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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 739 records · Page 41
All sourcesNASA NTRSDOE OSTI
DOE OSTI2014

Crystal Structure of Menin Reveals Binding Site for Mixed Lineage Leukemia (MLL) Protein

Menin is a tumor suppressor protein that is encoded by the MEN1 (multiple endocrine neoplasia 1) gene and controls cell growth in endocrine tissues. Importantly, menin also serves as a critical oncogenic cofactor of MLL (mixed lineage leukemia) fusion proteins in acute leukemias. Direct association of menin with MLL fusion proteins is required for MLL fusion protein-mediated leukemogenesis in vivo, and this interaction has been validated as a new potential therapeutic target for development of novel anti-leukemia agents. Here, we report the first crystal structure of menin homolog from Nematostella vectensis. Due to a very high sequence similarity, the Nematostella menin is a close homolog of human menin, and these two proteins likely have very similar structures. Menin is predominantly an {alpha}-helical protein with the protein core comprising three tetratricopeptide motifs that are flanked by two {alpha}-helical bundles and covered by a {beta}-sheet motif. A very interesting feature of menin structure is the presence of a large central cavity that is highly conserved between Nematostella and human menin. By employing site-directed mutagenesis, we have demonstrated that this cavity constitutes the binding site for MLL. Our data provide a structural basis for understanding the role of menin as a tumor suppressor protein and as an oncogenic co-factor of MLL fusion proteins. It also provides essential structural information for development of inhibitors targeting the menin-MLL interaction as a novel therapeutic strategy in MLL-related leukemias.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2012

PRECISE INFRARED RADIAL VELOCITIES FROM KECK/NIRSPEC AND THE SEARCH FOR YOUNG PLANETS

We present a high-precision infrared radial velocity (RV) study of late-type stars using spectra obtained with NIRSPEC at the W. M. Keck Observatory. RV precisions of 50 m s{sup -1} are achieved for old field mid-M dwarfs using telluric features for wavelength calibration. Using this technique, 20 young stars in the {beta} Pic (age {approx} 12 Myr) and TW Hya (age {approx} 8 Myr) Associations were monitored over several years to search for low-mass companions; we also included the chromospherically active field star GJ 873 (EV Lac) in this survey. Based on comparisons with previous optical observations of these young active stars, RV measurements at infrared wavelengths mitigate the RV noise caused by star spots by a factor of {approx}3. Nevertheless, star spot noise is still the dominant source of measurement error for young stars at 2.3 {mu}m, and limits the precision to {approx}77 m s{sup -1} for the slowest rotating stars (v sin i < 6 km s{sup -1}), increasing to {approx}168 m s{sup -1} for rapidly rotating stars (v sin i > 12 km s{sup -1}). The observations reveal both GJ 3305 and TWA 23 to be single-lined spectroscopic binaries; in the case of GJ 3305, the motion is likely caused by its 0.''09 companion, identified after this survey began. The large amplitude, short-timescale variations of TWA 13A are indicative of a hot Jupiter-like companion, but the available data are insufficient to confirm this. We label it as a candidate RV variable. For the remainder of the sample, these observations exclude the presence of any 'hot' (P < 3 days) companions more massive than 8 M{sub Jup} and any 'warm' (P < 30 days) companions more massive than 17 M{sub Jup}, on average. Assuming an edge-on orbit for the edge-on disk system AU Mic, these observations exclude the presence of any hot Jupiters more massive than 1.8 M{sub Jup} or warm Jupiters more massive than 3.9 M{sub Jup}.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2024

Improved Statistical Analysis for the Neutrinoless Double-Beta Decay Matrix Element of 136Xe

Neutrinoless double beta decay nuclear matrix element (M0ν) for 136Xe was recently analyzed using a statistical approach (Phys. Rev. C 107, 045501 (2023)). In the analysis, three initial shell model effective Hamiltonians were randomly altered, and their results for 23 measured observables were used to infer credibility for the M0ν nuclear matrix element (NME) based on a Bayesian Model Averaging approach. In that analysis, a reasonable Gamow-Teller quenching factor of 0.7 was assumed for each starting effective Hamiltonian. Given that the result of the statistical analysis was sensible to this choice, we are here improving that analysis by assuming that the Gamow-Teller quenching factor is also randomly chosen within reasonabe limits for all three starting Hamiltonians. The outcomes are slightly higher expectation values and uncertainties for the M0ν NME.

