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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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All sourcesNASA NTRSDOE OSTI
DOE OSTI2015

Design strategies for self-assembly of discrete targets

Both biological and artificial self-assembly processes can take place by a range of different schemes, from the successive addition of identical building blocks to hierarchical sequences of intermediates, all the way to the fully addressable limit in which each component is unique. In this paper, we introduce an idealized model of cubic particles with patterned faces that allows self-assembly strategies to be compared and tested. We consider a simple octameric target, starting with the minimal requirements for successful self-assembly and comparing the benefits and limitations of more sophisticated hierarchical and addressable schemes. Simulations are performed using a hybrid dynamical Monte Carlo protocol that allows self-assembling clusters to rearrange internally while still providing Stokes-Einstein-like diffusion of aggregates of different sizes. Our simulations explicitly capture the thermodynamic, dynamic, and steric challenges typically faced by self-assembly processes, including competition between multiple partially completed structures. Self-assembly pathways are extracted from the simulation trajectories by a fully extendable scheme for identifying structural fragments, which are then assembled into history diagrams for successfully completed target structures. For the simple target, a one-component assembly scheme is most efficient and robust overall, but hierarchical and addressable strategies can have an advantage under some conditions if high yield is a priority.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2016

SU-G-IeP3-04: Effective Dose Measurements in Fast Kvp Switch Dual Energy Computed Tomography

Purpose: The objective of this study was two-fold: (a) to test a new approach to approximating organ dose by using the effective energy of the combined 80kV/140kV beam in dual-energy (DE) computed tomography (CT), and (b) to derive the effective dose (ED) in the abdomen-pelvis protocol in DECT. Methods: A commercial dual energy CT scanner was employed using a fast-kV switch abdomen/pelvis protocol alternating between 80 kV and 140 kV. MOSFET detectors were used for organ dose measurements. First, an experimental validation of the dose equivalency between MOSFET and ion chamber (as a gold standard) was performed using a CTDI phantom. Second, the ED of DECT scans was measured using MOSFET detectors and an anthropomorphic phantom. For ED calculations, an abdomen/pelvis scan was used using ICRP 103 tissue weighting factors; ED was also computed using the AAPM Dose Length Product (DLP) method and compared to the MOSFET value. Results: The effective energy was determined as 42.9 kV under the combined beam from half-value layer (HVL) measurement. ED for the dual-energy scan was calculated as 16.49 ± 0.04 mSv by the MOSFET method and 14.62 mSv by the DLP method. Conclusion: Tissue dose in the center of the CTDI body phantom was 1.71 ± 0.01 cGy (ion chamber) and 1.71 ± 0.06 (MOSFET) respectively; this validated the use of effective energy method for organ dose estimation. ED from the abdomen-pelvis scan was calculated as 16.49 ± 0.04 mSv by MOSFET and 14.62 mSv by the DLP method; this suggests that the DLP method provides a reasonable approximation to the ED.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2023

Beyond the Hype: An Evaluation of Commercially Available Machine-Learning-Based Malware Detectors

There is a lack of scientific testing of commercially available malware detectors, especially those that boast accurate classification of never-before-seen (i.e., zero-day) files using machine learning (ML). Consequently, efficacy of malware detectors is opaque, inhibiting end users from making informed decisions and researchers from targeting gaps in current detectors. In this paper, we present a scientific evaluation of four prominent commercial malware detection tools to assist an organization with two primary questions: To what extent do ML-based tools accurately classify previously and never-before-seen files? Is purchasing a network-level malware detector worth the cost? To investigate, we tested each tool against 3,536 total files (2,554 or 72% malicious, 982 or 28% benign) of a variety of file types, including hundreds of malicious zero-days, polyglots, and APT-style files, delivered on multiple protocols. We present statistical results on detection time and accuracy, consider complementary analysis (using multiple tools together), and provide two novel applications of the recent cost-benefit evaluation procedure of Iannacone & Bridges. Although the ML-based tools are more effective at detecting zero-day files and executables, the signature-based tool might still be an overall better option. Both network-based tools provide substantial (simulated) savings when paired with either host tool, yet both show poor detection rates on protocols other than HTTP or SMTP. Our results show that all four tools have near-perfect precision but alarmingly low recall, especially on file types other than executables and office files—37% of malware, including all polyglot files, were undetected. Priorities for researchers and takeaways for end users are given. Code for future use of the cost model is provided.

