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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 829 records · Page 46
All sourcesNASA NTRSDOE OSTI
DOE OSTI2018

The influence of Arctic amplification on mid-latitude summer circulation

Accelerated warming in the Arctic, as compared to the rest of the globe, might have profound impacts on mid-latitude weather. Most studies analyzing Arctic links to mid-latitude weather focused on winter, yet recent summers have seen strong reductions in sea-ice extent and snow cover, a weakened equator-to-pole thermal gradient and associated weakening of the mid-latitude circulation. We review the scientific evidence behind three leading hypotheses on the influence of Arctic changes on mid-latitude summer weather: Weakened storm tracks, shifted jet streams, and amplified quasi-stationary waves. We show that interactions between Arctic teleconnections and other remote and regional feedback processes could lead to more persistent hot-dry extremes in the mid-latitudes. The exact nature of these non-linear interactions is not well quantified but they provide potential high-impact risks for society.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2022

Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the pandemic of the coronavirus induced disease 2019 (COVID-19) with evolving variants of concern. It remains urgent to identify novel approaches against broad strains of SARS-CoV-2, which infect host cells via the entry receptor angiotensin-converting enzyme 2 (ACE2). Herein, we report an increase in circulating extracellular vesicles (EVs) that express ACE2 (evACE2) in plasma of COVID-19 patients, which levels are associated with severe pathogenesis. Importantly, evACE2 isolated from human plasma or cells neutralizes SARS-CoV-2 infection by competing with cellular ACE2. Compared to vesicle-free recombinant human ACE2 (rhACE2), evACE2 shows a 135-fold higher potency in blocking the binding of the viral spike protein RBD, and a 60- to 80-fold higher efficacy in preventing infections by both pseudotyped and authentic SARS-CoV-2. Consistently, evACE2 protects the hACE2 transgenic mice from SARS-CoV-2-induced lung injury and mortality. Furthermore, evACE2 inhibits the infection of SARS-CoV-2 variants (α, β, and δ) with equal or higher potency than for the wildtype strain, supporting a broad-spectrum antiviral mechanism of evACE2 for therapeutic development to block the infection of existing and future coronaviruses that use the ACE2 receptor.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2022

Robust but weak winter atmospheric circulation response to future Arctic sea ice loss

The possibility that Arctic sea ice loss weakens mid-latitude westerlies, promoting more severe cold winters, has sparked more than a decade of scientific debate, with apparent support from observations but inconclusive modelling evidence. Here we show that sixteen models contributing to the Polar Amplification Model Intercomparison Project simulate a weakening of mid-latitude westerlies in response to projected Arctic sea ice loss. We develop an emergent constraint based on eddy feedback, which is 1.2 to 3 times too weak in the models, suggesting that the real-world weakening lies towards the higher end of the model simulations. Still, the modelled response to Arctic sea ice loss is weak: the North Atlantic Oscillation response is similar in magnitude and offsets the projected response to increased greenhouse gases, but would only account for around 10% of variations in individual years. We further find that relationships between Arctic sea ice and atmospheric circulation have weakened recently in observations and are no longer inconsistent with those in models.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2022

Model spread in tropical low cloud feedback tied to overturning circulation response to warming

Among models participating in the Coupled Model Intercomparison Project phase 6 (CMIP6), here we show that the magnitude of the tropical low cloud feedback, which contributes considerably to uncertainty in estimates of climate sensitivity, is intimately linked to tropical deep convection and its effects on the tropical atmospheric overturning circulation. First, a reduction in tropical ascent area and an increased frequency of heavy precipitation result in high cloud reduction and upper-tropospheric drying, which increases longwave cooling and reduces subsidence weakening, favoring low cloud reduction (Radiation-Subsidence Pathway). Second, increased longwave cooling decreases tropospheric stability, which also reduces subsidence weakening and low cloudiness (Stability-Subsidence Pathway). In summary, greater high cloud reduction and upper-tropospheric drying (negative longwave feedback) lead to a more positive cloud feedback among CMIP6 models by contributing to a greater reduction in low cloudiness (positive shortwave feedback). Varying strengths of the two pathways contribute considerably to the intermodel spread in climate sensitivity.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2023

