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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 793 records · Page 44

Life in extreme environments: how will humans perform on Mars?

This review of astronaut extravehicular activity (EVA) and the details of American and Soviet/Russian spacesuit design focuses on design recommendations to enhance astronaut safety and effectiveness. Innovative spacesuit design is essential, given the challenges of future exploration-class missions in which astronauts will be called upon to perform increasingly complex and physically demanding tasks in the extreme environments of microgravity and partial gravity.

Non-NASA Center↗

Autotropism, automorphogenesis, and gravity

Segments of organs that have undergone gravitropic curvature later straighten during the course of gravitropism or after the g-vector becomes randomized on a clinostat. Little is known about the mechanism underlying these and perhaps related phenomena which have been described with various overlapping terms such as autotropism, autotropic straightening, automorphosis, automorphogenesis, automorphic curvature, and gravitropic straightening. The types of phenomena that historically have been named by the above terms are reviewed critically with respect to an interaction with gravitropism. We suggest that the term "autotropism" should not be applied to the phenomenon of organ straightening that occurs during the course of gravitropism, since this straightening is part of a complex series of local growth adjustments overall through time, and since this phenomenon is not itself a tropistic response to a directional exogenous stimulus. It is suggested that the term autotropism should be used only for the phenomenon of organ straightening that occurs after the g-vector is randomized on a clinostat or withdrawn in the microgravity conditions of spaceflight. Usage of the term automorphogenesis is most appropriate for describing curvatures or orientations that result from morphological relationships such as in nastic curvatures.

STS Shuttle Project↗

New approaches to the Doppler echocardiographic assessment of diastolic function: from research laboratory to clinical practice

Over the past decade, Doppler echocardiography has become a well-established tool for the diagnosis of left ventricular diastolic dysfunction. Unfortunately, in many clinical situations traditional Doppler indices of transmittal and pulmonary venous flow are inconclusive, primarily due to their dependence on left atrial pressure. Recently, new Doppler indices that are much less dependent on preload have been developed, based on intraventricular flow propagation and intrinsic myocardial velocity. These methodologies provide direct assessment of ventricular relaxation and the small intraventricular pressure gradients essential to efficient filling of the ventricle. We review in this article the theoretical and experiment background of these new echo techniques as well as how they can be implemented in routine clinical practice.

NASA Discipline Cardiopulmonary↗

Composting on Mars or the Moon: I. Comparative evaluation of process design alternatives

As a candidate technology for treating solid wastes and recovering resources in bioregenerative Advanced Life Support, composting potentially offers such advantages as compactness, low mass, near ambient reactor temperatures and pressures, reliability, flexibility, simplicity, and forgiveness of operational error or neglect. Importantly, the interactions among the physical, chemical, and biological factors that govern composting system behavior are well understood. This article comparatively evaluates five Generic Systems that describe the basic alternatives to composting facility design and control. These are: 1) passive aeration; 2) passive aeration abetted by mechanical agitation; 3) forced aeration--O2 feedback control; 4) forced aeration--temperature feedback control; 5) forced aeration--integrated O2 and temperature feedback control. Each of the five has a distinctive pattern of behavior and process performance characteristics. Only Systems 4 and 5 are judged to be viable candidates for ALS on alien worlds, though which is better suited in this application is yet to be determined.

Review↗

Maintaining safety and high performance on shiftwork

This review of the shiftwork area focuses on aspects of safety and productivity. It discusses the situations in which shiftworker performance is critical, the types of problem that can develop and the reasons why shiftworker performance can be impaired. The review ends with a discnssion of the various advantages and disadvantages of several shift rotation systems, and of other possible solutions to the problem.

Review↗

High sustained +Gz acceleration: physiological adaptation to high-G tolerance

Since the early 1940s, a significant volume of research has been conducted in an effort to describe the impact of acute exposures to high-G acceleration on cardiovascular mechanisms responsible to maintaining cerebral perfusion and conscious in high performance aircraft pilots during aerial combat maneuvers. The value of understanding hemodynamic characteristics that underlie G-induced loss of consciousness has been instrumental in the evolution of optimal technology development (e.g., G-suits, positive pressure breathing, COMBAT EDGE, etc.) and pilot training (e.g., anti-G straining maneuvers). Although the emphasis of research has been placed on the development of protection against acute high +Gz acceleration effects, recent observations suggest that adaptation of cardiovascular mechanism associated with blood pressure regulation may contribute to a protective 'G-training' effect. Regular training at high G enhances G tolerance in humans, rats, guinea pigs, and dogs while prolonged layoff from exposure in high G profiles (G-layoff) can result in reduced G endurance. It seems probable that adaptations in physiological functions following chronically-repeated high G exposure (G training) or G-layoff could have significant impacts on performance during sustained high-G acceleration since protective technology such as G-suits and anit-G straining maneuvers are applied consistently during these periods of training. The purpose of this paper is to present a review of new data from three experiments that support the notion that repeated exposure on a regular basis to high sustained +Gz acceleration induces significant physiological adaptations which are associated with improved blood pressure regulation and subsequent protection of cerebral perfusion during orthostatic challenges.