Astronomy & Astrophysics↗
NASA NTRS1990

Thermal relics: Do we know their abundances

The relic abundance of a particle species that was once in thermal equilibrium in the expanding Universe depends upon a competition between the annihilation rate of the species and the expansion rate of the Universe. Assuming that the Universe is radiation dominated at early times the relic abundance is easy to compute and well known. At times earlier than about 1 sec after the bang there is little or no evidence that the Universe had to be radiation dominated, although that is the simplest and standard assumption. Because early-Universe relics are of such importance both to particle physics and to cosmology, three nonstandard possibilities are considered in detail for the Universe at the time a species' abundance froze in: energy density dominated by shear (i.e., anisotropic expansion), energy density dominated by some other nonrelativistic species, and energy density dominated by the kinetic energy of the scalar field that sets the gravitational constant in a Brans-Dicke-Jordan cosmological mode. In the second case the relic abundance is less than the standard value, while in the other two cases it can be enhanced by a significant factor. Two other more exotic possibilities for enhancing the relic abundance of a species are also mentioned--a larger value of Newton's constant at early times (e.g., as might occur in superstring or Kaluza-Klein theories) or a component of the energy density at early times with a very stiff equation of state (p greater than rho/3), e.g., a scalar field phi with potential V(phi) = Beta /phi/ (exp n) with n greater than 4. Results have implications for dark matter searches and searches for particle relics in general.

Kamionkowski, Marc↗
NASA NTRS1991

Measures of large-scale structure in the CfA redshift survey slices

Variations of the counts-in-cells with cell size are used here to define two statistical measures of large-scale clustering in three 6 deg slices of the CfA redshift survey. A percolation criterion is used to estimate the filling factor which measures the fraction of the total volume in the survey occupied by the large-scale structures. For the full 18 deg slice of the CfA redshift survey, f is about 0.25 + or - 0.05. After removing groups with more than five members from two of the slices, variations of the counts in occupied cells with cell size have a power-law behavior with a slope beta about 2.2 on scales from 1-10/h Mpc. Application of both this statistic and the percolation analysis to simulations suggests that a network of two-dimensional structures is a better description of the geometry of the clustering in the CfA slices than a network of one-dimensional structures. Counts-in-cells are also used to estimate at 0.3 galaxy h-squared/Mpc the average galaxy surface density in sheets like the Great Wall.

De Lapparent, Valerie↗
DOE OSTI2025

Assessment of Thin Plastic Scintillation Detectors for Beta-Particle Measurements at the Advanced Test Reactor Critical Facility