97 MATHEMATICS AND COMPUTING↗
DOE OSTI2023

Exploring Benchmarks for Self-Driving Labs using Color Matching

Self Driving Labs (SDLs) that combine automation of experimental procedures with autonomous decision making are gaining popularity as a means of increasing the throughput of scientific workflows. The task of identifying quantities of supplied colored pigments that match a target color, the color matching problem, provides a simple and flexible SDL test case, as it requires experiment proposal, sample creation, and sample analysis, three common components in autonomous discovery applications. We present a robotic solution to the color matching problem that allows for fully autonomous execution of a color matching protocol. Our solution leverages the WEI science factory platform to enable portability across different robotic hardware, the use of alternative optimization methods for continuous refinement, and automated publication of results for experiment tracking and post-hoc analysis.

Artificial intelligence↗
DOE OSTI2018

LCLS-II Cryomodule Production at JLAB

The LCLS-II cryomodule construction program leverages the mature XFEL cryomodule design to produce technologically sophisticated cryomodules with a minimum of R&D according to an accelerated manufacturing schedule. Jlab, as one of the partner labs, is producing 18 cryomodules for LCLS-II. To meet the quality and schedule demands of LCLS-II, many upgrades to the JLAB cryomodule assembly infrastructure and techniques have been made. JLab has installed a new cleanroom for string assembly and instituted new protocols to minimize particulate transfer into the cavities during the cryomodule construction process. JLab has also instituted a set of magnetic hygiene protocols to be used during the assembly process to minimize magnetic field impingement on the finished cavity structure. The goal has been to have gradients, both maximum and field emission onset, that do not degrade between the cavity vertical test and final cryomodule qualification, while maximizing the Q0 of each finished cavity. Results from the prototype and first production cryomodule assembly are presented.

Davis, Giles↗
DOE OSTI2015

Heat pump concepts for nZEB Technology developments, design tools and testing of heat pump systems for nZEB in the USA: Country report IEA HPT Annex 40 Task 2, Task 3 and Task 4 of the USA

The IEA HPT Annex 40 "Heat pump concepts for Nearly Zero Energy Buildings" deals with the application of heat pumps as a core component of the HVAC system for Nearly or Net Zero energy buildings (nZEB). This report covers Task 2 on the system comparison and optimisation and Task 3 dedicated to the development of adapted technologies for nZEB and field monitoring results of heat pump systems in nZEB. In the US team three institutions are involved and have worked on the following projects: The Oak Ridge National Laboratory (ORNL) will summarize development activities through the field demonstration stage for several integrated heat pump (IHP) systems electric ground-source (GS-IHP) and air-source (AS-IHP) versions and an engine driven AS-IHP version. The first commercial GS-IHP product was just introduced to the market in December 2012. This work is a contribution to Task 3 of the Annex. The University of Maryland will contribute a software development project to Task 2 of the Annex. The software ThermCom evaluates occupied space thermal comfort conditions accounting for all radiative and convective heat transfer effects as well as local air properties. The National Institute of Standards and Technology (NIST) is working on a field study effort on the NIST Net Zero Energy Residential Test Facility (NZERTF). This residential building was constructed on the NIST campus and officially opened in summer 2013. During the first year, between July 2013 and June 2014, baseline performance of the NZERTF was monitored under a simulated occupancy protocol. The house was equipped with an air-to-air heat pump which included a dedicated dehumidification operating mode. Outdoor conditions, internal loads and modes of heat pump operation were monitored. Field study results with respect to heat pump operation will be reported and recommendations on heat pump optimization for a net zero energy building will be provided. This work is a contribution to Task 3 of the Annex.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗
DOE OSTI2023