Likely accelerated weakening of Atlantic overturning circulation emerges in optimal salinity fingerprint

The long-term response of the Atlantic meridional overturning circulation (AMOC) to anthropogenic forcing has been difficult to detect from the short direct measurements available due to strong interdecadal variability. Here, we present observational and modeling evidence for a likely accelerated weakening of the AMOC since the 1980s under the combined forcing of anthropogenic greenhouse gases and aerosols. This likely accelerated AMOC weakening signal can be detected in the AMOC fingerprint of salinity pileup remotely in the South Atlantic, but not in the classic warming hole fingerprint locally in the North Atlantic, because the latter is contaminated by the “noise” of interdecadal variability. Our optimal salinity fingerprint retains much of the signal of the long-term AMOC trend response to anthropogenic forcing, while dynamically filtering out shorter climate variability. Given the ongoing anthropogenic forcing, our study indicates a potential further acceleration of AMOC weakening with associated climate impacts in the coming decades.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2023

Summer atmospheric circulation over Greenland in response to Arctic amplification and diminished spring snow cover

Abstract The exceptional atmospheric conditions that have accelerated Greenland Ice Sheet mass loss in recent decades have been repeatedly recognized as a possible dynamical response to Arctic amplification. Here, we present evidence of two potentially synergistic mechanisms linking high-latitude warming to the observed increase in Greenland blocking. Consistent with a prominent hypothesis associating Arctic amplification and persistent weather extremes, we show that the summer atmospheric circulation over the North Atlantic has become wavier and link this wavier flow to more prevalent Greenland blocking. While a concomitant decline in terrestrial snow cover has likely contributed to this mechanism by further amplifying warming at high latitudes, we also show that there is a direct stationary Rossby wave response to low spring North American snow cover that enforces an anomalous anticyclone over Greenland, thus helping to anchor the ridge over Greenland in this wavier atmospheric state.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2024

Increased Asian aerosols drive a slowdown of Atlantic Meridional Overturning Circulation

Observational evidence and climate model experiments suggest a slowdown of the Atlantic Meridional Overturning Circulation (AMOC) since the mid-1990s. Increased greenhouse gases and the declined anthropogenic aerosols (AAs) over North America and Europe are believed to contribute to the AMOC slowdown. Asian AAs continue to increase but the associated impact has been unclear. Using ensembles of climate simulations, here we show that the radiative cooling resulting from increased Asian AAs drives an AMOC reduction. The increased AAs over Asia generate circumglobal stationary Rossby waves in the northern midlatitudes, which shift the westerly jet stream southward and weaken the subpolar North Atlantic westerlies. Consequently, reduced transport of cold air from North America hinders water mass transformation in the Labrador Sea and thus contributes to the AMOC slowdown. The link between increased Asian AAs and an AMOC slowdown is supported by different models with different configurations. Thus, reducing emissions of Asian AAs will not only lower local air pollution, but also help stabilize the AMOC.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2025

Computational ranking identifies Plexin-B2 in circulating tumor cell clustering with monocytes in breast cancer metastasis

Abstract Multicellular circulating tumor cell (CTC) clusters can be up to 50 times more efficient than single CTCs in mediating viable metastasis. Here, combining computational ranking and functional determination, we identify the transmembrane protein Plexin-B2 (PLXNB2) as one of the top molecular targets associated with unfavorable distant metastasis-free survival, showing enriched expression in CTC clusters versus single CTCs from patients with advanced breast cancer (mostly female). Loss of PLXNB2 (Plxnb2) reduces the formation of homotypic tumor cell clusters and heterotypic tumor-myeloid cell clusters, reducing spontaneous metastases in female mice bearing human (mouse) breast cancer. Interactions of PLXNB2 with its ligands SEMA4C on tumor cells and SEMA4A on myeloid cells (monocytes) promote homotypic and heterotypic CTC cluster formation, respectively, thereby driving lung metastasis. Global proteomic analysis reveals downstream effectors of the PLXNB2 pathway associated with tumor cell clustering. Thus, PLXNB2 is a therapeutic target for preventing new metastasis in breast cancer.