The Fission Wire Measurement System is a custom measurement system designed in the 1960s to measure the beta-particle activity of irradiated uranium-aluminum fission wires. This measurement is conducted to determine the fission rate profile of the Advanced Reactor Test Critical facility. The Advanced Test Reactor Critical facility is an open-pool, low-power test reactor used to qualify experiment configurations and verify core models prior to full-power experiment irradiations in the Advanced Test Reactor. Power distribution measurements in ATR-C use uranium-aluminum wires that are distributed throughout the core to validate simulation and modeling results. These measurements require from 340 to 1500 wires to be irradiated and measured within a 12-hour window. The system consists of 4 measurement channels and one reference channel, each with a 2-pi proportional gas flow detector and the measurement channels each have an automated sample changer. The gas flow detectors are of a custom design for this detector system that use methane gas with a large anode wire compared to modern proportional counters. These detectors, which are nearly 60 years old are irreplaceable. The measurements from these gas detectors are affected by the gas flow rate, atmospheric and line pressure, and are very sensitive to the applied high voltage. Recent improvements have been made to the control and data acquisition system, but the detectors have remained the same. The nature of the measurement of the fission product decay activity is such that the energy spectrum of the signal is changing with time. Thin, 250-um thick, plastic scintillators were commercially obtained as a potential replacement for the gas flow detectors. The original calibration of the uranium-aluminum fission wires was conducted in 1965 using a series of irradiations of gold foils and the wires in a well-characterized thermal neutron field. These measurements provided a time-dependent fission rate conversion factor from the gold foil data to calibrate the fission wires based on the response from the 2-pi proportional gas detectors. Transitioning to the new detectors requires qualification and testing. The sensitivity of the scintillators to changes in the energy spectrum of the fission wires and translation of the calibration factor have been completed. These measurements indicated that the sensitivity of the scintillators over time changes at a different rate than the sensitivity of the gas flow detectors. However, the inverse activity of measurements of both detector types is linear with time. Initial results indicate that the scintillator detectors will be a sufficient replacement for the gas detectors with minor adjustments to the fission rate conversion factor. Replacement of the detectors will improve the fission wire measurements and provide a more stable and reliable measurement system.

46 - INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AN↗
DOE OSTI2011

Sensing actin dynamics: Structural basis for G-actin-sensitive nuclear import of MAL

Highlights: {yields} MAL has a bipartite NLS that binds to Imp{alpha} in an extended conformation. {yields} Mutational analyses verified the functional significance of MAL-Imp{alpha} interactions. {yields} Induced folding and NLS-masking by G-actins inhibit nuclear import of MAL. -- Abstract: The coordination of cytoskeletal actin dynamics with gene expression reprogramming is emerging as a crucial mechanism to control diverse cellular processes, including cell migration, differentiation and neuronal circuit assembly. The actin-binding transcriptional coactivator MAL (also known as MRTF-A/MKL1/BSAC) senses G-actin concentration and transduces Rho GTPase signals to serum response factor (SRF). MAL rapidly shuttles between the cytoplasm and the nucleus in unstimulated cells but Rho-induced depletion of G-actin leads to MAL nuclear accumulation and activation of transcription of SRF:MAL-target genes. Although the molecular and structural basis of actin-regulated nucleocytoplasmic shuttling of MAL is not understood fully, it is proposed that nuclear import of MAL is mediated by importin {alpha}/{beta} heterodimer, and that G-actin competes with importin {alpha}/{beta} for the binding to MAL. Here we present structural, biochemical and cell biological evidence that MAL has a classical bipartite nuclear localization signal (NLS) in the N-terminal 'RPEL' domain containing Arg-Pro-X-X-X-Glu-Leu (RPEL) motifs. The NLS residues of MAL adopt an extended conformation and bind along the surface groove of importin-{alpha}, interacting with the major- and minor-NLS binding sites. We also present a crystal structure of wild-type MAL RPEL domain in complex with five G-actins. Comparison of the importin-{alpha}- and actin-complexes revealed that the binding of G-actins to MAL is associated with folding of NLS residues into a helical conformation that is inappropriate for importin-{alpha} recognition.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2012