A Field Study of Nonintrusive Load Monitoring Devices and Implications for Load Disaggregation

Evaluations of nonintrusive load monitoring (NILM) algorithms and technologies have mostly occurred in constrained, artificial environments. However, few field evaluations of NILM products have taken place in actual buildings under normal operating conditions. This paper describes a field evaluation of a state-of-the-art NILM product, tested in eight homes. The match rate metric—a technique recommended by a technical advisory group—was used to measure the NILM’s success in identifying specific loads and the accuracy of the energy consumption estimates. A performance assessment protocol was also developed to address common issues with NILM mislabeling and ground-truth comparisons that have not been sufficiently addressed in past evaluations. The NILM product’s estimates were compared to the submetered consumption of eight major appliances. Overall, the product had good performance in disaggregating the energy consumption of the electric water heaters, which included both electric resistance and heat-pump water heaters, but only a fair accuracy with refrigerators, dryers, and air conditioners. The performance was poor for cooking equipment, furnace fans, clothes washers, and dishwashers. Moreover, the product was often unable to detect major loads in homes. Typically, two or more appliances were not detected in a home. At least two dryers, furnace fans, and air conditioners went undetected across the eight homes. On the other hand, the dishwasher was detected in all homes where available or monitored. The key findings were qualitatively compared to those of past field evaluations. Potential areas for improvement in NILM product performance were determined along with areas where complementary technologies may be able to aid in load-disaggregation applications.

47 OTHER INSTRUMENTATION↗
DOE OSTI2016

SU-F-T-227: A Comprehensive Patient Specific, Structure Specific, Pre-Treatment 3D QA Protocol for IMRT, SBRT and VMAT - Clinical Experience

Purpose: To present a 3D QA method and clinical results for 550 patients. Methods: Five hundred and fifty patient treatment deliveries (400 IMRT, 75 SBRT and 75 VMAT) from various treatment sites, planned on Raystation treatment planning system (TPS), were measured on three beam-matched Elekta linear accelerators using IBA’s COMPASS system. The difference between TPS computed and delivered dose was evaluated in 3D by applying three statistical parameters to each structure of interest: absolute average dose difference (AADD, 6% allowed difference), absolute dose difference greater than 6% (ADD6, 4% structure volume allowed to fail) and 3D gamma test (3%/3mm DTA, 4% structure volume allowed to fail). If the allowed value was not met for a given structure, manual review was performed. The review consisted of overlaying dose difference or gamma results with the patient CT, scrolling through the slices. For QA to pass, areas of high dose difference or gamma must be small and not on consecutive slices. For AADD to manually pass QA, the average dose difference in cGy must be less than 50cGy. The QA protocol also includes DVH analysis based on QUANTEC and TG-101 recommended dose constraints. Results: Figures 1–3 show the results for the three parameters per treatment modality. Manual review was performed on 67 deliveries (27 IMRT, 22 SBRT and 18 VMAT), for which all passed QA. Results show that statistical parameter AADD may be overly sensitive for structures receiving low dose, especially for the SBRT deliveries (Fig.1). The TPS computed and measured DVH values were in excellent agreement and with minimum difference. Conclusion: Applying DVH analysis and different statistical parameters to any structure of interest, as part of the 3D QA protocol, provides a comprehensive treatment plan evaluation. Author G. Gueorguiev discloses receiving travel and research funding from IBA for unrelated to this project work. Author B. Crawford discloses receiving travel funding from IBA for unrelated to this project work.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2019

Multicenter open-label randomized phase II study of second-line panitumumab and irinotecan with or without fluoropyrimidines in patients with KRAS wild-type metastatic colorectal cancer (PACIFIC study)

