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All sourcesNASA NTRSDOE OSTI
NASA NTRS2018

NASA's GEOS Composition Model Assessment of PM2.5 During Wildfires: Inferring the Impact of PM2.5 Exposure on Adverse Respiratory & Cardiovascular Conditions

Particulate matter pollution is a mixture of solid and liquid droplets floating in the air that can lead to reduced air quality and increased adverse health impact. Fine particulate matter (PM2.5) can be emitted into the air from anthropogenic sources such as the burning of fossil fuels, motor vehicles, and powerplant emissions. Exposure to PM2.5 can aggravate pre-existing respiratory and cardiovascular conditions. When PM2.5 is inhaled it can cause damage to the lungs such as reduced lung function and shortness of breath. After being inhaled PM2.5 can enter the bloodstream and cause harm to the heart. One major natural source of PM2.5 exposure is from wildfire smoke. The particulates within the smoke from the wildfires can spread from the initial source region, potentially impacting communities both near and far. During and after wildfire events, PM2.5 levels can exceed the WHO air quality guidelines (10 m.g/m^3 annual mean; 25 m.g/m^3 daily mean), becoming hazardous to an individual's health. Global models can be used to simulate the emission and transport of these particulates and subsequently they can be valuable to air quality forecasting in highly polluted areas. The NASA Goddard Earth Observing System (GEOS) Composition Forecast (GEOS-CF) system has been used to produce near-real time air quality forecasts of atmospheric composition at a high global resolution of 25x25 km2. The GEOS-CF system utilizes the GEOS weather forecast model coupled with GEOS-Chem (version 11) chemistry module to provide analyses and forecasts of various toxic air pollutants, including PM2.5. The GEOS-CF simulated high levels of PM2.5 (40 m.g/m^3 to 250 m.g/m^3 ), exceeding the WHO guidelines, during multiple recent regional and global wildfire seasons, including the 2017 Washington State and Northern and Southern California wildfire seasons. Furthermore, the GEOS-CF simulated PM2.5 applied to a human health assessment model, BenMAP (The Environmental Benefits Mapping and Analysis Program, version 1.3), estimates the impact on adverse respiratory health conditions due to PM2.5 exposure from wildfires. The GEOS-CF predicted PM2.5 during the wildfire season with the corresponding BenMAP results provides an assessment of the human health impact of PM2.5 exposure.

Saunders, Emily↗
NASA NTRS2018

GEOS-CF Model Assessment of PM2.5 During Wildfires: Inferring the Impact of PM2.5 Exposure on Adverse Respiratory & Cardiovascular Conditions

Exposure to fine particulate matter (PM2.5) can aggravate pre-existing respiratory and cardiovascular conditions. When PM2.5 is inhaled it can cause damage to the lungs such as reduced lung function and shortness of breath. After being inhaled PM2.5 can enter the bloodstream and cause harm to the heart. One major natural source of PM2.5 exposure is from wildfire smoke. The particulates within the smoke from the wildfires can spread from the initial source region, potentially impacting communities both near and far. During and after wildfire events, PM2.5 levels can exceed the WHO air quality guidelines (10 gm^3 annual mean; 25 gm^3 daily mean), becoming hazardous to an individual's health. Global models can be used to simulate the emission and transport of these particulates and subsequently they can be valuable to air quality forecasting in highly polluted areas. The NASA Goddard Earth Observing System (GEOS) version 5 Composition Forecast (GEOS-CF) system has been used to produce near-real time air quality forecasts of atmospheric composition at a high global resolution of 25 km. The GEOS-CF system utilizes the GEOS weather forecast model coupled with GEOS-Chem (version 11) chemistry module to provide analyses and forecasts of various toxic air pollutants, including PM2.5. The GEOS-CF simulated high levels of PM2.5 (40 gm^3 to 250 gm^3 ), exceeding the WHO guidelines, during multiple recent regional and global wildfire seasons, including the 2017 Seattle, WA and Los Angeles, CA wildfire seasons, and biomass burning events in India. Furthermore, the GEOS-CF simulated PM2.5 applied to a human health assessment model, BenMAP (The Environmental Benefits Mapping and Analysis Program, version 1.3), estimates the impact on adverse respiratory health conditions due to PM2.5 exposure from wildfires. The GEOS-CF predicted PM2.5 during the wildfire season with the corresponding BenMAP results provides an assessment of the human health impact of PM2.5 exposure.

