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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 739 records · Page 41
All sourcesNASA NTRSDOE OSTI
NASA NTRS2000

Training Select-in Interviewers for Astronaut Selection: A Program Evaluation

Psychological factors critical to the success of short and long-duration missions have been identified in previous research; however, evaluation for such critical factors in astronaut applicants leaves much room for human interpretation. Thus, an evaluator training session was designed to standardize the interpretation of critical factors, as well as the structure of the select-in interview across evaluators. The purpose of this evaluative study was to determine the effectiveness of the evaluator training sessions and their potential impact on evaluator ratings.

Hysong, S.↗
NASA NTRS1991

Performance, size, mass, and cost estimates for projected 1kW EOL Si, InP, and GaAs arrays

One method of evaluating the potential of emerging solar cell and array technologies is to compare their projected capabilities in space flight applications to those of established Si solar cells and arrays. Such an application-oriented comparison provides an integrated view of the elemental comparisons of efficiency, radiation resistance, temperature sensitivity, size, mass, and cost in combination. In addition, the assumptions necessary to make the comparisons provide insights helpful toward determining necessary areas of development or evaluation. Finally, as developments and evaluations progress, the results can be used in more precisely defining the overall potential of the new technologies in comparison to existing technologies. The projected capabilities of Si, InP, and GaAs cells and arrays are compared.

Slifer, Luther W., Jr.↗
DOE OSTI2018

Design Studies for Deep-Water Floating Offshore Vertical Axis Wind Turbines

Deep-water offshore sites are an untapped opportunity to bring large-scale offshore wind energy to coastal population centers. The primary challenge has been the projected high costs for floating offshore wind systems. This work presents a comprehensive investigation of a new opportunity for deep-water offshore wind using large-scale vertical axis wind turbines. Owing to inherent features of this technology, there is a potential transformational opportunity to address the major cost drivers for floating wind using vertical axis wind turbines. The focus of this report is to evaluate the technical potential for this new technology. The approach to evaluating this potential was to perform system design studies focused on improving the understanding of technical performance parameters while looking for cost reduction opportunities. VAWT design codes were developed in order to perform these design studies. To gain a better understanding of the design space for floating VAWT systems, a comprehensive design study of multiple rotor configuration options was carried out. Floating platforms and moorings were then sized and evaluated for each of the candidate rotor configurations. Preliminary LCOE estimates and LCOE ranges were produced based on the design study results for each of the major turbine and system components. The major outcomes of this study are a comprehensive technology assessment of VAWT performance and preliminary LCOE estimates that demonstrate that floating VAWTs may have favorable performance and costs in comparison to conventional HAWTs in the deep-water offshore environment where floating systems are required, indicating that this new technology warrants further study.

17 WIND ENERGY↗
DOE OSTI2024

Synthetic β-sheets mimicking fibrillar and oligomeric structures for evaluation of spectral X-ray scattering technique for biomarker quantification

Archetypical cross-β spines sharpen the boundary between functional and pathological proteins including β-amyloid, tau, α-synuclein and transthyretin are linked to many debilitating human neurodegenerative and non-neurodegenerative amyloidoses. An increased focus on development of pathogenic β-sheet specific fluid and imaging structural biomarkers and conformation-specific monoclonal antibodies in targeted therapies has been recently observed. Identification and quantification of pathogenic oligomers remain challenging for existing neuroimaging modalities. We propose two artificial β-sheets which can mimic the nanoscopic structural characteristics of pathogenic oligomers and fibrils for evaluating the performance of a label free, X-ray based biomarker detection and quantification technique. Highly similar structure with elliptical cross-section and parallel cross-β motif is observed among recombinant α-synuclein fibril, Aβ-42 fibril and artificial β-sheet fibrils. We then use these β-sheet models to assess the performance of spectral small angle X-ray scattering (sSAXS) technique for detecting β-sheet structures. sSAXS showed quantitatively accurate detection of antiparallel, cross-β artificial oligomers from a tissue mimicking environment and significant distinction between different oligomer packing densities such as diffuse and dense packings. The proposed synthetic β-sheet models mimicked the nanoscopic structural characteristics of β-sheets of fibrillar and oligomeric states of Aβ and α-synuclein based on the ATR-FTIR and SAXS data. The tunability of β-sheet proportions and shapes of structural motifs, and the low-cost of these β-sheet models can become useful test materials for evaluating β-sheet or amyloid specific biomarkers in a wide range of neurological diseases. By using the proposed synthetic β-sheet models, our study indicates that the sSAXS has potential to evaluate different stages of β-sheet-enriched structures including oligomers of pathogenic proteins.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2016

