that in the single trunk approach by 50%; (4) the deployment of two areostationary/areosynchronous Mars relay orbiters; one of them could also function as (or be served by) a notional Deep Space Habitat (DSH); (5) the opportunistic deployment of a science orbiter in a Pioneer-6 type orbit, equidistant Mars/Earth, that could also serve as an intermediary relay during the Mars superior solar conjunction perod; (6) the existence of the multi-function Mars proximity link that provides the demand-assigned, multiple access (DAMA) capability; and (7) the provision of tracking observables, by leveraging on the planned Mars orbiting and surface infrastructure, to enable the in-situ navigation for surface and orbiting vehicles. This paper provides the description of the proposed Mars Planetary Network in the human exploration era, the trade-off analysis for the various alternative architectures, and the optimal solutions to the key challenges in defining this end-to-end network.

Cheung, Kar-Ming↗

DOE OSTI2014

Concentrations of the urinary pyrethroid metabolite 3-phenoxybenzoic acid in farm worker families in the MICASA study

Indoor pesticide exposure is a growing concern, particularly from pyrethroids, a commonly used class of pesticides. Pyrethroid concentrations may be especially high in homes of immigrant farm worker families who often live in close proximity to agricultural fields, and are faced with poor housing conditions, causing higher pest infestation and more pesticide use. We investigate exposure of farm worker families to pyrethroids in a study of mothers and children living in Mendota, CA within the population-based Mexican Immigration to California: Agricultural Safety and Acculturation (MICASA) Study. We present pyrethroid exposure based on an ELISA analysis of urinary metabolite 3-phenoxybenzoic acid (3PBA) levels among 105 women and 103 children. The median urinary 3PBA levels (children=2.56 ug/g creatinine, mothers=1.46 ug/g creatinine) were higher than those reported in population based studies for the United States general population, but similar to or lower than studies with known high levels of pyrethroid exposure. A positive association was evident between poor housing conditions and the urinary metabolite levels, showing that poor housing conditions are a contributing factor to the higher levels of 3PBA seen in the urine of these farm worker families. Further research is warranted to fully investigate sources of exposure. - Highlights: • We investigate exposure of farm worker families to pyrethroids. • We present pyrethroid exposure based on an ELISA analysis of urinary 3PBA levels. • 3PBA levels were higher than those reported for the U.S. general population. • Poor housing conditions may be associated with pyrethroid exposure.

54 ENVIRONMENTAL SCIENCES↗

DOE OSTI2014

Effect of force-induced mechanical stress at the coronary artery bifurcation stenting: Relation to in-stent restenosis

The deployment of metallic stents during percutaneous coronary intervention has become common in the treatment of coronary bifurcation lesions. However, restenosis occurs mostly at the bifurcation area even in present era of drug-eluting stents. To achieve adequate deployment, physicians may unintentionally apply force to the strut of the stents through balloon, guiding catheters, or other devices. This force may deform the struts and impose excessive mechanical stresses on the arterial vessels, resulting in detrimental outcomes. This study investigated the relationship between the distribution of stress in a stent and bifurcation angle using finite element analysis. The unintentionally applied force following stent implantation was measured using a force sensor that was made in the laboratory. Geometrical information on the coronary arteries of 11 subjects was extracted from contrast-enhanced computed tomography scan data. The numerical results reveal that the application of force by physicians generated significantly higher mechanical stresses in the arterial bifurcation than in the proximal and distal parts of the stent (post hoc P < 0.01). The maximal stress on the vessels was significantly higher at bifurcation angle <70° than at angle ≧70° (P < 0.05). The maximal stress on the vessels was negatively correlated with bifurcation angle (P < 0.01). Stresses at the bifurcation ostium may cause arterial wall injury and restenosis, especially at small bifurcation angles. These finding highlight the effect of force-induced mechanical stress at coronary artery bifurcation stenting, and potential mechanisms of in-stent restenosis, along with their relationship with bifurcation angle.

42 ENGINEERING↗

DOE OSTI2015

Electrostatic capacitance and Faraday cage behavior of carbon nanotube forests

Understanding of the electrostatic properties of carbon nanotube (CNT) forests is essential to enable their integration in microelectronic and micromechanical devices. In this study, we sought to understand how the hierarchical geometry and morphology of CNT forests determines their capacitance. First, we find that at small gaps, solid micropillars have greater capacitance, yet at larger gaps the capacitance of the CNT forests is greater. The surface area of the CNT forest accessible to the electrostatic field was extracted by analysis of the measured capacitance, and, by relating the capacitance to the average density of CNTs in the forest, we find that the penetration depth of the electrostatic field is on the order of several microns. Therefore, CNT forests can behave as a miniature Faraday cage. The unique electrostatic properties of CNT forests could therefore enable their use as long-range proximity sensors and as shielding elements for miniature electronic devices.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

DOE OSTI2023

Single-cell profiling of Arabidopsis leaves to Pseudomonas syringae infection

Plant response to pathogen infection varies within a leaf, yet this heterogeneity is not well resolved. We expose Arabidopsis to Pseudomonas syringae or mock treatment and profile >11,000 individual cells using single-cell RNA sequencing. Integrative analysis of cell populations from both treatments identifies distinct pathogen-responsive cell clusters exhibiting transcriptional responses ranging from immunity to susceptibility. Pseudotime analyses through pathogen infection reveals a continuum of disease progression from an immune to a susceptible state. Confocal imaging of promoter-reporter lines for transcripts enriched in immune cell clusters shows expression surrounding substomatal cavities colonized or in close proximity to bacterial colonies, suggesting that cells within immune clusters represent sites of early pathogen invasion. Susceptibility clusters exhibit more general localization and are highly induced at later stages of infection. Overall, our work shows cellular heterogeneity within an infected leaf and provides insight into plant differential response to infection at a single-cell level.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2018