This phase II clinical trial compared the efficacy and safety of second-line irinotecan and panitumumab treatment (IRI + Pmab) with that of irinotecan, fluoropyrimidines and panitumumab treatment (control) in patients with KRAS wild-type mCRC. The primary endpoint was progression-free survival. In addition, early predictive markers of treatment efficacy were explored. Eighty patients were planned to be recruited. Due to a slow accrual rate, only 48 patients were recruited from 2012 to 2016, of which 23 were allocated to the control group and 25 were allocated to the IRI + Pmab group. The median progression-free survival was 254 days (95% confidence interval, 159–306) for control, and 190 days (95% confidence interval, 159–213) for IRI + Pmab (log-rank test, P = 0.26). The response rate without confirmation was 21.7% (5/23) for control and 40.0% (10/25) for IRI + Pmab. Neutropenia, leukopenia, and anorexia were the most common Grade 3/4 adverse events, and several early drop-outs from the treatment protocol were observed in the control group. As for the biomarkers, carcinoembryonic antigen and lactate dehydrogenase (LDH) smoothly declined immediately after the initial dosing in patients with a partial response or stable disease. After starting treatment, LDH-1 and − 2 increased, while LDH-4 and − 5 decreased, irrespective of tumor response. However, exceptions were frequent. In conclusion, this study failed to prove the safety and efficacy of irinotecan and panitumumab treatment due to insufficient patient accrual. Although LDH and its isozymes changed after initiation of treatment, their ability to predict the tumor response may not surpass that of carcinoembryonic antigen levels. The University Hospital Medical Information Network Clinical Trial Registry: UMIN000007658.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2016

Poster - 56: Preliminary comparison of FF- and FFF-VMAT for prostate plans with higher rectal dose

Purpose: A recent retrospective study found 53 patients previously treated to 78Gy/39 using flattened filtered (FF) 6X-VMAT at GRRCC had rectal DVH more than one standard deviation higher than the average. This study was to investigate if using 6FFFor10FFF beams could reduce these DVHs without compromising target coverage. Methods: Twenty patients’ plans were re-planed with 2-arc 6X-VMAT, 6FFF-VMAT and 10FFF-VMAT using the Eclipse TPS following departmental protocol. All plans had the same optimization and normalization, and were evaluated against the acceptance criteria from the QUANTEC and Emami. Statistical differences in the mean dose to OARs (D{sub m}) and PTV homogeneity index (HI) between energies were tested using the paired sample Wilcoxon signed rank statistical method (p<0.05). Beam delivery accuracy was checked on five patients using portal dosimetry (PD). Results: The PTV HI for the 10FFF shows no statistical difference from the 6X. All the OARs, except left femoral head with 6FFF, have significantly lower Dm using 6FFF and 10FFF .There is no difference in the maximum doses to rectum and bladder and are limited by the prescribed doses. Measurements show good agreements in the gamma evaluation (3%/3mm) for all energies. Conclusion: This preliminary study shows that doses to the OARs are reduced using 10FFF for the same target coverage. The plans using 6FFF result in lower doses to some OARs, and statistically different PTV HI. All plans showed very good agreement with measurements.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2017

EXPRESS: Accurate Measurement of the Optical Constants n and k for a Series of 57 Inorganic and Organic Liquids for Optical Modeling and Detection

For optical modeling and other purposes, we have created a library of 57 liquids for which we have measured the complex optical constants n and k. These liquids vary in their nature, ranging in properties including chemical structure, optical band strength, volatility and viscosity. By obtaining the optical constants one can in principle model most optical phenomena in media and at interfaces including reflection, refraction and dispersion. Based on the original methods of J.E. Bertie et al.1 [1Bert1], we have developed improved protocols using multiple path lengths to determine the optical constants n/k for dozens of liquids, including inorganic, organic and organophosphorus compounds. Detailed descriptions of the measurement and data reduction protocols are discussed; agreement of the derived optical constant n and k values with literature values are presented. We also present results using the n/k values as applied to an optical modeling scenario whereby the derived data are presented and tested for models of 1 µm and 100 µm layers for DMMP (dimethyl methyl phosphonate) on both metal (aluminum) and dielectric (soda lime glass) substrates to show substantial differences between the reflected signal from highly reflective substrates and less-reflective substrates.