Interdiffusion and Reaction between Uranium and Iron

Metallic uranium alloy fuels cladded in stainless steel are being examined for fast reactors that operate at high temperature. In this work, solid-to-solid diffusion couples were assembled between pure U and Fe, and annealed at 853K, 888K and 923K where U exists as orthorhombic {alpha}, and at 953K and 973K where U exists as tetragonal {beta}. The microstructures and concentration profiles developed during annealing were examined by scanning electron microscopy and electron probe microanalysis, respectively. U{sub 6}Fe and UFe{sub 2} intermetallics developed in all diffusion couples, and U{sub 6}Fe was observed to grow faster than UFe{sub 2}. The interdiffusion fluxes of U and Fe were calculated to determine the integrated interdiffusion coefficients in U{sub 6}Fe and UFe{sub 2}. The extrinsic (K{sub I}) and intrinsic growth constants (K{sub II}) of U{sub 6}Fe and UFe{sub 2} were also calculated according to Wagner's formalism. The difference between K{sub I} and K{sub II} of UFe{sub 2} indicate that its growth was impeded by the fast-growing U{sub 6}Fe phase. However, the thin UFe{sub 2} played only a small role on the growth of U{sub 6}Fe as its K{sub I} and K{sub II} values were determined to be similar. The allotropic transformation of uranium (orthorhombic {alpha} to tetragonal {beta} phase) was observed to influence the growth of U{sub 6}Fe directly, because the growth rate of U{sub 6}Fe changed based on variation of activation energy. The change in chemical potential and crystal structure of U due to the allotropic transformation affected the interdiffusion between U and U{sub 6}Fe. Faster growth of U{sub 6}Fe is also examined with respect to various factors including crystal structure, phase diagram, and diffusion.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2011

Charmless Hadronic B Decays at Belle and BaBar

I report on recent measurements from the Belle and BABAR collaborations on the decay of the B meson to hadronic final states without a charm quark. The study of the branching fractions and angular distributions of B meson decays to hadronic final states without a charm quark probes the dynamics of both the weak and strong interactions, and plays an important role in understanding CP Violation (CPV) in the quark sector. CP Violation at the B factories is described graphically by a triangle with sides formed from the CKM matrix elements V{sub qd}V*{sub qb} (q = u, c, t) and internal angles {alpha}, {beta} {gamma} (or {phi}{sub 2}, {phi}{sub 1}, {phi}{sub 3}). Discrepancies in the measured values of the sides and angles could be an indication of New Physics beyond the Standard Model (SM) due to enhanced branching fractions or modified CP asymmetries. The experimental measurements of branching fractions, CP asymmetries, polarization and phases (both weak and strong) can be compared to theoretical models based on, for example, QCD factorization, SU(3) symmetry and Lattice QCD.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2012

Divergent effects of 17-{beta}-estradiol on human vascular smooth muscle and endothelial cell function diminishes TNF-{alpha}-induced neointima formation

Highlights: Black-Right-Pointing-Pointer TNF-{alpha} augments neointimal hyperplasia in human saphenous vein. Black-Right-Pointing-Pointer TNF-{alpha} induces detrimental effects on endothelial and smooth muscle cell function. Black-Right-Pointing-Pointer Estradiol exerts modulatory effects on TNF-induced vascular cell functions. Black-Right-Pointing-Pointer The modulatory effects of estradiol are discriminatory and cell-type specific. -- Abstract: Coronary heart disease (CHD) is a condition characterized by increased levels of proinflammatory cytokines, including tumor necrosis factor-{alpha} (TNF-{alpha}). TNF-{alpha} can induce vascular endothelial cell (EC) and smooth muscle cell (SMC) dysfunction, central events in development of neointimal lesions. The reduced incidence of CHD in young women is believed to be due to the protective effects of estradiol (E2). We therefore investigated the effects of TNF-{alpha} on human neointima formation and SMC/EC functions and any modulatory effects of E2. Saphenous vein (SV) segments were cultured in the presence of TNF-{alpha} (10 ng/ml), E2 (2.5 nM) or both in combination. Neointimal thickening was augmented by incubation with TNF-{alpha}, an effect that was abolished by co-culture with E2. TNF-{alpha} increased SV-SMC proliferation in a concentration-dependent manner that was optimal at 10 ng/ml (1.5-fold increase), and abolished by E2 at all concentrations studied (1-50 nM). Surprisingly, E2 itself at low concentrations (1 and 5 nM) stimulated SV-SMC proliferation to a level comparable to that of TNF-{alpha} alone. SV-EC migration was significantly impaired by TNF-{alpha} (42% of control), and co-culture with E2 partially restored the ability of SV-EC to migrate and repair the wound. In contrast, TNF-{alpha} increased SV-SMC migration by 1.7-fold, an effect that was completely reversed by co-incubation with E2. Finally, TNF-{alpha} potently induced ICAM-1 and VCAM-1 expression in both SV-EC and SV-SMC. However there was no modulation by E2 in either cell-type. In conclusion, TNF-{alpha} induced SV neointima formation, increased SMC proliferation and migration, impaired SV-EC migration and increased expression of adhesion molecules. E2 exerted distinct cell-type and function-specific modulation, the mechanisms underlying which are worthy of further detailed study.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2018