Spatial analysis of concentrations of multiple air pollutants using NASA DISCOVER-AQ aircraft measurements: Implications for exposure assessment

Highlights: • Aircraft measurements showed spatially varying relations of multiple air pollutants. • NO{sub x}, toluene, and xylenes/ethylbenzene were reasonable proxies of traffic and urban air pollution. • Between-pollutant concentration correlations and ratios varied by space. • Multiple pollutant relations provided insights for exposure assessment and multipollutant epidemiology. In recent years, multipollutant approaches have been employed to investigate the association with health outcomes to better represent real-world conditions than more traditional analysis that considers a single pollutant. With regard to the exposure assessment of a mixture of air pollutants, it is critical to understand the spatial variability in multipollutant relations in order to assess their potential health implications. In this study, we investigated the spatial relations of multiple pollutant concentrations (i.e., NO{sub x}, NO{sub y}, black carbon, carbon monoxide, acetaldehyde, formaldehyde, toluene, xylenes/ethylbenzene, ozone, water-soluble organic carbon, and aerosol extinction) observed from the P-3B aircraft in the 2011 NASA field campaign in Baltimore/Washington D.C. areas during July 2011. The between-pollutant Pearson correlations and Z-scores (calculated from log-transformed concentrations) between near-highways and non-highways and between near-urban centers and non-urban centers varied by pollutant pair and space. We found generally lower correlations between NO{sub x} and other pollutants for near-highways (average r = 0.36) than for non-highways (average r = 0.41) and also for non-urban centers (average r = 0.37) than for near-urban centers (average r = 0.41). This indicated that the temporal associations between NO{sub x} and health outcomes might be less affected by other pollutants, which were also related to same health outcomes, for near-highways and non-urban centers. The analysis of between-pollutant Z-scores showed varying spatial relations for popular traffic-related pollutants with the Z-score differences of 0.43 (NO{sub x}-carbon monoxide), 0.29 (NO{sub x}-black carbon), and 0.17 (black carbon-carbon monoxide) between near-highways and non-highways. This result exhibited heterogeneous traffic-related pollutant mixtures with the proximity to highways, potentially leading to the diverse extent of health associations. Furthermore, a mixed effects model presented pollutant-specific associations between the concentrations and the proximity to highways and urban centers, showing larger declines for NO{sub x}, xylenes/ethylbenzene, toluene, and NO{sub y} than those for the pollutants related to secondary pollutant formation. The model also demonstrated the different sensitivity of each pollutant to meteorological parameters, which may modify the spatial and temporal variability in the relations between the pollutants. Our findings provide insights for exposure assessment studies to better understand the cumulative health consequences associated with multiple air pollutants simultaneously.

54 ENVIRONMENTAL SCIENCES↗

DOE OSTI2012

Nickel (II)-induced cytotoxicity and apoptosis in human proximal tubule cells through a ROS- and mitochondria-mediated pathway

Nickel compounds are known to be toxic and carcinogenic in kidney and lung. In this present study, we investigated the roles of reactive oxygen species (ROS) and mitochondria in nickel (II) acetate-induced cytotoxicity and apoptosis in the HK-2 human renal cell line. The results showed that the cytotoxic effects of nickel (II) involved significant cell death and DNA damage. Nickel (II) increased the generation of ROS and induced a noticeable reduction of mitochondrial membrane potential (MMP). Analysis of the sub-G1 phase showed a significant increase in apoptosis in HK-2 cells after nickel (II) treatment. Pretreatment with N-acetylcysteine (NAC) not only inhibited nickel (II)-induced cell death and DNA damage, but also significantly prevented nickel (II)-induced loss of MMP and apoptosis. Cell apoptosis triggered by nickel (II) was characterized by the reduced protein expression of Bcl-2 and Bcl-xL and the induced the protein expression of Bad, Bcl-Xs, Bax, cytochrome c and caspases 9, 3 and 6. The regulation of the expression of Bcl-2-family proteins, the release of cytochrome c and the activation of caspases 9, 3 and 6 were inhibited in the presence of NAC. These results suggest that nickel (II) induces cytotoxicity and apoptosis in HK-2 cells via ROS generation and that the mitochondria-mediated apoptotic signaling pathway may be involved in the positive regulation of nickel (II)-induced renal cytotoxicity.

60 APPLIED LIFE SCIENCES↗

DOE OSTI2016

Intermolecular Structural Change for Thermoswitchable Polymeric Photosensitizer

A switchable photosensitizer (PS), which can be activated at a spe-cific condition beside light, has tremendous advantages for photo-dynamic therapy (PDT). Herein, we developed a thermo-switchable polymeric photosensitizer (T-PPS) by conjugating PS (Pheophor-bide-a, PPb-a) to a temperature-responsive polymer backbone of biocompatible hydroxypropyl cellulose (HPC). Self-quenched PS molecules linked in close proximity by pi-pi stacking in T-PPS were easily transited to an active monomeric state by the tempera-ture induced phase transition of polymer backbones. The tempera-ture responsive inter-molecular interaction changes of PS molecules in T-PPS were demonstrated in synchrotron small-angle X-ray scattering (SAXS) and UV-Vis spectrophotometer analysis. The T-PPS allowed switchable activation and synergistically enhanced cancer cell killing effect at the hyperthermia temperature (45 °C). Our developed T-PPS has the considerable potential not only as a new class of photomedicine in clinics but also as a biosensor based on temperature responsiveness.

Park, Wooram↗