Assessment of potential greenhouse gas mitigation from changes to crop root mass and architecture

Reducing (and eventually reversing) the increase in greenhouse gases (GHGs) in the atmosphere due to human activities, and thus reducing the extent and severity of anthropogenic climate change, is one of the great challenges facing humanity. While most of the man-caused increase in GHGs has been due to fossil fuel use, land use (including agriculture) currently accounts for about 25% of total GHG emissions and thus there is a need to include emission reductions from the land use sector as part of an effective climate change mitigation strategy. In addition, analyses included in the recent IPCC 5th Climate Change Assessment report suggests that it may not be possible to achieve large enough emissions reductions in the energy, transport and industrial sectors alone to stabilize GHG concentrations at a level commensurate with a less than 2°C global average temperature increase, without the help of a substantial CO 2 sink (i.e., atmospheric CO 2 removal) from the land use sector. One of the potential carbon sinks that could contribute to this goal is increasing C storage in soil organic matter on managed lands. This report details a preliminary scoping analysis, to assess the potential agricultural area in the US – where appropriate soil, climate and land use conditions exist – to determine the land area on which ‘improved root phenotype’ crops could be deployed and to evaluate the potential long-term soil C storage, given a set of ‘bounding scenarios’ of increased crop root input and/or rooting depth for major crop species (e.g., row crops (corn, sorghum, soybeans), small grains (wheat, barley, oats), and hay and pasture perennial forages). The enhanced root phenotype scenarios assumed 25, 50 and 100% increase in total root C inputs, in combination with five levels of modifying crop root distributions (i.e., no change and four scenarios with increasing downward shift in root distributions). We also analyzed impacts of greater root production on the soil-crop nitrogen balance, from the standpoint of increased need for additional N inputs and consequences for increased N 2 O flux, as well as potential impacts if more and deeper roots contributed to reduced N leaching. In the enhanced root phenotype scenarios, the implicit assumption was that increases in overall plant production could be achieved (e.g., through increased CO 2 assimilation, greater growth efficiency) without reducing the harvested yield – that is, we did not include potential leakage and land substitution effects from potential decreased crop yield in the analysis.

54 ENVIRONMENTAL SCIENCES↗
NASA NTRS1992

Erosional landforms on the layered terrains in Valles Marineris

Many investigators have proposed potential lakes in Valles Marineris based on the relationship with outflow channels, and a proposed lacustrine origin of layered deposits. We have investigated the erosional style of the layered terrains and evaluated their potential origins as sedimentation in and erosional modification by these lakes. The erosional features that will be discussed are distributed in the central canyon area and classified into terraces and layered depressions. Many terraces can be explained by coastal erosion in lakes as well as by eolian erosion. The lack of terraces on the canyon walls is probably due to more recent sapping and mass wasting of materials with different mechanical response to erosion than the layered terrains. Catastrophic water discharges in Valles Marineris as hypothesized by an ocean model may have been the source of the lakes and the eventual catastrophic release of water from the canyons.