Saunders, Emily↗
NASA NTRS2007

Expression of Genes Associated with DNA Damage Sensing in Human Fibroblasts Exposed to Low-dose-rate Gamma Rays

Understanding of the molecular response to low-dose and low-dose-rate radiation exposure is essential for the extrapolation of high-dose radiation risks to those at dose levels relevant to space and other environmental concerns. Most of the reported studies of gene expressions induced by low-dose or low-dose-rate radiation were carried out on exponentially growing cells. In the present study, we analyzed expressions of 84 genes associated with DNA damage sensing using real time PCR in human fibroblasts in mostly G1 phase of the cell cycle. The cells were exposed continuously to gamma rays at a dose rate of 0.8 cGy/hr for 1, 2, 6 or 24 hrs at 37 C throughout the exposure. The total RNA was isolated immediately after the exposure was terminated. Of the 84 genes, only a few showed significant changes of the expression level. Some of the genes (e.g. DDit3 and BTG2) were found to be up or down regulated only after a short period of exposure, while other genes (e.g. PRKDC) displayed a highest expression level at the 24 hr time point. The expression profiles for the exposed cells which had a smaller portion of G1 cells indicated more cell cycle signaling and DNA repair genes either up or down regulated. Interestingly, the panel of genes changed from radiation exposure in G1 cells is different from the panel in cells having less G1 arrest cells. The gene expression profile of the cells responding to low-dose-radiation insult apparently depends on the cell growth stage. The response pathway in G1 cells may differ from that in exponentially growing cells.

Zhang, Ye↗
NASA NTRS2010

Environmental Health Standards for Human Spacecraft

The discussion of air and water quality standards includes evidence-based standards, factors unique to spaceflight, effects from exposures to combinations of compounds, contingency versus nominal standards, tables of ISO standards for air quality (ppm) and water quality (mg/L), and updating of standards.

James John T.↗
DOE OSTI2024

Effects of photon irradiation in the presence and absence of hindlimb unloading on the behavioral performance and metabolic pathways in the plasma of Fischer rats

The space environment astronauts experience during space missions consists of multiple environmental challenges, including microgravity. In this study, we assessed the behavioral and cognitive performances of male Fisher rats 2 months after sham irradiation or total body irradiation with photons in the absence or presence of simulated microgravity. We analyzed the plasma collected 9 months after sham irradiation or total body irradiation for distinct alterations in metabolic pathways and to determine whether changes to metabolic measures were associated with specific behavioral and cognitive measures. A total of 344 male Fischer rats were irradiated with photons (6 MeV; 3, 8, or 10 Gy) in the absence or presence of simulated weightlessness achieved using hindlimb unloading (HU). To identify potential plasma biomarkers of photon radiation exposure or the HU condition for behavioral or cognitive performance, we performed regression analyses. The behavioral effects of HU on activity levels in an open field, measures of anxiety in an elevated plus maze, and anhedonia in the M&M consumption test were more pronounced than those of photon irradiation. Phenylalanine, tyrosine, and tryptophan metabolism, and phenylalanine metabolism and biosynthesis showed very strong pathway changes, following photon irradiation and HU in animals irradiated with 3 Gy. Here, 29 out of 101 plasma metabolites were associated with 1 out of 13 behavioral measures. In the absence of HU, 22 metabolites were related to behavioral and cognitive measures. In HU animals that were sham-irradiated or irradiated with 8 Gy, one metabolite was related to behavioral and cognitive measures. In HU animals irradiated with 3 Gy, six metabolites were related to behavioral and cognitive measures. These data suggest that it will be possible to develop stable plasma biomarkers of behavioral and cognitive performance, following environmental challenges like HU and radiation exposure.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS2025

Time Course of Effects of Carbon Dioxide Exposure on Physical and Cognitive Performance in a Simulated Surface Extravehicular Activity Contingency Scenario