Science & Technology - Other Topics↗
DOE OSTI2019

The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain

A(H3N2) virus predominated recent influenza seasons, which has resulted in the rigorous investigation of haemagglutinin, but whether neuraminidase (NA) has undergone antigenic change and contributed to the predominance of A(H3N2) virus is unknown. In this work, we show that the NA of the circulating A(H3N2) viruses has experienced significant antigenic drift since 2016 compared with the A/Hong Kong/4801/2014 vaccine strain. This antigenic drift was mainly caused by amino acid mutations at NA residues 245, 247 (S245N/S247T; introducing an N-linked glycosylation site at residue 245) and 468. As a result, the binding of the NA of A(H3N2) virus by some human monoclonal antibodies, including those that have broad reactivity to the NA of the 1957 A(H2N2) and 1968 A(H3N2) reference pandemic viruses as well as contemporary A(H3N2) strains, was reduced or abolished. This antigenic drift also reduced NA-antibody-based protection against in vivo virus challenge. X-ray crystallography showed that the glycosylation site at residue 245 is within a conserved epitope that overlaps the NA active site, explaining why it impacts antibody binding. Our findings suggest that NA antigenic drift impacts protection against influenza virus infection, thus highlighting the importance of including NA antigenicity for consideration in the optimization of influenza vaccines.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2020

Noise-induced transitions of the Atlantic Meridional Overturning Circulation in CMIP5 models

By studying transition probabilities of the Atlantic Meridional Overturning Circulation (AMOC) in an ensemble of CMIP5 climate models, we revisit one of the stability indicators of the AMOC, i.e. the freshwater transport carried by the AMOC at the southern boundary of the Atlantic basin. A correction to this indicator, based on the transition probabilities, is suggested to measure whether an AMOC state is in a multiple equilibrium regime or not. As a consequence, the AMOC of all CMIP5 models considered is in a multiple equilibrium regime and hence, in principle, a collapsed AMOC state should exist in each of these models. The results further demonstrate the dependence of the Atlantic surface freshwater flux on the AMOC and the impact of extreme events in the AMOC on temperatures in the North Atlantic region.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2022

Changes in Hadley circulation and intertropical convergence zone under strategic stratospheric aerosol geoengineering

Stratospheric aerosol geoengineering has been proposed as a potential solution to reduce climate change and its impacts. Here, we explore the responses of the Hadley circulation (HC) intensity and the intertropical convergence zone (ITCZ) using the strategic stratospheric aerosol geoengineering, in which sulfur dioxide was injected into the stratosphere at four different locations to maintain the global-mean surface temperature and the interhemispheric and equator-to-pole temperature gradients at present-day values (baseline). Simulations show that, relative to the baseline, strategic stratospheric aerosol geoengineering generally maintains northern winter December–January–February (DJF) HC intensity under RCP8.5, while it overcompensates for the greenhouse gas (GHG)-forced southern winter June–July–August (JJA) HC intensity increase, producing a 3.5 ± 0.4% weakening. The residual change of southern HC intensity in JJA is mainly associated with stratospheric heating and tropospheric temperature response due to enhanced stratospheric aerosol concentrations. Geoengineering overcompensates for the GHG-driven northward ITCZ shifts, producing 0.7° ± 0.1° and 0.2° ± 0.1° latitude southward migrations in JJA and DJF, respectively relative to the baseline. These migrations are affected by tropical interhemispheric temperature differences both at the surface and in the free troposphere. Further strategies for reducing the residual change of HC intensity and ITCZ shifts under stratospheric aerosol geoengineering could involve minimizing stratospheric heating and restoring and preserving the present-day tropical tropospheric interhemispheric temperature differences.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2021