infrared↗
DOE OSTI2022

Cell-free Scaled Production and Adjuvant Addition to a Recombinant Major Outer Membrane Protein from Chlamydia muridarum for Vaccine Development

Subunit vaccines offer advantages over more traditional inactivated or attenuated whole-cell-derived vaccines in safety, stability, and standard manufacturing. To achieve an effective protein-based subunit vaccine, the protein antigen often needs to adopt a native-like conformation. This is particularly important for pathogensurface antigens that are membrane-bound proteins. Cell-free methods have been successfully used to produce correctly folded functional membrane protein through the co-translation of nanolipoprotein particles (NLPs), commonly known as nanodiscs. This strategy can be used to produce subunit vaccines consisting of membrane proteins in a lipid-bound environment. However, cell-free protein production is often limited to small scale (<1 mL). The amount of protein produced in small-scale production runs is usually sufficient for biochemical and biophysical studies. However, the cell-free process needs to be scaled up, optimized, and carefully tested to obtain enough protein for vaccine studies in animal models. Other processes involved in vaccine production, such as purification, adjuvant addition, and lyophilization, need to be optimized in parallel. This paper reports the development of a scaled-up protocol to express, purify, and formulate a membrane-bound protein subunit vaccine

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2019

R and DE Robotic Sensor Intern Team: Sensor Suite Mock Up Testing

Assess sensor suite performance: - Mounted on crawler typical to what would be used in tunnel; - In test bed simulating the tunnel environment. The SuperDroid fiber tethered LT-F crawler is a general-purpose surveillance robot that our team has refurbished as a testing platform for the sensor suite. This crawler was selected because its dimensions are similar to the actual crawler that will be deployed in the field. Crawler preparation included: - Communicating with vendor to resolve software and platform issues; - Configuring a laptop with the crawler control software; - Reconfiguration of communication protocol between computer and crawler; - Resolution of control board checksum errors; - Installation of a mounting fixture on the base; - In progress: addition of lighting needed for total darkness. A solution for hosting the selected sensors onto a single unit that could function standalone or be mounted on the crawler was needed. Sensor mount requirements included: - Host Lidar, panospheric cameras and IMU sensors; - Cable management for rotating Lidar; - House on-board crawler computer; - Method for affixing to crawler; - Robust and vibration proof. The Lidar sensor required a sturdy mount that ensured the axis of rotation be centered with the LiDAR's desired laser path and included a slender profile in order to not block the scanning FOV. The mounting plate holds two 180-degree cameras on either side and the servo on the center. The servo mount is located so the axis of rotation is in the center of the plate. The mount features a set of guides that hold the wires and ensure they wrap around the spool area properly. The sensor box design features thick walls for added strength, holes for mounting the sensor suite to the crawler, notches on the bottom for the different components and holes for cable routing and management. The sensor mounts were designed using CREO and printed in the R and DE Additive Manufacturing Lab. To test the performance of the sensor suite for our application it was desired to design and build a test bed simulating the H-Canyon tunnel environment. Requirements included: - Dimensions similar to the tunnel; - Wall surfaces simulating the eroded tunnel walls; - Complete darkness; - Even and uneven crawler path; - Ability to change the tunnel width to simulate erosion. The HCAEX tunnel changes in height and includes several bends ranging from approximately 30 to 80 degrees, for that reason a test bed capable of easily being changed was needed. The final design includes two sections that can be connected to provide a 16' tunnel or placed at an angle to create a tunnel bend. The test bed features caster wheels for easy movement and has a sliding inner wall that enables tunnel width to be controlled. In order to simulate the tunnel walls without adding a lot of weight to the test bed, sheets of faux stone are to be used on the inner walls. To create a completely dark tunnel, 100% black-out film will be draped over the tunnel structure. Carpet remnants in the lab will enable folds to be introduced in the floor to generate uneven surface data.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2016