INTRODUCTION Carbon dioxide (CO 2 ) is a metabolic byproduct produced by humans that must be scrubbed from the atmosphere by environmental control and life support systems in space vehicles and spacesuits to prevent buildup. Current nominal CO 2 limits are set by NASA Standard 3001, however, limits during contingency situations are not specified. The purpose of this study was to characterize and quantify the physiological, cognitive, and self-assessed symptom and performance metrics as a function of inspired CO 2 (P I CO 2 ) during a simulated 1-hour contingency lunar EVA scenario in virtual reality (VR). METHODS Fifteen healthy subjects completed 7 simulated EVA scenarios walking on a passive treadmill for one hour breathing dry, ambient air mixed with added CO 2 in a blind, counterbalanced manner (P I CO 2 : 0, 5, 10, 15, 20, 25, 30 mmHg) simulating a 2.0 km contingency EVA walkback to a habitat on the lunar surface in the event of a CO 2 scrubber malfunction. Subjects were immersed in a Lunar VR environment and asked to maintain their walking speed between 2.1 km/h and an upper limit individually calibrated to a fixed metabolic workload of 1.3 L/min of O 2 consumption, and performed periodic cognitive tasks and continuous cardiopulmonary measurements. Self-assessments of symptoms and task performance were measured via verbal Likert-scale survey at the onset of the walkback and at 10-minute intervals thereafter. RESULTS The time course of cardiopulmonary, cognitive, and self-reported responses at each level of P I CO 2 will be presented. All 15 subjects were able to complete the 1-hr walk back task at all CO 2 levels. Physiological responses were rapid, typically within 1 to 5 minutes. No effects of time were detected for cognitive measures. Symptomatic ratings of headache, shortness of breath, and fatigue demonstrated a time-course development, reaching asymptote after 40 minutes of CO 2 exposure. DISCUSSION These findings will inform the posture of risk associated with CO 2 exposure on human health and performance during microgravity and planetary surface operations, This will help inform decisions related to space suit and environmental life support hardware requirements and EVA operational limits for contingency extravehicular activity (EVA) scenarios.

carbon dioxide↗
NASA NTRSDate not supplied

The Effects of Spaceflight and Microgravity Exposure on Female Astronaut Health and Performance

Over the past half century, our understanding of the physiological effects of space exploration and microgravity exposure have improved immensely. Microgravity causes incredible changes to the human body that increase risk of injury upon return to Earth and lunar/planetary egress scenarios. This is due to deconditioning of the cardiovascular and skeletal muscle systems that reduce aerobic capacity and muscular strength. With upcoming exploration class missions, such as NASA’s Artemis lunar exploration program which aims to send the first female astronaut to the lunar surface by 2030, as well as a long-term goal of Martian exploration, maintaining astronaut health during extended-duration space flight is critical for achieving mission objectives. However, our understanding of these physiological implications due to microgravity are based primarily on flight studies of male astronauts and 1g bedrest analog study participants, with few investigations focusing specifically on females. Innate physiologic differences in endocrine signaling and reproductive function impact sex-dependent responses to various health conditions, treatments, and environmental factors in nearly every system in the body. Therefore, to assume comparable alterations in females in response to microgravity exposure may be inappropriate and consequentially, could lead to lasting impacts on female astronaut health and impact mission success. Moreover, differences in sex hormones may also influence the regulation of cardiovascular control during egress activity after space flight-induced deconditioning and blood volume loss (i.e., risk for orthostatic intolerance). Other potential physiological systems and factors related to musculoskeletal health and aerobic capacity that warrant investigation with respect to microgravity include endocrine/reproductive function, vascular control, bone mineral density/microarchitecture, and soft-tissue health. The purpose of this investigation is two-fold: 1) to summarize the data available from space flight and simulated bedrest analog exposures to begin addressing these gaps in knowledge regarding impacts to female astronaut health, and 2) to describe differences in demographic health characteristics, injury prevalence, and aerobic capacity and muscular strength in NASA female and male astronauts. Female astronauts make up 50% of Artemis-specific astronaut corps and the extent to which microgravity exposure impacts female cardiovascular and musculoskeletal health, and whether these alterations are consistent with their male counterparts, is inconclusive. With the growing inclusion of female astronauts in the NASA space program and the increased duration of missions beyond low Earth orbit, a greater understanding of the sex-specific adaptation to space travel will help determine the development of appropriate countermeasures for minimizing risk and maintaining health of all astronauts.