Review, Tutorial↗

The role of extraterrestrial phenomena in extinction

In the several years since the Alvarez report of anomalously high iridium concentrations at the Cretaceous-Tertiary boundary, evidence for the involvement of meteorite impacts in biological extinction has increased dramatically. Much more research will be needed, however, before meteorite impact is established as a general causal factor in extinction. Of ever greater long-term interest is the possibility that other extraterrestrial forces have had important influences on the evolution of life. To recognize the effects of such forces, it will be necessary to coordinate the research of astronomy and paleontology so that testable predictions can be formulated. It is possible that known, systematic changes in the Solar System or Galaxy have had effects on global biology and that these effects have been preserved in the paleontological record.

Non-NASA Center↗

Mass extinction: a commentary

Four neocatastrophist claims about mass extinction are currently being debated; they are that: 1, the late Cretaceous mass extinction was caused by large body impact; 2, as many as five other major extinctions were caused by impact; 3, the timing of extinction events since the Permian is uniformly periodic; and 4, the ages of impact craters on Earth are also periodic and in phase with the extinctions. Although strongly interconnected the four claims are independent in the sense that none depends on the others. Evidence for a link between impact and extinction is strong but still needs more confirmation through bed-by-bed and laboratory studies. An important area for future research is the question of whether extinction is a continuous process, with the rate increasing at times of mass extinctions, or whether it is episodic at all scales. If the latter is shown to be generally true, then species are at risk of extinction only rarely during their existence and catastrophism, in the sense of isolated events of extreme stress, is indicated. This is line of reasoning can only be considered an hypothesis for testing. In a larger context, paleontologists may benefit from a research strategy that looks to known Solar System and Galactic phenomena for predictions about environmental effects on earth. The recent success in the recognition of Milankovitch Cycles in the late Pleistocene record is an example of the potential of this research area.

Review, Tutorial↗

Theoretical constraints on oxygen and carbon dioxide concentrations in the Precambrian atmosphere

Simple (one-dimensional) climate models suggest that carbon dioxide concentrations during the Archean must have been at least 100-1000 times the present level to keep the Earth's surface temperature above freezing in the face of decreased solar luminosity. Such models provide only lower bounds on CO2, so it is possible that CO2 levels were substantially higher than this and that the Archean climate was much warmer than today. Periods of extensive glaciation during the early and late Proterozoic, on the other hand, indicate that the climate at these times was relatively cool. To be consistent with climate models CO2 partial pressures must have declined from approximately 0.03 to 0.3 bar around 2.5 Ga ago to between 10(-3) and 10(-2) bar at 0.8 Ga ago. This steep decrease in carbon dioxide concentrations may be inconsistent with paleosol data, which implies that pCO2 did not change appreciably during that time. Oxygen was essentially absent from the Earth's atmosphere and oceans prior to the emergence of a photosynthetic source, probably during the late Archean. During the early Proterozoic the atmosphere and surface ocean were apparently oxidizing, while the deep ocean remained reducing. An upper limit of 6 x 10(-3) bar for pO2 at this time can be derived by balancing the burial rate of organic carbon with the rate of oxidation of ferrous iron in the deep ocean. The establishment of oxidizing conditions in the deep ocean, marked by the disappearance of banded iron formations approximately 1.7 Ga ago, permitted atmospheric oxygen to climb to its present level. O2 concentrations may have remained substantially lower than today, however, until well into the Phanerozoic.

Review, Tutorial↗

Community living long before man: fossil and living microbial mats and early life

Microbial mats are layered communities of bacteria that form cohesive structures, some of which are preserved in sedimentary rocks as stromatolites. Certain rocks, approximately three and a half thousand million years old and representing the oldest known fossils, are interpreted to derive from microbial mats and to contain fossils of microorganisms. Modern microbial mats (such as the one described here from Matanzas, Cuba) and their fossil counterparts are of great interest in the interpretation of early life on Earth. Since examination of microbial mats and stromatolites increases our understanding of long-term stability and change, within the global environment, such structures should be protected wherever possible as natural science preserves. Furthermore, since they have existed virtually from the time of life's origin, microbial mats have developed exemplary mechanisms of local community persistence and may even play roles in the larger global environment that we do not understand.