Summertime low clouds mediate the impact of the large-scale circulation on Arctic sea ice

The rapid Arctic sea ice retreat in the early 21 st century is believed to be driven by several dynamic and thermodynamic feedbacks, such as ice-albedo feedback and water vapor feedback. However, the role of clouds in these feedbacks remains unclear since the causality between clouds and these processes is complex. Here, we use NASA CERES satellite products and NCAR CESM model simulations to suggest that summertime low clouds have played an important role in driving sea ice melt by amplifying the adiabatic warming induced by a stronger anticyclonic circulation aloft. The upper-level high pressure regulates low clouds through stronger downward motion and increasing lower troposphere relative humidity. The increased low clouds favor more sea ice melt via emitting stronger longwave radiation. Then decreased surface albedo triggers a positive ice-albedo feedback, which further enhances sea ice melt. Considering the importance of summertime low clouds, accurate simulation of this process is a prerequisite for climate models to produce reliable future projections of Arctic sea ice.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2023

Human-induced changes in the global meridional overturning circulation are emerging from the Southern Ocean

In a warming climate, the Global Meridional Overturning Circulation (GMOC) is expected to change significantly with a risk of disrupting the global redistribution of ocean properties that sustains marine ecosystems, carbon cycle, and others. Here we make a novel attempt to utilize a diagnostic ocean & sea-ice model to estimate the GMOC and its interdecadal changes since the mid-1950s that are consistent with historical hydrographic observations. We find that significant changes in the GMOC have already occurred, most notably in the upper and lower overturning cells in the Southern Ocean. The former has expanded poleward and into denser water and strengthened by 3–4 Sv since the mid-1970s, while the latter has contracted and weakened by a similar rate during the same period. These changes are driven by the increasing Southern Hemisphere (SH) Ferrel cell and associated increases in the westerlies and the surface buoyancy loss over its sinking branch, and the increasing Antarctic meltwater discharge, in response to ozone depletion in the SH stratosphere and increasing atmospheric CO 2 . A large-scale readjustment of the GMOC seems to be underway in the South Atlantic and Indo-Pacific Oceans since the mid-2000s in response to the Southern Ocean changes.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2016

A gas circulation and purification system for gas-cell-based low-energy RI-beam production

A gas circulation and purification system was developed at the RIKEN Radioactive Isotope Beam Factory that can be used for gas-cell-based low-energy RI-beam production. A high-flow-rate gas cell filled with one atmosphere of buffer gas (argon or helium) is used for the deceleration and thermalization of high-energy RI-beams. The exhausted buffer gas is efficiently collected using a compact dry pump and returned to the gas cell with a recovery efficiency of >97%. The buffer gas is efficiently purified using two gas purifiers as well as collision cleaning, which eliminates impurities in the gas. An impurity level of one part per billion is achieved with this method.

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEA↗
DOE OSTI2015

MERIDIONAL CIRCULATION IN THE SOLAR CONVECTION ZONE: TIME–DISTANCE HELIOSEISMIC INFERENCES FROM FOUR YEARS OF HMI/SDO OBSERVATIONS

We present and discuss results from time–distance helioseismic measurements of meridional circulation (MC) in the solar convection zone using 4 yr of Doppler velocity observations by the Helioseismic and Magnetic Imager on board the Solar Dynamics Observatory. Using a built-in mass conservation constraint in terms of the stream function, we invert helioseismic travel times to infer the MC in the solar convection zone. We find that the return flow that closes the MC is possibly beneath the depth of 0.77 R{sub ⊙}. We discuss the significance of this result in relation to other helioseismic inferences published recently and possible reasons for the differences in the results. Our results show clearly the pitfalls involved in the measurements of material flows in the deep solar interior given the current limits on the signal-to-noise ratio and our limited understanding of systematics in the data. We also discuss the implications of our results for the dynamics of solar interior and popular solar dynamo models.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2015

