Soft X-Ray Tomography Reveals Gradual Chromatin Compaction and Reorganization during Neurogenesis In Vivo
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A specially designed hemispherical deflector analyzer (HDA) with 5-element input lens having a movable entry position R{sub 0} suitable for electron energy analysis in atomic collisions was constructed and tested. The energy resolution of the HDA was experimentally determined for three different entry positions R{sub 0}= 84, 100, 112 mm as a function of the nominal entry potential V(R{sub 0}) under pre-retardation conditions. The resolution for the (conventional) entry at the mean radius R{sub 0}= 100 mm was found to be a factor of 1.6-2 times worse than the resolution for the two (paracentric) positions R{sub 0}= 84 and 112 mm at particular values of V(R{sub 0}). These results provide the first experimental verification and a proof of principle of the utility of such a paracentric HDA, while demonstrating its advantages over the conventional HDA: greater dispersion with reduced angular aberrations resulting in better energy resolution without the use of any additional fringing field correction electrodes. Supporting simulations of the entire lens plus HDA spectrometer are also provided and mostly found to be within 20%-30% of experimental values. The paracentric HDA is expected to provide a lower cost and/or more compact alternative to the conventional HDA particularly useful in modern applications utilizing a position sensitive detector.
Liquid Air Combined Cycle (LACC) is a hybrid liquid air energy storage (LAES) system combining energy storage with a combustion turbine to enable large-scale, long-duration energy storage (LDES) while reducing fuel intensity compared to the current state-of-the-art. The LACC technical approach employs proven equipment (cryogenic refrigeration, storage, tanks, pumps, gas turbines, exhaust heat recovery equipment, and turbines) to limit technical risk to a novel organic Rankine cycle (ORC), which was evaluated during this project and found to be feasible. Moreover, LACC storage is safe and relatively compact, to facilitate siting close to loads and within metropolitan regions. The air storage medium is freely available and eliminates supply chain constraints. LACC uses cryogenic air as a storage medium and a gas turbine as the source of heat to drive the discharge process. LACC is distinguished from other LAES technologies by several factors. The charge and discharge processes are decoupled so that cryogenic liquid air is the only storage medium. Other systems also store the higher temperature thermal energy from the liquefaction process in an additional medium. Subsequently, LACC focuses on maximization of the discharge energy and power. LACC also permits the use of commercially available cryogenic refrigeration and storage technologies to increase competition. This project identified product requirements to support market entry and commercialization of the LACC in modular units of approximately 117 MW, each drawing liquid air from customary cryogenic storage tanks capable of storing 75 GWh of dispatchable energy, more than pumped storage hydro or compressed air energy storage technologies. An economic analysis identified the specific liquid air consumption (quantity of liquid air per unit of discharge energy) as a critical parameter. Minimizing the air consumption reduces the specific capital cost ($\$ $/kW) for charging and discharging equipment by reducing the size of piping and turbomachinery. Likewise, the specific cost of energy capacity ($\$ $/kWh) is reduced by increasing the energy deliverable from a given size tank. The cycle was analyzed to identify the optimal equipment selection and operating conditions, which in turn were combined with quotes and cost estimates to calculate the cost of energy from an LACC system. A substantial effort was focused on the ORC, which draws low-temperature heat from the gas turbine exhaust and condenses at low temperature using the cryogenic liquid air as a heat sink. Alternative turbomachinery arrangements were evaluated for feasibility and cost. A technology maturation plan lays out a low-risk approach to development of the novel ORC components and demonstration of LACC technology at pilot scale.
The 2017 Electrical and Electronics Technical Team Roadmap [1] proposes aggressive research and development targets aimed at improving power electronics technology to enable the mass-market penetration of electric-drive vehicles. Achieving these aggressive targets will require a decrease in cost (year 2025 cost target: $2.70/kW) and an increase in power density (year 2025 power density target: 100 kW/L) as compared with current on-road technology. Replacing traditional silicon device-based components with more efficient and higher-temperature wide-bandgap (WBG) semiconductor device-based components will enable increased power density. However, meeting the power density target will also require innovative thermal management solutions to increase the heat fluxes dissipated and allow for compact electronics packaging.
The 2017 Electrical and Electronics Technical Team Roadmap [11] proposes aggressive research and development targets aimed at improving power electronics technology to enable the mass-market penetration of electric-drive vehicles. Achieving these aggressive targets will require a decrease in cost (year 2025 cost target: $2.70/kW) and an increase in power density (year 2025 power density target: 100 kW/L) as compared with current on-road technology. Replacing traditional silicon device-based components with more efficient and higher-temperature wide-bandgap (WBG) semiconductor device-based components will enable increased power density. However, meeting the power density target will also require innovative thermal management solutions to increase the heat fluxes dissipated and allow for compact electronics packaging. This project evaluates, designs, and develops thermal management strategies that use dielectric fluid (single-phase heat transfer) as coolants.