Cerebrospinal fluid from Alzheimer patients affects cell-mediated nerve growth factor production and cell survival in vitro

Highlights: • Alzheimer's disease is characterized by early degeneration of cholinergic neurons and decreased levels of nerve growth factor. • Encapsulated cell bio-delivery (ECB) is a potential treatment strategy. • Neither Aβ{sub 40} nor Aβ{sub 42} had any major impact on cell viability or NGF-production. • IL-1β dose-dependently affected NGF-production over time. • Proteins involved in inflammatory pathways may have negative effect on ECB cells. Alzheimer's disease (AD) is characterized by early degeneration of cholinergic neurons and decreased levels of nerve growth factor (NGF). Thus, increasing the NGF levels by for instance encapsulated cell bio-delivery (ECB) is a potential treatment strategy. The results from our previous first-in-human studies on ECB of NGF to the basal forebrain cholinergic neurons were promising, but indicated some variability of long-term viability of the encapsulated cells and associated reduced NGF-release. Here we studied the effect of amyloid beta-peptides (Aβ), interleukin 1-beta (IL-1β), and CSF from AD, Lewy body dementia (LBD) or subjective cognitive impairment (SCI) patients on the NGF overproducing cell line NGC-0295. At physiological concentrations, neither Aβ{sub 40} nor Aβ{sub 42} had any major impact on cell viability or NGF-production. In contrast, IL-1β dose-dependently affected NGF-production over time. Exposure of NGF-producing cells to CSF from AD patients showed significantly reduced NGF-release as compared to CSF from LBD or SCI patients. By mass spectrometry we found 3 proteins involved in inflammatory pathways to have an altered expression in AD CSF compared to LBD and SCI. Cell survival and NGF-release were not affected by Aβ. NGF-release was affected by IL-1β, suggesting that inflammation has a negative effect on ECB cells.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2021

Kinetic equilibrium reconstruction and the impact on stability analysis of KSTAR plasmas

High fidelity kinetic plasma equilibrium reconstructions are an essential requirement for accurate stability and disruption prediction analyses to support continuous operation of high beta tokamak plasmas. The present kinetic equilibrium reconstructions of plasmas in the KSTAR device include plasma density and temperature profiles from Thomson scattering and ion temperature from charge exchange spectroscopy diagnostics, and allowance for fast particle pressure. In addition, up to 25 channels of motional Stark effect diagnostic data are used to constrain the magnetic field pitch angle profile in the plasma to produce a reliable computation of the safety factor, q, profile. In this work, H-mode plasmas exhibit clear pedestal characteristics in the reconstructed pressure profile compared to internal transport barrier or L-mode plasmas. The plasma configuration and vertical position of inner strike points are validated by CCD and infrared camera images. Ideal and resistive magnetohydrodynamic (MHD) stability analyses using the DCON and resistive DCON codes utilize these kinetic equilibrium reconstructions to compare to experimental plasma stability. Equilibria with sufficiently low convergence error can provide reliable computation of ideal and resistive MHD stability analysis.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
NASA NTRS1991