Nicole Christine Strock↗
NASA NTRS2023

The Effects of Space Flight and Microgravity Exposure on Female Astronaut Health and Performance

Over the past half century, our understanding of the physiological effects of space exploration and microgravity exposure have improved immensely. Microgravity causes incredible changes to the human body that increase risk of injury upon return to Earth and lunar/planetary egress scenarios. This is due to deconditioning of the cardiovascular and skeletal muscle systems that reduce aerobic capacity and muscular strength. With upcoming exploration class missions, such as NASA’s Artemis lunar exploration program which aims to send the first female astronaut to the lunar surface by 2030, as well as a long-term goal of Martian exploration, maintaining astronaut health during extended-duration space flight is critical for achieving mission objectives. However, our understanding of these physiological implications due to microgravity are based primarily on flight studies of male astronauts and 1g bed rest analog study participants, with few investigations focusing specifically on females. Innate physiologic differences in endocrine signaling and reproductive function impact sex-dependent responses to various health conditions, treatments, and environmental factors in nearly every system in the body. Therefore, to assume comparable alterations in females in response to microgravity exposure may be inappropriate and consequentially, could lead to lasting impacts on female astronaut health and impact mission success. Moreover, differences in sex hormones may also influence the regulation of cardiovascular control during egress activity after space flight-induced deconditioning and blood volume loss (i.e., risk for orthostatic intolerance). Other potential physiological systems and factors related to musculoskeletal health and aerobic capacity that warrant investigation with respect to microgravity include endocrine/reproductive function, vascular control, bone mineral density/microarchitecture, and soft-tissue health. The purpose of this investigation is two-fold: 1) to summarize the data available from space flight and simulated bed rest analog exposures to begin addressing these gaps in knowledge regarding impacts to female astronaut health, and 2) to describe differences in demographic health characteristics, injury prevalence, and aerobic capacity and muscular strength in NASA female and male astronauts. Female astronauts make up 50% of Artemis-specific astronaut corps and the extent to which microgravity exposure impacts female cardiovascular and musculoskeletal health, and whether these alterations are consistent with their male counterparts, is inconclusive. With the growing inclusion of female astronauts in the NASA space program and the increased duration of missions beyond low Earth orbit, a greater understanding of the sex-specific adaptation to space travel will help determine the development of appropriate countermeasures for minimizing risk and maintaining health of all astronauts.

Female Astronaut↗
NASA NTRSDate not supplied

The Effects of Space Flight and Microgravity Exposure on Female Astronaut Health and Performance

Over the past half century, our understanding of the physiological effects of space exploration and microgravity exposure have improved immensely. Microgravity causes incredible changes to the human body that increase risk of injury upon return to Earth and lunar/planetary egress scenarios. This is due to deconditioning of the cardiovascular and skeletal muscle systems that reduce aerobic capacity and muscular strength. With upcoming exploration class missions, such as NASA’s Artemis lunar exploration program which aims to send the first female astronaut to the lunar surface by 2030, as well as a long-term goal of Martian exploration, maintaining astronaut health during extended-duration space flight is critical for achieving mission objectives. However, our understanding of these physiological implications due to microgravity are based primarily on flight studies of male astronauts and 1g bed rest analog study participants, with few investigations focusing specifically on females. Innate physiologic differences in endocrine signaling and reproductive function impact sex-dependent responses to various health conditions, treatments, and environmental factors in nearly every system in the body. Therefore, to assume comparable alterations in females in response to microgravity exposure may be inappropriate and consequentially, could lead to lasting impacts on female astronaut health and impact mission success. Moreover, differences in sex hormones may also influence the regulation of cardiovascular control during egress activity after space flight-induced deconditioning and blood volume loss (i.e., risk for orthostatic intolerance). Other potential physiological systems and factors related to musculoskeletal health and aerobic capacity that warrant investigation with respect to microgravity include endocrine/reproductive function, vascular control, bone mineral density/microarchitecture, and soft-tissue health. The purpose of this investigation is two-fold: 1) to summarize the data available from space flight and simulated bed rest analog exposures to begin addressing these gaps in knowledge regarding impacts to female astronaut health, and 2) to describe differences in demographic health characteristics, injury prevalence, and aerobic capacity and muscular strength in NASA female and male astronauts. Female astronauts make up 50% of Artemis-specific astronaut corps and the extent to which microgravity exposure impacts female cardiovascular and musculoskeletal health, and whether these alterations are consistent with their male counterparts, is inconclusive. With the growing inclusion of female astronauts in the NASA space program and the increased duration of missions beyond low Earth orbit, a greater understanding of the sex-specific adaptation to space travel will help determine the development of appropriate countermeasures for minimizing risk and maintaining health of all astronauts.