Komatsu, G.↗
NASA NTRS1996

Atomic Oxygen Durability of Second Surface Silver Microsheet Glass Concentrators

Second surface silver microsheet glass concentrators are being developed for potential use in future solar dynamic space power systems. Traditional concentrators are aluminum honeycomb sandwich composites with either aluminum or graphite epoxy face sheets, where a reflective aluminum layer is deposited onto an organic leveling layer on the face sheet. To protect the underlying layers, a SiO2 layer is applied on top of the aluminum reflective layer. These concentrators may be vulnerable to atomic oxygen degradation due to possible atomic oxygen attack of the organic layers at defect sites in the protective and reflective coatings. A second surface microsheet glass concentrator would be inherently more atomic oxygen durable than these first surface concentrators. In addition, a second surface microsheet glass concentrator design provides a smooth optical surface and allows for silver to be used as a reflective layer, which would improve the reflectivity of the concentrator and the performance of the system. A potential threat to the performance of second surface microsheet glass concentrators is atomic oxygen attack of the underlying silver at seams and edges or at micrometeoroid and debris (MMD) impacts sites. Second surface silver microsheet glass concentrator samples were fabricated and tested for atomic oxygen durability. The samples were iteratively exposed to an atomic oxygen environment in a plasma asher. Samples were evaluated for potential degradation at fabrication seams, simulated MMD impact sites, and edges. Optical microscopy was used to evaluate atomic oxygen degradation. Reflectance was obtained for an impacted sample prior to and after atomic oxygen exposure. After an initial atomic oxygen exposure to an effective fluence of approx. 1 x 10(exp 21) atoms/cm(exp 2), oxidation of the silver at defect sites and edges was observed. Exposure to an additional approx. 1 x 10(exp 21) atoms/cm(exp 2) caused no observed increase in oxidation. Oxidation at an impact site caused negligible changes in reflectance. In all cases oxidation was found to be confined to the vicinity of the seams, impact sites, edges or defect sites. Asher to in-space atomic oxygen correlation issues will be addressed.

deGroh, Kim K.↗
NASA NTRS2010

Aeroheating Mapping to Thermal Model for Autonomous Aerobraking Capability

Thermal modeling has been performed to evaluate the potential for autonomous aerobraking of a spacecraft in the atmosphere of a planet. As part of this modeling, the aeroheating flux during aerobraking must be applied to the spacecraft solar arrays to evaluate their thermal response. On the Mars Reconnaissance Orbiter (MRO) mission, this was done via two separate thermal models and an extensive suite of mapping scripts. That method has been revised, and the thermal analysis of an aerobraking pass can now be accomplished via a single thermal model, using a new capability in the Thermal Desktop software. This capability, Boundary Condition Mapper, has the ability to input heating flux files that vary with time, position on the solar array, and with the skin temperature. A recently added feature to the Boundary Condition Mapper is that this module can also utilize files that describe the variation of aeroheating over the surface with atmospheric density (rather than time); this is the format of the MRO aeroheating files. This capability has allowed a huge streamlining of the MRO thermal process, simplifying the procedure for importing new aeroheating files and trajectory information. The new process, as well as the quantified time savings, is described.

Amundsen, Ruth M.↗
NASA NTRS2014

Ocean Color Measurements from Landsat-8 OLI using SeaDAS

The Operational Land Imager (OLI) is a multi-spectral radiometer hosted on the recently launched Landsat-8 satellite. OLI includes a suite of relatively narrow spectral bands at 30-meter spatial resolution in the visible to shortwave infrared that make it a potential tool for ocean color radiometry: measurement of the reflected spectral radiance upwelling from beneath the ocean surface that carries information on the biogeochemical constituents of the upper ocean euphotic zone. To evaluate the potential of OLI to measure ocean color, processing support was implemented in SeaDAS, which is an open-source software package distributed by NASA for processing, analysis, and display of ocean remote sensing measurements from a variety of satellite-based multi-spectral radiometers. Here we describe the implementation of OLI processing capabilities within SeaDAS, including support for various methods of atmospheric correction to remove the effects of atmospheric scattering and absorption and retrieve the spectral remote-sensing reflectance (Rrs; sr exp 1). The quality of the retrieved Rrs imagery will be assessed, as will the derived water column constituents such as the concentration of the phytoplankton pigment chlorophyll a.