ESTIMATING THE DEEP SOLAR MERIDIONAL CIRCULATION USING MAGNETIC OBSERVATIONS AND A DYNAMO MODEL: A VARIATIONAL APPROACH

We show how magnetic observations of the Sun can be used in conjunction with an axisymmetric flux-transport solar dynamo model in order to estimate the large-scale meridional circulation throughout the convection zone. Our innovative approach rests on variational data assimilation, whereby the distance between predictions and observations (measured by an objective function) is iteratively minimized by means of an optimization algorithm seeking the meridional flow that best accounts for the data. The minimization is performed using a quasi-Newton technique, which requires knowledge of the sensitivity of the objective function to the meridional flow. That sensitivity is efficiently computed via the integration of the adjoint flux-transport dynamo model. Closed-loop (also known as twin) experiments using synthetic data demonstrate the validity and accuracy of this technique for a variety of meridional flow configurations, ranging from unicellular and equatorially symmetric to multicellular and equatorially asymmetric. In this well-controlled synthetic context, we perform a systematic study of the behavior of our variational approach under different observational configurations by varying their spatial density, temporal density, and noise level, as well as the width of the assimilation window. We find that the method is remarkably robust, leading in most cases to a recovery of the true meridional flow to within better than 1%. These encouraging results are a first step toward using this technique to (i) better constrain the physical processes occurring inside the Sun and (ii) better predict solar activity on decadal timescales.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2023

Polymerase chain reaction for the in vitro detection of the pESI plasmid associated with the globally circulating Salmonella Infantis outbreak strain

Abstract A globally circulating strain of Salmonella enterica serotype Infantis containing the pESI plasmid has increased in prevalence in poultry meat samples and cases of human infections. In this study, a polymerase chain reaction (PCR) protocol was designed to detect the pESI plasmid and confirm the Infantis serotype of Salmonella isolates. Primers were tested bioinformatically to predict specificity, sensitivity, and precision. A total of 54 isolates of Salmonella serotypes Infantis, Senftenberg, and Alachua were tested, with and without the pESI plasmid carriage. Isolates of 31 additional serotypes were also screened to confirm specificity to Infantis. Specificity, sensitivity, and precision of each primer were >0.95. All isolates tested produced the expected band sizes. This PCR protocol provides a rapid and clear result for the detection of the pESI plasmid and serotype Infantis and will allow for the in vitro detection for epidemiological studies where whole-genome sequencing is not available.

McMillan, Elizabeth A. (ORCID:000000027503514X)↗
DOE OSTI2017

Statistics of velocity fluctuations of Geldart A particles in a circulating fluidized bed riser

Here, the statistics of fluctuating velocity components are studied in the riser of a closed-loop circulating fluidized bed with fluid catalytic cracking catalyst particles. Our analysis shows distinct similarities as well as deviations compared to existing theories and bench-scale experiments. The study confirms anisotropic and non-Maxwellian distribution of fluctuating velocity components. The velocity distribution functions (VDFs) corresponding to transverse fluctuations exhibit symmetry, and follow a stretched-exponential behavior up to three standard deviations. The form of the transverse VDF is largely determined by interparticle interactions. The tails become more overpopulated with an increase in particle loading. The observed deviations from the Gaussian distribution are represented using the leading order term in the Sonine expansion, which is commonly used to approximate the VDFs in kinetic theory for granular flows. The vertical fluctuating VDFs are asymmetric and the skewness shifts as the wall is approached. In comparison to transverse fluctuations, the vertical VDF is determined by the local hydrodynamics. This is an observation of particle velocity fluctuations in a large-scale system and their quantitative comparison with the Maxwell-Boltzmann statistics.

42 ENGINEERING↗