GLObal Backscatter Experiment (GLOBE) Pacific survey mission

NASA conducted the GLObal Backscatter Experiment (GLOBE) Survey Mission over the near coastal and remote Pacific Ocean during 6 to 30 Nov. 1989 (GLOBE 1) and 13 May to 5 Jun. 1990 (GLOBE 2). These missions studied the optical, physical, and chemical properties of atmospheric aerosols. Particular emphasis was given to the magnitude and spatial variability of aerosol backscatter coefficients at mid-infrared wavelengths, and to the remote middle and upper troposphere, where these aerosol properties are poorly understood. Survey instruments were selected to provide either direct beta measurements at the key wavelengths, empirical links with long term or global scale aerosol climatologies, or aerosol microphysics data required to model any of these quantities. The survey deployment included both long distance 6 to 8 hour transit flights and detailed 4 to 6 hour local flights. Several general features were observed from preliminary Survey data analyses. Validation and intercomparison results have shown good agreement, usually better than a factor of two. Atmospheric aerosols frequently exhibited a three layer vertical structure, with (1) high and fairly uniform backscatter in the shallow cloud capped marine boundary layer; (2) moderate and highly variable backscatter in a deeper overlaying cloud pumped layer; and (3) low, regionally uniform, but seasonally and latitudinally variable backscatter in the middle and upper troposphere. The survey missions represent two isolated snapshots of a small portion of the global aerosol system. Consequently, Survey results can best be understood by synthesizing them with the more comprehensive GLOBE data base, which is being compiled at NASA-Marshall.

Bowdle, David A.↗
NASA NTRS2003

Ionizing radiation induces heritable disruption of epithelial cell interactions

Ionizing radiation (IR) is a known human breast carcinogen. Although the mutagenic capacity of IR is widely acknowledged as the basis for its action as a carcinogen, we and others have shown that IR can also induce growth factors and extracellular matrix remodeling. As a consequence, we have proposed that an additional factor contributing to IR carcinogenesis is the potential disruption of critical constraints that are imposed by normal cell interactions. To test this hypothesis, we asked whether IR affected the ability of nonmalignant human mammary epithelial cells (HMEC) to undergo tissue-specific morphogenesis in culture by using confocal microscopy and imaging bioinformatics. We found that irradiated single HMEC gave rise to colonies exhibiting decreased localization of E-cadherin, beta-catenin, and connexin-43, proteins necessary for the establishment of polarity and communication. Severely compromised acinar organization was manifested by the majority of irradiated HMEC progeny as quantified by image analysis. Disrupted cell-cell communication, aberrant cell-extracellular matrix interactions, and loss of tissue-specific architecture observed in the daughters of irradiated HMEC are characteristic of neoplastic progression. These data point to a heritable, nonmutational mechanism whereby IR compromises cell polarity and multicellular organization.

Non-NASA Center↗
DOE OSTI2020

Cause and impact of low-frequency chirping modes in DIII-D hybrid discharges

Significant variations in MHD activity and fast-ion transport are observed in the DIIID high-beta, steady-state hybrid discharges with a mixture of Electron Cyclotron (EC) waves and Neutral Beam Injection (NBI). When Electron Cyclotron Heating (ECH) or Current Drive (ECCD) is applied, Alfven Eigenmodes (AEs) are usually suppressed and replaced by low-frequency bursting modes. The analysis of a recently compiled database of hybrid discharges suggests that the change of the fast-ion pressure especially the perpendicular pressure is the main factor responsible for the instability transition. The lower ratio of fast-ion injection speed v inj to Alfven speed v alfven and slight drop of safety factor q min during ECCD may also facilitate the transition. The database shows that AEs mainly occur when the fast-ion fraction P f /P total is less than 0.53 and v inj /v alfven is greater than 0.50, while low-frequency bursting modes appear in the opposite regime. In this research, P f and P total are the central fast-ion pressure from classical prediction and total plasma pressure, respectively. The reason why the instability transition correlates with P f /P total and v inj /v alfven is that they can significantly modify the drive of low-frequency bursting modes and AEs. The explanation is supported by the observation that low-frequency bursting modes are rarely seen in the hybrids with NBI only, with EC waves and counter-NBI, or with high plasma density. A careful check of the low-frequency bursting modes suggests that they are mainly chirping (neoclassical) tearing modes [referred to as chirping (N)TM], i.e. the mode frequency firstly jumps up from the steady (N)TM frequency, then chirps down, and finally returns to the steady (N)TM frequency. Sometimes, the (N)TMs are fully stabilized and replaced with pure fishbones. Lastly, the resonance condition calculation and ’Kick’ model simulations suggest that (N)TMs and fishbones can interact through modification of the fast ion distribution in phase space, which influences the drive.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2013