ocean color↗
DOE OSTI2024

Helium-4 gravitational form factors: Exchange currents

We evaluate the leading exchange corrections to the helium-4 gravitational form factors (GFFs) to momenta of the order of the nucleon mass. We use both the K-harmonic method with simple pair nucleon potential, and a Jastrow trial function using the Argonne 𝑣 14 potential, to evaluate the helium-4 GFFs. The exchange current contributions include the pair interaction, plus the seagull and the pion exchange interactions, modulo the recoil corrections. To estimate the off-shellness of the pion nucleon coupling in this momenta range, we discuss the results using either the pseudoscalar (PS) or pseudovector (PV) pion-nucleon couplings. When the PV coupling is used, the pair diagram contribution is higher order in the nonrelativistic expansion. The results for the helium-4 A-GFF are comparable to those given by the impulse approximation, especially for the PS coupling using both the K-harmonic method and variational method. The exchange current contributions with the PS coupling for the charge form factor of helium-4, yield better agreement with the existing data over a broad range of momenta, especially when the Argonne 𝑣 14 potential including the D-wave admixture is used.

A ≤ 5↗
DOE OSTI2023

Exploration of a Potential Desirability of Outcome Ranking Endpoint for Complicated Intra-Abdominal Infections Using 9 Registrational Trials for Antibacterial Drugs

Abstract Background Desirability of outcome ranking (DOOR) is a novel approach to clinical trial design that incorporates safety and efficacy assessments into an ordinal ranking system to evaluate overall outcomes of clinical trial participants. Here, we derived and applied a disease-specific DOOR endpoint to registrational trials for complicated intra-abdominal infection (cIAI). Methods Initially, we applied an a priori DOOR prototype to electronic patient-level data from 9 phase 3 noninferiority trials for cIAI submitted to the US Food and Drug Administration between 2005 and 2019. We derived a cIAI-specific DOOR endpoint based on clinically meaningful events that trial participants experienced. Next, we applied the cIAI-specific DOOR endpoint to the same datasets and, for each trial, estimated the probability that a participant assigned to the study treatment would have a more desirable DOOR or component outcome than if assigned to the comparator. Results Three key findings informed the cIAI-specific DOOR endpoint: (1) a significant proportion of participants underwent additional surgical procedures related to their baseline infection; (2) infectious complications of cIAI were diverse; and (3) participants with worse outcomes experienced more infectious complications, more serious adverse events, and underwent more procedures. DOOR distributions between treatment arms were similar in all trials. DOOR probability estimates ranged from 47.4% to 50.3% and were not significantly different. Component analyses depicted risk-benefit assessments of study treatment versus comparator. Conclusions We designed and evaluated a potential DOOR endpoint for cIAI trials to further characterize overall clinical experiences of participants. Similar data-driven approaches can be utilized to create other infectious disease–specific DOOR endpoints.

Immunology↗
NASA NTRS1973

Development of a computer-aided procedure for the national program of inspection of dams

An effort was undertaken to determine the utility of ERTS-1 MSS data, together with automatic data processing (ADP) techniques, to detect and locate surface water, and transfer the related technology to the Texas Water Rights Commission (TWRC). A test site was selected, ERTS-1 MSS and ancillary data obtained, and existent ADP classification programs applied. During the course of this effort a linear discriminant function was developed. The results were evaluated for potential candidates for a transferable procedure. A computer-aided technique using a linear discriminant function was selected and recommended, for inclusion in an operational system, which met detection and location criteria. Specifically, evaluation of the selected computer-aided procedure for the test site resulted in the detection of 100 percent of areas of surface water 10 acres or greater in areal extent and the geographic location of areas classified as water to a positional accuracy of 1000 feet or closer. The procedure was recommended for inclusion in an operational computer-aided procedure for transfer to TWRC.