International Linear Collider (ILC), a proposed linear electron-positron collider, plans to utilize crab cavities to enhance its luminosity. By introducing a transverse kick to the beams, the crab cavities (CC) rotate the beam bunches, allowing for increased overlap at the interaction points. High intensity of the beam current and limited transverse space along the beam pipe near the interaction point resulted in choosing superconducting technology for the ILC/CC. We present a scalable design of a superconducting Quasi-waveguide Multicell Resonator (QMiR) seamlessly connected with a beam vacuum chamber. The cavity is completely open at both ends, which avoids complex HOM couplers, and thus simplifies the mechanical design of the cavity.
Staged Pressurized Oxy-Combustion (SPOC) is a low-carbon coal combustion power technology being developed by Washington University in St. Louis (WUSTL). Oxy-combustion plants enable straightforward capture of carbon dioxide (CO 2 ) by removing most of the nitrogen in the combustion air prior to use, thereby burning fuel in near-pure oxygen instead of air, producing a flue gas containing primarily CO 2 and water. CO 2 capture at amounts > 90% is possible, often using cryogenic air separation. Oxy-combustion typically relies on flue gas recycle (FGR) to reduce the peak temperature and radiation that would otherwise occur in a fuel/oxygen only flame. SPOC reduces the peak temperatures of combustion by utilizing two or more pressurized boiler modules connected in series to produce fuel staging; hence, only a portion of the fuel is combusted in any given furnace module. This means that the thermal energy released at each stage can be captured and removed from the gases prior to subsequent stages, when more fuel is introduced. This allows the SPOC process to operate with minimal FGR, avoiding the associated efficiency losses and additional costs. Also, the process operates at an elevated gas-side pressure, reducing boiler size, enhancing heat transfer to achieve a compact boiler configuration as compared to an atmospheric-pressure boiler design, and allowing for recovery of the latent heat of the water from the flue gas at a temperature useful to the steam cycle. The resultant net efficiency of the system is over 3 percentage points greater than traditional atmospheric-pressure oxy-combustion, and 7 percentage points greater than the post combustion variant, representing a step-change improvement over first-generation capture technologies. To further develop the concept, WUSTL and the Electric Power Research Institute, Inc., organized a project with American Air Liquide, Inc., Doosan Babcock Limited, and the U.S. Department of Energy to investigate a practicable and workable boiler design. The team has identified the potential for enhanced process flexibility for controlling power generation over a wider load range than is normally available to conventional coal-fired power plants due to the staged nature of the heat release. With increasing intermittent renewable generator contribution, on-demand generators need to be highly flexible to participate in the future energy market, requiring extensive operation at reduced load. Conventional coal-fired steam generators typically face challenges in maintaining temperature control of the reheat steam and main steam at reduced loads. This results in inefficient operation, both in terms of the boiler efficiency and steam turbine heat rate. The results of this project show the SPOC process is capable of exceptional turndown, both on a stage basis and with the ability to bypass entire stages. Oxygen-supply flexibility was also investigated, as this is also a key consideration for the overall flexibility of the SPOC process given the operating constraints of conventional air separation units. A boiler design concept assessment was conducted and was focused on delivering compact and constructible design. The assessment checked appropriate tube operating metal temperatures at full load and at lower operating loads, balanced against the needs of efficient coal combustion, and the resultant slagging and ash environments. Combustion testing in the 100-kWth pressurized combustion test rig at WUSTL was carried out to validate the combustion, heat flux profiles and burnout at multiple loads. Combustion parameters investigated were flame stability, fuel burnout, ash composition, radiative heat flux, and temperature profiles. The results of these tests formed the basis of a full-scale boiler design that will encompass improvements in both efficiency and flexibility over conventional oxy-combustion processes. The air separation unit flexibility was investigated, and associated cost implications were addressed. Detailed economic assessment results for a 550 MWe net power block are also provided, allowing for a comparison against the baseline NETL oxy-combustion and post combustion capture cases.