Reexamining the Beta Decay of 53,54 Ni, 52,53 Co, 51 Fe, and 50 Mn

he decay of 53,54Ni, 52,53Co, 51Fe, and 50Mn was investigated via the fragmentation of a 58Ni primary beam with an energy of 68.6 MeV/u. The proton- coincidences of 53Ni -delayed proton emission were observed. Based on the analysis of the proton- coincidence events, it was inferred that the previous assignment of the excitation energy for the isobaric analog state in 53Co may be problematic. The half-lives of these nuclei were obtained, in which the uncertainty of 52Co half-life was reduced by a factor of 3. The half-lives were evaluated and used as inputs of nucleosynthesis calculations of the rapid proton-capture process in an x-ray burst.

Su, J.↗
DOE OSTI2012

FAST MAGNETIC RECONNECTION AND PARTICLE ACCELERATION IN RELATIVISTIC LOW-DENSITY ELECTRON-POSITRON PLASMAS WITHOUT GUIDE FIELD

Magnetic reconnection and particle acceleration in relativistic Harris sheets in low-density electron-positron plasmas with no guide field have been studied by means of two-dimensional particle-in-cell simulations. Reconnection rates are of the order of one when the background density in a Harris sheet is of the order of 1% of the density in the current sheet, which is consistent with previous results in the non-relativistic regime. It has been demonstrated that the increase of the Lorentz factors of accelerated particles significantly enhances the collisionless resistivity needed to sustain a large reconnection electric field. It is shown analytically and numerically that the energy spectrum of accelerated particles near the X-line is the product of a power law and an exponential function of energy, {gamma}{sup -1/4}exp (- a{gamma}{sup 1/2}), where {gamma} is the Lorentz factor and a is a constant. However, in the low-density regime, while the most energetic particles are produced near X-lines, many more particles are energized within magnetic islands. Particles are energized in contracting islands by multiple reflection, but the mechanism is different from Fermi acceleration in magnetic islands for magnetized particles in the presence of a guide field. In magnetic islands, strong core fields are generated and plasma beta values are reduced. As a consequence, the fire-hose instability condition is not satisfied in most of the island region, and island contraction and particle acceleration can continue. In island coalescence, reconnection between two islands can accelerate some particles, however, many particles are decelerated and cooled, which is contrary to what has been discussed in the literature on particle acceleration due to reconnection in non-relativistic hydrogen plasmas.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2022

Cavity Qualification and Production Update for SNS-PPU Cryomodules at Jefferson Lab

The Proton Power Upgrade (PPU) project at Oak Ridge National Lab’s Spallation Neutron Source (SNS) currently being constructed will double the proton beam power capability from 1.4 to 2.8 MW by adding seven cryomodules, each containing four six-cell high-beta (β = 0.81) superconducting radio frequency cavities. Research Instruments, located in Germany, built and processed the cavities at the vendor site, including electropolishing as the final active chemistry step. Twenty-eight cavities for seven cryomodules and an additional four cavities for a spare cryomodules were delivered to Jefferson Lab and first qualification tests were completed on all cavities as received from the vendor. The performance largely exceeded the requirements on quality factor and accelerating gradient. Here we present the status of initial cavity qualification tests, rework on unqualified cavities and final cavity qualification with helium vessel prior to installation in cryomodules. In addition, an update on cryomodule production is presented.

Dhakal, P.↗