Source record↗
NASA NTRS2002

Recent Observing System Simulation Experiments at the NASA DAO

Since the advent of meteorological satellites in the 1960's, numerous experiments have been conducted in order t o evaluate the impact of these and other data on atmospheric analysis and prediction. Such studies have included both OSE'S (Observing System Experiments) and OSSE's (Observing System Simulation Experiments). The OSE's were conducted to evaluate the impact of specific observations or classes of observations on analyses and forecasts. Such experiments have been performed for selected types of conventional data and for various satellite data sets as they became avail- able. (See for example the 1989 ECMWF/EUMETSAT workshop proceedings on "The use of satellite data in operational numerical weather prediction" and the references contained therein.) The OSSE's were con- ducted to evaluate the potential for future observing systems to improve Numerical Weather Prediction (NWP) and to plan for the Global Weather Experiment and more recently for EOS. In addition, OSSE's have been run t o evaluate trade-offs in the design of observing systems and observing net-works, and to test new methodology for data assimilation.

Atlas, Robert↗
NASA NTRS2007

EVA Hazards due to TPS Inspection and Repair

Tile inspection and repair activities have implicit hazards associated with them. When an Extra Vehicular Activities (EVA) crewmember and associated hardware are added into the equation, additional hazards are introduced. Potential hazards to the Extravehicular Mobility Unit (EMU), the Orbiter or the crew member themselves are created. In order to accurately assess the risk of performing a TPS inspection or repair, an accurate evaluation of potential hazards and how adequately these hazards are controlled is essential. The EMU could become damaged due to sharp edges, protrusions, thermal extremes, molten metal or impact with the Orbiter. Tools, tethers and the presence of a crew member in the vicinity of the Orbiter Thermal Protection System (TPS) pose hazards to the Orbiter. Hazards such as additional tile or Reinforced Carbon-Carbon (RCC) damage from a loose tool, safety tethers, crewmember or arm impact are introduced. Additionally, there are hazards to the crew which should be addressed. Crew hazards include laser injury, electrical shock, inability to return to the airlock for EMU failures or Orbiter rapid safing scenarios, as well as the potential inadvertent release of a crew member from the arm/boom. The aforementioned hazards are controlled in various ways. Generally, these controls are addressed operationally versus by design, as the majority of the interfaces are to the Orbiter and the Orbiter design did not originally account for tile repair. The Shuttle Remote Manipulator System (SRMS), for instance, was originally designed to deploy experiments, and therefore has insufficient design controls for retention of the Orbiter Boom Sensor System (OBSS). Although multiple methods to repair the Orbiter TPS exist, the majority of the hazards are applicable no matter which specific repair method is being performed. TPS Inspection performed via EVA also presents some of the same hazards. Therefore, the hazards common to all TPS inspection or repair methods will be addressed.

Stewart, Christine E.↗
DOE OSTI2016

MEK-ERK inhibition potentiates WAY-600-induced anti-cancer efficiency in preclinical hepatocellular carcinoma (HCC) models