Ultrawide-band-gap (UWBG) semiconductors are promising for fast, compact, and energy-efficient power-electronics devices. Their wider band gaps result in higher breakdown electric fields that enable high-power switching with a lower energy loss. Yet, the leading UWBG semiconductors suffer from intrinsic materials' limitations with regard to their doping asymmetry that impedes their adoption in CMOS technology. Improvements in the ambipolar doping of UWBG materials will enable a wider range of applications in power electronics as well as deep-UV optoelectronics. These advances can be accomplished through theoretical insights on the limitations of current UWBG materials coupled with the computational prediction and experimental demonstration of alternative UWBG semiconductor materials with improved doping and transport properties. As an example, we discuss the case of rutile GeO2 (r-GeO 2 ), a water-insoluble GeO 2 polytype, which is theoretically predicted to combine an ultra-wide gap with ambipolar dopability, high carrier mobilities, and a higher thermal conductivity than β-Ga 2 O 3 . The subsequent realization of single-crystalline r-GeO 2 thin films by molecular beam epitaxy provides the opportunity to realize r-GeO 2 for electronic applications. Future efforts toward the predictive discovery and design of new UWBG semiconductors include advances in first-principles theory and high-performance computing software, as well as the demonstration of controlled doping in high-quality thin films with lower dislocation densities and optimized film properties.
Microalgae cultivation is a promising technology for carbon sequestration and wastewater remediation. It is economically and logistically critical to find viable applications for the large quantities of produced biomass. In current research, a structural material is developed by using nearly 100% Chlorella sorokiniana. The otherwise non-cohesive microalgae cells are first surface-activated and then compacted under a relatively high pressure. The resulting material is a dense solid, stronger than typical steel-reinforced concrete in flexural tests. The processing procedure is simple and fast, and the setup is scalable. This technique may be useful for next-generation green construction and provide a use-case for sustainable microalgae biomass.
Single photon sources (SPS) are quantum light sources where photons are emitted one at a time instead of randomly (e.g. lasers) or in a bunch (e.g. thermal) that can significantly impact quantum information science (computing and secure communications) and quantum metrology. Some highly desirable features of SPS are low second order correlation (g 2 ),controllable emission, electrically injected room temperature operation with high photon rate, high extraction efficiency and controllable directionality. Approaches taken thus far using different material systems have only addressed a subset of these features. III-nitride based approach offers a clear pathway to deterministic, room temperature (R.T.), electrically injected practical SPS as one can potentially also leverage the knowledge and technology from the light emitting diode (LED) world. Here we will describe a hybrid approach wherein a TiO2 based photonic crystal (PC) cavity is fabricated around an InGaN quantum dot (QD) embedded nanoscale post deterministically placed inside a photonic crystal cavity. This project takes the initial steps necessary to achieve a practical, compact SPS. We have used finite difference time domain simulations to optimize the cavity design to achieve high quality factor, mode overlap with QD and high extraction. We have fabricated InGaN quantum dots using a top-down approach involving dry etch and photoelectrochemical etch followed by electron beam lithography based nanofabrication of photonic crystal cavities.
GTI Energy and Air Liquide Advanced Separations (ALaS) have been developing a novel hollow fiber membrane contactor (HFMC) technology for post-combustion CO 2 capture. The process combines advantageous features of both absorption and membrane-based separation processes to separate CO 2 from flue gas cost-effectively. The key component of the HFMC technology is the super-hydrophobic, porous hollow fiber, which is made from polyether ether ketone (PEEK). Compared to conventional absorption/desorption technologies, the critical advantage of the HFMC process is the high contact surface area provided by the hollow fibers enabling an increased volumetric mass-transfer rate. In the PEEK HFMC process, the specific surface area has been increased by an order of magnitude over structurally packed or trayed columns, resulting in compact systems with small footprints.
Fermilab is developing a compact superconducting (CSRF) accelerator as a source of a high-power, high-energy electron beam to produce an x-ray beam comparable to $\geq$ 2 MCi of cobalt-60. As part of this development, we are presently assembling a 20 kW, 1.6 MeV prototype that incorporates the four enabling technologies described below. These technologies support a heat budget that is within the capacity of commercially available cryocoolers and eliminate the need for liquid cryogens. The use of superconducting technologies promises efficiencies, wall-plug to beam, of 80% or greater. A summary of the design and progress to date will be given. In addition, we will present a review of developments within the medical device sterilization industry that are motivating the development of this technology.