Female Astronaut↗
NASA NTRS2000

Effects of microgravity on vestibular development and function in rats: genetics and environment

Our anatomical and behavioral studies of embryonic rats that developed in microgravity suggest that the vestibular sensory system, like the visual system, has genetically mediated processes of development that establish crude connections between the periphery and the brain. Environmental stimuli also regulate connection formation including terminal branch formation and fine-tuning of synaptic contacts. Axons of vestibular sensory neurons from gravistatic as well as linear acceleration receptors reach their targets in both microgravity and normal gravity, suggesting that this is a genetically regulated component of development. However, microgravity exposure delays the development of terminal branches and synapses in gravistatic but not linear acceleration-sensitive neurons and also produces behavioral changes. These latter changes reflect environmentally controlled processes of development.

manned↗
NASA NTRS2007

NASA-STD 3001 and the Human Integration Design Handbook (HIDH): Evolution of NASA-STD-3000

The Habitability & Environmental Factors and Space Medicine Divisions have developed the Space Flight Human System Standard (SFHSS) (NASA-STD-3001) to replace NASA-STD-3000 as a new NASA standard for all human spaceflight programs. The SFHSS is composed of 2 volumes. Volume 1, Crew Health, contains medical levels of care, permissible exposure limits, and fitness for duty criteria, and permissible outcome limits as a means of defining successful operating criteria for the human system. Volume 2, Habitability and Environmental Health, contains environmental, habitability and human factors standards. Development of the Human Integration Design Handbook (HIDH), a companion to the standard, is currently under construction and entails the update and revision of NASA-STD-3000 data. This new handbook will, in the fashion of NASA STD-3000, assist engineers and designers in appropriately applying habitability, environmental and human factors principles to spacecraft design. Organized in a chapter-module-element structure, the HIDH will provide the guidance for the development of requirements, design considerations, lessons learned, example solutions, background research, and assist in the identification of gaps and research needs in the disciplines. Subject matter experts have been and continue to be solicited to participate in the update of the chapters. The purpose is to build the HIDH with the best and latest data, and provide a broad representation from experts in industry, academia, the military and the space program. The handbook and the two standards volumes work together in a unique way to achieve the required level of human-system interface. All new NASA programs will be required to meet Volumes 1 and 2. Volume 2 presents human interface goals in broad, non-verifiable standards. Volume 2 also requires that each new development program prepare a set of program-specific human factors requirements. These program-specific human and environmental factors requirements must be verifiable and tailored to assure the new system meets the Volume 2 standards. Programs will use the HIDH to write their verifiable program-specific requirements.

Pickett, Lynn↗
DOE OSTI2025

Genomic reconstruction of Bacillus anthracis from complex environmental samples enables high-throughput identification and lineage assignment in Pakistan

Bacillus anthracis, the causative agent of anthrax, is a highly virulent zoonotic pathogen primarily affecting domesticated and wild herbivores. Human exposure to B. anthracis is primarily through contact with infected animals or contaminated animal products. In Pakistan, where livestock vaccines are largely unavailable and infected carcasses are often disposed of improperly, the risk to humans, wildlife and livestock is significant. Currently, the diagnosis of anthrax infections and outbreak tracing necessitates the isolation and culturing of B. anthracis, a process that requires BSL-3 facilities. In this study, we show that positive identification, genome reconstruction and lineage assignment can be accomplished using bioinformatic analysis of DNA extracted directly from environmental samples that would otherwise provide the starting material for isolation and culturing. This approach does not require laboratory target enrichment as is necessary for other pathogens, due in part to the extremely high bacterial load in the bloodstream in the deceased animals. Using these methods, we greatly expand the knowledge of endemic B. anthracis in Pakistan. We provide the first reference B. anthracis genomes from Pakistan since the 1970s and identify A.Br.014 Aust94 as a minor circulating sublineage alongside the dominant A.Br.047 Vollum. Future work will focus on the limits of detection and will determine if this bioinformatic method can be expanded more broadly for B. anthracis or other pathogens to replace typical culture-based methods.