The search for novel anti-hepatocellular carcinoma (HCC) agents is important. Mammalian target of rapamycin (mTOR) hyper-activation plays a pivotal role in promoting HCC tumorigenesis and chemoresistance. The current preclinical study evaluated the potential anti-HCC activity by a potent mTOR kinase inhibitor, WAY-600. We showed that WAY-600 inhibited survival and proliferation of HCC cell lines (HepG2 and Huh7) and primary human HCC cells. Caspase-dependent apoptosis was activated by WAY-600 in above HCC cells. Reversely, caspase inhibitors largely attenuated WAY-600's lethality against HCC cells. At the signaling level, WAY-600 blocked mTOR complex 1/2 (mTORC1/2) assemble and activation, yet activated MEK-ERK pathway in HCC cells. MEK-ERK inhibitors, PD-98059 and MEK-162, or MEK1/2 shRNA significantly potentiated WAY-600's cytotoxicity in HCC cells. Further studies showed that WAY-600 intraperitoneal (i.p.) administration in nude mice inhibited p-AKT Ser-473 and displayed significant anti-cancer activity against HepG2 xenografts. Remarkably, co-administration of MEK-162 further potentiated WAY-600's anti-HCC activity in vivo. These preclinical results demonstrate the potent anti-HCC activity by WAY-600, either alone or with MEK-ERK inhibitors. -- Highlights: •WAY-600 inhibits HCC cell survival and proliferation in vitro. •WAY-600 activates caspase-dependent apoptosis in HCC cells. •WAY-600 blocks mTORC1/2 activation, but activates MEK-ERK in HCC cells. •MEK-ERK inhibitors or MEK1/2 shRNA enhances WAY-600's cytotoxicity against HCC cells. •MEK-162 co-administration potentiates WAY-600-induced the anti-HepG2 tumor efficacy.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1972

Manned space flight nuclear system safety. Volume 7: Literature review. Part 1: Literature search and evaluation

A review of the literature used in conducting the manned space flight nuclear system safety study is presented. The objectives of the presentation are to identify and evaluate for potential application to study the existing related literature and to provide the information required to include the related literature in the NASA Aerospace Safety Research and Data Institute. More than 15,000 documents were evaluated and identification forms were prepared for 850 reports.

Source record↗
NASA NTRS2005

Development of Spacecraft to Exploit Electric Propulsion for Outer Planetary Exploration

Outer planetary exploration spacecraft have relied on Radioisotope Power Systems (RPS) to provide power. This is necessary as solar power is not useful beyond the inner planets. For propulsion these spacecraft have made use of chemical systems. A study was undertaken to look at the possibility of designing a spacecraft for outer planetary exploration that would use an RPS in combination with Electric Propulsion. That is, the RPS would be the sole power provider to the EP system. Recent improvements in RPS s have made Radioisotope Electric Propulsion (REP) more of a possibility. The combined power and propulsion technologies of REP and a direct trajectory would potentially enable a new class of missions - high delta V, beyond Mars orbit for a small spacecraft primarily suited for small body capture (orbit capture or co-orbit). A study was undertaken to evaluate the feasibility of a REP spacecraft for a selected representative mission of this type. To evaluate the potential of these technologies, a design reference mission was established and a conceptual design of a spacecraft developed. The following paper describes the Ion Propulsion System, one particular subsystem onboard of the spacecraft.

Roche, Joseph M.↗
NASA NTRS2007

KSC Vertical Launch Site Evaluation

RS&H was tasked to evaluate the potential available launch sites for a combined two user launch pad. The Launch sites were to be contained entirely within current Kennedy Space Center property lines. The user launch vehicles to be used for evaluation are in the one million pounds of first stage thrust range. Additionally a second evaluation criterion was added early on in the study. A single user launch site was to be evaluated for a two million pound first stage thrust vehicle. Both scenarios were to be included in the report. To provide fidelity to the study criteria, a specific launch vehicle in the one million pound thrust range was chosen as a guide post or straw-man launch vehicle. The RpK K-1 vehicle is a current Commercial Orbital Transportation System (COTS), contract awardee along with the SpaceX Falcon 9 vehicle. SpaceX, at the time of writing, is planning to launch COTS and possibly other payloads from Cx-40 on Cape Canaveral Air Force Station property. RpK has yet to declare a specific launch site as their east coast US launch location. As such it was deemed appropriate that RpK's vehicle requirements be used as conceptual criteria. For the purposes of this study those criteria were marginally generalized to make them less specifiC.

Phillips, Lynne V.↗