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Results for “MODEL VALIDATION”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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All sourcesNASA NTRSDOE OSTI
DOE OSTI2015

Testing and certification of the SAVY 4000 nuclear material container for DOT Type A liquid transport - 15636

Los Alamos National Laboratory has contracted with Nuclear Filter Technology, Inc. to perform testing and certification of the SAVY 4000 container for DOT Type A liquid transport. The container was originally designed to meet DOE M441.1-1 requirements for safe storage of nuclear material, and it is currently being used for storage at Los Alamos National Laboratory, Livermore National Laboratory, Idaho National Laboratory and Nevada National Security Site. The SAVY 4000 container is manufactured from 316L stainless steel in a range of sizes from 1 quart to 10 gallon capacity, it can be opened and closed easily by hand, it is sealed with a Viton{sup R} O-Ring, and the filter retains particulates and resists liquid water entry while allowing hydrogen gas to escape. Finite element analysis has been used to guide the development of a testing regime that includes a 30 foot drop, bar penetration, vibration, water spray and stacking for the 5 quart capacity container. The results of the tests will be compared with the finite element analysis to validate the model. The validated model is being used to extend the Type A certification to the other container sizes. This poster will describe the results of the Type A liquid testing, the finite element analysis, and the benefits of broadening the use and versatility of the container. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2021

Dark Energy Survey Year 3 Results: Multi-Probe Modeling Strategy and Validation

This paper details the modeling pipeline and validates the baseline analysis choices of the DES Year 3 joint analysis of galaxy clustering and weak lensing (a so-called "3$\times$2pt" analysis). These analysis choices include the specific combination of cosmological probes, priors on cosmological and systematics parameters, model parameterizations for systematic effects and related approximations, and angular scales where the model assumptions are validated. We run a large number of simulated likelihood analyses using synthetic data vectors to test the robustness of our baseline analysis. We demonstrate that the DES Year 3 modeling pipeline, including the calibrated scale cuts, is sufficiently accurate relative to the constraining power of the DES Year 3 analyses. Our systematics mitigation strategy accounts for astrophysical systematics, such as galaxy bias, intrinsic alignments, source and lens magnification, baryonic effects, and source clustering, as well as for uncertainties in modeling the matter power spectrum, reduced shear, and estimator effects. We further demonstrate excellent agreement between two independently-developed modeling pipelines, and thus rule out any residual uncertainties due to the numerical implementation.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2025

Modeling Sepsis: Establishment and Validation of a 72-Hour Swine Model of Penetrating Abdominal Trauma

Background/Objectives: Fecal peritonitis following penetrating abdominal trauma is a serious condition that often results in sepsis and organ failure. The aim of our study was to develop a novel conscious porcine model of sepsis and organ dysfunction caused by multiple penetrating injuries to the small and large intestines. Methods: Twelve female Yorkshire pigs (average weight 50.6 ± 6.5 kg) were divided into two groups: Penetrating Abdominal Trauma (PAT) (n = 8) and Control (n = 4). All surgical procedures were performed under anesthesia with adequate analgesia. In the PAT group, the small and large intestines were punctured, and feces mixed with saline were introduced into the abdominal cavity to induce peritonitis. The Control group received sham surgery with only saline solution. The animals were observed in a conscious state over a period of 72 h, vital parameters were recorded, and blood samples were taken regularly. We adapted a pig-specific SOFA score and developed pig-specific SIRS criteria and NEWS2 score to assess organ function. The model was validated by independent investigators. Results: The survival rate in the PAT group was 75%, with an average survival time of 58.5 h, while all animals in the Control group survived to euthanasia. Monitoring showed pathophysiological changes, such as tachycardia, leucopenia, and thrombocytopenia, indicative of sepsis and organ dysfunction. Blinded investigators independently confirmed the model’s validity. Conclusions: A new swine model of penetrating abdominal trauma and sepsis has been successfully developed that demonstrates significant physiological and immunologic changes comparable to human sepsis. This new model provides a realistic platform for future research into sepsis, its diagnostics, and the evaluation of therapeutic strategies.

General & Internal Medicine↗