Poster - 44: Development and implementation of a comprehensive end-to-end testing methodology for linac-based frameless SRS QA using a modified commercial stereotactic anthropomorphic phantom

Purpose: An end-to-end testing methodology was designed to evaluate the overall SRS treatment fidelity, incorporating all steps in the linac-based frameless radiosurgery treatment delivery process. The study details our commissioning experience of the Steev (CIRS, Norfolk, VA) stereotactic anthropomorphic head phantom including modification, test design, and baseline measurements. Methods: Repeated MR and CT scans were performed with interchanging inserts. MR-CT fusion accuracy was evaluated and the insert spatial coincidence was verified on CT. Five non-coplanar arcs delivered a prescription dose to a 15 mm spherical CTV with 2 mm PTV margin. Following setup, CBCT-based shifts were applied as per protocol. Sequential measurements were performed by interchanging inserts without disturbing the setup. Spatial and dosimetric accuracy was assessed by a combination of CBCT hidden target, radiochromic film, and ion chamber measurements. To facilitate film registration, the film insert was modified in-house by etching marks. Results: MR fusion error and insert spatial coincidences were within 0.3 mm. Both CBCT and film measurements showed spatial displacements of 1.0 mm in similar directions. Both coronal and sagittal films reported 2.3 % higher target dose relative to the treatment plan. The corrected ion chamber measurement was similarly greater by 1.0 %. The 3 %/2 mm gamma pass rate was 99% for both films Conclusions: A comprehensive end-to-end testing methodology was implemented for our SRS QA program. The Steev phantom enabled realistic evaluation of the entire treatment process. Overall spatial and dosimetric accuracy of the delivery were 1 mm and 3 % respectively.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2018

National Renewable Energy Laboratory (NREL) Topic 2 Final Report: End-to-End Communication and Control System to Support Clean Energy Technologies

This document is the final report of a two-year development, test, and demonstration project, 'Cohesive Application of Standards- Based Connected Devices to Enable Clean Energy Technologies.' The project was part of the National Renewable Energy Laboratory's (NREL's) Integrated Network Testbed for Energy Grid Research and Technology (INTEGRATE) initiative hosted at Energy Systems Integration Facility (ESIF). This project demonstrated techniques to control distribution grid events using the coordination of traditional distribution grid devices and high-penetration renewable resources and demand response. Using standard communication protocols and semantic standards, the project examined the use cases of high/low distribution voltage, requests for volt-ampere-reactive (VAR) power support, and transactive energy strategies using Volttron. Open source software, written by EPRI to control distributed energy resources (DER) and demand response (DR), was used by an advanced distribution management system (ADMS) to abstract the resources reporting to a collection of capabilities rather than needing to know specific resource types. This architecture allows for scaling both horizontally and vertically. Several new technologies were developed and tested. Messages from the ADMS based on the common information model (CIM) were developed to control the DER and DR management systems. The OpenADR standard was used to help manage grid events by turning loads off and on. Volttron technology was used to simulate a homeowner choosing the price at which to enter the demand response market. Finally, the ADMS used newly developed algorithms to coordinate these resources with a capacitor bank and voltage regulator to respond to grid events.