NASA Discipline Exobiology↗

Metabolism of proteinoid microspheres

The literature of metabolism in proteinoids and proteinoid microspheres is reviewed and criticized from a biochemical and experimental point of view. Closely related literature is also reviewed in order to understand the function of proteinoids and proteinoid microspheres. Proteinoids or proteinoid microspheres have many activities. Esterolyis, decarboxylation, amination, deamination, and oxidoreduction are catabolic enzyme activities. The formation of ATP, peptides or oligonucleotides is synthetic enzyme activities. Additional activities are hormonal and inhibitory. Selective formation of peptides is an activity of nucleoproteinoid microspheres; these are a model for ribosomes. Mechanisms of peptide and oligonucleotide syntheses from amino acids and nucleotide triphosphate by proteinoid microspheres are tentatively proposed as an integrative consequence of reviewing the literature.

Non-NASA Center↗

Metabolism of proteinoid microspheres

The literature of metabolism in proteinoids and proteinoid microspheres is reviewed and criticized from a biochemical and experimental point of view. Closely related literature is also reviewed in order to understand the function of proteinoids and proteinoid microspheres. Proteinoids or proteinoid microspheres have many activities. Esterolysis, decarboxylation, amination, deamination, and oxidoreduction are catabolic enzyme activities. The formation of ATP, peptides or oligonucleotides is synthetic enzyme activities. Additional activities are hormonal and inhibitory. Selective formation of peptides is an activity of nucleoproteinoid microspheres; these are a model for ribosomes. Mechanisms of peptide and oligonucleotide syntheses from amino acids and nucleotide triphosphate by proteinoid microspheres are tentatively proposed as an integrative consequence of reviewing the literature.

Non-NASA Center↗

Molecular selection in a unified evolutionary sequence

With guidance from experiments and observations that indicate internally limited phenomena, an outline of unified evolutionary sequence is inferred. Such unification is not visible for a context of random matrix and random mutation. The sequence proceeds from Big Bang through prebiotic matter, protocells, through the evolving cell via molecular and natural selection, to mind, behavior, and society.

Review, Tutorial↗

Diagnosis and management of baroreflex failure

Baroreflex failure has a range of presentations, varying from the acute onset of a hypertensive crisis to a chronically volatile blood pressure and heart rate with hypertensive surges in response to stress, punctuated by periods of normal or even low blood pressure during rest. Differentiating this syndrome from other causes of labile hypertension is essential in devising effective treatment.

Review, Tutorial↗

Engineering plants for spaceflight environments

The conversion efficiency of radiation into biomass and yield has steadily increased for centuries because of continued improvement in both plant genetics and environmental control. Considerable effort has gone into improving the environment for plant growth in space, but work has only begun to engineer plants for spaceflight. Genetic manipulation offers tremendous potential to improve our ability to study gravitational effects. Genetic manipulation will also be necessary to build an efficient regenerative life support system. We cannot fully characterize plant response to the spaceflight environment without understanding and manipulating their genetic composition. Identification and selection of the existing germplasm is the first step. There are thousands of cultivars of each of our major crop plants, each specifically adapted to a unique environment on our planet. Thousands of additional lines are held in national germplasm collections to maintain genetic diversity. Spaceflight imposes the need to tap this diversity. Existing lines need to be evaluated in the environment that is characteristic of closed-system spaceflight conditions. Many of the plant growth challenges we confront in space can be better solved through genetic change than by hardware engineering. Ten thousand years of plant breeding has demonstrated the value of matching genetics with the environment. For example, providing continuous light can increase plant growth in space, but this often induces calcium deficiencies because Ca is not supplied by guttation during a dark period. This deficiency cannot be eliminated through increased root-zone and foliar Ca applications. It can be solved, in wheat, through genetic selection of lines that do not have the deficiency. Subsequent comparison of lines with and without the Ca deficiency has also helped us understand the nature of the problem.

Non-NASA Center↗

Microgravity cultivation of cells and tissues

In vitro studies of cells and tissues in microgravity, either simulated by cultivation conditions on earth or actual, during spaceflight, are expected to help identify mechanisms underlying gravity sensing and transduction in biological organisms. In this paper, we review rotating bioreactor studies of engineered skeletal and cardiovascular tissues carried out in unit gravity, a four month long cartilage tissue engineering study carried out aboard the Mir Space Station, and the ongoing laboratory development and testing of a system for cell and tissue cultivation aboard the International Space Station.

Review, Tutorial↗