A.Br.047 Vollum↗
NASA NTRS2005

Formaldehyde Concentration Dynamics of the International Space Station Cabin Atmosphere

Formaldehyde presents a significant challenge to maintaining cabin air quality on board crewed spacecraft. Generation sources include offgassing from a variety of non-metallic materials as well as human metabolism. Because generation sources are pervasive and human health can be affected by continual exposure to low concentrations, toxicology and air quality control engineering experts jointly identified formaldehyde as a key compound to be monitored as part the International Space Station's (ISS) environmental health monitoring and maintenance program. Data acquired from in-flight air quality monitoring methods are the basis for assessing the cabin environment's suitability for long-term habitation and monitoring the performance of passive and active controls that are in place to minimize crew exposure. Formaldehyde concentration trends and dynamics served in the ISS cabin atmosphere are reviewed implications to present and future flight operations discussed.

Perry, J. L.↗
NASA NTRS1996

Effects of Sonic Booms on Marine Mammals: Problem Review and Recommended Research

By flying the High-Speed Civil Transport (HSCT) exclusively over uninhabited areas and mo over water, human annoyance will be reduced to acceptable levels. However, this strategy will for HSCT proponents to contend with the potential effects of sonic booms on animals, particularly ma mammals. What follows is a summary of the environmental regulations that must be addressed, the scientific community's concerns about the potential effects of the HSCT, and recommendations fox research to address the most important concerns. The recommendations included herein are based both on existing scientific evidence and regulatory needs. One cannot over-emphasize the importance of obtaining the appropriate information prior to substantial public exposure. Recent controversies over other human-made acoustic sources in the ocean suggest that the HSCT will receive intense scrutiny. It seems certain that an Environmental Impact Statement (EIS) and Incidental Harassment Authorization (IHA) under the Marine Mammal Protection Act (MMPA) or its equivalent will be necessary.

Bowles, Ann E.↗
DOE OSTI2025

Tree architectural characteristics and stem and leaf functional traits for 17 individuals in the Central Amazon

Given recent increases in tree mortality rates in the Amazon forest following extreme drought and wind events, we tested if lower wood density and acquisitive plant functional traits were associated with increased growth and mortality for common co-occurring trees in the Central Amazon. Research was conducted at the ZF2 Research Station located north or Manaus, Brazil, managed by the Instituto Nacional de Pesquisas da Amazônia (INPA). Seventeen trees of different species with similar sizes but a range in wood density (WD) and wood traits were felled, then assessed for 27 different individual functional parameters, including whole tree architecture, stem xylem anatomical and hydraulic traits and leaf traits. Wood logs were collected at DBH, 50% stem length and at 100% stem length (at the base of the canopy). For wood anatomy samples, n=3-6 subsamples from each height. For leaf samples, 30 leaves were collected from the upper sunlit canopy. The methodology is detailed in the accompanying manuscript. The trait data are summarized in this file: "Trait_Summary.CSV". Summary Trait code abbreviations and units are described in this file: "Sample_Info_Traits_Summary.CSV". Stem traits measured along the bole from the base of the tree (DBH, diameter breast height), mid-stem, and base of the canopy are described in these files: "Sapwood_Area_height.CSV"; "Species_Info_height.CSV"; "Sample_Info_height.CSV"

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2023

Light Water Reactor Sustainability Program: Materials Research Pathway: FY 23 Technical Program Plan

Components in operating commercial nuclear power plants must withstand very harsh environments that include extended time at neutron and gamma irradiation, stress, and temperature, as well as possible exposure to corrosive media. The many modes of materials degradation are complex and often include synergies between multiple environmental variables and conditions that vary depending on locations and materials. Understanding and managing materials degradation is a requirement for the continued safe and reliable operation of nuclear power plants.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