A cleaning method using a laser ablation technology is widely used in various industries such as automobile, aviation, and semiconductor industries. Recently, applying this technology to decontamination works has been receiving attention as a useful and effective decontamination method. The laser decontamination method allows for decreasing a generation of secondary radioactive waste because materials like abrasive and water are not required. This is one of big advantages in use for decontamination works. Additionally, the system is compact and requires less than 100 W electric power. These features provide a low running cost. Remote operation obviously plays an important role in terms of a dose reduction in highly-radioactive and contaminated environment. The laser decontamination method is also suitable for remote works using manipulators as the laser head is light and compact, and a reaction force during operation is small, compared to the other types of decontamination tools. This paper provides an outline and a capability of the remote laser decontamination system developed by IHI Corporation (IHI) with some results of component tests for this system. (authors)
The scaling of reaction yields in light ion fusion to low reaction energies is important for our understanding of stellar fuel chains and the development of future energy technologies. Experiments become progressively more challenging at lower reaction energies due to the exponential drop of fusion cross sections below the Coulomb barrier. We report on experiments where deuterium-deuterium (D-D) fusion reactions are studied in a pulsed plasma in the glow discharge regime using a benchtop apparatus. We model plasma conditions using particle-in-cell codes. Advantages of this approach are relatively high peak ion currents and current densities (0.1 to several A/cm 2 ) that can be applied to metal wire cathodes for several days. We detect neutrons from D-D reactions with scintillator-based detectors. For palladium targets, we find neutron yields as a function of cathode voltage that are over 100 times higher than yields expected for bare nuclei fusion at ion energies below 2 keV (center of mass frame). A possible explanation is a correction to the ion energy due to an electron screening potential of 1000 ± 250 eV, which increases the probability for tunneling through the repulsive Coulomb barrier. Finally, our compact, robust setup enables parametric studies of this effect at relatively low reaction energies.
Hypothesis Small-Angle Neutron Scattering (SANS) is a powerful technique for studying soft matter systems such as colloids, polymers, and lyotropic phases, providing nanoscale structural insights. However, its effectiveness is limited by low neutron flux, leading to long acquisition times and noisy data. Here, we hypothesize that Bayesian statistical inference using Gaussian Process Regression (GPR) can reconstruct high-fidelity scattering data from sparse measurements by leveraging intensity smoothness and continuity. Experiments and Simulations The method was benchmarked computationally and validated through SANS experiments on various soft matter systems, including wormlike micelles, colloidal suspensions, polymeric structures, and lyotropic phases. GPR-based inference was applied to both experimental and synthetic data to evaluate its effectiveness in noise reduction and intensity reconstruction. Findings GPR significantly enhances SANS data quality and therefore reducing measurement times by up to two orders of magnitude. This cost-effective approach maximizes experimental efficiency, enabling high-throughput studies and real-time monitoring of dynamic systems. It is particularly beneficial for weakly scattering and time-sensitive studies. Beyond SANS, this framework applies to other low-SNR techniques, including laboratory-based small-angle X-ray scattering and various dynamical scattering methods. Furthermore, it offers transformative potential for compact neutron sources, enhancing their viability for structural analysis in resource-limited settings.
In this paper, we present a theoretical model that allows a fast and accurate evaluation of ionic transport properties of realistic plasmas spanning from warm and dense to hot and dilute conditions, including mixtures. This is achieved by combining a recent kinetic theory based on effective interaction potentials with a model for the equilibrium radial density distribution based on an average atom model and the integral equations theory of fluids. Lastly, the model should find broad use in applications where nonideal plasma conditions are traversed, including inertial confinement fusion, compact astrophysical objects, solar and extrasolar planets, and numerous present-day high energy density laboratory experiments.
This ARPA-E BETHE project was aimed to design, build and test a fast-ramping HighTemperature Superconducting (HTS) Central Solenoid Model Coil (CSMC) that significantly derisks a full-size HTS Central Solenoid (CS) capable of driving and controlling the plasma current in a compact, high-field, low-cost tokamak power plant. The LBNL objectives and milestones for this project were divided into two distinct tracts: Diagnostics and Quench Simulation.
The development of new neutron detectors to replace helium-3 (3He) detectors is imperative due to a worldwide shortage of 3He following the draw down in nuclear weapons production since the end of the Cold War. The United States Department of Homeland Security would like to deploy monitors for the detection of neutron emissions from shipping containers housing illicit nuclear material; however, this effort has been put on hold until new replacements for 3He detectors can be developed. Scintillation Hydro-Gel for isotopic Neutron Emitters (SHINE) is a unique, first of its kind, 6Li-loaded quantum dot gel scintillator developed at INL. By incorporating 6Li with quantum dots in a gel matrix, SHINE displays the best properties of liquid and solid scintillators without their disadvantages such as continuous filtering to keep liquids free of contaminates, slow throughput of containers, higher base component costs, ‘dead’ voids in solid scintillators, and a high loading of 6Li without compromising on light transparency. Additionally, SHINE is completely eco-friendly, a breakthrough in high-efficiency detection systems. SHINE is a unique combination of 6LiCl, a highly water-soluble compound, and InP/ZnS core/shell quantum dots, which are poured into a gel-form using cross-linking polymers. In this presentation, SHINE has been successfully tested for neutron detection and shows promise as both a replacement for current 3He neutron detectors as well as potential use in handheld, compact neutron detection units and antineutrino detection.