24 POWER TRANSMISSION AND DISTRIBUTION↗
DOE OSTI2020

A 20 Gbps Data Transmitting ASIC with PAM4 for Particle Physics Experiments

We present the design principle and test results of a data transmitting ASIC, GBS20, for particle physics experiments. The goal of GBS20 will be an ASIC that employs two serializers each from the 10.24 Gbps lpGBT SerDes, sharing the PLL also from lpGBT. A PAM4 encoder plus a VCSEL driver will be implemented in the same die to use the same clock system, eliminating the need of CDRs in the PAM4 encoder. This way the transmitter module, GBT20, developed using the GBS20 ASIC, will have the exact lpGBT data interface and transmission protocol, with an output up to 20.48 Gbps over one fiber. With PAM4 embedded FPGAs at the receiving end, GBT20 will halve the fibers needed in a system and better use the input bandwidth of the FPGA. A prototype, GBS20v0 is fabricated using a commercial 65 nm CMOS technology. This prototype has two serializers and a PAM4 encoder sharing the lpGBT PLL, but no user data input. An internal PRBS generator provides data to the serializers. GBS20v0 is tested barely up to 20.48 Gbps. With lessons learned from this prototype, we are designing the second prototype, GBS20v1, that will have 16 user data input channels each at 1.28 Gbps. We present the design concept of the GBS20 ASIC and the GBT20 module, the preliminary test results, and lessons learned from GBS20v0 and the design of GBS20v1 which will be not only a test chip but also a user chip with 16 input data channels.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2015

Hybrid detection of lung nodules on CT scan images

Purpose: The diversity of lung nodules poses difficulty for the current computer-aided diagnostic (CAD) schemes for lung nodule detection on computed tomography (CT) scan images, especially in large-scale CT screening studies. We proposed a novel CAD scheme based on a hybrid method to address the challenges of detection in diverse lung nodules. Methods: The hybrid method proposed in this paper integrates several existing and widely used algorithms in the field of nodule detection, including morphological operation, dot-enhancement based on Hessian matrix, fuzzy connectedness segmentation, local density maximum algorithm, geodesic distance map, and regression tree classification. All of the adopted algorithms were organized into tree structures with multi-nodes. Each node in the tree structure aimed to deal with one type of lung nodule. Results: The method has been evaluated on 294 CT scans from the Lung Image Database Consortium (LIDC) dataset. The CT scans were randomly divided into two independent subsets: a training set (196 scans) and a test set (98 scans). In total, the 294 CT scans contained 631 lung nodules, which were annotated by at least two radiologists participating in the LIDC project. The sensitivity and false positive per scan for the training set were 87% and 2.61%. The sensitivity and false positive per scan for the testing set were 85.2% and 3.13%. Conclusions: The proposed hybrid method yielded high performance on the evaluation dataset and exhibits advantages over existing CAD schemes. We believe that the present method would be useful for a wide variety of CT imaging protocols used in both routine diagnosis and screening studies.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2018

Modeling Large-Scale Slim Fly Networks Using Parallel Discrete-Event Simulation

As supercomputers approach exascale performance, the increased number of processors translates to an increased demand on the underlying network interconnect. We present that the slim fly network topology, a new low-diameter, low-latency, and low-cost interconnection network, is gaining interest as one possible solution for next-generation supercomputing interconnect systems. In this article, we present a high-fidelity slim fly packet-level model leveraging the Rensselaer Optimistic Simulation System (ROSS) and Co-Design of Exascale Storage (CODES) frameworks. We validate the model with published work before scaling the network size up to an unprecedented 1 million compute nodes and confirming that the slim fly observes peak network throughput at extreme scale. In addition to synthetic workloads, we evaluate large-scale slim fly models with real communication workloads from applications in the Design Forward program with over 110,000 MPI processes. We show strong scaling of the slim fly model on an Intel cluster achieving a peak network packet transfer rate of 2.3 million packets per second and processing over 7 billion discrete events using 128 MPI tasks. Enabled by the strong performance capabilities of the model, we perform a detailed application trace and routing protocol performance study. Lastly, through analysis of metrics such as packet latency, hop count, and congestion, we find that the slim fly network is able to leverage simple minimal routing and achieve the same performance as more complex adaptive routing for tested DOE benchmark applications.

97 MATHEMATICS AND COMPUTING↗